基本信息
姓名：张焱
职称：教授
职位：
所属系：生物科学系
办公地点：丽湖校区守慧楼306
办公电话：
邮箱：zhangyan@szu.edu.cn
工作职责：

个人简介
张焱，男，1974年5月生，博士，深圳大学生命与海洋科学学院****，深圳大学脑病与大数据研究所所长，深圳大学神经系统疾病临床医学研究中心副主任。1997年毕业于浙江大学医学院临床医学系，获学士学位; 2002年于中国医学科学院&北京协和医学院基础所生物医学工程系获博士学位。2002年至2009年在美国内布拉斯加大学林肯分校任博士后和高级研究助理。2009年至2011年在美国哈佛医学院&布莱根妇女医院医学系担任讲师和副遗传学家。2011年至2016年任中科院上海生命科学研究院研究员，2012年入选中科院“****”。2015年获深圳市“鹏城****”****。2017年入职深圳大学生命与海洋科学学院。先后主持多项国家自然科学基金、中科院和省部级项目。已在国外学术刊物上发表论文70余篇，包括在Chemical Reviews，Genome Biology，Nucleic Acids Research，ISME Journal等高水平期刊上发表第一作者和通讯作者论文，总影响因子在400分以上。作为通讯作者参与多部英文书籍章节的撰写，并作为副主编参与编写了《硒：分子生物学与人体健康》一书。获2017年深圳市自然科学奖二等奖。目前是中国生物物理学会生物微量元素分会理事和多个国内外学会的会员。

主要研究方向：
1. 微量元素（如硒和金属）代谢、功能与进化规律的生物信息学研究，寻找元素代谢新基因和新调控机制；
2. 复杂疾病（如神经退行性疾病、糖尿病、肿瘤等）的系统生物学研究，基于组学大数据，开发新算法，揭示疾病发生发展的新分子机制，寻找新型生物标记物，建立智能化早期预警与监测平台。

近5年发表论文（*: 通讯作者）：
1.Xu Y, Cao J, Jiang L, Zhang Y*. (2020) Biogeographic and evolutionary patterns of trace element utilization in marine microbial world. Genomics Proteomics Bioinformatics, in press （IF：7.051，中科院一区）
2.Chen D, Li G, Ji C, Lu Q, Qi Y, Tang C, Xiong J, Hu J, Yasar FBA, Zhang Y*, Hoon DSB, Yao Y*, Zhou L. (2020) Enhanced B7-H4 expression in gliomas with low PD-L1 expression identifies super-cold tumors. J ImmunoTher Cancer 8(1):e000154. （IF：9.913，中科院一区）
3.Ying H, Zhang Y*. (2019) Systems biology of selenium and complex disease. Biol Trace Elem Res. 192(1):38-50. （IF：2.639，中科院三区）
4.Zhang Y*, Ying H, Xu Y. (2019) Comparative genomics and metagenomics of the metallomes. Metallomics 11(6):1026-1043. （IF：3.796，中科院二区，封面文章）
5.Shen Z, Lin J, Teng J, Zhuang Y, Zhang H, Wang C, Zhang Y*, Ding X*, Zhang X*. (2020) Association of Urinary Ionomic Profiles and Acute Kidney Injury and Mortality in Patients after Cardiac Surgery. J Thorac Cardiovasc Surg. 159(3):918-926. （IF：5.261，中科院二区）
6.Li Q, Hu C, Lin J, Yang Z, Zhou Q, Yang R, Yuan H, Zhu X, Lv Y, Liang Q, Lv Z, Sun L, Zhang Y*. (2019) Urinary ionomic analysis reveals new relationship between minerals and longevity in a Han Chinese population. J Trace Elem Med Biol. 53:69-75. （IF：3.245，中科院三区）
7.Lin J, Wu YJ, Liang X, Ji M, Ying HM, Wang XY, Sun X, Shao CH, Zhan LX, Zhang Y*. (2019) Network-based integration of mRNA and miRNA profiles reveals new target genes involved in pancreatic cancer. Mol Carcinog. 58(2):206-218.（IF：3.825，中科院二区）
8.Yao F, Zhang K, Zhang Y, Guo Y, Li A, Xiao S, Liu Q, Shen L, Ni J. (2019) Identification of Blood Biomarkers for Alzheimer's Disease Through Computational Prediction and Experimental Validation. Front Neurol. 9:1158.（IF：2.635，中科院三区）
9.Li F, Liu CF, Xu YZ, Guo YL, Xue SW, Kong XD, Zhang HB, Zhang Y, Kang JS. (2019) Neonatal lethality and recycling defect of transferrin receptor in mice with Syntaxin12/13 disruption. Protein Cell 10(1):67-71. （IF：10.164，中科院一区）
