王立岩博士。2003年在沈阳药科大学中药系获得理学博士学位，师从我国著名天然产物化学家姚新生院士，博士期间（2001/1-2003/7）被选派到日本大学药学部生药学研究室进行合作研究，并获得日中医学会的在留中国人研究者资助。博士毕业后先后在日本大学药学部（2003/9-2005/6），美国威斯康新州立大学麦迪逊分校药学院（2005/7-2009/4SchoolofPharmacyUniversityofWisconsin-Madison师从国际著名天然产物化学家BenShen教授），和北卡中心大学（2009/5-2010/1NorthCarolinaCentralUnviersity）进行了共7年的博士后研究。研究范围涉及天然产物化学，天然产物生物合成过程和食品化学等。2010年开始工作于深圳大学生命科学学院。对多种天然产物资源（药用植物，微生物，以及基因工程突变菌株）进行了系统的化学成分多样性及有效成分的研究。利用活性追踪分离的方法从多种药用植物中共发现天然产物100余个，其中具有新颖结构的活性成分近30个。从基因工程突变菌株中分离得到11个新的代谢中间体，修改了市售抗癌药物博莱霉素类化合物的2步关键生合成步骤。对多种放线菌的菌种，发酵工艺进行了改良，其中一些菌株提高了产量10倍以上，并分离得到了一种重要的博莱霉素类似物Zorbamycin，这个及其复杂的化合物在被发现30多年后首次被确定其化学结构。在J.Biol.Chem.,J.Nat.Prod.,Mol.Biosyst.,Chem.Pharm.Bull.,Bioogan.Med.Chem.等国际主流刊物发表论文20篇，全部为SCI论文，尚有2篇高质量的SCI论文待发表。
学会成员
MembershipoftheAmericanChemicalSociety(2007-2008)
MembershipofSigmaXi,theScientificResearchSociety(2007-2008)
MembershipofPharmaceuticalSocietyofJapan.(2002-2005)
MembershipofJapaneseSocietyofPharmacognosy.(2001-2005)
主要研究论文
1.MeifengTao*,LiyanWang*,EvelynWendt-Pienkowski,NingningZhang,DongYang,UteGalm,JaneM.Coughlin,ZhinanXu,?andBenShen?.FunctionalcharacterizationoftlmHinStreptoalloteichushindustanusE465-94ATCC31158unveilingnewinsightintotallysomycinbiosynthesisandaffordinganovelbleomycinanalog.Mol.BioSyst.,2010,6,349-356(impactfactor4.2)共同第一作者
2.LiyanWang,MeifengTao,EvelynWendt-Pienkoski,UteGalm,JaneM.Coughlin,andBenShen.FunctionalCharacterizationoftlmKUnveilingUnstableCarbinolamideIntermediatesintheTallysomycinBiosyntheticPathway.J.Biol.Chem.2009，284，8256-8264.(impactfactor5.8)
3.ZhiyangFeng,LiyanWang,ScottR.Rajski,ZhinanXu,MarieF.Coeffet-LeGal,andBenShen.EngineeredProductionofiso-MigrastatininHeterologousStreptomycesHosts.Bioorgan.Med.Chem.2008,17,2147-2153.(impactfactor2.66)
4.UteGalm,EvelynWendt-Pienkowski,LiyanWang,NicholasP.George,Tae-JinOh,FanYi,MeifengTao,JaneM.Coughlin,andBenShen.TheBiosyntheticGeneClusterofZorbamycin,aMemberoftheBleomycinFamilyofAntitumorAntibiotics,fromStreptomycesflavoviridisATCC21892.Mol.BioSyst.2009,5,77-90.
5.UteGalm,LiyanWang,EvelynWendt-Pienkowski,RunyingYang,WenLiu,MeifengTao,JaneM.Coughlin,andBenShen.InvivomanipulationofthebleomycinbiosyntheticgeneclusterinstreptomycesverticillusATCC15003revealingnewinsightsintoitsbiosyntheticpathway.J.Biol.Chem.2008.283,28236-28245.
6.HeranLi,LiyanWang,ShoheiMiyata,andSusumuKitanaka.KadsuracoccinicAcidsA−C,Ring-Aseco-LanostaneTriterpenesfromKadsuracoccineaandTheirEffectsonEmbryonicCellDivisionofXenopuslaevis.J.Nat.Prod.2008.71(4);739-741.(impactfactor2.55)
7.LiyanWang,Bong-SikYun,NicholasP.George,EvelynWendt-Pienkowski,UteGalm,Tae-JinOh,JaneM.Coughlin,GuodongZhang,MeifengTao,andBenShen.TheglycopeptideantitumorantibioticZorbamycinfromStreptomycesflavoviridisATCC21892:strainimprovementandstructureelucidation.J.Nat.Prod.2007,70,402-406.
