科　　室：脊柱外科
职　　称：教授,主任医师
导师资格：博士生导师
最高学历：博士




医疗特长：
苏教授擅长脊柱侧/后凸、颈椎病、胸腰椎管狭窄、腰椎滑脱、脊柱截骨矫形术、脊柱肿瘤完整切除、后路寰枢椎固定、脊柱微创手术等。尤其对脊柱外科核心技术--椎弓根螺钉精准置入有独到研究。其团队与广东省教育厅及广州市合作，开展骨骼畸形普查，成立广东省儿童青少年脊柱侧凸科普基地，同时定位致病基因、研究发病机制，协助家族遗传病患者使用三代试管婴儿技术生出健康宝宝。科研合作上，与哈佛大学、UTSW、TSRH医院等开展联合研究。

研究方向：运动系统发育畸形与基因调控

教育经历：
2005.09-2008.07 中山大学 骨科学 博士学位，导师：刘尚礼
2000.09-2003.07 中山大学 外科学 硕士学位，导师：黄东生
1993.09-1998.07 中山医科大学 临床医学 学士学位
工作经历：
2017.12-至今 中山大学附属第一医院 教授/主任医师/研究员
2016.12-至今 中山大学附属第一医院 主任医师/研究员
2013.12-2016.12 中山大学附属第一医院 研究员
2011.03-2013.02 美国德州大学西南医学研究中心 联合博士后培训
2009.12-2013.12 中山大学附属第一医院 副教授/副主任医师
2005.07-2005.09 香港中文大学威尔斯亲王医院 进修临床医师
2003.07-2009.08 中山大学附属第二医院 住院医师-主治医师
1998.07-2000.08 深圳沙井人民医院 住院医师

社会兼职：
国际脊柱遗传、发育和疾病研究协会（ICSGDD） 委员
国际矫形与创伤外科学会骨科基础学会 常务委员
中国医疗保健国际交流促进会脊柱侧凸研究分会 委员
中华医学会骨科学分会基础学组 委员
中华医学会骨科学分会创新与转化学组 委员
中国康复医学会脊柱脊髓基础研究学组 委员/理事
广东医学会脊柱外科分会/脊柱畸形学组委员/副组长

论著：
Taifeng Zhou, Bo Gao, Yi Fan, Yuchen Liu, Shuhao Feng, QianCong, Xiaolei Zhang, Yaxing Zhou, Prem S Yadav, Jiachen Lin, Nan Wu, LiangZhao, Dongsheng Huang, Shuanhu Zhou, Peiqiang Su*, Yingzi Yang*.Piezo1/2 mediate mechanotransduction essential for bone formation throughconcerted activation of NFAT-YAP1-β-catenin. Elife. 2020 Mar; 9.pii:e52779.
Caixia Xu#, Xiaoming Yang#, Hang Zhou, Yongyong Li, ChaoXing, Taifeng Zhou, Dongmei Zhong, Chengjie Lian, Mei Yan, Tao Chen, ZhihengLiao, Bo Gao, Deying Su, Tingting Wang, Swarkar Sharma, Chandra Mohan, NadavAhituv, Sajid Malik, Quan-Zhen Li*, Peiqiang Su*. A novel ZRS variantcauses preaxial polydactyly type I by increased sonic hedgehog expression inthe developing limb bud. Genetics in Medicine. 2020 Jan; 22(1):189-198.
Xianjian Qiu#, Xudong Wang#, Jincheng Qiu#, Yuanxin Zhu,Tongzhou Liang, Bo Gao, Zizhao Wu,Chengjie Lian, Yan Peng, Anjing Liang, Peiqiang Su*, Dongsheng Huang*.Melatonin rescued reactive oxygen species-impaired osteogenesis of human bonemarrow mesenchymal stem cells in the presence of tumor necrosis factor-alpha. StemCells International. 2019 Sep; 2019:**.
