[学位/学历]
医学博士学位/研究生


[学术简历]
博士研究生导师（2006年）。华南肿瘤学国家重点实验室，肿瘤分子流行病课题组负责人，中山大学肿瘤中心肿瘤资源库负责人，肿瘤学与分子医学招生专业方向博士生导师，中山大学公共卫生学院流行病学与卫生统计专业博士生导师。
1998年7月毕业于中国协和医科大学流行病学专业，获医学博士学位。1999年10月进入中山大学（原中山医科大学）肿瘤学博士后流动站从事博士后研究工作。2005年7月获UICC资助在美国JohnHopkins大学合作研究。研究方向为肿瘤基因组与分子遗传学、分子流行病学。
贾卫华教授在肿瘤基因组学和分子流行病学研究领域取得了一系列突破和重要科学发现：(1)在环境基因组学的研究领域，采用基于通路（Pathway-basedapproach）的研究策略，发现RAD51L1基因与鼻咽癌的发病风险显著关联。这项研究是与鼻咽癌全基因组关联研究同时展开，新的易感位点的发现，标志候选基因策略是全基因组关联研究策略的重要补充。（CancerRes，2011）（2）采用候选基因策略，在TLR系列基因和CYP系列基因上进行了卓有成效的工作，发现了CYP2E1、TLR4、TLR10基因多态性与鼻咽癌危险的相关性。（Carcinogenesis,2010等）（3）通过对鼻咽癌高发区四会和苍梧鼻咽癌发病和死亡率的长期趋势进行研究，首度在国际刊物上对中国高发区鼻咽癌的发病和死亡情况进行系统的研究报道，提出中国鼻咽癌的发病和死亡趋势并没有像世界大部分地区一样呈现显著下降趋势（如新加坡，香港，美国），我国鼻咽癌高发区的防治形势依然严峻。同时，证实广东某些生活习惯并没有发生显著改变，仍然是鼻咽癌发病的危险因素；（BMCcancer2007等）（4）提出EB病毒特定抗体阳性这一鼻咽癌高危标志物，受个体遗传易感基因所影响；同时，人群流行病学和细胞生物学研究证实环境因素-吸烟对EB病毒具有激活作用；共享的家庭环境因素在EB病毒再激活中发生作用（JNatCancerInstit，accept；IntJCancer2011等）。
贾卫华教授负责组建的大规模的华南肿瘤资源库，已建成了全国最大的肿瘤资源库之一。在参与国家重大专项的立项和实施上，起到了举足轻重的作用：以华南肿瘤资源库为平台，贾卫华教授作为主要参加人参与了鼻咽癌、食管癌、肝癌的全基因组关联研究，三项研究分别在2010、2011年国际遗传学杂志Naturegenet上发表，具有国际影响。在国际合作上，亚洲结直肠癌全基因组关联研究协作组的研究已经取得了新的进展。作为中国医药生物技术协会组织生物杨本库分会的副主任委员，作为主要牵头人编制了中华人民共和国医药生物技术《生物样本库》行业标准，为行业发展起到了积极的作用。
贾卫华教授在上述领域已经取得了广泛的国际、国内影响。研究成果多次在国际刊物上作为重点推荐文章；并应邀撰写世界卫生组织（WHO）蓝皮书系列：头颈部肿瘤的部分章节（In:WHOClassificationofTumors,PathologyandGeneticsofHeadandNeckTumors,95-97.IARCpress,Lyon2005.）；及SeminCancerBiology杂志邀请撰写综述;成为国际肿瘤专业杂志如PlosOne，EuropeanJournalCancer，BMCCancer，CancerEpidemiology等的审稿人；作为第一执行主席，于2009年成功举办的“肿瘤易感基因及复杂性状疾病研究策略”青年科学家论坛（中国科协、中华医学会中华预防医学杂志），作为当年中华预防医学杂志社的年度重要事件；作为中国生物医药技术协会组织生物样本库分会的副主任委员，每年在国内年度会议上做大会报告，积极推动该项工作在国内的发展。
作为项目负责人获得多项国家自然科学基金资助，两项美国NIH项目资助，作为课题负责人或主要完成人参加国家十二五新药创制重大专项、十五863重大专项、十一五863重大专项、科技部国际科技合作重点项目等国家级重大攻关项目的研究。2009年入选“新世纪优秀人才支持计划”





[近五年发表的论文]
(1)XuFH,XiongD，XuYF,CaoSM,XueWQ,QinHD,LiuWS,CaoJY,ZhangY,FengQS,ChenLZ,LiMZ,LiuZW,LiuQ,HongMH,ShugartYY,ZengYX,ZengMS,JiaWH*.SmokingRelatedtotheRiskofNasopharyngealCarcinomaandEffectsonEpstein-BarrVirusActivation:AnEpidemiologicalandCellBiologicalStudy.JNatlCancerInst.(Accepted)(IF=14.697)
(2)ShenGP,XuFH,HeF,RuanHL,CuiC,ChenLZ,ZengYX,JiaWH*.PretreatmentLifestyleBehaviorsasSurvivalPredictorsforPatientswithNasopharyngealCarcinoma.PLoSOne.(Accepted)(IF=4.411)
(3)HeJR,ShenGP,RenZF,QinH,CuiC,ZhangY,ZengYX,JiaWH*.Pretreatmentlevelsofperipheralneutrophilsandlymphocytesasindependentprognosticfactorsinpatientswithnasopharyngealcarcinoma.HeadNeck.2012Feb9.doi:10.1002/hed.22008.[Epubaheadofprint].(IF=2.182)
(4)JiaWH*,QinHD.Non-viralenvironmentalriskfactorsfornasopharyngealcarcinoma:Asystematicreview.SeminCancerBiol.2012Jan30.[Epubaheadofprint].(IF=7.758)
(5)QinHD,JiaWH*,ZhangLL,LiuN,ZhouXX,WangMH,FengQS,ChenLZ,ZhangY,JorgensenTJ,ZengYX,ShugartYY.ElevatedEpstein-Barrvirusseroreactivityamongunaffectedmembersoffamilieswithnasopharyngealcarcinoma.JMedVirol.2011Oct;83(10):1792-8.(IF=2.895)