10.Lin S, Liu Y, Goldin LR, Lyu C, Kong X, Zhang Y, Caporaso NE, Xiang S, Gao Y. (2019) Sex-related DNA methylation differences in B cell chronic lymphocytic leukemia. Biol Sex Differ. 10(1):2.（IF：3.188，中科院三区）
11.Peng T, Xu Y, Zhang Y*. (2018) Comparative genomics of molybdenum utilization in prokaryotes and eukaryotes. BMC Genomics 19(1):691. （IF：3.501，中科院二区）
12.Yao F, Hong X, Li S, Zhang Y, Zhao Q, Du W, Wang Y, Ni J. (2018) Urine-Based Biomarkers for Alzheimer's Disease Identified Through Coupling Computational and Experimental Methods. J Alzheimers Dis. 65(2):421-431. （IF：3.517，中科院二区）
13.Xie Y, Liu Q, Zheng L, Wang B, Qu X, Ni J, Zhang Y, Du X. (2018) Se-Methylselenocysteine Ameliorates Neuropathology and Cognitive Deficits by Attenuating Oxidative Stress and Metal Dyshomeostasis in Alzheimer Model Mice. Mol Nutr Food Res. 62(12):e**. （IF：4.653，中科院二区）
14.Zhang F, Hu Z, Li G, Huo S, Ma F, Cui A, Xue Y, Han Y, Gong Q, Gao J, Bian H, Meng Z, Wu H, Long G, Tan Y, Zhang Y, Lin X, Gao X, Xu A, Li Y. (2018) Hepatic CREBZF couples insulin to lipogenesis by inhibiting insig activity and contributes to hepatic steatosis in diet-induced insulin-resistant mice. Hepatology 68(4):1361-1375. （IF：14.971，中科院一区）
15.应慧敏, 张焱*. (2018) 复杂疾病的离子组学研究进展. 生理学报 70(4):413-423.（中国科技核心期刊）
16.Zhang Y*. (2017) Trace Elements and Healthcare: A Bioinformatics Perspective. Adv Exp Med Biol. 1005:63-98.（IF：1.760，中科院四区）
17.张茂娜, 姜亮*, 张焱*. (2017) 硒代谢网络与硒蛋白质组的生物信息学研究进展. 生物技术进展 7(5):537-544. （中国科技核心期刊）
18.Zheng L, Zhu HZ, Wang BT, Zhao QH, Du XB, Zheng Y, Jiang L, Ni JZ, Zhang Y*, Liu Q*. (2016) Sodium selenate regulates the brain ionome in a transgenic mouse model of Alzheimer's disease. Sci Rep. 6:39290. （IF：4.259，中科院三区）
19.Gladyshev VN, Arnér ES, Berry MJ, Brigelius-Flohé R, Bruford EA, Burk RF, Carlson BA, Castellano S, Chavatte L, Conrad M, Copeland PR, Diamond AM, Driscoll DM, Ferreiro A, Flohé L, Green FR, Guigó R, Handy DE, Hatfield DL, Hesketh J, Hoffmann PR, Holmgren A, Hondal RJ, Howard MT, Huang K, Kim HY, Kim IY, K?hrle J, Krol A, Kryukov GV, Lee BJ, Lee BC, Lei XG, Liu Q, Lescure A, Lobanov AV, Loscalzo J, Maiorino M, Mariotti M, Sandeep Prabhu K, Rayman MP, Rozovsky S, Salinas G, Schmidt EE, Schomburg L, Schweizer U, Simonovi? M, Sunde RA, Tsuji PA, Tweedie S, Ursini F, Whanger PD, Zhang Y. (2016) Selenoprotein Gene Nomenclature. J Biol Chem. 291(46):24036-24040.（IF：4.125，中科院二区）
20.Li GP, Liu L, Li P, Chen L, Song H, Zhang Y*. (2016) Gene expression profiling of selenophosphate synthetase 2 knockdown in Drosophila melanogaster. Metallomics 8(3):354-365. （IF：3.975，中科院二区）
21.Peng T, Lin J, Xu YZ, Zhang Y*. (2016) Comparative genomics reveals new evolutionary and ecological patterns of selenium utilization in bacteria. ISME J. 10(8):2048-2059. （IF：9.664，中科院一区）
22.Yang Z, Zhang Y*, Chen L*. (2015) Single amino acid changes in naked mole rat may reveal new anti-cancer mechanisms in mammals. Gene 572(1):101-107. （IF：2.319，中科院三区）
