王成
副教授 副主任医师 博士生导师


导师简介

广州市珠江科技新星
广东特支计划百千万工程青年拔尖人才
广东省“千百十人才工程”第八批培养对象
[学位/学历]
医学硕士 （中山大学 口腔临床医学）
医学博士 （中山大学 口腔临床医学）
[学术简历]
2010-2011年 美国伊利诺伊大学芝加哥分校 访问****
2011-2013年 中山大学光华口腔医学院 主治医师/讲师
2014年-至今 中山大学光华口腔医学院 副主任医师/副教授
[研究方向]
1.口腔癌分子发病机制
2.口腔癌精准治疗
[主持课题]
1.2016-2019年，FOSL1 ceRNA网络调控舌鳞癌Tumor budding细胞侵袭转移的分子机制，国家自然科学基金面上项目，72万
2.2014-2017年，PRC2-ncRNA“交互对话”调控舌鳞癌侵袭转移的分子机制，广州市珠江科技新星专项目，30万
3.2013-2015年，EZH2调控miRNAs促进舌鳞癌侵袭转移的分子机制，国家自然科学基金青年项目，24万
4.2012-2014年，miR-204调控EMT促进舌鳞癌侵袭转移的分子机制，中央高校基本科研业务费专项资金，15万
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[发表论文]
1.Molecular Mechanisms of Chemoresistance in Oral Cancer. Chin J Dent Res. 2016;19(1):25-33.
2.Tumor budding correlates with occult cervical lymph node metastasis and poor prognosis in clinical early-stage tongue squamous cell carcinoma. J Oral Pathol Med. J Oral Pathol Med. 2015 ;44(4):266-72.
3.Beclin1 inhibits proliferation, migration and invasion in tongue squamous cell carcinoma cell lines. Oral Oncol. 2014;50(10):983-90.
4.Decrease of autophagy activity promotes malignant progression of tongue squamous cell carcinoma. J Oral Pathol Med. 2013 Aug;42(7):557-64.
5.Polycomb group protein EZH2-mediated E-cadherin repression promotes metastasis of oral tongue squamous cell carcinoma. Mol Carcinog. 2013;52(3):229-36.
6.Deregulation of Snai2 is associated with metastasis and poor prognosis in tongue squmous cell carcinoma. Int J Cancer. 2012;130(10):2249-58.
7.Tumor budding correlates with poor prognosis and epithelial- mesenchymal transition in tongue squamous cell carcinoma. J Oral Pathol Med. 2011;40(7):545-51.
8.Molecular characterization of the microRNA-138-Fos-like antigen 1 (FOSL1) regulatory module in squamous cell carcinoma. J Biol Chem. 2011;286(46):40104-9.
9.MicroRNA-138 suppresses epithelial-mesenchymal transition in squamous cell carcinoma cell lines. Biochem J. 2011;440(1):23-31.
10.Simultaneous maxillomandibular distraction osteogenesis in severe progressive hemifacial atrophy with two distractors. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011;111(3):292-7.
11.The study of distraction osteogenesis with nitinol shape memory alloy controlled by infrared light. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;110(2):157-66.
12.Osteofascial Compartment Syndrome: A Rare and Severe Complication Involved in Free Fibula Osteocutaneous Flaps and a Kind of Its Treatments. J Craniofac Surg. 2011;22(3):1100-2.
13.MicroRNA-375 sensitizes tumour necrosis factor-alpha (TNF-α)-induced apoptosis in head and neck squamous cell carcinoma in vitro. Int J Oral Maxillofac Surg. 2013;42(8):949-55
14.p53 regulates the expression of human angiotensin II AT(2) receptor interacting protein (ATIP1) gene. Oncol Lett. 2011;2(5):919-922.
15.Identification and experimental validation of G protein alpha inhibiting activity polypeptide 2 (GNAI2) as a microRNA-138 target in tongue squamous cell carcinoma. Hum Genet. 2011;129(2):189-97.
16.Dendrimers-delivered short hairpin RNA targeting hTERT inhibits oral cancer cell growth in vitro and in vivo. Biochem Pharmacol. 2011;82(1):17-23.
17.The expression and significance of MRP1, LRP, TOPOIIβ, and BCL2 in tongue squamous cell carcinoma. J Oral Pathol Med. 2012;41(2):141-8.
18.Down-regulation of the microRNA-99 family members in head and neck squamous cell carcinoma. Oral Oncol. 2012;48(8):686-91.
19.Application of CAD/CAM-assisted technique with surgical treatment in reconstruction of the mandible. J Craniomaxillofac Surg. 2012;40(8):e432-7.
20.Immediate Reconstruction of Bilateral Mandible Defects: Management Based on Computer-Aided Design/Computer-Aided Manufacturing Rapid Prototyping Technology in Combination with Vascularized Fibular Osteomyocutaneous Flap. J Oral Maxillofac Surg. 2011;69(6):1792-7.

[参编教材与论著]
1.编委 全国卫生专业技术资格考试习题集丛书《口腔颌面外科学习题精选》 人民卫生出版社 2016,2015,2014
[获奖及学术荣誉]
1. 专利 温控镍钛形状记忆合金牵引器 专利号ZL1.6 中华人民共和国知识产权局 2008年
[社会兼职]
1.中华口腔医学会口腔颌面外科专业委员会青年委员
2.中华口腔医学会口腔生物医学专业委员会青年委员
3.广东省口腔医学会口腔颌面外科专业委员会青年委员
[联系方式]
地 址：广州市陵园西路56号中山大学光华口腔医学院?附属口腔医院（510055）
电 话：
传 真：
E-mail：drwangcheng@outlook.com
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