Xudong Wang#, Tongzhou Liang#, Yuanxin Zhu#, Jincheng Qiu,Xianjian Qiu, Chengjie Lian, Bo Gao,Yan Peng, Anjing Liang, Hang Zhou, XiaomingYang, Zhiheng Liao, Yongyong Li, Caixia Xu, Peiqiang Su*, DongshengHuang*. Melatonin prevents bone destruction in mice with retinoic acid-induced osteoporosis.Molecular Medicine. 2019 Aug; 25(1):43.
Lei Liu, Tingting Wang, Xiaoming Yang, Caixia Xu, ZhihengLiao, Xudong Wang, Deying Su, Yongyong Li, Hang Zhou, Xianjian Qiu, Yuyu Chen,Dongsheng Huang, Chengjie Lian*, Peiqiang Su*. MTNR1B loss promoteschordoma recurrence by abrogating melatonin-mediated β-catenin signalingrepression. Journal of Pineal Research. 2019 Sep; 67(2):e12588.
Hang Zhou#, Chengjie Lian#, Tingting Wang, Xiaoming Yang,Caixia Xu, Deying Su, Shuhui Zheng, Xiangyu Huang, Zhiheng Liao, Taifeng Zhou,Xianjian Qiu, Yuyu Chen, Bo Gao, Yongyong Li, Xudong Wang, Guoling You, QihuaFu, Christina Gurnett, Dongsheng Huang, Peiqiang Su*. MET mutationcauses muscular dysplasia and arthrogryposis. EMBO Molecular Medicine. 2019Mar ; 11(3): e9709.
Kai Han#, Yongqian Wang#, Shangbin Cui, Caixia Xu*, PeiqiangSu*. Successful surgery for a neuromuscular scoliosis patient by pulmonaryrehabilitation with forced vital capacity below 30%. European Spine Journal.2018 Sep;27(9):2072-2075.
Shuhui Zheng#, Hang Zhou#, Bo Gao, YongyongLi, Zhiheng Liao,Taifeng Zhou, Chengjie Lian, Zizhao Wu, Deying Su, Tingting Wang，Peiqiang Su*，Caixia Xu*. Estrogenpromotes the onset and development of idiopathic scoliosis via disproportionateendochondral ossification of the anterior and posterior column in a bipedal ratmodel. Experimental & Molecular Medicine. 2018 Nov; 50(11): 144.
Shuhui Zheng#, Hang Zhou#, Zhuohui Chen, Yongyong Li, TaifengZhou, Chengjie Lian, Bo Gao, Peiqiang Su*, Caixia Xu*. Type IIITransforming Growth Factor-β Receptor RNA Interference (RNAi) EnhancesTGF-β3-induced Chondrogenesis Signaling in Human Mesenchymal Stem Cells. StemCells Internation. 2018; 2018: **.
Zizhao Wu#, Xianjian Qiu#, Bo Gao#, Chengjie Lian, Yan Peng,Anjing Liang, Caixia Xu, Wenjie Gao,Liangming Zhang, Peiqiang Su, Limin Rong*, Dongsheng Huang*.Melatonin-mediated miR-526b-3p and miR-590-5p upregulation promoteschondrogenic differentiation of human mesenchymal stem cells. Journal OfPineal Research. 2018 Aug;65(1):e12483.
Bo Gao#, Wenjie Gao#, Zizhao Wu#, Taifeng Zhou, Xianjian Qiu,Xudong Wang, Chengjie Lian, Yan Peng, Anjing Liang, Jincheng Qiu, Yuanxin Zhu,Caixia Xu, Yibing Li, Peiqiang Su*, Dongsheng Huang*. Melatonin rescuedinterleukin 1β-impaired chondrogenesis of human mesenchymal stem cells. StemCell Research & Therapy. 2018 Jun 14;9(1):162.
Taifeng Zhou#, Yongqian Wang#, Hang Zhou#, Zhiheng Liao, BoGao, Deying Su, Shuhui Zheng,Caixia Xu*, Peiqiang Su*. Dual novelmutations in SLC26A2 in two siblings with multiple epiphyseal dysplasia 4 froma Chinese family: a case report. BMC Medical Genetics. 2018 May3;19(1):70.
