研究领域
招生信息
教育背景
工作经历
专利与奖励
代表性文章
基本信息
张键 研究员/博导
能量代谢与生殖研究中心/中国科学院深圳先进技术研究院
电子邮件： jian.zhang@siat.ac.cn
通信地址： 深圳市南山区学苑大道1068号
邮政编码： 518055
研究领域
1）研究多肽及其受体在内分泌代谢、生殖及衰老中的作用及转化。
代谢与衰老包括：肥胖症，脂肪肝，糖尿病，和骨质疏松。
生殖与衰老包括：不孕（卵巢早衰，多囊卵巢综合征及子宫内膜异位症等），妊娠代谢性疾病（GDM、PE、obesity等）、内分泌相关肿瘤（子宫内膜癌，卵巢癌/乳腺癌等）。
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2）生物材料及分子影像技术在内分泌代谢、生殖及衰老中的应用探索。
招生信息
招生专业
071009-细胞生物学071010-生物化学与分子生物学071008-发育生物学招生方向
代谢、生殖与衰老生物材料与分子影像的应用内分泌相关肿瘤教育背景
1999-07--2003-06中国科学院动物研究所博士学历
博士
学位
博士
工作经历
2010年12月至今， 中国科学院深圳先进技术研究院 研究员
2008-2010， 美国斯坦福大学/ELIXIR/PAIRE Research Scientist
2003-2008， 美国斯坦福大学/妇产科系 博士后
专利与奖励
授权专利
序号
专利类型
专利号
专利公布号
本人排序
专利名称
授权日期
1
发明专利
ZL8.X
CNA
1/6
一种GPR1拮抗多肽及其衍生物与应用
2020.10.02
2
发明专利
ZL2.5
CNA
1/3
CMKLR1基因在诊断或治疗骨生长或骨质异常增加疾病的应用
2020.09.25
3
发明专利
ZL1.6
CNA
1/4
一种趋化素及其衍生多肽的检测测试条及其制备方法
2020.08.10
4
发明专利
ZL2.4
CNA
2/5
调节能量代谢的多肽及其用途
2020.06.12
5
实用新型
ZL3.X
CNU
1/7
一种微型膜内切除装置
2019.05.28
6
实用新型
ZL6.9
CNU
1/5
一种旋转式3D打印机
2018.10.12
7
实用新型
ZL7.8
CNU
1/5
一种拉丝式3D打印机
2018.07.31
8
发明专利
ZL4.2
CNA
1/6
趋化素衍生肽及其表达基因与应用
2016.12.21
9
发明专利
ZL7.5
CNA
2/6
动物模拟失重训练仪
2016.02.24
10
发明专利
ZL7.0
CNA
1/6
一种GPR1拮抗多肽及其衍生物与应用
2020.11.4
11
发明专利
ZL2.6
CNA
1/7
一种GPR1拮抗多肽及其衍生物与应用
2020.11.27
12
发明专利
ZL0.7
CNA
1/7
一种GPR1拮抗多肽及其衍生物与应用
2020.11.4
13
发明专利
ZL7.8
CNA
1/6
一种GPR1拮抗多肽及其衍生物与应用
2020.11.3
14
发明专利
ZL8.X
CNA
1/6
一种GPR1拮抗多肽及其衍生物与应用
2020.11.3
15
发明专利
ZL9.8
CNA
1/6
一种GPR1拮抗多肽及其衍生物与应用
2020.11.3
16
发明专利
ZL3.0
CNA
1/5
一种拉丝式3D打印方法及拉丝式3D打印机
2020.11.10
17
发明专利
ZL3.2
CNA
3/8
一种胎盘样硫酸软骨素A 或其衍生物的亲和层析纯化方法
2020.07.03
奖励信息：
（1）中国科学院院长优秀奖,一等奖,研究所（学校）,2003
代表性文章
（一）通讯作者论文（39篇）
1.HUANG C#, DAI X Y#, CAI J X#, CHEN J, WANG B B,ZHU W, WANG E, WEI W*, ZHANG J V*(通讯). A screened GPR1 peptide exerts antitumor effects on triple-negative breast cancer[J]. Mol Ther-oncolytics,2020.
