基本情况
曹日晖（RihuiCao）,男，1970年8月出生，籍贯湖南新化，理学博士，副教授，硕士生导师。

近五年来，先后在国际学术刊物《CurrentMedicinalChemistry》、《InternationalJournalofCancer》、《Biochemical&BiophysicalResearchCommunication》、《Bioorganic&MedicinalChemistry》、《Bioorganic&MedicinalChemistryLetters》、《CancerBiologyTherapy》、《EuropeanJournalofMedicinalChemistry》、《FoodChemistry》、《Chemical&PharmaceuticalBulletin》、《ActaPharmacologicaSinica》等上发表SCI收录论文32篇，其中第一作者（含通讯作者）19篇，IF>3.0的16篇，IF>4.5的2篇。现担任国际学术刊物《EuropeanJournalofMedicinalChemistry》、《AppliedBiochemistryandBiotechnology》和《LettersinDrugDesignandDiscovery》审稿人。

联系方式
·E-mail：caorihui@mail.sysu.edu.cn
·联系电话：020-84110918（O）
·通讯地址：广州市新港西路135号中山大学化学与化学工程学院丰盛堂
·实验室地址：中山大学南校区化学南楼211/213室
·邮政编码：510275

教育经历
·1989.9－1993.6湖南师范大学生命科学学院生物学系学士
·1993.9－1996.6武汉大学生命科学学院病毒学系硕士
·2001.9－2004.6中山大学生命科学学院生物化学系博士

工作经历
·1996.7－2000.11珠海金沙制药有限公司药物研究所
·2000.12－2001.3深圳云大科技实业开发有限公司技术部项目经理
·2001.4－2001.8深圳创新慧生物技术开发有限公司项目经理
·2004.8－2007.11中山大学化工学院/新疆华世丹药物研究有限公司博士后
·2007.12－2012.1中山大学化学与化学工程学院有机研究所副教授

讲授课程
1.本科生《细胞生物学》、《综合化学实验》
2.研究生《结构生物学》

科研方向
1.新型抗肿瘤药物的设计、合成、筛选及分子机理研究；
2.新型酪氨酸酶抑制剂的设计、合成、筛选及机制研究；

科研项目
1.基于拓扑异构酶I靶点的新型抗肿瘤化合物β-咔啉碱的优化设计、合成及构效关系研究（项目负责人教育部高等学校青年培育项目2009.1-2011.12）
2.新型拓扑异构酶I抑制剂β-咔啉碱的分子设计与生物活性研究（项目负责人教育部博士点基金新教师基金2011.1-2013.12）
3.基于鱼腥草素结构优化的新型抗菌药物研究（项目负责人广东省科技计划项目2010.1-2012.12）
4.高性能氯化聚丙烯改性树脂的研发(项目负责人广东省科技厅省部产学研项目2009.1－2010.12)
5.去氢骆驼蓬碱结构改造与抗肿瘤构效关系研究（项目负责人中国博士后科学基金2005.1－2007.12）
6.香豆素衍生物构效关系研究(项目负责人企业横向课题2009.9-2010.10)
7.去氢骆驼蓬碱结构改造与抗肿瘤构效关系研究（项目负责人企业横向课题2008.1-2008.12）

