更新日期：2018年9月6日
姓 名 杜金志 性 别 男
出生年月 1983年8月 籍贯 安徽萧县
民 族 汉族 政治面貌 群众
最后学历 博士研究生 最后学位 理学博士
技术职称 教授 导师类别 博、硕导
行政职务Email djzhi@scut.edu.cn
工作单位 华南理工大学医学院 邮政编码 510006
通讯地址 广州市番禺区华南理工大学大学城校区B2楼
单位电话 **


个人简介
杜金志，华南理工大学特聘研究员，广东省杰出青年
2006年毕业于中国科学技术大学高分子化学专业，获理学学士学位；2011年毕业于中国科学技术大学高分子化学与物理专业，获理学博士学位。2012年至2016年在美国Emory University从事博士后研究。2016年加入华南理工大学生命科学研究院，任特聘研究员、博士生导师。主要研究方向包括纳米材料、药物载体与递送、肿瘤免疫治疗。主持或参与国家自然科学基金委面上项目、广东省杰出青年基金、国家重点研发计划纳米科技专项、广东省“珠江人才计划”引进创新团队、广州市科技计划项目等。近年来，在Proc. Natl. Acad. Sci. USA、J. Am. Chem. Soc.、Angew. Chem. Int. Ed.、Nano Lett.、ACS Nano、Adv. Mater.、Biomaterials、J. Controlled Release等国际著名杂志发表研究论文近40篇，其中一作/通讯作者论文16篇，影响因子10以上的论文7篇，影响因子5-10的论文7篇。截至目前，论文被SCI引用2700余次，单篇引用超100次的论文10篇，最高达600余次，H-index为23。7篇论文入选ESI高被引，参与撰写2部专著的章节，获得2项中国发明专利授权。研究成果被Phys.org、Science Daily、凤凰网、光明网等国内外媒体报道。多次参加国内外学术会议做大会报告、邀请报告和口头报告。
工作经历
2016.10-至今，华南理工大学 医学院、生命科学研究院，特聘研究员、博士生导师
国家人体组织功能重建工程技术研究中心，研究员
2012.05-2016.09，美国埃默里大学（Emory University）医学院生物医学工程系 博士后
教育经历
2006.09-2011.12，中国科学技术大学 高分子化学与物理 博士
2002.09-2006.07，中国科学技术大学 高分子化学 学士
获奖、荣誉称号
2017年，广东省杰出青年
2016年，华南理工大学高层次引进人才
2011年，中国科学院院长优秀奖
2010年，GE基金会科技创新一等奖
社会、学会及学术兼职
1、中国抗癌协会纳米肿瘤学专业委员会第一届青年委员会委员
2、《材料导报》客座主编
3、ACS Nano, Biomaterials, Journal of Controlled Release, Molecular Pharmaceutics, Theranostics, Nanomedicine: Nanotechnology, Biology and Medicine, ACS Applied Materials & Interfaces, Chemical Communications, Biomacromolecules, Polymer Chemistry, Journal of Materials Chemistry B, International Journal of Pharmaceutics等多个SCI杂志审稿人
研究领域
生物材料、纳米医学、纳米载体与药物递送、肿瘤免疫、分子影像
发表论文
After SCUT
1.Jin-Zhi Du*, Hong-Jun Li, Jun Wang*, Tumor-acidity cleavable maleic acid amide (TACMAA): a powerful tool for designing smart nanoparticles to overcome delivery barriers in cancer nanomedicine, Accounts of Chemical Research, Revised.
2.Ya-Ru Zhang, Run Lin, Hong-Jun Li, Wei-ling He, Jin-Zhi Du*, Jun Wang, Strategies to improve tumor penetration of nanomedicines through nanoparticle design WIREs Nanomed & Nanobiotech, 2018, DOI:10.1002/wnan.1519.
3.Xiao-Jiao Du, Ji-Long Wang, Shoaib Iqbal, Hong-Jun Li, Zhi-Ting Cao, Yu-Cai Wang, Jin-Zhi Du and Jun Wang* The effect of surface charge on oral absorption of polymeric nanoparticles Biomater. Sci., 2018, 6, 642.
4.Song Shen#, Hong-Jun Li#, Kai-Ge Chen, Yu-Cai Wang, Xian-Zhu Yang, Zhe-Xiong Lian, Jin-Zhi Du*, Jun Wang*, Spatial Targeting of Tumor-Associated Macrophages and Tumor Cells with a pH-Sensitive Cluster Nanocarrier for Cancer Chemoimmunotherapy, Nano Lett., 2017, 17, 3822–3829.