2.HUANG B B#, ZHU W#, ZHAO H S#, ZENG F, WANG E, WANG H F, CHEN J, LI M X, HUANG C,REN L R*, NIU J M*, ZHANG J V*(通讯). Placenta-derived Osteoprotegerin is Required for Glucose Homeostasis in Gestational Diabetes Mellitus[J]. Front Cell Dev Biol,2020.
3.TENG B#, HUANG C#, CHENG C L, UDDUTTULA A, YU X F, LIU C, LI J, YAO Z Y, LONG J, MIAO L F, ZOU C, CHU J, ZHANG J V*（共同通讯）, REN P G*. Newly identified peptide hormone inhibits intestinal fat absorption and improves NAFLD through its receptor GPRC6A [J]. J Hepatol, 2020, S0168-8278(20)30125-2.
4.UDDUTTULA A#, TENG B#, CHANDRASHEKAR B N, LI J, YU X F, LIU C, SHI R, CHENG C, ZHANG J V*（共同通讯）, REN P G*. Novel Sr5(PO4)2SiO4-graphene nanocomposites for applications in bone regeneration in vitro [J]. Applied Surface Science, 2020, 507:1-9.
5.HUANG B B#, ZHAO H S#, HUANG C#, WU L L, XIANG L, CHEN J, WANG B B, XIAO T X, LI M X, REN L R, NIU J M*, ZHANG J V*(通讯). CMKLR1 deficiency attenuates androgen-induced lipid accumulation in mice [J]. Am J Physiol-Endocrinol Metab, 2020, 318(3): E371-E80.
6.ZHAO H S#, YAN D W#, XIANG L#, HUANG C, LI J, YU X F, HUANG B B, WANG B B, CHEN J, XIAO T X, REN P G*, ZHANG J V*（通讯）. Chemokine-like receptor 1 deficiency leads to lower bone mass in male mice [J]. Cell Mol Life Sci, 2019, 76(2): 355-67.
7.YAO Z Y#, LIU C#, YU X F, MENG J, TENG B, SUN Y T, KEREM O E, ISMAYIL A, FANG P, ZHANG J*(共同通讯), REN P G*. Microarray Profiling and Coexpression Network Analysis of Long Noncoding RNAs in Adipose Tissue of Obesity-T2DM Mouse [J]. Obesity, 2019, 27(10): 1644-51.
8.UDDUTTULA A#, LI J#, ZHAO P Y, WANG G C, ZHANG J V*（共同通讯）, REN P G*. Sol-gel derived nanosized Sr5(PO4)2SiO4 powder with enhanced in vitro osteogenesis and angiogenesis for bone regeneration applications [J]. Ceramics International, 2019, 45(3): 3148-58.
9.SUN L F#, YANG Y L#, XIAO T X, LI M X, ZHANG J V（通讯）. Removal of DHT can relieve polycystic ovarian but not metabolic abnormalities in DHT-induced hyperandrogenism in mice [J]. Reprod Fertil Dev, 2019, 31(10): 1597-606.
10.JIN P#*, CHEN X F#, YU G Y, LI Z Y, ZHANG Q Q, ZHANG J V*（共同通讯）. The Clinical and Experimental Research on the Treatment of Endometriosis with Thiostrepton [J]. Anti-Cancer Agents Med Chem, 2019, 19(3): 323-9.
11.HUANG B B, LIU X C, QIN X Y, CHEN J, REN P G, DENG W F*, ZHANG J*（通讯）. Effect of High-Fat Diet on Immature Female Mice and Messenger and Noncoding RNA Expression Profiling in Ovary and White Adipose Tissue [J]. Reprod Sci, 2019, 26(10): 1360-72.
12.HUANG B B#, ZHU W#, CHANG J L#, DAI X Y, YU G Y, HUANG C, WANG E, LI Z H, LIN L L, WANG B B, CHEN J, XIAO T X, NIU J M*, ZHANG J*（通讯）. Role of G protein-coupled receptor 1 in choriocarcinoma progression [J]. Am J Physiol-Cell Physiol, 2019, 317(3): C556-C65.
13.HUANG B B#, HUANG C#, ZHAO H S#, ZHU W, WANG B B, WANG H F, CHEN J, XIAO T X, NIU J M*, ZHANG J*（通讯）. Impact of GPR1 signaling on maternal high-fat feeding and placenta metabolism in mice [J]. Am J Physiol-Endocrinol Metab, 2019, 316(6): E987-E97.