论著一览
1.ChunmingMa,RihuiCao*,BuxiShi,XiantaiZhou,QinMa,JieSun,LiangGuo,WeiYi,ZhiyongChen,HuacanSong*.Synthesisandcytotoxicevaluationof1-carboxamideand1-aminosidechainsubstitutedβ-carbolines.EuropeanJournalMedicinalChemistry.2010,45,5513-5519.(通讯作者,SCI收录，IF=3.269).
2.ZhiyongChen,RihuiCao*,LiangYu,BuxiShi,JieSun,LiangGuo,QinMa,WeiYi,XiaoSong,HuacanSong*.Synthesis,cytotoxicactivitiesandDNAbindingpropertiesofβ-carbolinederivatives.EuropeanJournalMedicinalChemistry.2010,45,4740-4745.(通讯作者,SCI收录，IF=3.269).
3.LiangYu,RihuiCao,WeiYi,QinYan,ZhiyongChen,LinMa,HuacanSong.Design,synthesisandevaluationofdifunctionalized4-hydroxybenzaldehydederivativesasnovelcholinesteraseinhibitors.Chemical&PharmaceuticalBulletin.2010,58(9),1216-1220.(SCI收录，IF=1.698).
4.ZhiyongChen,RihuiCao*,BuxiShi,WeiYi,LiangYu,HuacanSong*,ZhenhuaRen,WenliePeng.Synthesisofnovelβ-carbolineswithefficientDNA-bindingcapacityandpotentcytotoxicity.Bioorganic&MedicinalChemistryLetters.2010,20,3876-3879.(通讯作者,SCI收录，IF=2.650).
5.LiangYu,RihuiCao,WeiYi,QinYan,ZhiyongChen,LinMa,WenliePeng,HuacanSong*.Synthesisof4-[(diethylamino)methyl]-phenolderivativesasnovelcholinesteraseinhibitorswithselectivitytowardsbutyrylcholinesterase.Bioorganic&MedicinalChemistryLetters.2010,20,3254-3258.(SCI收录，IF=2.650).
6.WeiYi,RihuiCao,ZhiyongChen,LiangYu,HuanWen,QinYan,LinMaandHuacanSong*.RationalDesignandSynthesisof4-O-SubstitutedPhenylmethylenethiosemicarbazonesasNovelTyrosinaseInhibitors.Chemical&PharmaceuticalBulletin.2010,58,752-754.(SCI收录，IF=1.698).
7.ZhiyongChen,RihuiCao,BuxiShi,WeiYi,LiangYu,HuacanSong*,ZhenhuaRen*.SynthesisandBiologicalEvaluationofNovelβ-CarbolinesasPotentCytotoxicandDNAIntercalatingAgents.Chemical&PharmaceuticalBulletin.2010,58(7),901-907.(SCI收录，IF=1.698).
8.RihuiCao*,XiangdongGuan,BuxiShi,ZhiyongChen,ZhenhuaRen,WenliePeng,HuacanSong.Design,synthesisand3D-QSARofβ-carbolinederivativesaspotentantitumoragents.EuropeanJournalMedicinalChemistry.2010,45(6)2503-2515.(通讯作者,SCI收录，IF=3.269).
9.ChunmingMa,RihuiCao*,BuxiShi,ShaoxueLi,ZhiyongChen,WeiYi,WenliePeng,ZhenhuaRen,HuacanSong*.SynthesisandcytotoxicevaluationofN2-benzylatedquaternaryβ-carbolineaminoacidesterconjugates.EuropeanJournalMedicinalChemistry.2010,45：1515-1523.(通讯作者,SCI收录，IF=3.269).
10.WeiYi,RihuiCao*,WenliePeng,HuanWen,QinYan,BinhuaZhou,LinMa,HuacanSong*.Synthesisandbiologicalevaluationofnovel4-hydroxybenzaldehydederivativesastyrosinaseinhibitors.EuropeanJournalMedicinalChemistry.2010,45，639-646.(通讯作者,SCI收录，IF=3.269).
11.WeiYi,RihuiCao,ZhiyongChen,LiangYu,LinMa,HuacanSong*.Design,synthesisandbiologicalevaluationofhydroxy-ormethoxy-substitutedphenylmethylenethiosemicarbazonesastyrosinaseinhibitors.Chemical&PharmaceuticalBulletin.2009,57,1273-1277.(SCI收录，IF=1.698).
12.WeiYi,RihuiCao*,HuanWen,QinYan,BinhuaZhou,LinMa,HuacanSong*.Discoveryof4-functionalizedphenyl-O-β-D-glycosidesasanewclassofmushroomtyrosinaseinhibitors.Bioorganic&MedicinalChemistryLetters.2009,19,6157-6160.(通讯作者,SCI收录，IF=2.650).
13.QinYan,RihuiCao*,WeiYi,LiangYu,ZhiyongChen,LinMa,HuacanSong*.Synthesisandevaluationof5-benzylidene(thio)barbiturate-β-D-glycosidesasmushroomtyrosinaseinhibitors.Bioorganic&MedicinalChemistryLetters.2009,19,4055-4058.(通讯作者,SCI收录，IF=2.650).
14.QinYan,RihuiCao*,WeiYi,ZhiyongChen,HuanWen,LinMa,HuacanSong*.Inhibitoryeffectsof5-benzylidenebarbituratederivativesonmushroomtyrosinaseandtheirantibacterialactivities.EuropeanJournalMedicinalChemistry.2009,44,4235-4243.(通讯作者,SCI收录，IF=3.269).
15.YiWei,XiaoqinWu,RihuiCao,HuacanSong,LinMa*.BiologicalevaluationsofnovelvitaminCestersasmushroomtyrosinaseinhibitorsandantioxidants.FoodChemistry.2009,117,381-386.(SCI收录，IF=3.146).
16.JinbingLiu,RihuiCao*,WeiYi,ChunmingMa,YiqianWan,BinhuaZhou,LinMa,HuacanSong*.Aclassofpotenttyrosinaseinhibitors:Alkylidenethiosemicarbazidecompounds.EuropeanJournalMedicinalChemistry.2009,44:1773-1778.(通讯作者,SCI收录，IF=3.269).