23.Lin J, Peng T, Jiang L, Ni JZ, Liu Q, Chen L, Zhang Y*. (2015) Comparative genomics reveals new candidate genes involved in selenium metabolism in prokaryotes. Genome Biol Evol. 7(3):664-676. （IF：4.098，中科院二区）
24.Li GP, Jiang L, Ni JZ, Liu Q, Zhang Y*. (2014) Computational identification of a new SelD-like family that may participate in sulfur metabolism in hyperthermophilic sulfur-reducing archaea. BMC Genomics 15:908. （IF：3.986，中科院二区）
25.Yu T, Tao Y, Yang M, Chen P, Gao X, Zhang Y, Zhang T, Chen Z, Hou J, Zhang Y, Ruan K, Wang H, Hu R. (2014) Profiling human protein degradome delineates cellular responses to proteasomal inhibition and reveals a feedback mechanism in regulating proteasome homeostasis. Cell Res. 24(10):1214-1230. （IF：12.413，中科院一区）
26.Sun L, Lin J, Du H, Hu C, Huang Z, Lv Z, Zheng C, Shi X, Zhang Y*, Yang Z*. (2014) Gender-specific DNA methylome analysis of a Han Chinese longevity population. Biomed Res Int. 2014:396727.（IF：1.868，中科院三区）
27.Malinouski M, Hasan NM, Zhang Y, Seravalli J, Lin J, Avanesov A, Lutsenko S, Gladyshev VN. (2014) Genome-wide RNAi ionomics screen reveals new genes and regulation of human trace element metabolism. Nat Commun. 5:3301.（IF：11.470，中科院一区）


编写书籍：
1.Gladyshev VN, Zhang Y*. (2013) The Metallome, in Metals in Cells. Encyclopedia of Inorganic and Bioinorganic Chemistry, John Wiley & Sons, Ltd, pp. 17-38.
2.Gladyshev VN, Zhang Y*. (2013) Comparative genomics analysis of the metallomes, in Metal Ions in Life Sciences 12, Metallomics and the Cell, Springer, pp. 529-580.
3.Zhang Y*. (2013) Several chapters in Encyclopedia of Systems Biology, Springer.
4.Zhang Y*. (2016) Prokaryotic selenoproteins and selenoproteomes, in Selenium - Its Molecular Biology and Role in Human Health, 4th Edition, Springer, pp. 141-150.
5.Gladyshev VN, Zhang Y*. (2016) Abundance, ubiquity, and evolution of molybdoenzymes, in Molybdenum and Tungsten Enzymes: Biochemistry, The Royal Society of Chemistry, pp. 81-99.
6.Zhang Y*. (2017) Trace elements and healthcare: a bioinformatics perspective, in Translational Informatics in Smart Healthcare, Springer, pp. 63-98.
7.硒：分子生物学与人体健康. (2018) 主编：雷新根，王福俤，副主编：刘琼，闵军霞，张焱等，科学出版社。

近期发表的论文
1、Lin J, Wu YJ, Liang X, Ji M, Ying HM, Wang XY, Sun X, Shao CH, Zhan LX, Zhang Y*. Network-based integration of mRNA and miRNA profiles reveals new target genes involved in pancreatic cancer. Mol Carcinog. 2019, 58(2):206-218. SCI


2、Peng T, Xu Y, Zhang Y*. Comparative genomics of molybdenum utilization in prokaryotes and eukaryotes. BMC Genomics 2018, 19(1):691. SCI


3、Zheng L, Zhu HZ, Wang BT, Zhao QH, Du XB, Zheng Y, Jiang L, Ni JZ, Zhang Y*, Liu Q*. Sodium selenate regulates the brain ionome in a transgenic mouse model of Alzheimer's disease. Sci Rep. 2016, 6:39290.