14.ZHANG B Z#, TAN L B#, YU Y#, WANG B B, CHEN Z L, HAN J Y, LI M X, CHEN J, XIAO T X, AMBATI B K, CAI L T, YANG Q, NAYAK N R, ZHANG J*(共同通讯), FAN X J*. Placenta-specific drug delivery by trophoblast-targeted nanoparticles in mice [J]. Theranostics, 2018, 8(10): 2765-81.
15.YANG Y L#, SUN L F#, YU Y, XIAO T X, WANG B B, REN P G, TANG H R*, ZHANG J V*(通讯). Deficiency of Gpr1 improves steroid hormone abnormality in hyperandrogenized mice [J]. Reprod Biol Endocrinol, 2018, 16(1): 50.
16.HUANG C#, HUANG B B#, NIU J M#, YU Y, QIN X Y, YANG Y L, XIAO T X, CHEN J, REN L R*, ZHANG J V*（通讯）. Global mRNA and Long Non-Coding RNA Expression in the Placenta and White Adipose Tissue of Mice Fed a High-Fat Diet During Pregnancy [J]. Cell Physiol Biochem, 2018, 50(6): 2260-71.
17.LI J#, XIANG L#, JIANG X T#, TENG B, SUN Y T, CHEN G L, CHEN J, ZHANG J V*（共同通讯）, REN P G*. Investigation of bioeffects of G protein-coupled receptor 1 on bone turnover in male mice [J]. J Orthop Translat, 2017, 10:42-51.
18.YANG Y L#, REN L R#, SUN L F#, HUANG C, XIAO T X, WANG B B, CHEN J, ZABEL B A, REN P G*, ZHANG J V*（通讯）. The role of GPR1 signaling in mice corpus luteum [J]. J Endocrinol, 2016, 230(1): 55-65.
19.TANG M#, HUANG C#, WANG Y F, REN P G, CHEN L, XIAO T X, WANG B B, PAN Y F, TSANG B K, ZABEL B A, MA B H*, ZHAO H Y*, ZHANG J V*（通讯）. CMKLR1 deficiency maintains ovarian steroid production in mice treated chronically with dihydrotestosterone [J]. Sci Rep, 2016, 6:21328.
20.HUANG C#, WANG M M#, REN L R, XIANG L, CHEN J, LI M X, XIAO T X, REN P G, XIONG L K*, ZHANG J V*(通讯). CMKLR1 deficiency influences glucose tolerance and thermogenesis in mice on high fat diet [J]. Biochem Biophys Res Commun, 2016, 473(2): 435-41.
21.GUO C Z#, LI J#, SHE C, SHAO X Z, TENG B, FENG J, ZHANG J V*（共同通讯）, REN P G*. Bioeffects of micron-size magnesium particles on inflammatory cells and bone turnover in vivo and in vitro [J]. J Biomed Mater Res Part B, 2016, 104(5): 923-31.
22.田小飞, 马玮娟, 方光光, 肖天霞, 陈杰, 张键(通讯). 干预GPR1通路对实验性小鼠脂肪累积的影响 [J]. 生物化学与生物物理进展, 2015, 42(05): 457-67.
23.ZHANG Q Q, FAN X J, ZHANG J（通讯）. The Role of Adipokine Chemerin in Pregnancy Complications [J]. Prog Biochem Biophys, 2015, 42(10): 962-8.
24.QIU C*, ZHANG J*（共同通讯）, SU M P, FAN X J. Nuclear factor-kappa B mediates the phenotype switching of airway smooth muscle cells in a murine asthma model [J]. International Journal of Clinical and Experimental Pathology, 2015, 8(10): 12115-28.
25.LI L#, MA P#, HUANG C, LIU Y J, ZHANG Y, GAO C, XIAO T X, REN P G, ZABEL B A, ZHANG J V(通讯). Expression of chemerin and its receptors in rat testes and its action on testosterone secretion [J]. J Endocrinol, 2014, 220(2): 155-63.
