姜双英  女  博导  中国科学院深圳先进技术研究院
电子邮件： sy.jiang@siat.ac.cn
通信地址： 南山区西丽大学城学苑大道1068号

最新信息可以参考原文信息https://people.ucas.edu.cn/~jiangsy

研究领域

合成基因组学

表观遗传学
招生信息
   
招生专业
071005-微生物学
071010-生物化学与分子生物学
0710Z1-基因组学
招生方向
合成基因组学
合成生物学
表观遗传学
教育背景
2011-09--2017-06   清华大学   博士
2007-09--2011-06   东北农业大学   学士
工作经历
   
工作简历
2020-01~现在, 中国科学院深圳先进技术研究院, 副研究员
2019-07~2020-01,中科院深圳先进技术研究院, 助理研究员
2017-08~2019-07,中国科学院深圳先进技术研究院, 博士后
专利与奖励

专利成果
[1] 戴俊彪, 姜双英, 蔡泽霖, 曾诚. 一种 rDNA 阵列的快速构建方法及其在人工调控 rDNA 拷贝数中的应用. 202311134312.7, 2023-09-05.
[2] 戴俊彪, 李敏, 方圆, 姜双英, 罗周卿. 文本信息存储和读取方法及其装置. CN: CN112749247B, 2023-08-18.
[3] 戴俊彪, 李敏, 方圆, 姜双英, 罗周卿. 文本信息存储和读取方法及其装置. CN: CN112749247A, 2021-05-04.
[4] 李敏, 戴俊彪, 王洋, 姜青山, 罗周卿, 姜双英. 基于DNA的数据存储方法、数据恢复方法及终端设备. CN: CN112527736A, 2021-03-19.
[5] 戴俊彪, 姜双英, 唐园玮. 基于合成基因和酿酒酵母同源重组机制的分子克隆方法. CN: CN112175984A, 2021-01-05.
出版信息
   