Yoji Ogura, Kazuki Takeda, Ikuyo Kou, Anas Khanshour, AnnaGrauers, Hang Zhou, Gang Liu, Yan-Hui Fan, Taifeng Zhou, Zhihong Wu, YoheiTakahashi, Morio Matsumoto, Japan Scoliosis Clinical Research Group (JSCRG),Texas Scottish Rite Hospital for Children Clinical Group (TSRHCCG), ElisabetEinarsdottir, Juha Kere, Dongsheng Huang, Guixing Qiu, Leilei Xu, Yong Qiu,Carol A. Wise, You-Qiang Song, Nan Wu, Peiqiang Su, Paul Gerdhem#, KotaWatanabe,Shiro Ikegawa#. An international meta-analysis confirms theassociation of BNC2 with adolescent idiopathic scoliosis. Scientificreports. 2018 Mar 16;8(1):4730.
Chengjie Lian#, Bo Gao#, Zizhao Wu, Xianjian Qiu, Yan Peng,Anjing Liang, Caixia Xu, Peiqiang Su*, Dongsheng Huang*. Collagen typeII is downregulated in the degenerative nucleus pulposus and contributes to thedegeneration and apoptosis of human nucleus pulposus cells. Mol Med Rep.2017 Oct;16(4):4730-4736.
Wenjie Gao#, Chong Chen#, Taifeng Zhou#, Shulan Yang, Bo Gao,Hang Zhou, Chengjie Lian, Zizhao Wu, Xianjian Qiu, Xiaoming Yang, Esam Alattar,Wentao Liu, Deying Su, Silong Sun, Yulan Chen, Kenneth M. C. Cheung, YouqiangSong, Keith K. D. Luk, Danny Chan, Pak Chung Sham, Chao Xing, Chiea Chuen Khor,Gabriel Liu, Junlin Yang, Yubin Deng, Dingjun Hao, Dongsheng Huang, Quan-ZhenLi, Caixia Xu*, Peiqiang Su*.Rare coding variants in MAPK7 predispose to adolescent idiopathic scoliosis. HumanMutation. 2017 Nov;38(11):1500-1510.
Bo Gao, Wenjie Gao, Chong Chen, Qinghua Wang, Shaochun Lin,Caixia Xu, Dongsheng Huang, Peiqiang Su*. What is the Difference inMorphologic Features of the Thoracic Pedicle Between Patients With AdolescentIdiopathic Scoliosis and Healthy Subjects? A CT-based Case-control Study. ClinicalOrthopaedics and Related Research. 2017 Nov;475(11):2765-2774.
Chong Chen#, Caixia Xu#, Taifeng Zhou, Bo Gao, Hang Zhou,Changhua Chen, Changli Zhang, Dongshen Huang*, Peiqiang Su*. Abnormalosteogenic and chondrogenic differentiation of human mesenchymal stem cellsfrom patients with adolescent idiopathic scoliosis in response to melatonin. Molecularmedicine reports. 2016 Aug;14(2):1201-9.
Yifeng Cai, Jiaquan Luo, Junjun Huang, Chengjie Lian, HangZhou, Hao Yao, Peiqiang Su *. Interspinous spacers versus posteriorlumbar interbody fusion for degenerative lumbar spinal diseases: ameta-analysis of prospective studies. International Orthopaedics (SICOT).2016 Jun;40(6):1135-42.
Chengjie Lian#, Zizhao Wu#, Bo Gao#, Yan Peng, Anjing Liang,Caixia Xu, Lei Liu, XianjianQiu, Junjun Huang, Hang Zhou, Yifeng Cai, PeiqiangSu*, Dongsheng Huang*. Melatonin reversed tumor necrosisfactor-alpha-inhibited osteogenesis of human mesenchymal stem cellsbystabilizing SMAD1 protein. Journal of Pineal Research. 2016Oct;61(3):317-27.
