更新日期：2018年9月25日
姓 名 杨显珠 性 别 男
出生年月 1984年11月 籍贯 安徽枞阳县
民 族 汉族 政治面貌 党员
最后学历 博士研究生 最后学位 哲学博士
技术职称 教授 导师类别 博、硕导
行政职务Email yangxz@scut.edu.cn
工作单位 医学院/生命科学研究院 邮政编码
通讯地址 大学城校区B2-303
单位电话


个人简介
博士，教授。主要研究领域为生物医用高分子材料、纳米药物载体等。以第一或通讯作者在Adv Mater、Nano Lett、JACS、Adv Funct Mater、ACS Nano、Chem Mater、Biomaterials等杂志发表论文41篇（IF>10论文10篇，IF>8论文26篇），含单篇他引超过100次的论文4篇，3篇（曾）入选ESI高被引论文，1篇ESI热点论文；所有论文他引2400余次；获授权发明专利8件；获得国家自然科学基金青年、面上、优青（2018年）、广东省杰青（2017年）等项目资助。
工作经历
2017-至今，华南理工大学教授，博士生导师
2013-2017，合肥工业大学教授，博士生导师，入选“黄山青年学者”
2012-2012，中国科学技术大学生命科学学院从事博士后研究
教育经历
2006-2011，中国科学技术大学攻读博士学位
2002-2006，合肥工业大学攻读高分子化学与工程专业学士学位
研究领域
实验组致力于是高分子纳米药物研究，利用功能高分子材料的设计合成，解决siRNA、化疗药物、小分子抑制剂等药物体内递送难题，为癌症等重大疾病的治疗提供新策略。
发表论文
1.Junxia Wang#, Song Shen#, Dongdong Li, Changyou Zhan, Youyong Yuan, and Xianzhu Yang*, Photoswitchable Ultrafast Transactivator of Transcription (TAT) Targeting Effect for Nanocarrier-Based On-Demand Drug Delivery,Advanced Functional Materials, 2018, 28, **.

2.Ying-Li Luo#, Cong-Fei Xu#, Hong-Jun Li, Zhi-Ting Cao, Jing Liu, Ji-Long Wang, Xiao-Jiao Du, Xian-Zhu Yang*, Zhen Gu, Jun Wang*, Macrophage-Specific In Vivo Gene Editing Using Cationic Lipid-Assisted Polymeric Nanoparticles, ACS Nano, 2018, 12, 994–1005.

3.Ziyang Cao#, Yinchu Ma#, Chunyang Sun#, Zidong Lu#, Zeyu Yao, Junxia Wang, Dongdong Li, Youyong Yuan, Xianzhu Yang*, ROS-Sensitive Polymeric Nanocarriers with Red Light-Activated Size Shrinkage for Remotely Controlled Drug Release, Chemistry of Materials, 2018, 30, 517–525.

4.Ziyang Cao#, Liangzhu Feng#, Guobing Zhang#, Junxia Wang, Song Shen, Dongdong Li, Xianzhu Yang*, Semiconducting polymer-based nanoparticles with strong absorbance in NIR-II window for in vivophotothermal therapy and photoacoustic imaging, Biomaterials, 2018, 155, 103-111.

5.Jie Li#, Chunyang Sun#, Wei Tao#, Ziyang Cao, Haisheng Qian, Xianzhu Yang*, Jun Wang*, Photoinduced PEG Deshielding from ROS-Sensitive Linkage-Bridged Block Copolymer-based Nanocarriers for On-Demand Drug Delivery, Biomaterials, 2018, 170, 147-155.

6.Chun-Yang Sun1, Ziyang Cao, Xue-Jun Zhang, Rong Sun, Chun-Shui Yu*, Xianzhu Yang*, Cascade-amplifying synergistic effects of chemo-photodynamic therapy using ROS-responsive polymeric nanocarriers, Theranostics, 2018,8, 2939-2953.

7.Dong-Dong Li#, Yinchu Ma#, Jinzhi Du, Wei Tao, Xiao-Jiao Du, Xian-Zhu Yang*, Jun Wang*, Tumor Acidity/NIR Controlled Interaction of Transformable Nanoparticle with Biological Systems for Cancer Therapy, Nano Letters, 2017, 17, 2871–2878.

8.Yang Liu#, Cong-Fei Xu#, Shoaib Iqbal, Xian-Zhu Yang*, Jun Wang*, Responsive Nanocarriers as an emerging platform for cascaded delivery of nucleic acids to cancer, Advanced Drug Delivery Review, 2017, 115, 98-114.

9.Meng Gao#, Feng Fan#, Dongdong Li, Yue Yu*, Kuirong Mao, Tianmeng Sun*, Haisheng Qian, Wei Tao, Xianzhu Yang*, Tumor acidity-activatable TAT targeted nanomedicine for enlarged fluorescence/magnetic resonance imaging-guided photodynamic therapy, Biomaterials, 2017, 133, 165-175.

10.Dongdong Li#, Guobing Zhang#, Weiguo Xu#, Junxia Wang, Yucai Wang*, Longzhen Qiu, Jianxun Ding*, Xianzhu Yang*, Investigating the Effect of Chemical Structure of Semiconducting Polymer Nanoparticle on Photothermal Therapy and Photoacoustic Imaging, Theranostics, 2017, 7, 4029-4040.

