职称:博士、教授、博士生导师
职务:华南肿瘤学国家重点实验室PI
科室:实验研究部
一直从事肿瘤细胞生物学的研究工作,主要研究细胞周期调控及其在肿瘤靶向和个体化治疗中的临床价值和意义等。在SCI杂志发表论著32篇,其中以通讯或第一作者在CancerCell(IF:26.99)、JournalofNationalCancerInstitute(IF:14.79)、JournalofClinicalInvestigation(IF:14.15)、CancerResearch(IF:8.23)、Oncogene(IF:7.41)、FASEBJ(IF:6.51)、JournalofBiologicalChemistry(IF:5.33)等国际主流杂志发表论著16篇。
研究方向:细胞周期调控、肿瘤分子靶向和个体化治疗的基础研究。
主要在研项目基金:
2011年,国家杰出青年科学基金(肿瘤学,81125015,200万元)
2011年,“973”计划(2012CB967000,学术骨干,160万元)
2009年,国家自然基金重点项目(30930045,174万元)
2009年,“973”计划(2010CB912201,课题组长,280万元)
代表性论文(10篇,*为通讯作者):
1.HongJ,HuK,YuanY*,SangY,ChenG,YangL,LiB,HuangP,ChenD1,LiangY,ZhangR,ZengYX,KangT*(通讯作者)Chk1TargetsSpleenKinase(L)forProteolysisinHumanHepatocellularCarcinoma
J.Clin.Invest.(JCI)(accepted).2012.
2.TangQL,XieXB,WangJ,ChenQ,HanAJ,ZouCY,YinJQ,LiuDW,LiangY,ZhaoZQ,YongBC,ZhangRH,FengQS,DengWD,ZhuXF,ZhouBP,ZengYX1,ShenJN*,andKangT*(通讯作者).GlycogenSynthaseKinase-3β,NF-κBSignaling,andTumorigenesisofHumanOsteosarcoma
J.Natl.CancerInst.(JNCI)willbepublishedonMay16,2012.
3.XuS,FengZ,ZhangM,WuY,SangY,XuH,LvX,HuK,CaoJ,ZhangR,ChenL,LiuM,YunJP,ZengYX,KangT*(通讯作者).hSSB1bindsandprotectsp21fromubiquitin-mediateddegradationandpositivelycorrelateswithp21inhumanhepatocellularcarcinomas.Oncogene,30,2219-29,2011.
4.FengZ,XuS,LiuM,ZengYX,KangT*(通讯作者).Chk1inhibitorG?6976enhancesthesensitivityofnasopharyngealcarcinomacellstoradiotherapyandchemotherapyinvitroandinvivo.CancerLetters,297,190-7,2010.
5.LvXB,XieF,HuK,WuY,CaoLL,HanX,SangY,ZengYX,KangT*(通讯作者).DDB1interactswithCdh1andmodulatesthefunctionofAPC/CCdh1.
J.Biol.Chem.,285,18234-40,2010
6.LiangY,ZhongZ,HuangY,DengW,CaoJ,TsaoG,LiuQ,PeiD,KangT*(共同通讯作者),ZengYX*.Stem-likeCancerCellsareinduciblebyIncreasingGenomicInstabiltyinCancerCells.J.Biol.Chem.,285,4931-40,2010.
7.KangT,WeiY,ChiangY,YamaguchiH,AppellaE,HungMC,andPiwnica-WormsH*.GSK-3beta?TargetsCdc25AforUbiquitin-MediatedProteolysisandGSK-3betaInactivationCorrelateswithCdc25AOverproductioninHumanCancers.
CancerCell.13,36-47,2008.
8.KangT,NagaseH,PeiD*.ActivationofMembrane-typeMatrixMetalloproteinase3ZymogenbytheProproteinConvertaseFurininthetrans-GolgiNetwork.
CancerRes.,62,675-81,2002.
9.KangT,ParkHI,SuhY,ZhaoYG,TschescheH,SangQX*.AutolyticprocessingatGlu(586)-Ser(587)withinthecysteine-richdomainofhumanadamalysin19/disintegrin-metalloproteinase19isnecessaryforitsproteolyticactivity.
J.Biol.Chem.,277,48514-22,2002.
10.KangT,ZhaoYG,PeiD,SucicJF,SangQX*.IntracellularActivationofHumanAdamalysin19/DisintegrinandMetalloproteinase19byFurinOccursviaOneoftheTwoConsecutiveRecognitionSites.
J.Biol.Chem.,277,25583-91,2002.