26.LI L#, HUANG C#, ZHANG X, WANG J B, MA P, LIU Y J, XIAO T X, ZABEL B A, ZHANG J V(通讯). Chemerin-Derived Peptide C-20 Suppressed Gonadal Steroidogenesis [J]. American Journal of Reproductive Immunology, 2014, 71(3): 265-77.
27.ZHANG J V#*（通讯）, LI L#, HUANG Q S#, REN P G*. Obestatin receptor in energy homeostasis and obesity pathogenesis [J]. Prog Mol Biol Transl Sci, 2013, 114: 89-107.
28.LI L#, MA P#, LIU Y J, HUANG C, O W S, TANG F, ZHANG J V(通讯). Intermedin Attenuates LPS-induced Inflammation in the Rat Testis [J]. Plos One, 2013, 8(6): e65278.
29.李荣荣, 薛丽, 马保华*, 张键*（共同通讯）. Adipsin相关疾病的研究进展 [J]. 公共卫生与预防医学, 2019, 30(02): 74-8.
30.范秀军, 黄晨, 陈指龙, 王鹤霏, 黄斌斌, 张键（通讯）. 妊娠期代谢性疾病与胎盘发育 [J]. 中国实用妇科与产科杂志, 2018, 34(09): 959-63.
31.XUE L, YU Y, ZENG F, TANG H R, XIANG L, CHEN J, XIAO T X, REN PG, ZHANG JV（通讯）. Alleviation of Diet-Induced Fat Accumulation by a Small Molecule CMKLR1 Antagonist in Mice [J]. Journal of Steroids & Hormonal Science, 2018, 09(01): 10.4172 / 21 57-7536.**.
32.孙立峰, 杨雅莉, 黄晨, 薛丽, 张键（通讯）. 脂肪因子Chemerin与多囊卵巢综合征的研究进展综述 [J]. 集成技术, 2017, 6(06): 59-71.
33.孙立峰, 薛丽, 杨雅莉, 张键（通讯）. 鸢尾素(Irisin)与能量代谢相关研究进展 [J]. 生理科学进展, 2017, 48(06): 409-16.
34.姜晓彤, 向亮, 范秀军, 葛利江*, 张键*（通讯）. Chemokine-Like Receptor 1信号通路对双氢睾酮诱导小鼠骨密度增加的影响 [J]. 集成技术,2017, 6(02): 32-40.
35.黄斌斌, 秦逍云, 汤惠茹, 金平, 张键（通讯）. 长链非编码RNA及其在代谢疾病中研究进展 [J]. 公共卫生与预防医学, 2017, 28(02): 80-4.
36.田小飞, 马玮娟, 张键（通讯）. 脂肪因子Chemerin与非酒精性脂肪肝病的关系 [J]. 公共卫生与预防医学, 2015, 26(02): 75-8.
37.孙立峰, 杨雅莉, 张键（通讯）. 肥胖引起的氧化应激及其对两性生殖的影响 [J]. 公共卫生与预防医学, 2015, 26(04): 71-3.
38.黄庆生, 肖天霞, 张键*(共同通讯), 魏彦杰*. 内皮素-1在均匀流中构象改变的分子动力学模拟 [J]. 集成技术, 2014, 3(02): 17-26.
39.陈曾, 徐展望, 向亮, 张鹏, 张键(通讯). 脂肪因子chemerin与骨质疏松症的关系展望 [J]. 中国骨质疏松杂志, 2014, 20(12): 1506-10.
（二）第一/共一作者论文（15篇）
1.WANG L W#, LI J#, ZHANG J#（共一）, HE Q, WENG X W, HUANG Y M, GUAN M J, QIU C. Inhibition of TRPC3 downregulates airway hyperresponsiveness, remodeling of OVA-sensitized mouse [J]. Biochem Biophys Res Commun, 2017, 484(1): 209-17.
2.ZHANG J V, JAHR H, LUO C W, KLEIN C, VAN KOLEN K, VER DONCK L, DE A, BAART E, LI J, MOECHARS D, HSUEH A J. Obestatin induction of early-response gene expression in gastrointestinal and adipose tissues and the mediatory role of G protein-coupled receptor, GPR39 [J]. Mol Endocrinol, 2008, 22(6): 1464-75.
