汕头大学医学院导师简介-化学教研室

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师资队伍

化学教研室现有教师5人，其中教授2名，副教授1名，讲师2名，另有教辅人员2人。所有教师均具有研究生学历，4人有博士学位，1人有硕士学位。

学术骨干：

郑锦鸿：

男，1967年3月生，药物化学教授，硕士生导师，汕头大学医学院化学教研室主任，广东省药学会药物化学委员会委员。1989年毕业于中国药科大学化学制药专业。同年考取中国药科大学药物化学专业5年硕博连读的博士研究生，师从为廖清江教授从事甾体药物的开发研制工作，1994年获得药物化学博士学位。1994年7月至今在汕头大学医学院化学教研室和药物研究室工作，为临床医学本科本硕班讲授《有机化学》，2007年荣获李嘉诚基金会卓越教学奖。

此期间曾于1998年11月到2000年3月在美国密西西比州立大学化学系做博士后，从事天然药物有效成分的全合成工作。近年来，作为项目负责人获得广东省自然科学基金项目、广东省科技计划项目和教育部留学回国人员科研启动基金项目各1项，厅级课题2项；作为第二申请人，获得国家自然科学基金2项、国家新药基金1项，省部级课题2项，获得2006年度广东省科学技术奖二等奖1项，广东省自然科学基金研究团队项目核心成员1项。主要著作目录如下：

1. Ying Pan，Yicun Chen, Xiaoyu Yu, Jinzhi Wang, Lumian Zhang, Ying He, Yu Zheng, Jinhong Zheng*. The Synthesis of a Novel Chalcone and eva luation for Anti-free Radical Activity and Antagonizing the Learning Impairments in Alzheimer's Model. Cell Physiol Biochem. Accepted

2. 郑锦鸿, 曾小耘, 盘鹰. 国家发明专利：1-芥子酰基-4-苄基哌嗪衍生物及其制备方法及抗自由基或抗炎活性应用。专利号：ZL 2010 1 0112900.7

3.Qinrong Wang, Ying Pan, Jinzhi Wang, Qing Peng, Hongjun Luo, Jinhong Zheng*. Synthesis and biological activities of substituted benzoyl acylhydrazone derivatives. African Journal of Biotechnology. 2011;10(78):18013-18021.

4. Hua-Ming SHENG, Zuo-Juan XIANG, Jun-Ting YE, Jin-Hong ZHENG*, SUN Hong-Bin*. Synthesis of Novel Alkylamino Substituted cis and trans Apovincamate Derivatives. Chinese Journal of Natural Medicines. 2011;9(1):0051-0057.

5. ZHU Chuan-jun, ZHU Mei-ling, CUI Yu-xin, JIANG Biao*, ZHENG Jin-hong*. Characteristics and Conformational Analysis of (E)-3-(4-hydroxyphenyl)-1-(piperidin -1-yl)prop-2-en-1-one Derivatives. Chinese Journal of Magnetic Resonance. 2011;28 (3):390-398.

6. Chen Y, Zheng J, Zheng F, Wang J, Zhang Y, Gao F, Huang Z, Shi G*. Design, Synthesis, and Pharmacological eva luation of Haloperidol Derivatives as Novel Potent Calcium Channel Blockers with Vasodilator Activity. PLoS One. 2011;6(11):e27673.

7. Wang JZ, Cai CY, Zhang YM, Zheng JH, Chen YC, Li WQ, Shi GG.*. N-n-butyl haloperidol iodide protects against hypoxia/reoxygenation-induced cardiomyocyte injury by modulating protein kinase C activity. Biochem Pharmacol. 2010;79(10):1428-1436.

8. Chen Y, Zheng J, Zhang Y, Wang J, Liu Q, Huang Z, Gao F, Zhou Y, Shi G*. N-4-tert-butyl benzyl haloperidol chloride suppresses Ca2+-dependent Egr-1 expression and subsequently inhibits vascular smooth muscle cell proliferation induced by angiotensin II. Cell Physiol Biochem. 2009;23(4-6):295-304.

刘道军：

男，1969年11月生，化学教授，博士生导师。1992年毕业于青岛化工学院（现青岛科技大学）应用化学系工业分析专业，获学士学位。1995年毕业于青岛化工学院应用化学专业，获硕士学位。同年考取北京大学化学与分子工程学院博士研究生，师从马季铭教授从事混合反胶束的结构与性能研究，1998年获物理化学博士学位。1998年11月至1999年12月于瑞士苏黎世联邦工学院（ETH）材料系做博士后，从事囊泡辅助的氨基酸和多肽的缩聚研究。2000年5月至2003年6月在比利时鲁汶大学（KULeuven）化学系De Schryver教授课题组从事研究员工作，研究课题为树枝状超支化高分子的自组装和光化学研究。其后转至美国德克萨斯农工大学（Texas A&M University）Crooks教授课题组继续研究员工作，研究领域为微流体体系中生物大分子的微电化学检测。2004年7月回国到汕头大学医学院化学教研室任教，为临床医学本硕全英班全英讲授《基础化学》。发表学术论文40余篇，其中20余篇被Macro. Rapid Commun., Macromolecules, Langmuir等SCI期刊收录。近年来，作为项目负责人获得国家自然科学基金面上项目2项，教育部留学回国人员科研基金1项，广东省自然科学基金研究团队项目核心成员1项。主要著作目录如下：

