科　　室：内分泌科
职　　称：教授
导师资格：博士生导师
最高学历：博士




医疗特长：
从事内分泌代谢疾病临床和研究工作三十多年，在糖尿病、甲状腺疾病(甲亢、甲减、甲状腺炎、甲状腺结节)、垂体－肾上腺疾病、继发性高血压、生长发育异常、骨质疏松症等方面积累了丰富的经验。
研究方向：糖尿病胰岛B细胞功能及早期保护、糖尿病慢性并发症发病机理及防治。
主要教育和工作经历：
1984年毕业于中山医科大学，历经硕士、博士研究生培养
2002年-2003年在美国UAB大学研修一年
社会兼职：
广东省糖尿病学会主任委员
广东省健康管理学会代谢与内分泌专业委员会主任委员
中华医学会糖尿病分会委员、血糖监测学组副组长
广东省内分泌学会常委、广东省内分泌医师学会常委
J Diabetes Res 客座主编、Diabetes Res ClinPract客座编辑、ClinEndocrino等特约审稿人
中华内分泌代谢杂志、中华糖尿病杂志、中华全科医师杂志、中国糖尿病杂志、国际糖尿病等杂志编委
广东省干部保健专家组成员、广东省健康教育首席专家
广东省卫生厅重点实验室主任
中山一院内分泌国家药理基地负责人、中山一院内分泌专科医师/住院医师培训基地主任
论著：
Insulin requirement profiles of short-term intensive insulin therapy in patients with newly diagnosed type 2 diabetes and its association with long-term glycemic remission. Diabetes Res ClinPract. 2015 Feb 21.[Epub ahead of print]
Daidzein and genistein fail to improve glycemic control and insulin sensitivity in Chinese women with impaired glucose regulation: A double-blind, randomized, placebo-controlled trial. Mol. Nutr. Food Res. 2015, 59, 240–249
Transmembrane Protease Serine 4 Promotes Thyroid Cancer Proliferation via CREB Phosphorylation.Thyroid. 2015 Jan;25(1):85-94.
The experimental and clinical aspects of Beta cell function and its underlying mechanism.J Diabetes Res. 2014; 2014:659149.
Down-regulation of miR-144 promotes thyroid cancer cell invasion by targeting ZEB1 and ZEB2. Endocrine. 2015 Mar;48(2):566-74.
Downregulation of Bcl-2 Expression by miR-34a Mediates Palmitate-Induced Min6 Cells Apoptosis. J Diabetes Res. 2014;2014:258695. doi: 10.1155/2014/258695.
Short-term continuous subcutaneous insulin infusion combined with insulin sensitizers rosiglitazone, metformin, or antioxidant α-lipoic acid in patients with newly diagnosed type 2 diabetes mellitus.Diabetes TechnolTher. 2013 Oct;15(10):859-69
Adverse effect of metformin therapy on serum vitamin B12 and folate: Short-term treatment causes disadvantages? MedHypotheses 2013 Aug;81(2):149-51.
Down-regulation of miR-218-2 and its host gene SLIT3 cooperate to promote invasion and progression of thyroid cancer.J ClinEndocrinolMetab. 2013 Aug;98(8):E1334-44.
Impact of vitamin D on chronic kidney diseases in non-dialysis patients: a meta-analysis of randomized controlled trials. PLoS One. 2013 Apr 23;8(4):e61387.
Fasting plasma glucose after intensive insulin therapy predicted long-term glycemic control in newly diagnosed type 2 diabetic patients.Endocr J. 2013 Jun 30;60(6):725-32.
Increased1,5-Anhydroglucitol Predicts Glycemic Remission in Patients with NewlyDiagnosed Type 2 Diabetes Treated with Short-Term Intensive Insulin Therapy. Diabetes TechnolTher. 2012 Sep;14(9):756-61.
AttitudesToward Diabetes Affect Maintenance of Drug-Free Remission in Patients WithNewly Diagnosed Type 2 Diabetes After Short-Term Continuous SubcutaneousInsulin Infusion Treatment. DiabetesCare. 2012 Mar;35(3):474-81..
Early intensive insulin therapy attenuates the p38 pathway in the renalcortex and indices of nephropathy in diabetic rats. Endocrine J. 2012 Jan 31;59(1):81-90.
The Akt/FoxO1/p27 pathway mediates the proliferative action of liraglutidein β cells. Mol Med Report. 2012Jan; 5(1):233-8.
SphingosineKinase 1 Is Overexpressed and Promotes Proliferation in Human Thyroid Cancer.MolEndocrinol. 2011, 25(11): 1858–1866
Fulminanttype 1 diabetes mellitus with rhabdomyolysis: Have we overlooked the situation?DiabetesRes ClinPract. 2010 Dec90(3):e47-9.
Hyperinsulinaemichypoglycaemia associated with a heterozygous missensemutation of R1174W in the insulin receptor (IR) gene. Clin Endocrinol.2009;71:659-65.
Effect of intensive insulin therapy on β-cell function and glycaemiccontrol in patients with newly diagnosed type 2 diabetes. Lancet 2008; 371:1753-60.
Induction of long-term glycemic control in newly diagnosed type 2 diabetic patients is associated with improvement of beta-cell function. Diabetes Care 2004, 27: 2597-2602
专著：
内分泌及风湿病临床诊断与治疗方案 科学技术文献出版社
糖尿病病人最关心的300个问题 湖北科学技术出版社
处方学概论 湖北科学技术出版社
其他主要工作成绩（比如获奖情况）：
获奖：国家科技进步奖二等奖（2011年、第2完成人）
广东省科技进步一等奖（2008年、第2完成人）
教育部科技进步一等奖（2007年、第3完成人）