3.SAMSON W K*#, ZHANG J V#(共一), AVSIAN-KRETCHMER O, CUI K, YOSTEN G L, KLEIN C, LYU R M, WANG Y X, CHEN X Q, YANG J, PRICE C J, HOYDA T D, FERGUSON A V, YUAN X B, CHANG J K, HSUEH A J*. Neuronostatin encoded by the somatostatin gene regulates neuronal, cardiovascular, and metabolic functions [J]. J Biol Chem, 2008, 283(46): 31949-59.
4.ZHANG J V, KLEIN C, REN P G, KASS S, DONCK L V, MOECHARS D, HSUEH A J W. Response to Comment on "Obestatin, a Peptide Encoded by the Ghrelin Gene, Opposes Ghrelin's Effects on Food Intake" [J]. Science, 2007, 315(5813): 766d-d.
5.ZHANG J V, REN P G, AVSIAN-KRETCHMER O, LUO C W, RAUCH R, KLEIN C, HSUEH A J. Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake [J]. Science, 2005, 310(5750): 996-9.
6.赵田夫#, 张键#（共一）, 李晶, 曹宇静, 李素敏, 周家喜, 李福洋, 药立波, 段恩奎. 血管生长抑素在小鼠胚泡中的调节作用 [J]. 生物化学与生物物理进展, 2003, 05): 778-83.
7.ZHANG J, CAO Y J, LI F Y, LI J, YAO L B, DUAN E K. Effects of Fibronectin, VEGF and Angiostatin on the Expression of MMPs through Different Signaling Pathways in the JEG‐3 Cells [J]. American Journal of Reproductive Immunology, 2003, 50(4): 273-85.
8.ZHANG J, ZHAO Y G, CAO Y J, SANG Q X A, DUAN EK. Expression and implications of tissue inhibitor of metalloproteinases-4 in mouse embryo [J]. Molecular human reproduction,2003, 9(3): 143-49.
9.LI S M#, CAO Y J#, ZHANG J#（共一）, TIAN Y Q, ZHENG X, DUAN E K. Effects of vascular endothelial growth factor on MMPs during embryo implantation in mice [J]. Chinese Science Bulletin, 2002, 47(24): 2071-4.
10.ZHANG J#, CAO Y J#, ZHAO Y J, SANG Q X A, DUAN EK. Expression of matrix metalloproteinase-26 and tissue inhibitor of metalloproteinase-4 in human normal cytotrophoblast cells and a choriocarcinoma cell line, JEG-3 [J]. Molecular human reproduction, 2002, 8(7): 659-66.
11.ZHANG J, CAO Y J, LIU W M, ZHAO B S, ZENG G Q, DUAN E K. Expression of matrix metalloproteinase-28 in human normal cytotrophoblast cells and a choriocarcinoma cell line, JEG-3 [J]. Chinese Science Bulletin, 2002, 47(9): 732-6.
12.张键, 段恩奎. 子宫珠蛋白的结构与功能 [J]. 生物化学与生物物理进展, 2001, 05): 627-30.
13.ZHANG J, TIE G D, CAO Y J, DUAN E K. Effect of fibronectin and leukaemia inhibitory factor on matrix metalloproteinases in mouse blastocyst [J]. Chinese Science Bulletin, 2001, 46(15): 1296-300.
14.赵田夫#, 张键#（共一） 李晶, 曹宇静, 李素敏, 周家喜, 段恩奎. 血管生长抑素抑制小鼠胚胎植入的最低有效量及其作用机理 [J]. 动物学报, 2003, 03): 332-8.
15.张键, 段恩奎. 空间生殖与发育生物学及组织工程研究展望 [J]. 中华航空航天医学杂志, 2001, 03): 57-9.
（三）其他论文（非一作或者通讯）（27篇）
1.LI N, HE F, GAO H, GE Y, FAN X, ZHANG J, QI H, REN L. Elevated cell-free fetal DNA contributes to placental inflammation and antiangiogenesis via AIM2 and IFI16 during pre-eclampsia [J]. J Cell Physiol, 2020 May 7. doi: 10.1002/jcp.29766.