Peiqiang Su#, Ye Wang#, David N. Cooper, Wenjuan Zhu, DongshengHuang, Claude Férec, Yiming Wang, Jian-Min Chen*. Disclosing the HiddenStructure and Underlying Mutational Mechanism of a Novel Type of DuplicationCNV Responsible for Hereditary Multiple Osteochondromas. Human Mutation.2015 Aug;36(8):758-63.
Ye Wang#, Peiqiang Su#, Bin Hu#, Wenjuan Zhu#, QibinLi, Ping Yuan, Jiangchao Li, Xinyuan Guan, Fucheng Li, Xiangyi Jing, Ru Li,Yongling Zhang, Claude Férec, David N. Cooper, Jun Wang, Dongsheng Huang*,Jian-Min Chen*, Yiming Wang*. Characterization of 26 deletion CNVs reveals thefrequent occurrence of micro-mutations within the breakpoint-flanking regionsand frequent repair of double-strand breaks by templated insertions derivedfrom remote genomic regions. Human Genetics. June 2015, Volume 134,Issue 6, pp 589-603.
Guoyan Liang#, Chengjie Lian#, Di Huang, Wenjie Gao, AnjingLiang, Yan Peng, Wei Ye, Zizhao Wu, Peiqiang Su*, Dongsheng Huang*.Endoplasmic Reticulum Stress-Unfolding Protein Response-Apoptosis CascadeCauses Chondrodysplasia in a col2a1 p.Gly1170Ser Mutated Mouse Model. PLoSOne. 2014,9(1):e86894.
Wenjie Gao#, Mianlong Lin#, Anjing Liang#, LiangmingZhang,Changhua Chen, Guoyan Liang, Caixia Xu, Yan Peng, ChongChen, DongshengHuang*, Peiqiang Su*. Melatonin enhances chondrogenic differentiation ofhuman mesenchymal stem cells. Journal of Pineal Research. 2014,56(1):62-70.
Wenjie Gao#, Yan Peng#, Guoyan Liang, Anjing Liang, Wei Ye,Liangming Zhang, Swarkar Sharma, Peiqiang Su*, Dongsheng Huang*.Association between Common Variants near LBX1 and Adolescent IdiopathicScoliosis Replicated in the Chinese Han Population. PLoS One. 2013,8(1): e53234.
Liangming Zhang#, Jinling Zhang#, You Ling, Changhua Chen,Anjing Liang, Yan Peng, Hong Chang, Peiqiang Su *, Dongsheng Huang*.Sustained release of melatonin from poly (lactic-co-glycolic acid) (PLGA)microspheres to induce osteogenesis of human mesenchymal stem cells in vitro.Journal of Pineal Research. 2013,54:24–32.
Guoyan Liang#, Wenjie Gao#, Anjing Liang, Wei Ye,Yan Peng,Liangming Zhang, Swarkar Sharm, Peiqiang Su *, Dongsheng Huang*. Normalleptin expression, lower adipogenic ability, decreased leptin receptor andhyposensitivity to leptin in adolescent idiopathic scoliosis. PLoS One. 2012,7(5):e36648.
Yan Peng#, Guoyan Liang#, Yuanyuan Pei, Wei Ye, Anjing Liang,Peiqiang Su *. Genomic polymorphisms of G-Protein Estrogen Receptor 1are associated with severity of adolescent idiopathic scoliosis. InternationalOrthopaedics (SICOT). 2012 Mar;36(3):671-7
Peiqiang Su#, Wentong Zhang#, Yan Peng, Anjing Liang, Kaili Du,Dongsheng Huang*. Use of computed tomographic reconstruction to establish theideal entry point for pedicle screws in idiopathic scoliosis. European SpineJournal. 2012 Jan;21(1):23-30.
Dongsheng Huang, Kaili Du, Shingxing Zeng, Wenjie Gao,Lingzhi Huang, Peiqiang Su *. The security analysis of transpedicularscrew fixation in the lower cervical spine and a case report. Spine (PhilaPa 1976). 2011 Dec 15;36(26): E1702-8.