5.Dongdong Li, Yinchu Ma, Jinzhi Du, Wei Tao, Xiaojiao Du, Xianzhu Yang*, and Jun Wang*, Tumor Acidity/NIR Controlled Interaction of Transformable Nanoparticle with Biological Systems for Cancer Therapy, Nano Letters 2017, 17, 2871–2878
Before SCUT
6.Hong-Jun Li#, Jin-Zhi Du*,#, Jing Liu, Xiao-Jiao Du, Song Shen, Yan-Hua Zhu, Xiaoyan Wang, Xiaodong Ye, Shuming Nie*, Jun Wang*, Smart Superstructures with Ultrahigh pH-Sensitivity for Targeting Acidic Tumor Microenvironment: Instantaneous Size Switching and Improved Tumor Penetration, ACS Nano 2016, 10, 6753–6761.
7.Hong-Jun Li#, Jin-Zhi Du#, Xiao-Jiao Du#, Cong-Fei Xu, Chun-Yang Sun, Hong-Xia Wang, Zhi-Ting Cao, Xian-Zhu Yang, Yan-Hua Zhu, Shuming Nie*, Jun Wang*, Stimuli-Responsive Clustered Nanoparticles for Improved Tumor Penetration and Therapeutic Efficacy, Proc. Natl. Acad. Sci. U. S. A. 2016, 113, 4164–4169.
8.Jin-Zhi Du, Xiao-Jiao Du, Cheng-Qiong Mao, Jun Wang*, Tailor-Made Dual pH-Sensitive Polymer-Doxorubicin Nanoparticles for Efficient Anti-Cancer Drug Delivery, J. Am. Chem. Soc. 2011, 133, 17560–17563.
9.Jin-Zhi Du, Tian-Meng Sun, Wen-Jing Song, Juan Wu, Jun Wang*, A Tumor-Acidity-Activated Charge-Conversional Nanogel as an Intelligent Vehicle for Promoted Tumoral-Cell Uptake and Drug Delivery, Angew. Chem. Int. Ed. 2010, 49, 3621–3626.
10.Chun-Yang Sun#, Yang Liu#, Jin-Zhi Du#, Zhi-Ting Cao, Cong-Fei Xu, Jun Wang*, Facile Generation of Tumor-pH-Labile Linkage-Bridged Block Copolymers for Chemotherapeutic Delivery, Angew. Chem. Int. Ed. 2016, 55, 1010–1014.
11.Jinzhi Du, Lucas A. Lane, Shuming Nie*, Stimuli-Responsive Nanoparticles for Targeting the Tumor Microenvironment, J. Controlled Release 2015, 219, 205–214.
12.Jin-Zhi Du, Cheng-Qiong Mao, You-Yong Yuan, Xian-Zhu Yang, Jun Wang*, Tumor Extracellular Acidity-activated Nanoparticles as Drug Delivery Systems for Enhanced Cancer Therapy, Biotech. Adv. 2014, 32, 789–803.
13.Hong-Jun Li, Hong-Xia Wang, Chun-Yang Sun, Jin-Zhi Du*, Jun Wang*, Shell-Detachable Nanoparticles Based on A Light-Responsive Amphiphile for Enhanced siRNA Delivery, RSC Adv. 2014, 4, 1961–1964.
14.Jin-Zhi Du, Hong-Yan Long, You-Yong Yuan, Meng-Meng Song, Liang Chen, Hong Bi, Jun Wang*, Micelle-to-Vesicle Morphological Transition via Light-Induced Rapid Hydrophilic Arm Detachment from A Star Polymer. Chem. Comm. 2012, 48, 1257-1259.
15.Dongdong Li, Yinchu Ma, Jinzhi Du, Wei Tao, Xiaojiao Du, Xianzhu Yang*, and Jun Wang*, Tumor Acidity/NIR Controlled Interaction of Transformable Nanoparticle with Biological Systems for Cancer Therapy, Nano Letters 2017, 17, 2871–2878
16.Hong-Xia Wang#, Zu-Qi Zuo#, Jin-Zhi Du, Yu-Cai Wang*, Rong Sun, Zhi-Ting Cao, Xiao-Dong Ye, Ji-Long Wang, Jin-Xian Yang, Hong-Jun Li, Xiao-Jiao Du, Yan-Hua Zhu, Xian-Zhu Yang, Kam W. Leong, and Jun Wang*, Surface Charge Critically Affects Tumor Penetration and Therapeutic Efficacy of Cancer Nanomedicines, Nano Today 2016, 11, 133–144.
