张秀丽
学院： 深圳大学第一附属医院
专业： 肾脏病学（招生方向）
职称： 教授
简介：
张秀丽（Xiuli Zhang），中国医科大学肾内科博士，瑞典卡洛琳斯卡医学院分子医学研究中心和中国医科大学细胞生物国家重点实验室博士后，现任深圳第二人民医院肾内科主任医师，深圳大学硕士研究生导师，广东医科大学硕士研究生导师，深圳市医学会肾脏病分会委员等。主要从事糖尿病及糖尿病肾病的病理生理学和临床医学研究。获国家自然科学基金面上项目、中国博士后科学基金面上项目、省自然科学基金面上项目等科研基金资助，总经费超过63万元。以第一作者或通讯作者在Metabolism Clinical and Experimental等国际期刊和国内核心杂志发表学术论文余篇，参加由英国Nature Springer出版社编写的The Handbook of Famine, Starvation, and Nutrient Deprivation专著一部。
?
科研项目
1.国家?自然科学基金委面上基金（**），2017-2020，主持
2.省级-自然科学基金面上基金（），2016-2019，主持
?
代表性成果（近五年代表作5-10篇）
1.Zhang X, Guan T, Yang B et al. Protective effect of Berberine on high glucose and hypoxia-induced apoptosis via the modulation of HIF-1α in renal tubular epithelial cells. American Journal of Translational Research, 2019; 11(2):669-682.
2.Zhang X, Gu HF, Frystyk J et al. Analyses of IGFBP2 DNA methylation and mRNA expression in visceral and subcutaneous adipose tissues of obese subjects. Growth Hormone & IGF Researc. 2019; 45:31-36. ?
3.Zhang X, Guan?T,?Yang?B, et al. A novel role for zinc transporter 8 in the facilitation of zinc accumulation and regulation of testosterone synthesis in Leydig cells of human and mouse testicles. Metabolism Clinical and Experimental. 2018(88):40–50. ?
4.Zhang X, Lian X, Liang D et al. Protective Effect of ZnT7 on High Glucose-induced Epithelial-to-Mesenchymal Transition in Renal Tubular Epithelial Cells. Kidney and Blood Pressure Research. Kidney and Blood pressure Research. 2018; 43:500-512.
5.Zhang X, Liang D, Fan J et al. Zinc Attenuates Tubulointerstitial Fibrosis in Diabetic Nephropathy Via Inhibition of HIF Through PI- 3K Signaling. Biol Trace Elem Res. 2016; 173(2):372-83.
6.Zhang X, Liang D, Lian X et al. Berberine activates Nrf2 nuclear translocation and inhibits apoptosis induced by high glucose in renal tubular epithelial cells through a phosphatidylinositol 3-kinase/Akt-dependent mechanism. Apoptosis. 2016; 21(6): 721-36.
7.Zhang X, He H, Liang D et al. Protective Effects of Berberine on Renal Injury in Streptozotocin (STZ)-Induced Diabetic Mice. Int J Mol Sci. 2016; 17(8). pii: E1327.
8.Chu Q, Chi ZH*, Zhang X*?et al. A potential role for zinc transporter-7 in testosteronesynthesis in mouse Leydig tumor cells. International Journal of Molecular Medicine: 2016; 37: 1619-1626. *Co-corresponding authorship
9.Zhang X, Liang D, Guo L et al. Curcumin protects renal tubular epithelial cells from high glucose-induced epithelial-to-mesenchymal transition through Nrf2-mediated upregulation of heme oxygenase-1. Mol Med Rep; 2015;12: 1347-1355.
10.Zhang X, Liang D, Chi Z et al. Effect of zinc on high glucose-induced epithelial-tomesenchymal transition in renal tubular epithelial cells. Int J Mol Med; 2015; 35: 1747- 1754.