(6)ShenGP,PanQH,HongMH,QinHD,XuYF,ChenLZ,FengQS,JorgensenTJ,ShugartYY,ZengYX,JiaWH*.HumangeneticvariantsofhomologousrecombinationrepairgenesfirstfoundtobeassociatedwithEpstein-BarrvirusantibodytitersinhealthyCantonese.IntJCancer.2011Sep15;129(6):1459-66.(IF=4.926)
(7)LiY,YuH,LuoRZ,ZhangY,ZhangMF,WangX,JiaWH*.ElevatedexpressionofRad51iscorrelatedwithdecreasedsurvivalinresectableesophagealsquamouscellcarcinoma.JSurgOncol.2011Nov1;104(6):617-22.(IF=2.428)
(8)LiY,WenZS,YangHX,LuoRZ,ZhangY,ZhangMF,WangX,JiaWH*.HighExpressionofY-Box-BindingProtein-1isAssociatedwithPoorSurvivalinResectableEsophagealSquamousCellCarcinoma.AnnSurgOncol.2011Nov;18(12):3370-6.(IF=4.182)
(9)LiY,YangHX,LuoRZ,ZhangY,LiM,WangX,JiaWH*.Highexpressionofp300hasanunfavorableimpactonsurvivalinresectableesophagealsquamouscellcarcinoma.AnnThoracSurg.2011,91(5):1531-8.(IF=3.558)
(10)QinHD,ShugartYY,BeiJX,PanQH,ChenL,FengQS,ChenLZ,HuangW,LiuJJ,JorgensenTJ,ZengYX,JiaWH*.ComprehensivePathway-BasedAssociationStudyofDNARepairGeneVariantsandtheRiskofNasopharyngealCarcinoma.CancerRes.2011,71(8):3000-8.(IF=8.234)
(11)HeJR,QinH,RenZF,CuiC,ZhangY,RanatungaD,ZengYX,JiaWH*.MMP-9expressioninperipheralbloodmononuclearcellsandtheassociationwithclinicopathologicalfeaturesandprognosisofnasopharyngealcarcinoma.ClinChemLabMed.2011,49(4):705-10.(IF=2.069)
(12)XuYF,LiuWL,DongJQ,LiuWS,FengQS,ChenLZ,ZengYX,ZengMS,JiaWH*.SequencingofDC-SIGNpromoterindicatesanassociationbetweenpromotervariationandriskofnasopharyngealcarcinomaincantonese.BMCMedGenet.2010Nov11;11:161.(IF=2.439)
(13)JiaWH*,LuoXY,FengBJ,RuanHL,BeiJX,LiuWS,QinHD,FengQS,ChenLZ,YaoSY,ZengYX.TraditionalCantonesedietandnasopharyngealcarcinomarisk:alarge-scalecase-controlstudyinGuangdong,China.BMCCancer.2010Aug20;10:446.(IF=3.153)
(14)RenZF,LiuWS,QinHD,XuYF,YuDD,FengQS,ChenLZ,ShuXO,ZengYX,JiaWH*.EffectoffamilyhistoryofcancersandenvironmentalfactorsonriskofnasopharyngealcarcinomainGuangdong,China.CancerEpidemiol.2010Aug;34(4):419-24.(IF=1.182)
(15)JiaWH*,PanQH,QinHD,XuYF,ShenGP,ChenL,ChenLZ,FengQS,HongMH,ZengYXetal.Acase-controlandafamily-basedassociationstudyrevealinganassociationbetweenCYP2E1polymorphismsandnasopharyngealcarcinomariskinCantonese.Carcinogenesis.2009Dec;30(12):2031-6.(IF=5.402)
(16)HeJF,JiaWH*,FanQ,ZhouXX,QinHD,ShugartYY,ZengYX.GeneticpolymorphismsofTLR3areassociatedwithNasopharyngealcarcinomariskinCantonesepopulation.BMCCancer.2007Oct17;7:194.(IF=3.153)
(17)JiaWH,HuangQH,LiaoJ,YeW,ShugartYY,LiuQ,ChenLZ,LiYH,LinX,WenFL,AdamiHO,ZengY,ZengYX.Trendsinincidenceandmortalityofnasopharyngealcarcinomaovera20-25yearperiod(1978/1983-2002)inSihuiandCangwucountiesinsouthernChina.BMCCancer.2006Jul6;6:178.