30. Jiayan Li, Shaoqiang, Xu, Jinhong Zheng, Ying Pan, Jinzhi Wang, Lumian Zhang, Xiaoying He, Daojun Liu*. Polypeptide-Based Star-Block Quadripolymers as Unimolecular Nanocarriers for the Simultaneous Encapsulation of Hydrophobic and Hydrophilic guests. Eur. Polym. J. 2012, 48, 1696-1708.

29. Qinrong Wang, Jun Yu, Yunsong Yan, Shaoqiang Xu, Fangfang Wang, Qingnan Li, Jinzhi Wang, Xin Zhang*, Daojun Liu*. Controlled Biomimetic Silica Formation Using Star-Shaped Poly(L-Lysine). Polym. Chem. 2012, 3, 1284-1290.

28. Yunsong Yan, Jiayan Li, Jinhong Zheng, Ying Pan, Jinzhi Wang, Xiaoying He, Lumian Zhang, Daojun Liu.* Poly(L-lysine)-Based Star-Block Copolymers as pH-Responsive Nanocarriers for anionic drugs. Colloids Surface B: Biointerf. 2012, 95, 137-143.

27. Yunsong Yan, Daixu Wei,* Jiayan Li, Jinhong Zheng, Ganggang Shi, Wenhong Luo, Ying Pan, Jinzhi Wang, Lumian Zhang, Xiaoying He, Daojun Liu.* A Poly(L-lysine)-Based Hydrophilic Star-Block Copolymer as a Protein Nanocarrier with Facile Encapsulation and pH-Responsive Release. Acta Biomater. 2012, 8, 2113-2120.

26. Xiang Zeng, Jinhu Li, Ying Pan, Jinzhi Wang, Lumian Zhang, Daojun Liu.* Amphiphilic Cylindrical Copolypeptide Brushes as Potential Nanocarriers for Simultaneous Encapsulation of Hydrophobic and Cationic Drugs. Colloids Surfaces B: Biointerfaces 2012, 94, 324-332.

25. Huihong Huang, Jiayan Li, Lihui Liao, Jinhu Li, Lixin Wu, Chaoke Dong, Peibao Lai, Daojun Liu.* Poly(L-glutamic acid)-Based Star-Block Copolymers as pH-Responsive Release Systems. Eur. Polym. J. 2012, 48, 696-704.

24. Xiaoying Qi, Can Xue, Xiao Huang, Yizhong Huang, Xiaozhu Zhou, Hai Li, Daojun Liu, Freddy, Boey, Qingyu Yan, Wei Huang, Steven De Feyter, Klaus Müllen, Hua Zhang.* Polyphenylene Dendrimer-templated in situ Construction of Inorganic-organic Hybrid Rice-shaped Architectures. Adv. Funct. Mater. 2009, 19, 1-7.

23. Wensheng Zhuang, Lihui Liao, Heru Chen, Jinzhi Wang, Ying Pan, Lumian Zhang, Daojun Liu.* Water-Soluble Star-block Copolypeptides: Towards Biodegradable Nanocarriers for Versatile and Simultaneous Encapsulation. Macromol. Rapid Commun. 2009, 30, 920-924.

22 Wensheng Zhuang, Hua Zhang, Daojun Liu.* Preparation of Thin Oligopeptide Films Using Self-Organized Dendrimer Monolayer as an Anchoring Scaffold. Current Applied Phys. 2007, 7S1, e53-e57.

21. Chunhong Tian, Daojun Liu, Roel Gronheid, Mark Van der Auweraer, Frans C. De Schryver. Mesoscopic Organization of Two-Dimensional J Aggregates of Thiacyanine in Langmuir-Schaefer Films. Langmuir 2004, 20, 11569-11576.

20. Daojun Liu, Robbyn K. Perdue, Li Sun, Richard M. Crooks. Immobilization of DNA onto Poly(dimethylsiloxane) Surfaces and Application to a Microelectrochemical Enzyme-Amplified DNA hybridization Assay. Langmuir 2004, 20, 5905-5910.

19. Jianqiang Qu, Neil G. Pschirer, Daojun Liu, Alina Stefan, Frans C. De Schryver, K. Müllen. Dendronized Perylenetetracarboxdiimides with Peripheral Triphenylamines for Intramolecular Energy and Electron Transfer. Chem.Eur. J. 2004, 10, 528-537.

18. Jianqiang Qu, Daojun Liu, S. De Feyter, Jingying Zhang, F. C. De Schryver, K. Müllen. Synthesis and Optical properties of Polyphenylene Dendrimers Based on Perylenes. J. Org. Chem. 2003, 68, 9802-9808.

