张健
学院： 药学院
专业： 药理学
职称： 教授

简介： 张健，男，54岁，神经生物学博士，“广东省天然小分子创新药物工程实验中心”主任，深圳大学医学院教授、神经内科主任医师。
主持或参与了多项国家、省、市自然科学基金项目，采用免疫组化和电生理学技术，在脑缺血、癫痫、焦虑抑郁、亨廷顿病、神经肌肉疾病、疼痛信号传导与调制等的细胞与分子机制及诊疗方面开展了系统、深入的研究，在国际权威杂志发表SCI论文100余篇，主编或参编多本神经科学专著与教材。
长期从事神经病学临床诊疗、教学及科研工作。在脑卒中、失眠、焦虑抑郁以及老年痴呆、认知障碍等方面奠定了丰富的临床经验与研究基础。
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研究经历：
主持或作为第二主持人参与了多项国家、省、市自然科学基金项目:
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1、国家自然科学基金面上项目《绞股蓝属植物诱导内质网应激抗胃癌肿瘤干细胞的活性物质基础及作用机制研究》（编号：**，2020-2023，直接经费55万）。
2、国家自然科学基金面上项目《焦虑对经典决策偏向的影响及其脑机制》（**，2015.01.01-2018.12.31， 70万元）。
3、国家自然科学基金青年基金项目《五羟色胺调节舌下运动神经元活动的机制及该调控对呼吸的影响》（**， 2015.01.01-2017.12.31， 23万元）。
4、国家自然青年科学基金项目《纹状体投射神经元对HD损伤敏感差异性的机制研究以及mHtt对其的影响》（**，2014-2016，23万）。
5、国家自然科学基金面上项目《低频超声微泡介导NGF脂质体修复损伤胆碱能神经元的研究》（基金号NO **，已结题）。
6、深圳市重点科技项目《杜氏肌营养不良症产前/早期细胞及基因学诊断技术的研发》的实验研究(JCA,2010-2013,30万元)。
7、深圳市重点科技项目《高等灵长类动物模型来源椎间盘干细胞和骨髓间充质干细胞的体内外功能活性比较研究》（JCA,2010-2013,30万元）。
8、深圳市科技计划项目《P物质对酸通道的调制作用及其机制》(,2006-2008,4万元).
近10年内发表的代表性学术论文
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1.???? Zheng MG, Sui WY, He ZD, Liu Y, Huang YL, Mu SH, Xu XZ, Zhang JS, Qu JL, Zhang J, Wang D. TrkA regulates the regenerative capacity of bone marrow stromal stem cells in nerve grafts. Neural Regen Res. 2019; 14(10): 1765-1771.? (IF:2.472)
2. Chen SH, Zhang J, Ruan XL, Deng K, Zhang JN, Zou DF, He XM, Li F, Bin G, Zeng HW, Huang BS. Voxel-based morphometry analysis and machine learning based classification in pediatric mesial temporal lobe epilepsy with hippocampal sclerosis[J]. Brain Imaging and Behavior, 2019(9):1931-7565.
3. Zheng LY, Bin G, Zeng HW, Zou DF, Gao JL, Zhang J, Huang BS. Meta-analysis of voxel-based morphometry studies of gray matter abnormalities in patients with mesial temporal lobe epilepsy and unilateral hippocampal sclerosis[J]. Brain Imaging and Behavior, 2018.12(5):1497-1503.
4.Zheng M, Duan J, He Z, Wang Z, Mu S, Zeng Z, Qu J, Wang D, Zhang J. Transplantation of bone marrow stromal stem cells overexpressing Tropomyosin- receptor-kinase A for peripheral nerve repair. Cytotherapy. 2017, 19(8):916-926. (IF:3.993，2区)
5.Guo Bin, Tianfu Wang, Hongwu Zeng, Xiaoming He, Feng Li, Jian Zhang,
Bingsheng Huang.Patterns of Gray Matter Abnormalities in
Idiopathic Generalized Epilepsy: A Meta-Analysis of Voxel-Based Morphology Studies.PLOS ONE | DOI:10.1371/journal.pone.** January 6, 2017
6.MEIGE ZHENG, JUNXIU DUAN, ZHENDAN HE, ZHIWEI WANG, SHUHUA MU, ZHIWEN ZENG, JUNLE QU, JIAN ZHANG, DONG WANG.Overexpression of tropomyosin receptor kinase A improves the survival and Schwann-like cell differentiation of bone marrow stromal cells in nerve grafts for bridging rat sciatic nerve defects.Cytotherapy, 2016; 18: 1256–1269
7.Han L,?Mu S(Co-first author),?He Z,?Wang Z,?Qu J,?Ye W,?Zhang J*. CNQX?Facilitates Inhibitory Synaptic Transmission in?Rat?Hypoglossal?Nucleus. Brain Res.??2016 Apr 15;1637:71-80(IF:2.843, 中科院三区)
8.Mu S,?Han L,?Zhou G,?Mo C,?Duan J,?He Z,?Wang Z,?Ren L,?Zhang J*.Protein regulation ofinduced?pluripotent?stem?cells?by?transplanting?in a?Huntington's?animal?model. Neuropathol Appl Neurobiol.?2016 Feb 9. doi: 10.1111/nan.12315. [Epub ahead of print] (IF:3.927, 中科院二区)
9. Zheng M, Duan J, He Z, Wang Z, Mu S, Zeng Z, Qu J, Zhang J, Wang D. Overexpression of tropomyosin receptor kinase A improves the survival and Schwann-like cell differentiation of bone marrow stromal cells in nerve grafts for bridging rat sciatic nerve defects. Cytotherapy. 2016, 18(10):1256-1269. (IF:3.993，2区)
10.郑嵋戈，段军秀，贺震旦，王志伟，穆淑花，曾志文，屈军乐，张健，王东。TrkA过表达及抑制表达慢病毒载体转染对骨髓基质干细胞存活的影响[J]。中华显微外科杂志，2016(39): 476-480。