(18)ZhouXX,JiaWH（共同第一作者）,ShenGP,QinHD,YuXJ,ChenLZ,FengQS,ShugartYY,ZengYX.SequenceVariantsinToll-LikeReceptor10AreAssociatedwithNasopharyngealCarcinomaRisk.CancerEpidBiomarkPrev.2006May;15(5):862-6.
(19)JiaWH,CollinsA,ZengYX,FengBJ,YuXJ,HuangLX,FengQS,HuangP,YaoMH,ShugartYY.ComplexsegregationanalysisofnasopharyngealcarcinomainGuangdong,China:evidenceforamultifactorialmodeofinheritance.EurJHumGenet.2005Feb;13:248-52.
(20)JiaWH,FengBJ,XuZL,ZhangXS,HuangP,HuangLX,YuXJ,FengQS,YaoMH,ShugartYY,ZengYX.Familialriskandclusteringofnasopharyngealcarcinoma（NPC）inGuangdong,China.Cancer.2004Jul15;101:363-9.
(21)JiaWH,ShaoJY,FengBJ,ZengYX.GeneticcomponentinvolvedinNasopharyngealcarcinomadevelopment.CancerReviews:Asia-Pacific.1(2003):31-49.
(22)ZengYX,JiaWH.Familialnasopharyngealcarcinoma.SeminCancerBiol.2002Dec;12(6):443-50.Review.
(23)JiaWH.NasopharyngealCarcinoma,In:WHOClassificationofTumors,PathologyandGeneticsofHeadandNeckTumors,95-97.IARCpress,Lyon2005.
(24)BeiJX,JiaWH,ZengYX.Familialandlarge-scalecase-controlstudiesidentifygenesassociatedwithnasopharyngealcarcinoma.SeminCancerBiol.2012Feb1.[Epubaheadofprint].
(25)LiuY,HuangQ,LiuW,LiuQ,JiaW,ChangE,ChenF,LiuZ,GuoX,MoH,ChenJ,RaoD,YeW,CaoS,HongM.EstablishmentofVCAandEBNA1IgA-basedcombinationbyenzyme-linkedimmunosorbentassayaspreferredscreeningmethodfornasopharyngealcarcinoma:atwo-stagedesignwithapreliminaryperformancestudyandamassscreeninginsouthernChina.IntJCancer.2011Aug22.doi:10.1002/ijc.26380.[Epubaheadofprint]
(26)WuC,HuZ,HeZ,JiaW,WangF,ZhouY,LiuZ,ZhanQ,LiuY,YuD,ZhaiK,ChangJ,QiaoY,JinG,LiuZ,ShenY，GuoC,FuJ,MiaoX,TanW,ShenH，KeY,ZengY,WuT&LinD.Genome-wideassociationstudyidentifiesthreenewsusceptibilitylociforesophagealsquamous-cellcarcinomainChinesepopulations.NatGenet.2011Jun5;43(7):679-84.
(27)CaoSM,LiuZ,JiaWH,HuangQH,LiuQ,GuoX,HuangTB,YeW,HongMH.Fluctuationsofepstein-barrvirusserologicalantibodiesandriskfornasopharyngealcarcinoma:aprospectivescreeningstudywitha20-yearfollow-up.PLoSOne.2011Apr22;6(4):e19100.