8.HeranLi,LiyanWang,ZhigangYang,andSusumuKitanaka.KadsuralignansH−KfromKadsuracoccineaandTheirNitricOxideProductionInhibitoryEffects.J.Nat.Prod.2007.70,1999-2002.
9.JueWang,LiyanWang,andSusumuKitanaka.StilbeneanddihydrophenanthrenederivativesfromPholidotachinensisandtheirnitricoxideinhibitoryandradical-scavengingactivities.JournalofNaturalMedicines.2007,61,381-386.(impactfactor0.424)
10.MeifengTao,LiyanWang,Wendt-Pienkowski,E,George,N.P,Galm,U,Zhang,G,Coughlin,J.M,Shen,B.ThetallysomycinbiosyntheticgeneclusterfromStreptoalloteichushindustanusE465-94ATCC31158unveilingnewinsightsintothebiosynthesisofthebleomycinfamilyofantitumorantibiotics.Mol.Biosyst,2007,3,60-74.
学会论文
1.UteGalm,JaneM.Coughlin,MeifengTao,LiyanWang,EvelynWendt-Pienkowski,GuodongZhang,andBenShen.Towardsnewbleomycingroupantibiotics:Investigationsonthebiosyntheticpathwaysofbleomycin,zorbamycin,andtallysomycininwild-typeandrecombinantstrainsoftherespectiveproducerorganisms.SIM(SocietyforindustrialMicrobiology)annualmeeting.P36.(2007,7,30,Denver,CO,US)
2.LiyanWang,TadahiroN.,SusumuK.,FlavonoidsThatMimicHumanLigandsfromthewholePlantsofEuphorbialunulata.the125thannualmeetingofthethePharmaceuticalSocietyofJapan.P.145.(2005,3,29-31,Tokyo,Japan).
3.LiyanWang,TomokoU.,SusumuK.,TheResearchontheanti-allergicconstituentsofWikstroemiaindica.the51thannualmeetingoftheJapaneseSocietyofPharmacognosy.P.112.(2004,9,9-10,kobe,Japan).
4.LiyanWang,KitanakaS.,TheResearchontheanti-allergicconstituentsofEuphorbialunulata.the124thannualmeetingofthethePharmaceuticalSocietyofJapan.(2004,3,29-31,Osaka,Japan).
5.LiyanWang,WangN.L.,YaoX.S.,MiyataS.,KitanakaS.,TheBioactivityResearchofEuphorbiakansui.(4)the123thannualmeetingofthethePharmaceuticalSocietyofJapanP.72.(2003,3,27-29,Nagasaki,Japan).
6.LiyanWang,WangN.L.,YaoX.S.,MiyataS.,KitanakaS.,TheBioactivityResearchofEuphorbiakansui.(3)the49thannualmeetingoftheJapaneseSocietyofPharmacognosy.P.142.(2002,9,5-6,Fukuoka,Japan).
7.LiyanWang,WangN.L.,YaoX.S.,MiyataS.,KitanakaS.,TheBioactivityResearchofEuphorbiakansui.(2)the122thannualmeetingofthethePharmaceuticalSocietyofJapanP.143.(2002,3,26-28,Makuhari,Japan).
8.LiyanWang,WangN.L.,YaoX.S.,MiyataS.,KitanakaS.,TheBioactivityResearchofEuphorbiakansui.(1)the48thannualmeetingoftheJapaneseSocietyofPharmacognosy.P.235.(2001,9,7-8,Kanazawa,Japan).
取得专利
1.AboutDiterpenesfromEuphorbiakansui
a)Japanpatent
SusumuKitanaka,ShoheiMiyata,LiyanWang,Nai-LiWang,Sin-ShengYao.Diterpeneshavingcelldivision-inhibitingactivityderivedfromEuphorbiakansui.Jpn.KokaiTokkyoKoho(2005),JP2005041800A220050217.
b)USpatent
SusumuKitanaka,ShoheiMiyata,LiyanWang,Nai-LiWang,Xin-ShengYao.Diterpenecompounds.USpatent(2006),7009061.
2.AboutbioactiveextractfromWikstroemiaindecaC.A.May
SusumuKitanaka,LiyanWang,Wikstroemiaindecaextracttheirproductionofanti-inflammatorypharmaceuticaluses.PCTInt.Appl.(2006),WO/2006/012779.
3.AboutbioactivecomponentsfromEuphorbialunulate
LiyanWang,SusumuKitanaka.TheEuphorbialunulateBgeextractionandproductionmethodandusethereof.PCTInt.Appl.(2005),WO/2005/084662