11.Mu S, Liu B, Ouyang L, Zhan M, Chen S, Wu J, Chen J, Wei X, Wang W, Zhang J*, and Lei W* Characteristic changes of astrocyte and microglia in rat striatum induced by 3-NP and MCAO. Neurochemical research, 2016 Apr;41(4):707-14 (IF:2.593, 中科院三区)
12.Mu S, Wang J, Zhou G, Peng W, He Z, Zhao Z, Mo C, Qu J*, Zhang J*. Transplantation of Induced Pluripotent Stem Cells Improves Functional Recovery in Huntington's Disease Rat Model. PLoS One. 2014 Jul 23; 9(7): e101185. (IF:3.234; 中科院三区)
13.Mu S, Lin E, Liu B, Ma Y, OuYang L, Li Y, Chen S, Zhang J*, Lei W*. Melatonin reduces projection neuronal injury induced by 3-nitropropionic acid in the rat striatum.Neurodegener Dis 2014;14:139–150. (IF:3.511, 中科院三区)
14.Zhang, D., Gu, R., Broster, L., Jiang, Y., Luo, W., Zhang, J., & Luo, Y.J. (2014).Linking brain electrical signals elicited by current outcomes with future risk decision-making. Frontiers in Behavioral Neuroscience, 2014, doi: 10.3389/fnbeh.2014.00084.
15.Chen-yang Li, David Tai-wai Lau, Tina Ting-xia Dong, Jian Zhang, Roy Chi-yan Choi, Hai-qiang Wu, Li-yan Wang, Rui-sha Hong, Shi-he Li, Xun Song, Tian Yu, Wei-wei Su, Karl Wah-keung Tsim, and Zhen-dan He. Dual?indexes evaluation of character changes for Panax ginseng C. A. Mey stored in different conditions. Journal of Agricultural and Food Chemistry, 2013, 61(26), 6568-6573.
16. XunSong, Chen-yang Li, Yong Zeng, Hai-qiang Wu, Zhong Huang, Jian Zhang, ? Rui-sha Hong, Xiao-xiong Chen,? Li-yan Wang, Xiao-peng Hu, Yan Li, Wei-wei Su , Zhen-dan He.Immunomodulatery effects of crude phenylethanoid glycosides from ligustrum purpurascens. Journal of ?Enthnopharmacology,144(2012)584-591.
17. Xiang-Yuan Li*，Jian Zhang*(co-first author)，Jia-Pei Dai, et al.Actions of bis(7)-tacrine and tacrine on transient potassium current in rat DRG neurons and potassium current mediated by KV4.2 expressed? in Xenopus Oocyte.[J]. Brainresearch, 2010 1318:23-32. [*The first two authors contributed equally to this work].
18. Zhi-Wang Li *, Jian Zhang *(co-first author), Chang-han Ouyang et al. Potentiation by WIN 55,212-2 of GABA-activated currents in rat trigeminal ganglion neurones. [J].British Journal of Pharmacology 2009, 158: 1904–1910.[*The first two authors contributed equally to this work].
19. Zhang J, Li M, Li XY et al. Modulation of proton-gated current by substance P in trigeminal ganglion neurons of rat. [J]. Chinese Journal of Neuromedicine，2008,7(6):562-566.
20. Zhang J, Liao ZM, Li ZW et al. The outward current of S-type and O-type proton-gated ion channels in rat DRG neurons. [J]. Chinese Journal of Neuromedicine，2008, 7(2):134-138.
21. Zhang J, Liao ZM, Li ZW et al. Current classification of proton-gated ion channels and correlation with their underlying ASICs subunit assembly in rat DRG neurons. [J]. Chinese Journal of Neuromedicine, 2008, 7(1):06-11.
22. Zhang J, Luo JL, Zhou KC et al. Synergic effect of ATP and bradykinin on the induction of nociceptive responses: an electrophysiological and behavioural study. [J]. Chinese Journal of Neuromedicine，2007，6（9）：914-919.
23. Zhang J, Hu WP, Zou KC et al. Interaction of 5-HT2 and 5-HT3 receptor subtype in 5-HT-induced nociceptive responses in peripheral primary sensory nerve ending. [J]. Chinese Journal of applied physiology, 2006, 22（1）：40－44.
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主编或参编专著：
1.《细胞电生理学基本原理与膜片钳技术》，P296-300，科学出版社，2013年1月，参编。
2.全国高等医药院校国家级实验教学示范中心“十二五”规划教材《生理学实验》，华中科技大学出版社，2012年1月，副主编，.
3.《神经科学基础》，清华大学出版社，2004年7月，编委。