17.Tian-Meng Sun#, Jin-Zhi Du#, Yan-Dan Yao#, Cheng-Qiong Mao, Shuang Dou, Song-Yin Huang, Pei-Zhuo Zhang, Kam W. Leong, Er-Wei Song*, Jun Wang*, Simultaneous Delivery of siRNA and Paclitaxel via a “Two-in-One” Micelleplex Promotes Synergistic Tumor Suppression, ACS Nano 2011, 5, 1483–1494.
18.Tian-Meng Sun#, Jin-Zhi Du#, Li-Feng Yan, Hai-Quan Mao, Jun Wang*, Self-Assembled Biodegradable Micellar Nanoparticles of Amphiphilic and Cationic Block Copolymer for siRNA Delivery, Biomaterials 2008, 29, 4348–4355.
19.Jin-Zhi Du, Ling-Yan Tang, Wen-Jing Song, Yue Shi, Jun Wang*, Evaluation of Polymeric Micelles from Brush Polymer with Poly(ε-caprolactone)-b-Poly(ethylene glycol) Side Chains as Drug Carrier, Biomacromolecules 2009, 10, 2169–2174.
20.Jin-Zhi Du, Tian-Meng Sun, Song-Qing Weng, Xue-Si Chen, Jun Wang*, Synthesis and Characterization of Photocrosslinked Hydrogel Based on Biodegradable Polyphosphoester and Poly(ethylene glycol) Copolymer, Biomacromolecules 2007, 8, 3375–3381.
21.Jin-Zhi Du, Dong-Ping Chen, Yu-Cai Wang, Chun-Sheng Xiao, Yi-Jie Lu, Jun Wang*, Guang-Zhao Zhang, Synthesis and Micellization of Amphiphilic Brush-Coil Block Copolymer Based on Poly(?-caprolactone) and PEGylated Polyphosphoester, Biomacromolecules 2006, 7, 1898–1903.
22.Jin-Zhi Du, Ling-Yan Tang, You-Yong Yuan, Jun Wang*, Phosphoester Modified Poly(ethylenimine) as Efficient and Low Cytotoxic Gene Vectors. Sci. China Chem. 2011, 54, 351–358.
23.You-Yong Yuan, Jin-Zhi Du, Feng Wang, Xian-Zhu Yang, Meng-Hua Xiong, Wen-Jing Song, Jun Wang*, Biocompatible and Functionalizable Polyphosphate Nanogel with a Branched Structure. J. Mater. Chem. 2012, 22, 9322–9329.
24.Xian-Zhu Yang, Jin-Zhi Du, Cheng-Qiong Mao. Shuang Dou, Hong-Yan Long, Jun Wang*, Sheddable Nanoparticles for Tumor-Acidity Targeting Small Interfering RNA Delivery. ACS Nano 2012, 6, 771–781.
25.You-Yong Yuan, Jin-Zhi Du, Jun Wang*, Two Consecutive Click Reactions as a General Route to Functional Cyclic Polyesters. Chem. Comm. 2011, 48, 570–572.
26.Cheng-Qiong Mao, Jin-Zhi Du, Tian-Meng Sun, Yan-Dan Yao, Pei-Zhuo Zhang, Wen-Jing Song, Jun Wang*, A Biodegradable Amphiphilic and Cationic Triblock Copolymer for the Delivery of siRNA Targeting the Acid Ceramidase Gene for Cancer Therapy, Biomaterials 2011, 32, 3124–3133.
27.Wen-Jing Song, Jin-Zhi Du, Tian-Meng Sun, Pei-Zhuo Zhang, Jun Wang*, Gold Nanoparticles Capped with Polyethyleneimine for Enhanced siRNA Delivery, Small 2010, 6, 239–246.
28.Xi-Qiu Liu, Jin-Zhi Du, Chu-Pei Zhang, Fang Zhao, Xian-Zhu Yang, Jun Wang*, Brush-shaped Polycation with Poly(ethylenimine)-b-Poly(ethylene glycol) Side Chains as Highly Efficient Gene Delivery Vector, Int. J. Pharm. 2010, 392, 118–126.