2.ZHAO K#*, CHENG G G#, ZHANG B Z#, LI D, HAN J Y, CHEN J, WANG B B, LI M X, XIAO T X, LE A W, SUN B N, JIN Z, ZHANG J, FAN X J. Targeting delivery of partial VAR2CSA peptide guided N-2-Hydroxypropyl trimethyl ammonium chloride chitosan nanoparticles for multiple cancer types [J]. Mater Sci Eng C-Mater Biol Appl, 2020, 106:110171.
3.ZHAO K, LI D, CHENG G, ZHANG B, HAN J, CHEN J, WANG B, LI M, XIAO T, ZHANG J, ZHOU D, JIN Z, FAN X. Targeted Delivery Prodigiosin to Choriocarcinoma by Peptide-Guided Dendrigraft Poly-l-lysines Nanoparticles [J]. Int J Mol Sci, 2019, 20(21):: 5458.
4.ZHANG B Z#, CHENG G G#, ZHENG M B, HAN J Y, WANG B B, LI M X, CHEN J, XIAO T X, ZHANG J, CAI L T, LI S J, FAN X J. Targeted delivery of doxorubicin by CSA-binding nanoparticles for choriocarcinoma treatment [J]. Drug Deliv, 2018, 25(1): 461-71.
5.XIAO Z L, LI S J, YU Y, LI M X, CHEN J, WANG F, ZHANG J, DENG W F*, YANG Q*, FAN X J*. VEGF-A regulates sFlt-1 production in trophoblasts through both Flt-1 and KDR receptors [J]. Mol Cell Biochem, 2018, 449(1-2): 1-8.
6.肖仲琳, 杨青*, 张键, 范秀军*. 子痫前期动物模型的研究进展 [J]. 生物化学与生物物理进展, 2016, 43(06): 563-9.
7.LIU H D, XIONG W, LIU Q Y, ZHANG J, DONG S H. Chemokine-Like Receptor 1 Regulates the Proliferation and Migration of Vascular Smooth Muscle Cells [J]. Med Sci Monitor, 2016, 22:4054-61.
8.LI J, XU Q, TENG B, YU C, LI J, SONG L, LAI Y X, ZHANG J, ZHENG W, REN P G. Investigation of angiogenesis in bioactive 3-dimensional poly(d,l-lactide-co-glycolide)/ nano-hydroxyapatite scaffolds by in vivo multiphoton microscopy in murine calvarial critical bone defect [J]. Acta Biomater, 2016, 42:389-99.
9.LE A W, SHAN L L, DAI X Y, XIAO T H, LI X R, WANG Z H, ZHANG J, CHEN X Y. PI3K, AKT, and P-AKT levels in thin endometrium [J]. Genet Mol Res, 2016, 15(1): doi: 10.4238/gmr.**.
10.JIA Q Y, CHENG W X, YUE Y, HU Y P, ZHANG J, PAN X H, XU Z W, ZHANG P. Cucurbitacin E inhibits TNF-alpha-induced inflammatory cytokine production in human synoviocyte MH7A cells via suppression of PI3K/Akt/NF-kappa B pathways [J]. Int Immunopharmacol, 2015, 29(2): 884-90.
11.PANDEY V#, WU Z S#, ZHANG M, LI R, ZHANG J, ZHU T*, LOBIE P E*. Trefoil factor 3 promotes metastatic seeding and predicts poor survival outcome of patients with mammary carcinoma [J]. Breast Cancer Research, 2014, 16(5): 429.
12.GRAHAM K L, ZHANG J V, LEWEN S, BURKE T M, DANG T, ZOUDILOVA M, SOBEL R A, BUTCHER E C, ZABEL B A. A Novel CMKLR1 Small Molecule Antagonist Suppresses CNS Autoimmune Inflammatory Disease [J]. Plos One, 2014, 9(12): e112925.
13.ZHAO L M, PURANDARE B, ZHANG J, HANTASH B M. beta 2-Microglobulin-free HLA-G activates natural killer cells by increasing cytotoxicity and proinflammatory cytokine production [J]. Hum Immunol, 2013, 74(4): 417-24.
14.LI J, ZHANG J V, CAO Y J, ZHOU J X, LIU W M, FAN X J, DUAN E K. Inhibition of the beta-catenin signaling pathway in blastocyst and uterus during the window of implantation in mice [J]. Biol Reprod, 2005, 72(3): 700-6.
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