发表论文
[1] Shuangying Jiang, Zelin Cai, Yun Wang, Cheng Zeng, Jiaying Zhang, Wenfei Yu, Chenghao Su, Shijun Zhao, Ying Chen, Yue Shen, Yingxin Ma, Yizhi Cai, Junbiao Dai. High plasticity of ribosomal DNA organization in budding yeast. CELL REPORTS[J]. 2024, 43(2): 113742-, http://dx.doi.org/10.1016/j.celrep.2024.113742.
[2] Nature Communicationsnull. 2024, [3] Shuangying Jiang, Zhouqing Luo, Jie Wu, Kang Yu, Shijun Zhao, Zelin Cai, Wenfei Yu, Hui Wang, Li Cheng, Zhenzhen Liang, Hui Gao, Marco Monti, Daniel Schindler, Linsen Huang, Cheng Zeng, Weimin Zhang, Chun Zhou, Yuanwei Tang, Tianyi Li, Yingxin Ma, Yizhi Cai, Jef D. Boeke, Qiao Zhao, Junbiao Dai. Building a eukaryotic chromosome arm by de novo design and synthesis. NATURE COMMUNICATIONS[J]. 2023, 14(1): http://dx.doi.org/10.1038/s41467-023-43531-5.
[4] Daniel Schindler, Roy SK Walker, Shuangying Jiang, Aaron N Brooks, Yun Wang, Carolin A Mller, Charlotte Cockram, Yisha Luo, Alicia Garca, Daniel Schraivogel, Julien Mozziconacci, Noah Pena, Mahdi Assari, Mara del Carmen Snchez Olmos, Yu Zhao, Alba Ballerini, Benjamin A Blount, Jitong Cai, Lois Ogunlana, Wei Liu, Katarina Jnsson, Dariusz Abramczyk, Eva GarciaRuiz, Tomasz W Turowski, Reem Swidah, Tom Ellis, Tao Pan, Francisco Antequera, Yue Shen, Conrad A Nieduszynski, Romain Koszul, Junbiao Dai, Lars M Steinmetz, Jef D Boeke, Yizhi Cai. Design, construction, and functional characterization of a tRNA neochromosome in yeast. CELL[J]. 2023, 186(24): 5237-5253.e22, http://dx.doi.org/10.1016/j.cell.2023.10.015.
[5] Yue Shen, Feng Gao, Yun Wang, Yuerong Wang, Ju Zheng, Jianhui Gong, Jintao Zhang, Zhouqing Luo, Daniel Schindler, Yang Deng, Weichao Ding, Tao Lin, Reem Swidah, Hongcui Zhao, Shuangying Jiang, Cheng Zeng, Shihong Chen, Tai Chen, Yong Wang, Yisha Luo, Leslie Mitchell, Joel S Bader, Guojie Zhang, Xia Shen, Jian Wang, Xian Fu, Junbiao Dai, Jef D Boeke, Huanming Yang, Xun Xu, Yizhi Cai. Dissecting aneuploidy phenotypes by constructing Sc2.0 chromosome VII and SCRaMbLEing synthetic disomic yeast. CELL GENOMICS[J]. 2023, 3(11): http://dx.doi.org/10.1016/j.xgen.2023.100364.
[6] Hu, Xin, Jiang, Shuangying, Xu, Feifei, Zeng, Cheng, Wang, Xiangxiang, Liu, Wei, Cheng, Aimin, Ma, Chengying, Gao, Ning, Zhao, Yuyu, Dai, Junbiao, Zhao, Guanghou. Engineering and functional analysis of yeast with a monotypic 40S ribosome subunit. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2022, 119(6): http://dx.doi.org/10.1073/pnas.2114445119.
[7] Jiang, Shuangying, Tang, Yuanwei, Xiang, Liang, Zhu, Xinlu, Cai, Zelin, Li, Ling, Chen, Yingxi, Chen, Peishuang, Feng, Yuge, Lin, Xin, Li, Guoqiang, Sharif, Jafar, Dai, Junbiao. Efficient de novo assembly and modification of large DNA fragments. SCIENCE CHINA-LIFE SCIENCES[J]. 2022, 65(7): 1445-1455, [8] Luo, Zhouqing, Yu, Kang, Xie, Shangqian, Monti, Marco, Schindler, Daniel, Fang, Yuan, Zhao, Shijun, Liang, Zhenzhen, Jiang, Shuangying, Luan, Meiwei, Xiao, Chuanle, Cai, Yizhi, Dai, Junbiao. Compacting a synthetic yeast chromosome arm. GENOME BIOLOGY[J]. 2021, 22(1): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7780613/.
[9] Dai, Junbiao, Boeke, Jef D, Luo, Zhouqing, Jiang, Shuangying, Cai, Yizhi. Sc3.0: revamping and minimizing the yeast genome. GENOME BIOLOGY. 2020, 21(1): http://dx.doi.org/10.1186/s13059-020-02130-z.
[10] Jiang, Shuangying, Si, Tong, Dai, Junbiao. Whole-Genome Regulation for Yeast Metabolic Engineering. SMALL METHODSnull. 2020, 4(2): https://www.webofscience.com/wos/woscc/full-record/WOS:000496824800001.
[11] Luo, Zhouqing, Hoffmann, Stefan A, Jiang, Shuangying, Cai, Yizhi, Dai, Junbiao. Probing eukaryotic genome functions with synthetic chromosomes. EXPERIMENTAL CELL RESEARCHnull. 2020, 390(1): http://dx.doi.org/10.1016/j.yexcr.2020.111936.