17.WeiYi,RihuiCao*,HuanWen,QinYan,BinhuaZhou,YiqianWan,LinMa,HuacanSong*.Synthesisandbiologicalevaluationofhelicidanaloguesasmushroomtyrosinaseinhibitors.Bioorganic&MedicinalChemistryLetters.2008,18:6490-6493.(通讯作者,SCI收录，IF=2.650).
18.JinbingLiu,RihuiCao,QifengWu,ChunmingMa,ZihouWang,WenliePeng,HuacanSong*.Synthesisandantibacterialevaluationofnovel4-alkylsubstitutedphenylβ-aldehydeketonederivatives.EuropeanJournalMedicinalChemistry.2009,44:1737-1744.(SCI收录，IF=3.269).
19.QifengWu,RihuiCao*,ManxiuFeng,XiangdongGuan,ChunmingMa,JinbingLiu,HuacanSong,WenliePeng*.Synthesisandinvitrocytotoxicevaluationofnovel3,4,5-trimethoxyphenylsubstitutedβ-carbolinederivatives.EuropeanJournalMedicinalChemistry.2009,44,533-540.(通讯作者，SCI收录，IF=3.269).
20.RihuiCao*,WeiYi,QifengWu,XiangdongGuan,Manxiu,Feng,ChunmingMa,ZhiyongChen,HuacanSong,WenliePeng*.Synthesisandcytotoxicactivitiesof1-benzylidinesubstitutedβ-carbolinederivatives.Bioorganic&MedicinalChemistryLetters.2008,18:6558-6561.(通讯作者，SCI收录，IF=2.650).
21.RihuiCao,WenliePeng,ZihouWang，AnlongXu*.β-Carbolinealkaloids:Biochemical&pharmacologicalfunctions.CurrentMedicinalChemistry.2007,14:479-500.(SCI收录，IF=4.708).
22.RihuiCao,WenliePeng,HongshengChen，YanMa,XiaodongLiu,XueruiHou,HuajiGuan,WenliePeng,AnlongXu*.DNAbindingpropertiesof9-substitutedharminederivatives.BiochemicalandBiophysicalResearchCommunication.2005,338:1157-1563.(SCI收录，IF=2.548).
23.RihuiCao,WenliePeng,HongshengChen,XueruiHou,HuajiGuan,QiChen,YanMa,AnlongXu*.Synthesisandinvitrocytotoxicevaluationof1,3-bisubstitutedand1,3,9-trisubstitutedbeta-carbolinederivatives.EuropeanJournalMedicinalChemistry.2005,40:249-257.(SCI收录，IF=3.269).
24.RihuiCao,QiChen,XueruiHou,HongshengChen,HuajiGuan,YanMa,WenliePeng,AnlongXu*.Synthesis,acutetoxicitiesandantitumoreffectsofnovel9-substitutedβ-carbolinederivatives.Bioorganic&MedicinalChemistry.2004,12:4613-4623.(SCI收录，IF=2.822).
25.RihuiCao,HongshengChen,WenliePeng,YanMa,XueruiHou,HuajiGuan,XiaodongLiu,AnlongXu*.Design,synthesisandinvitroandinvivoantitumoractivitiesofnovelβ-carbolinederivatives.EuropeanJournalMedicinalChemistry.2005,40:991-1001.(SCI收录，IF=3.269).
26.QiChen,RihuiChao,HongshengChen,XueruiHou,HuifangYan,ShufengZhou,WenliePeng,AnlongXu*.Antitumorandneurotoxiceffectsofnovelharminederivativesandstructure-activityrelationshipanalysis.InternationalJournalofCancer,2004,114:675-682(并列第一作者,SCI收录，IF=4.722).
27.JingZhang,YanLi,LiangGuo,RihuiCao,PeiZhao,WeiJiang,QinMa,HongYi,ZhuorongLi,JiandongJiang,JialinWu,YanchangWang,ShuyiSi*.DH166,abeta-carbolinederivative,inhibitsthekinaseactivityofPLK1.CancerBiologyTherapy.2009,8:2374-2383.(SCI收录，IF=2.711).
28.YanLi,FengshanLiang,WeiJiang,FushengYu,RihuiCao,QingheMa,XiuyongDai,JiandongJiang,YanchangWang*,ShuyiSi*.DH334,aβ-carbolineanti-cancerdrug,inhibitstheCDKactivityofbuddingyeast.CancerBiologyTherapy.2007,6:1193-1199.(SCI收录，IF=2.711).
29.HuajiGuan,HongshengChen,WenliePeng,YanMa,RihuiCao,XiaodongLiu,AnlongXu*.Designofβ-carbolinederivativesasDNA-targetingantitumoragents.EuropeanJournalMedicinalChemistry.2006,41:1167-1179.(SCI收录，IF=3.269).
30.HuajiGuan,XiaodongLiu,WenliePeng,RihuiCao,YanMa,HongshengChen,AnlongXu*.β-carbolinederivatives－NovelphotosensitizersthatintercalateintoDNAtocausedirectDNAdamageinphotodynamictherapy.BiochemicalandBiophysicalResearchCommunication.2005,342:894-901.(SCI收录，IF=2.548).
31.Xue-ruiHOU,QiCHEN,Ri-huiCAO,Wen-liePENG,An-longXU*.Acomparativemolecularfieldanalysisofcytotoxicbeta-carbolineanalogs.ActaPharmacologicaSinica.2004；25(7):959-965.(SCI收录，IF=1.783).
32.HuanWen,ChonglanLin,LingQue,HuiGe,LinMa,RihuiCao,YiqianWan,WenliePeng,ZihouWang,HuacanSong*.Synthesisandbiologicalevaluationofhelicidanaloguesasnovelacetylcholinesteraseinhibitors.EuropeanJournalofMedicinalChemistry2008,43:166-173.(SCI收录，IF=3.269).

相关成果
暂未更新。