17. Daojun Liu, S. De Feyter, M. Cotlet, U.-M. Wiesler, T. Weil, A. Herrmann, K. Müllen, F. C. De Schryver. Fluorescent Self-Assembled Polyphenylene Dendrimer Nanofibers. Macromolecules 2003, 36, 8489-8498.

16. Daojun Liu, S. De Feyter, M. Cotlet, A. Stefan, U.-M. Wiesler, A. Herrmann, D. Grebel-Koehler, K. Müllen, F. C. De Schryver. Fluorescence and Intramolecular Energy Transfer in Polyphenylene Dendrimers. Macromolecules 2003, 36, 5918-5925.

15. D. Grebel-Koehler, Daojun Liu, S. De Feyter, C. Engels, C. Samyn, F. C. De Schryver, K. Müllen. Synthesis and Photomodulation of Rigid Polyphenylene Dendrimers with an Azobenzene Core. Macromolecules 2003, 36, 578-590.

14. Daojun Liu, S. De Feyter, P. C. M. Grim, T. Vosch, D. Grebel-Koehler, U.-M. Wiesler, A. J. Berresheim, K. Müllen and F. C. De Schryver. Self-Assembled Polyphenylene Dendrimer Nanofibers on Highly Oriented Pyrolytic Graphite Studied by Atomic Force Microscopy. Langmuir 2002, 18, 8223-8230.

13. Hua Zhang, P. C. M. Grim, Daojun Liu, U.-M. Wiesler, A. J. Berresheim, K. Müllen, F. C. De Schryver. Probing Carboxylic Acid Groups in Replaced and Mixed Self-Assembled Monolayers by Individual Ionized Dendrimer Molecules: An Atomic Force Microscopy Study. Langmuir 2002, 18, 1801-1810.

12. Daojun Liu, Hua Zhang, P. C. M. Grim, S. De Feyter, U.-M. Wiesler, A. J. Berresheim, K. Müllen, F. C. De Schryver. Self-Assembly of Polyphenylene Dendrimers into Micrometer Long Nanofibers: An Atomic Force Microscopy Study. Langmuir 2002, 18, 2385-2391.

11. Markus Blocher, Daojun Liu, Pier Luigi Luisi. Liposome-Assisted Selective Polycondensation of alpha-Amino Acids and Peptides: The case of Charged Liposomes. Macromolecules 2000, 33, 5787-5796.

10. Pier Luigi Luisi, Peter Walde, Markus Blocher, Daojun Liu. Research on the Origin of Life: Membrane-Assisted Polycondensations of Amino Acids and Peptides. Chimia 2000, 54, 52-53.

9. Markus Blocher, Daojun Liu, Peter Walde, Pier Luigi Luisi. Liposome-Assisted Selective Polycondensation of alpha-Amino Acids and Peptides. Macromolecules 1999, 32, 7332-7334.

8. Daojun Liu, Jiming Ma, Humin Cheng, Zhenguo Zhao. Conducting Properties of Mixed Reverse Micelles. Colloids Surfaces A 1999, 148, 291-298.

7. Guowen Xing, Daojun Liu, Yunhua Ye, Jiming Ma. Enzymatic Synthesis of Oligopeptides in Mixed Reverse Micelles. Tetrahedron Lett. 1999, 40, 1971-1974.

6. Daojun Liu, Jiming Ma, Humin Cheng, Zhenguo Zhao. Study on Percolation of Mixed Reverse Micelles. J. Dispers. Sci. Technol. 1999, 20, 513-533.

5. Daojun Liu, Jiming Ma, Humin Cheng, Zhenguo Zhao. Solubilization Behaviors of Mixed Reverse Micelles: Effect of Surfactant Composition, Electrolyte Concentration and Solvent. Colloids Surfaces A 1998, 143, 59-68.

4. Daojun Liu, Jiming Ma, Humin Cheng, Zhenguo Zhao. Investigation on the Basic Hydrolysis of Crystal Violet in Mixed Reverse Micelles Formed with AOT and Nonionic Surfactants. Colloid Polym. Sci. 1998, 276, 610-616.

3. Daojun Liu, Jiming Ma, Humin Cheng, Zhenguo Zhao. Fluorescence Probing of Mixed Reverse Micelles Formed with AOT and Nonionic Surfactants in n-Heptane. Colloids Surfaces A 1998, 139, 21-26.

2. Daojun Liu, Jiming Ma, Humin Cheng, Zhenguo Zhao. Investigation on the Conductivity and Microstructure of AOT/Nonionic Surfactants/Water/n-Heptane Mixed Reverse Micelles. Colloids Surfaces A 1998, 135, 157-164.

1. Daojun Liu, Jiming Ma, Humin Cheng, Zhenguo Zhao. Solubilization in Mixed Reverse Micellar Systems of AOT/Nonionic Surfactants/n-Heptane. J. Dispers. Sci. Technol. 1998, 19, 599-611.