Peiqiang Su#, Hongke Ding#, Dongsheng Huang, Yan Zhou, WeijunHuang, Liangying Zhong, Tim J Vyse, Yiming Wang*. A 4.6 kb genomic duplicationon 20p12.2-12.3 is associated with brachydactyly type A2 in a Chinese family. JMed Genet. 2011 May;48(5):312-6.
Yuanyuan Pei, Yiming Wang, Weijun Huang, Bin Hu, DongshengHuang, Yan Zhou, Peiqiang Su*. Novel mutations of EXT1 and EXT2 genesamong families and sporadic cases with multiple exostoses. Genetic Testingand Molecular Biomarkers. 2010 Dec;14(6):865-72.
Caixia Xu, Peiqiang Su, Xiaofeng Chen, Yongchun Meng,Weihua Yu, Andy Peng Xiang*, Yingjun Wang*. Biocompatibility and osteogenesisof biomimetic Bioglass-Collagen-Phosphatidylserine composite scaffolds for bonetissue engineering. Biomaterials. 2011 Feb;32(4):1051-8
Liangming Zhang, Peiqiang Su*, Caixia Xu, ChanghuaChen, Anjing Liang, Kaili Du, Yan Peng, Dongsheng Huang*. Melatonin inhibitsadipogenesis and enhances osteogenesis of human mesenchymal stem cells bysuppressing PPARγ expression and enhancing Runx2 expression. Journal OfPineal Research. 2010 Nov;49(4):364-72
Caixia Xu, Peiqiang Su, Yingjun Wang, Xiaofeng Chen,Yongchun Meng, Chang Liu, Xinbing Yu, Xuhui Yang, Weihua Yu, Xiuming Zhang,Andy Peng Xiang*. A novel biomimetic composite scaffold hybridized withmesenchymal stem cells in repair of rat bone defects models. Journal OfBiomedical Materials Research A. 2010 Nov;95(2):495-503.
Liangming Zhang, Peiqiang Su, Caixia Xu, Junlin Yang,Weihua Yu, Dongsheng Huang*. Chondrogenic differentiation of human mesenchymalstem cells: a comparison between micromass and pellet culture systems. BiotechnolLett. 2010 Sep;32(9):1339-46.
Peiqiang Su#, Liangming Zhang#, Yan Peng, Anjing Liang, Kaili Du,Dongsheng Huang*. A histological and ultrastructural study of femoral headcartilage in a new type II collagenopathy. International Orthopaedics(SICOT). 2010 Dec;34(8):1333-9.
Peiqiang Su#, Ru Li#, Shangli Liu, Yan Zhou, Xinguang Wang, NileshPatil, Christopher S. Mow, Justin C. Mason, Dongsheng Huang*, Yiming Wang*. Ageat onset-dependent presentations of premature hip osteoarthritis, avascularnecrosis of the femoral head, or Legg-Calvé-Perthes disease in a single family,consequent upon a p.Gly1170Ser mutation of COL2A1. Arthritis Rheumatism.2008 Jun;58(6):1701-6.
Peiqiang Su, Ruofan Ma, Chunhai Li, Shangli Liu, Dongsheng Huang*.Pedicle screw fixation of the cervical spine: guidance by computed tomography. Clinicalorthopaedics and related research. 2007 Sep; 462:99-104.
其他主要工作成绩（比如获奖情况）：
荣誉称号：
1.“广东特支计划”百千万工程领军人才
2. 教育部新世纪优秀人才
3. 广东省****医学人才
4. 广东省高等学校千百十人才培养工程第八批省级培养对象
获奖情况：
1.骨与软骨发育、退变的分子机制研究—广东省自然科学奖二等奖 2020年
2.X基因突变引起特发性脊柱侧凸的发生--COA赵以甦骨科基础奖二等奖 2014年
3.中山大学实习医生临床技能大赛--"教官组"特等奖 2013年
4.股骨颈骨折外科治疗的基础与临床研究--广州市科技进步二等奖 2008年
5.新技术治疗退变性腰椎间盘病的基础与临床研究-- 广东省科技进步二等奖 2006年