王韵
助理研究员 硕士生导师


导师简介

[学位/学历]
医学博士 ?（四川大学华西口腔医学院 ?口腔基础医学 ?硕博连读）
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[学术简历]
2010—2011年 ?美国伊利诺伊大学牙学院，访问****
2014—2016年 ?中山大学光华口腔医学院，博士后
2017年—至今 ?中山大学光华口腔医学院，助理研究员，硕士生导师
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[研究方向]
1. 表观遗传调控在口腔肿瘤发生发展过程中的作用与机制
2. 代谢重编程对口腔肿瘤发生发展的影响及其机制
3. 单核苷酸多态性（SNP）对口腔肿瘤易感性的影响及其机制
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[主持课题]
1. 国家自然科学基金青年项目， ?LncRNA-p15135-miR-378a信号轴调节口腔鳞癌糖酵解的功能与机制研究，2016.1-2018.12，21.6万元
2. 广州市科技计划项目，LncRNA-p4713通过Jak-STAT3通路调节口腔鳞癌恶性转化的功能与机制，2018.4-2020.3，20万元
3. 中国博士后科学基金特别资助，LncRNA-p23154介导FUT8甲基化在口腔癌中的作用机制，2016.7-2016.11，15 万
4. 中国博士后科学基金面上项目一等资助，LncRNA-p23154调节口腔鳞癌糖酵解的功能与机制研究，2015.5-2016.11，8 万元
5. 中山大学青年教师培育项目，LncRNA-p15135介导m6A结合蛋白HNRNPA2B1调控UHRF1在口腔癌中的机制研究，2018.1-2020.12，15万元
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[发表论文]
1. LncRNA-p23154 ?promotes the invasion-metastasis potential of oral squamous cell carcinoma by ?regulating Glut1-mediated glycolysis Cancer ?Letters. 2018 Oct 10;434:172-183.
2. Long ?non-coding RNA P4713 contributes to the malignant phenotypes of oral squamous ?cell carcinoma by activating the JAK/STAT3 pathway International Journal of ?Clinical and Experimental Pathology. 2017 10(11): 10947-10958
3. Integrative approach ?detected association between genetic variants of microRNA binding sites of ?TLRs pathway genes and OSCC susceptibility in Chinese Han Population.PloS ?One. 2014 ?Jul 7;9(7):e101695.
4. Genetic variants in the AKT1 gene are associated with ?risk of oral cancer: a Case-control study of the Chinese Han Population.J ?OralPathol Med. 2015 Jan;44(1):45-50.
5. Polymorphisms of ?microRNA-Binding Sites in Integrin Genes Are Associated with Oral Squamous ?Cell Carcinoma Susceptibility and Progression.The ?Tohoku Journal of Experimental Medicine. 2014 May;233(1):33-41.
6. Host ?genetic susceptibility to oral cancer: evidence from meta-analyses and pooled ?analyses. Oral ?Dis. 2014 Oct;20(7):644-9.
7. The association between hypoxia-inducible factor-1 α ?gene G1790A polymorphism and cancer risk: a meta-analysis of 28 case–control studies.Cancer ?Cell International. 2014, ?14:37 doi:10.1186/1475-2867-14-37
8. Prognostic significance of tumor infiltrating immune ?cells in oral squamous cell carcinoma.BMC cancer. 2017; 17: 375.
9. Foxp3 overexpression in tumor cells predicts poor ?survival in oral squamous cell carcinoma.BMC cancer. 2016 Jul 26; 16:530.
10. Overexpression of proteasonmal activator ?PA28αserves as a prognostic factor in oral squamous cell carcinoma. J Exp Clin Cancer Res. 2016 Feb 19; 35:35
11. Associations between proteasomal activator ?PA28γ and outcome of oral squamous cell carcinoma: Evidence from cohort studies and functional analyses.EBioMedicine. 2015 Jul 10; 2(8):851-8.
12. Receptor for Activated C Kinase1 (RACK1): ?a regulator for migration and invasion in oral squamous cell carcinoma cells. J Cancer Res Clin Oncol. 2012 Apr; 138(4):563-71. 2011 Dec 30.
13. MicroRNA-138 suppresses ?epithelial-mesenchymal transition in squamous cell carcinoma cell lind. Biochem J. 2011 Nov 15; 440(1):23-31.
14. p53 regulates the expression of human ?angiotensin II AT(2) receptor interacting protein (ATIP1) gene. Oncol Lett. 2011 Sep; 2(5): 919-922.10.
15. Biodegradablethermosensitive ?hydrogel for SAHA and DDP delivery: therapeutic effects on oral squamous cell carcinoma. PLoS One. 2012;7(4): e33860.
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[获奖及学术荣誉]
1. ?2016 ? 中华口腔医学会第五届口腔生物医学优秀青年研究奖
2. ?2017 ? IADR中国分会第十三届********奖
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[联系方式]
地 ?址：广州市陵园西路56号中山大学光华口腔医学院·附属口腔医院（510055）
电 ?话：
传 ?真：
E-mail：@qq.com