4、Peng T, Lin J, Xu YZ, Zhang Y*. Comparative genomics reveals new evolutionary and ecological patterns of selenium utilization in bacteria. ISME J. 2016, 10(8):2048-2059. SCI


5、Lin J, Peng T, Jiang L, Ni JZ, Liu Q, Chen L, Zhang Y*. Comparative genomics reveals new candidate genes involved in selenium metabolism in prokaryotes. Genome Biol Evol. 2015, 7(3):664-676. SCI



职称 教授 职位
所属系 生物科学系 办公室 丽湖校区守慧楼306
办公电话 邮箱 zhangyan@szu.edu.cn
工作职责 个人简介 张焱，男，1974年5月生，博士，深圳大学生命与海洋科学学院****，深圳大学脑病与大数据研究所所长，深圳大学神经系统疾病临床医学研究中心副主任。1997年毕业于浙江大学医学院临床医学系，获学士学位; 2002年于中国医学科学院&北京协和医学院基础所生物医学工程系获博士学位。2002年至2009年在美国内布拉斯加大学林肯分校任博士后和高级研究助理。2009年至2011年在美国哈佛医学院&布莱根妇女医院医学系担任讲师和副遗传学家。2011年至2016年任中科院上海生命科学研究院研究员，2012年入选中科院“****”。2015年获深圳市“鹏城****”****。2017年入职深圳大学生命与海洋科学学院。先后主持多项国家自然科学基金、中科院和省部级项目。已在国外学术刊物上发表论文70余篇，包括在Chemical Reviews，Genome Biology，Nucleic Acids Research，ISME Journal等高水平期刊上发表第一作者和通讯作者论文，总影响因子在400分以上。作为通讯作者参与多部英文书籍章节的撰写，并作为副主编参与编写了《硒：分子生物学与人体健康》一书。获2017年深圳市自然科学奖二等奖。目前是中国生物物理学会生物微量元素分会理事和多个国内外学会的会员。<br><br>主要研究方向：<br>1. 微量元素（如硒和金属）代谢、功能与进化规律的生物信息学研究，寻找元素代谢新基因和新调控机制；<br>2. 复杂疾病（如神经退行性疾病、糖尿病、肿瘤等）的系统生物学研究，基于组学大数据，开发新算法，揭示疾病发生发展的新分子机制，寻找新型生物标记物，建立智能化早期预警与监测平台。<br><br>近5年发表论文（*: 通讯作者）：<br>1. Xu Y, Cao J, Jiang L, Zhang Y*. (2020) Biogeographic and evolutionary patterns of trace element utilization in marine microbial world. Genomics Proteomics Bioinformatics, in press （IF：7.051，中科院一区）<br>2. Chen D, Li G, Ji C, Lu Q, Qi Y, Tang C, Xiong J, Hu J, Yasar FBA, Zhang Y*, Hoon DSB, Yao Y*, Zhou L. (2020) Enhanced B7-H4 expression in gliomas with low PD-L1 expression identifies super-cold tumors. J ImmunoTher Cancer 8(1):e000154. （IF：9.913，中科院一区）<br>3. Ying H, Zhang Y*. (2019) Systems biology of selenium and complex disease. Biol Trace Elem Res. 192(1):38-50. （IF：2.639，中科院三区）<br>4. Zhang Y*, Ying H, Xu Y. (2019) Comparative genomics and metagenomics of the metallomes. Metallomics 11(6):1026-1043. （IF：3.796，中科院二区，封面文章）<br>5. Shen Z, Lin J, Teng J, Zhuang Y, Zhang H, Wang C, Zhang Y*, Ding X*, Zhang X*. (2020) Association of Urinary Ionomic Profiles and Acute Kidney Injury and Mortality in Patients after Cardiac Surgery. J Thorac Cardiovasc Surg. 159(3):918-926. （IF：5.261，中科院二区）<br>6. Li Q, Hu C, Lin J, Yang Z, Zhou Q, Yang R, Yuan H, Zhu X, Lv Y, Liang Q, Lv Z, Sun L, Zhang Y*. (2019) Urinary ionomic analysis reveals new relationship between minerals and longevity in a Han Chinese population. J Trace Elem Med Biol. 53:69-75. （IF：3.245，中科院三区）<br>7. Lin J, Wu YJ, Liang X, Ji M, Ying HM, Wang XY, Sun X, Shao CH, Zhan LX, Zhang Y*. (2019) Network-based integration of mRNA and miRNA profiles reveals new target genes involved in pancreatic cancer. Mol Carcinog. 58(2):206-218.