个人简介


李利艳，汕头大学医学院，讲师，博士，硕士研究生导师，汕头大学医学院肿瘤研究中心学术骨干。2009年，齐齐哈尔医学院毕业，获得临床医学学士学位。2015年，获得汕头大学硕博连读生物化学与分子生物学专业博士学位，同时获得该年度汕头大学医学院唯一的优秀博士论文。2017年11月至2019年12月，在美国Cedars-Sinai Medical Center做访问****。主要研究方向是小分子药物的肿瘤靶向治疗、肿瘤分子生物学以及脂质代谢相关分子在肿瘤中的转录调控。迄今为止，累计发表SCI研究论文15篇，其中第一作者5篇，共同第一作者2篇；主持国家自然科学基金青年基金项目1项。


代表性研究论文（#共同第一作者，*通讯作者或共同通讯作者）


1. Li LY#, Xie YH#, Xie YM, Liao LD, Xu XE, Zhang Q, Zeng FM, Tao LH, Xie WM, Xie JJ, Xu LY, Li EM. Ezrin Ser66 phosphorylation regulates invasion and metastasis of esophageal squamous cell carcinoma cells by mediating filopodia formation. Int J Biochem Cell Biol. 2017;88:162-171.
2. Xie L, Li LY, Zheng D, Xie YM, Xu XE, Tao LH, Liao LD, Xie YH, Cheng YW, Xu LY, Li EM. F806 Suppresses the Invasion and Metastasis of Esophageal Squamous Cell Carcinoma via Downregulating F-Actin Assembly-Related Rho Family Proteins. Biomed Res Int. 2018;2018:**.
3. Li LY#, Jiang H#, Xie YM, Liao LD, Cao HH, Xu XE, Chen B, Zeng FM, Zhang YL, Du ZP, Chen H, Huang W, Jia W, Zheng W, Xie JJ, Li EM*, Xu LY*. Macrolide analog F806 suppresses esophageal squamous cell carcinoma (ESCC) by blocking β1 Integrin activation. Oncotarget. 2015;6(18):15940-15952.
4. Li LY#, Zhang K#, Jiang H#, Xie YM, Liao LD, Chen B, Du ZP, Zhang PX, Chen H, Huang W, Jia W, Cao HH, Zheng W, Li EM*, Xu LY*. Quantitative Proteomics reveals the downregulation of GRB2 as a prominent node of F806-targeted cell proliferation network. J Proteomics. 2015;117:145-155.
5. Zhang K#*, Li L#, Zhu M, Wang G, Xie J, Zhao Y, Fan E, Xu L*, Li E*. Comparative analysis of histone H3 and H4 post-translational modifications of esophageal squamous cell carcinoma with different invasive capabilities. J Proteomics. 2015;112:180-189.
6. Li LY, Li EM, Wu ZY, Cao HH, Shen JH, Xu XE, Chen B, Xu LY*. Overexpression of GRB2 is correlated with lymph node metastasis and poor prognosis in esophageal squamous cell carcinoma. Int J Clin Exp Pathol. 2014;7(6):3132-3140.
7. Li LY , Li EM, Wu ZY, Huang X, Shen JH, Xu XE, Wu JY, Huang Q, Xu LY*. Connective tissue growth factor expression in precancerous lesions of human esophageal epithelium and prognostic significance in esophageal squamous cell carcinoma. Dis Esophagus. 2011;24(5):337-345.
8. Fang WK, Liao LD, Li LY, Xie YM, Xu XE, Zhao WJ, Wu JY, Zhu MX, Wu ZY, Du ZP, Wu BL, Xie D, Guo MZ, Xu LY*, Li EM*. Down-regulated desmocollin-2 promotes cell aggressiveness through redistributing adherens junctions and activating beta-catenin signalling in oesophageal squamous cell carcinoma. J Pathol. 2013;231(2):257-270.
9. Zhang HF, Zhang K, Liao LD, Li LY, Du ZP, Wu BL, Wu JY, Xu XE, Zeng FM, Chen B, Cao HH, Zhu MX, Dai LH, Long L, Wu ZY, Lai R, Xu LY*, Li EM*. miR-200b suppresses invasiveness and modulates the cytoskeletal and adhesive machinery in esophageal squamous cell carcinoma cells via targeting Kindlin-2. Carcinogenesis. 2014;35(2):292-301.
10. Zeng FM, Xie YM, Liao LD, Li LY, Chen B, Xie JJ, Xu LY, Li EM. Biological characterization of three immortalized esophageal epithelial cell lines. Mol Med Rep. 2016;14(5):4802-4810.


主要的科研项目