[12] Braberg, Hannes, Echeverria, Ignacia, Bohn, Stefan, Cimermancic, Peter, Shiver, Anthony, Alexander, Richard, Xu, Jiewei, Shales, Michael, Dronamraju, Raghuvar, Jiang, Shuangying, Dwivedi, Gajendradhar, Bogdanoff, Derek, Chaung, Kaitlin K, Huttenhain, Ruth, Wang, Shuyi, Mavor, David, Pellarin, Riccardo, Schneidman, Dina, Bader, Joel S, Fraser, James S, Morris, John, Haber, James E, Strahl, Brian D, Gross, Carol A, Dai, Junbiao, Boeke, Jef D, Sali, Andrej, Krogan, Nevan J. Genetic interaction mapping informs integrative structure determination of protein complexes. SCIENCE[J]. 2020, 370(6522): 1294-+, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946025/.
[13] Shuangying Jiang, Shijun Zhao, Zelin Cai, Yuanwei Tang, Junbiao Dai. Synthetic yeast genomes for studying chromosomal features. CURRENT OPINION IN SYSTEMS BIOLOGY. 2020, 23: 1-7, http://dx.doi.org/10.1016/j.coisb.2020.09.001.
[14] Jiang, Shuangying, Dai, Junbiao. Inevitability or contingency: how many chromosomes do we really need?. SCIENCE CHINA-LIFE SCIENCES[J]. 2019, 62(1): 140-143, http://lib.cqvip.com/Qikan/Article/Detail?id=6100172052.
[15] Auxillos, Jamie Y, GarciaRuiz, Eva, Jones, Sally, Li, Tianyi, Jiang, Shuangying, Dai, Junbiao, Cai, Yizhi. Multiplex Genome Engineering for Optimizing Bioproduction in Saccharomyces cerevisiae. BIOCHEMISTRY[J]. 2019, 58(11): 1492-1500, http://dx.doi.org/10.1021/acs.biochem.8b01086.
[16] Cheng, Li, Liu, Chengxi, Jiang, Shuangying, Hou, Sha, Huang, Jinguo, Chen, Ziqing, Sun, Yangyang, Qi, Huan, Jiang, Hewei, Wang, Jingfang, Zhou, Yiming, Czajkowsky, Daniel M, Dai, Junbiao, Tao, Shengce. Cell Lysate Microarray for Mapping the Network of Genetic Regulators for Histone Marks. MOLECULAR & CELLULAR PROTEOMICS[J]. 2018, 17(9): 1720-1736, http://dx.doi.org/10.1074/mcp.RA117.000550.
[17] Luo, Zhouqing, Yang, Qing, Geng, Binan, Jiang, Shuangying, Yang, Shihui, Li, Xiaozheng, Cai, Yizhi, Dai, Junbiao. Whole genome engineering by synthesis. SCIENCE CHINA-LIFE SCIENCES[J]. 2018, 61(12): 1515-1527, http://lib.cqvip.com/Qikan/Article/Detail?id=6100154586.
[18] Zhang, Weimin, Zhao, Guanghou, Luo, Zhouqing, Lin, Yicong, Wang, Lihui, Guo, Yakun, Wang, Ann, Jiang, Shuangying, Jiang, Qingwen, Gong, Jianhui, Wang, Yun, Hou, Sha, Huang, Jing, Li, Tianyi, Qin, Yiran, Dong, Junkai, Qin, Qin, Zhang, Jiaying, Zou, Xinzhi, He, Xi, Zhao, Li, Xiao, Yibo, Xu, Meng, Cheng, Erchao, Huang, Ning, Zhou, Tong, Shen, Yue, Walker, Roy, Luo, Yisha, Kuang, Zheng, Mitchell, Leslie A, Yang, Kun, Richardson, Sarah M, Wu, Yi, Li, BingZhi, Yuan, YingJin, Yang, Huanming, Lin, Jiwei, Chen, GuoQiang, Wu, Qingyu, Bader, Joel S, Cai, Yizhi, Boeke, Jef D, Dai, Junbiao. Engineering the ribosomal DNA in a megabase synthetic chromosome. SCIENCE[J]. 2017, 355(6329): http://dx.doi.org/10.1126/science.aaf3981.
[19] Jiang, Shuangying, Liu, Yan, Xu, Caiyue, Wang, Yun, Gong, Jianhui, Shen, Yue, Wu, Qingyu, Boeke, Jef D, Dai, Junbiao. Dissecting Nucleosome Function with a Comprehensive Histone H2A and H2B Mutant Library. G3-GENES GENOMES GENETICS[J]. 2017, 7(12): 3857-3866, https://doaj.org/article/9b93a751e2e8436c81df0da79af1f8ed.
[20] Jiang, Shuangying, Liu, Yan, Wang, Ann, Qin, Yiran, Luo, Maoguo, Wu, Qingyu, Boeke, Jef D, Dai, Junbiao. Construction of Comprehensive Dosage-Matching Core Histone Mutant Libraries for Saccharomyces cerevisiae. GENETICS[J]. 2017, 207(4): 1263-1273, https://www.webofscience.com/wos/woscc/full-record/WOS:000417013900009.
[21] Ng, Tessie M, Lenstra, Tineke L, Duggan, Nicole, Jiang, Shuangying, Ceto, Steven, Holstege, Frank C P, Dai, Junbiao, Boeke, Jef D, Biggins, Sue. Kinetochore Function and Chromosome Segregation Rely on Critical Residues in Histones H3 and H4 in Budding Yeast. GENETICS[J]. 2013, 195(3): 795-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000329874100013.
科研活动
   
科研项目
（ 1 ） 葡萄糖对组蛋白H4 K8 2-羟异丁酰修饰的调控机制研究, 负责人, 国家任务, 2019-01--2021-12
（ 2 ） 真核微生物基因组的人工设计与合成, 参与, 国家任务, 2019-07--2024-06
（ 3 ） 酿酒酵母中新型rDNA阵列的设计合成与转录分析, 参与, 国家任务, 2019-01--2021-12
（ 4 ） 第17条酿酒酵母染色体的合成及功能评价, 参与, 中国科学院计划, 2018-01--2019-12
（ 5 ） 酿酒酵母中组蛋白二羟异丁酰化修饰的调控机制研究, 负责人, 国家任务, 2018-01--2019-07
（ 6 ） 酿酒酵母rDNA组织形式的可塑性研究, 负责人, 地方任务, 2023-01--2025-12