（IF：3.825，中科院二区）<br>8. Yao F, Zhang K, Zhang Y, Guo Y, Li A, Xiao S, Liu Q, Shen L, Ni J. (2019) Identification of Blood Biomarkers for Alzheimer's Disease Through Computational Prediction and Experimental Validation. Front Neurol. 9:1158.（IF：2.635，中科院三区）<br>9. Li F, Liu CF, Xu YZ, Guo YL, Xue SW, Kong XD, Zhang HB, Zhang Y, Kang JS. (2019) Neonatal lethality and recycling defect of transferrin receptor in mice with Syntaxin12/13 disruption. Protein Cell 10(1):67-71. （IF：10.164，中科院一区）<br>10. Lin S, Liu Y, Goldin LR, Lyu C, Kong X, Zhang Y, Caporaso NE, Xiang S, Gao Y. (2019) Sex-related DNA methylation differences in B cell chronic lymphocytic leukemia. Biol Sex Differ. 10(1):2.（IF：3.188，中科院三区）<br>11. Peng T, Xu Y, Zhang Y*. (2018) Comparative genomics of molybdenum utilization in prokaryotes and eukaryotes. BMC Genomics 19(1):691. （IF：3.501，中科院二区）<br>12. Yao F, Hong X, Li S, Zhang Y, Zhao Q, Du W, Wang Y, Ni J. (2018) Urine-Based Biomarkers for Alzheimer's Disease Identified Through Coupling Computational and Experimental Methods. J Alzheimers Dis. 65(2):421-431. （IF：3.517，中科院二区）<br>13. Xie Y, Liu Q, Zheng L, Wang B, Qu X, Ni J, Zhang Y, Du X. (2018) Se-Methylselenocysteine Ameliorates Neuropathology and Cognitive Deficits by Attenuating Oxidative Stress and Metal Dyshomeostasis in Alzheimer Model Mice. Mol Nutr Food Res. 62(12):e**. （IF：4.653，中科院二区）<br>14. Zhang F, Hu Z, Li G, Huo S, Ma F, Cui A, Xue Y, Han Y, Gong Q, Gao J, Bian H, Meng Z, Wu H, Long G, Tan Y, Zhang Y, Lin X, Gao X, Xu A, Li Y. (2018) Hepatic CREBZF couples insulin to lipogenesis by inhibiting insig activity and contributes to hepatic steatosis in diet-induced insulin-resistant mice. Hepatology 68(4):1361-1375. （IF：14.971，中科院一区）<br>15. 应慧敏, 张焱*. (2018) 复杂疾病的离子组学研究进展. 生理学报 70(4):413-423.（中国科技核心期刊）<br>16. Zhang Y*. (2017) Trace Elements and Healthcare: A Bioinformatics Perspective. Adv Exp Med Biol. 1005:63-98.（IF：1.760，中科院四区）<br>17. 张茂娜, 姜亮*, 张焱*. (2017) 硒代谢网络与硒蛋白质组的生物信息学研究进展. 生物技术进展 7(5):537-544. （中国科技核心期刊）<br>18. Zheng L, Zhu HZ, Wang BT, Zhao QH, Du XB, Zheng Y, Jiang L, Ni JZ, Zhang Y*, Liu Q*. (2016) Sodium selenate regulates the brain ionome in a transgenic mouse model of Alzheimer's disease. Sci Rep. 6:39290. （IF：4.259，中科院三区）<br>19. Gladyshev VN, Arnér ES, Berry MJ, Brigelius-Flohé R, Bruford EA, Burk RF, Carlson BA, Castellano S, Chavatte L, Conrad M, Copeland PR, Diamond AM, Driscoll DM, Ferreiro A, Flohé L, Green FR, Guigó R, Handy DE, Hatfield DL, Hesketh J, Hoffmann PR, Holmgren A, Hondal RJ, Howard MT, Huang K, Kim HY, Kim IY, K?hrle J, Krol A, Kryukov GV, Lee BJ, Lee BC, Lei XG, Liu Q, Lescure A, Lobanov AV, Loscalzo J, Maiorino M, Mariotti M, Sandeep Prabhu K, Rayman MP, Rozovsky S, Salinas G, Schmidt EE, Schomburg L, Schweizer U, Simonovi? M, Sunde RA, Tsuji PA, Tweedie S, Ursini F, Whanger PD, Zhang Y. (2016) Selenoprotein Gene Nomenclature. J Biol Chem. 291(46):24036-24040.