29.Wen-Jing Song, Jin-Zhi Du, Nan-Jun Liu, Shuang Dou, Jing Cheng, Jun Wang*, Functionalized Diblock Copolymer of Poly(?-caprolactone) and Polyphosphoester Bearing Hydroxyl Pendent Groups: Synthesis, Characterization and Self-Assembly, Macromolecules 2008, 41, 6935–6941.
30.Chun-Yang Sun, Shuang Dou, Jin-Zhi Du, Xian-Zhu Yang, Ya-Ping Li, Jun Wang*, Doxorubicin Conjugate of Poly(ethylene glycol)-block-Polyphosphoester for Cancer Therapy, Adv. Healthc. Mater. 2014, 3, 261–272.
31.Tian-Meng Sun, Yu-Cai Wang, Feng Wang, Jin-Zhi Du, Cheng-Qiong Mao, Chun-Yang Sun, Rui-Zhi Tang, Yang Liu, Jing Zhu, Yan-Hua Zhu, Xian-Zhu Yang, Jun Wang* Cancer Stem Cell Therapy using Doxorubicin Conjugated to Gold Nanoparticles via Hydrazone Bonds, Biomaterials 2014, 35, 836–845.
32.You-Yong Yuan, Yu-Cai Wang, Jin-Zhi Du, Jun Wang*, Synthesis of Amphiphilic ABC 3-Miktoarm Star Terpolymer by Combination of Ring Opening Polymerization and “Click” Chemistry, Macromolecules 2008, 41, 8620–8625.
33.Chun-Sheng Xiao, Yu-Cai Wang, Jin-Zhi Du, Xue-Si Chen, Jun Wang*, Kinetics and Mechanism of 2-Ethoxy-2-oxo-1,3,2-dioxaphospholane Polymerization Initiated by Stannous Octoate, Macromolecules 2006, 39, 6825–6831.
34.Yu-Cai Wang, You-Yong Yuan, Jin-Zhi Du, Xian-Zhu Yang, Jun Wang*, Recent Progress in Polyphosphoesters: From Controlled Synthesis to Biomedical Applications, Macromol. Biosci. 2009, 9, 1154–1164.
35.Ling-Yan Tang, Yu-Cai Wang*, Yang Li, Jin-Zhi Du, Jun Wang*, Shell-Detachable Micelles Based on Disulfide-Linked Block Copolymer as Potential Carrier for Intracellular Drug Delivery, Bioconjugate Chem. 2009, 20, 1095–1099.
36.Yang Li, Feng Wang, Tian-Meng Sun, Jin-Zhi Du, Jun Wang*, Surface-Modulated and Thermoresponsive Polyphosphoester Nanoparticles for Enhanced Intracellular Drug Delivery, Sci. China Chem. 2014, 57, 579–585.
37.You-Yong Yuan, Chen-Qiong Mao, Xiao-Jiao Du, Jin-Zhi Du, Feng Wang, Jun Wang*, Surface Charge Switchable Nanoparticles Based on Zwitterionic Polymer for Enhanced Drug Delivery to Tumor, Adv. Mater. 2012, 24, 5476–5480.
38.Yi-Quan Wu*, I-Chien Liao, Scott J. Kennedy, Jin-Zhi Du, Jun Wang, Kam. W. Leong and Robert L. Clark, Electrosprayed Core-Shell Microspheres for Protein Delivery, Chem. Comm. 2010, 46, 4743–4745.
39.李来胜，童景，吴卷，杜金志，王均，用于输送 siRNA 的聚乙烯亚胺-聚乙二醇二丙烯酸酯纳米凝胶，高分子学报 2009, 3, 257-263.
40.Yu-Cai Wang, Juan Wu, Yang Li, Jin-Zhi Du, You-Yong Yuan, Jun Wang*, Engineering Nanoscopic Hydrogels via Photo-Crosslinking Salt-Induced Polymer Assembly for Targeted Drug Delivery, Chem. Comm. 2010, 46, 3520–3522.
41.Weiwei Liu, Yucai Wang, Feng Wang, Xianzhu Yang, Tianmeng Sun, Jinzhi Du, Jun Wang*, Multiresponsive Polymer Assemblies Achieved by a Subtle Chain Terminal Modification, Chinese J. Chem. 2014, 32, 51–56.
出版专著和教材
1.Jun Wang*, You-Yong Yuan, Jin-Zhi Du
Polyphosphoesters: Controlled Ring-Opening Polymerization and Biological Applications
In: In: Matyjaszewski K and M?ller M (eds.) Polymer Science: A Comprehensive Reference, Volume 4, pp. 719-747. Amsterdam: Elsevier BV.