(28)HuangL,ZhengM,ZhouQM,ZhangMY,JiaWH,YunJP,WangHY.Identificationofagene-expressionsignatureforpredictinglymphnodemetastasisinpatientswithearlystagecervicalcarcinoma.Cancer.2011Aug1;117(15):3363-73.
(29)BeiJX,LiY,JiaWH,FengBJ,ZhouG,ChenLZ,FengQS,LowHQ,ZhangH,HeFetal.Agenome-wideassociationstudyofnasopharyngealcarcinomaidentifiesthreenewsusceptibilityloci.NatGenet.2010Jul,42(7):599-603.
(30)ZhangH,ZhaiY,HuZ,WuC,QianJ,JiaW,MaF,HuangW,YuL,YueWetal.Genome-wideassociationstudyidentifies1p36.22asanewsusceptibilitylocusforhepatocellularcarcinomainchronichepatitisBviruscarriers.NatGenet.2010,42(9):755-8.
(31)XiongY,FangJH,YunJP,YangJ,ZhangY,JiaWH,ZhuangSM.EffectsofmicroRNA-29onapoptosis,tumorigenicity,andprognosisofhepatocellularcarcinoma.Hepatology.2010Mra;51(3):836-45.
(32)ChenJ,ZhengH,BeiJX,SunL,JiaWH,LiT,ZhangF,SeielstadM,ZengYX,ZhangXetal.GeneticstructureoftheHanChinesepopulationrevealedbygenome-wideSNPvariation.AmJHumGenet.2009Dec;85(6):775-85.
(33)GuAD,LuLX,XieYB,ChenLZ,FengQS,KangT,JiaWH,ZengYX.ClinicalvaluesofmultipleEpstein-Barrvirus(EBV)serologicalbiomarkersdetectedbyxMAPtechnology.JTranslMed.2009Aug23;7:73.
(34)GuAD,MoHY,XieYB,PengRJ,BeiJX,PengJ,LiMY,ChenLZ,FengQS,JiaWHetal.Evaluationofamultianalyteprofilingassayandanenzyme-linkedimmunosorbentassayforserologicalexaminationofEpstein-Barrvirus-specificantibodyresponsesindiagnosisofnasopharyngealcarcinoma.ClinVaccineImmunol.2008Nov15(11):1684-8.
(35)YuanSH,LiangXF,JiaWH,HuangJL,WeiM,DengL,LiangLZ,WangXY,ZengYX.Moleculardiagnosisofsentinellymphnodemetastasesincervicalcancerusingsquamouscellcarcinomaantigen.ClinCancerRes.2008Sep1;14(17):5571-8.
(36)GuAD,XieYB,MoHY,JiaWH,LiMY,LiM,ChenLZ,FengQS,LiuQ,QianCNetal.AntibodiesagainstEpstein-Barrvirusgp78antigen:anovelmarkerforserologicaldiagnosisofnasopharyngealcarcinomadetectedbyxMAPtechnology.JGenVirol.2008May;89(Pt5):1152-8.
(37)ShugartYY,WangY,JiaWH,ZengYX.GWASsignalsacrosstheHLAregions:revealingaclueforcommonetiologyunderlyinginfectioustumorsandotherimmunitydiseases.ChinJCancer.2011Apr;30(4):226-30.
(38)RuanHL,XuFH,LiuWS,FengQS,ChenLZ,ZengYX,JiaWH.AlcoholandteaconsumptioninrelationtotheriskofnasopharyngealcarcinomainGuangdong,China.FrontMedChina.2010Dec;4(4):448-56.
(39)JiangRC,QinHD,ZengMS,HuangW,FengBJ,ZhangF,ChenHK,JiaWH,ChenLZ,FengQS,ZhangRH,YuXJ,ZhengMZ,ZengYX.AfunctionalvariantinthetranscriptionalregulatoryregionofgeneLOC344967cosegregateswithdiseasephenotypeinfamilialnasopharyngealcarcinoma.CancerRes.2006Jan15;66(2):693-700.
(40)JiangJH,JiaWH,ChenHK,FengBJ,QinHD,PanZG,ShenGP,HuangLX,FengQS,ChenLZ,LinDX,ZengYX.GeneticpolymorphismsofCYP2A13anditsrelationshiptonasopharyngealcarcinomaintheCantonesepopulation.JTranslMed.2004Jun29;2(1):24.




[社会兼职]
中国医药生物技术协会组织生物样本库分会副主任委员
中国抗癌协会肿瘤病因学专业委员会常务委员
中国抗癌协会肿瘤流行病学专业委员会委员
广东省青年科学家协会委员
《ChineseJournalofCancer》杂志责任编委
《中华预防医学杂志》通讯编委


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