（IF：4.125，中科院二区）<br>20. Li GP, Liu L, Li P, Chen L, Song H, Zhang Y*. (2016) Gene expression profiling of selenophosphate synthetase 2 knockdown in Drosophila melanogaster. Metallomics 8(3):354-365. （IF：3.975，中科院二区）<br>21. Peng T, Lin J, Xu YZ, Zhang Y*. (2016) Comparative genomics reveals new evolutionary and ecological patterns of selenium utilization in bacteria. ISME J. 10(8):2048-2059. （IF：9.664，中科院一区）<br>22. Yang Z, Zhang Y*, Chen L*. (2015) Single amino acid changes in naked mole rat may reveal new anti-cancer mechanisms in mammals. Gene 572(1):101-107. （IF：2.319，中科院三区）<br>23. Lin J, Peng T, Jiang L, Ni JZ, Liu Q, Chen L, Zhang Y*. (2015) Comparative genomics reveals new candidate genes involved in selenium metabolism in prokaryotes. Genome Biol Evol. 7(3):664-676. （IF：4.098，中科院二区）<br>24. Li GP, Jiang L, Ni JZ, Liu Q, Zhang Y*. (2014) Computational identification of a new SelD-like family that may participate in sulfur metabolism in hyperthermophilic sulfur-reducing archaea. BMC Genomics 15:908. （IF：3.986，中科院二区）<br>25. Yu T, Tao Y, Yang M, Chen P, Gao X, Zhang Y, Zhang T, Chen Z, Hou J, Zhang Y, Ruan K, Wang H, Hu R. (2014) Profiling human protein degradome delineates cellular responses to proteasomal inhibition and reveals a feedback mechanism in regulating proteasome homeostasis. Cell Res. 24(10):1214-1230. （IF：12.413，中科院一区）<br>26. Sun L, Lin J, Du H, Hu C, Huang Z, Lv Z, Zheng C, Shi X, Zhang Y*, Yang Z*. (2014) Gender-specific DNA methylome analysis of a Han Chinese longevity population. Biomed Res Int. 2014:396727.（IF：1.868，中科院三区）<br>27. Malinouski M, Hasan NM, Zhang Y, Seravalli J, Lin J, Avanesov A, Lutsenko S, Gladyshev VN. (2014) Genome-wide RNAi ionomics screen reveals new genes and regulation of human trace element metabolism. Nat Commun. 5:3301.（IF：11.470，中科院一区）<br><br><br>编写书籍：<br>1. Gladyshev VN, Zhang Y*. (2013) The Metallome, in Metals in Cells. Encyclopedia of Inorganic and Bioinorganic Chemistry, John Wiley & Sons, Ltd, pp. 17-38.<br>2. Gladyshev VN, Zhang Y*. (2013) Comparative genomics analysis of the metallomes, in Metal Ions in Life Sciences 12, Metallomics and the Cell, Springer, pp. 529-580.<br>3. Zhang Y*. (2013) Several chapters in Encyclopedia of Systems Biology, Springer.<br>4. Zhang Y*. (2016) Prokaryotic selenoproteins and selenoproteomes, in Selenium - Its Molecular Biology and Role in Human Health, 4th Edition, Springer, pp. 141-150.<br>5. Gladyshev VN, Zhang Y*. (2016) Abundance, ubiquity, and evolution of molybdoenzymes, in Molybdenum and Tungsten Enzymes: Biochemistry, The Royal Society of Chemistry, pp. 81-99.<br>6. Zhang Y*. (2017) Trace elements and healthcare: a bioinformatics perspective, in Translational Informatics in Smart Healthcare, Springer, pp. 63-98.<br>7. 硒：分子生物学与人体健康. (2018) 主编：雷新根，王福俤，副主编：刘琼，闵军霞，张焱等，科学出版社。