11.Feng Fan#, Yue Yu#, Fei Zhong#, Meng Gao#, Tianmeng Sun, Jiaxin Liu, Huimao Zhang, Haisheng Qian, Wei Tao, Xianzhu Yang*, Design of Tumor Acidity-Responsive Sheddable Nanoparticles for Fluorescence/Magnetic Resonance Imaging-Guided Photodynamic Therapy, Theranostics, 2017, 7, 1290–1302.

12.Junxia Wang, Yang Liu, Yinchu Ma, Chunyang Sun, Wei Tao, Yucai Wang, Xianzhu Yang*, Jun Wang, NIR-Activated Super-Sensitive Drug Release using Nanoparticles with A Flow Core, Advanced Functional Materials, 2016, 26, 7516–7525.

13.Cong-Fei Xu, Hou-Bing Zhang, Chun-Yang Sun, Yang Liu, Song Shen, Xian-Zhu Yang*, Yan-Hua Zhu, Jun Wang*, Tumor Acidity-Sensitive Linkage-Bridged Block Copolymer for Therapeutic siRNA Delivery, Biomaterials, 2016, 88, 48–59.

14.Hui Wang#, Xian-Zhu Yang#, Wei Shao, Shi-Chuan Chen, Jun-Feng Xie, Xiao-Dong Zhang*, Jun Wang, and Yi Xie*, Ultrathin Black Phosphorus Nanosheets for Efficient Singlet Oxygen Generation, Journal of the American Chemical Society, 2015, 137, 11376–11382.

15.Shi Liang, Xian-Zhu Yang*, Xiao-Jiao Du, Hong-Xia Wang, Hong-Jun Li, Wei-Wei Liu, Yan-Dan Yao, Yan-Hua Zhu, Yin-Chu Ma, Jun Wang* and Er-Wei Song*, Optimizing the Size of Micellar Nanoparticles for Efficient siRNA Delivery, Advanced Functional Materials, 2015, 25, 4778–4787.

16.Xian-Zhu Yang#, Xiao-Jiao Du#, Yang Liu, Yan-Hua Zhu,Yang-Zhong Liu, Ya-Ping Li, Jun Wang*,Rational Design of Polyion Complex Nanoparticles to Overcome Cisplatin Resistance in Cancer Therapy, Advanced Materials, 2014, 26, 931–936.

17.Hong-Xia Wang#, Xian-Zhu Yang#, Chun-Yang Sun, Cheng-Qiong Mao, Yan-Hua Zhu, Jun Wang*, Matrix metalloproteinase 2-responsive micelle for siRNA delivery, Biomaterials, 2014, 35, 7622–7634.

18.Xian-Zhu Yang, Shuang Dou, Yu-Cai Wang, Hong-Yan Long, Meng-Hua Xiong, Cheng-Qiong Mao, Yan-Dan Yao, Jun Wang*, Single-Step Assembly of Cationic Lipid-Polymer Hybrid Nanoparticles for Systemic Delivery of siRNA, ACS Nano, 2012, 6, 4955-4965

19.Xian-Zhu Yang, Jin-Zhi Du, Shuang Dou, Cheng-Qiong Mao, Hong-Yan Long, Jun Wang*, Sheddable Ternary Nanoparticles for Tumor Acidity-Targeted siRNA Delivery, ACS Nano, 2012, 6, 771-781 (most read articles, ACS Nano, Jan., 2012; highlighted by Nanomedicine 2012, 7, 182)

20.Xian-Zhu Yang, Shuang Dou (co-first author), Tian-Meng Sun, Cheng-Qiong Mao, Hong-Xia Wang, Jun Wang*, Systemic delivery of siRNA with cationic lipid assisted PEG-PLA nanoparticles for cancer therapy, Journal of Controlled Release, 2011, 156, 203-211.
科研创新
1.杨显珠、王均、曹紫洋，一种缩醛键骨架的超支化聚磷酸酯材料及其制备方法与应用，申请号：CN **8.X，申请日期，2018年5月31日

2.杨显珠、曹紫洋、马寅初、钱海生、陶伟，一种还原响应性的载药纳米颗粒及其制备方法和用途，申请号：CN **2，申请日期，2014年10月29日

3.杨显珠、马寅初、李冬冬、钱海生、陶伟、樊峰、王俊侠，一种亲水性聚乙二醇-疏水性聚磷酸酯嵌段共聚物及其制备方法和用途，授权号：ZL**1.1

4.王均、杨显珠、王育才、唐凌燕，一种聚磷酸酯-聚乳酸三嵌段共聚物及其应用，中国发明专利，授权号：ZL 2008 1 **.6

5.钱海生、刘坤、陆杨、陶伟、董云雷、杨显珠，一种亚10纳米NaGdF4纳米晶的表面修饰方法以及核磁共振应用，授权专利号：ZL**3.X

6.钱海生、彭煌用、杨显珠、丁彬彬、张洪斌，一种SiO2/Ag复合微米球及其制备方法，授权专利号： ZL**1.7

7.钱海生、丁彬彬、章富、刘坤、李耀武、彭煌用、陶伟、杨显珠，一种亚10纳米NaGdF4纳米晶的制备方法，授权专利号：ZL**9.4

8.钱海生、彭煌用、刘坤、杨显珠、马寅初，一种油溶性上转换荧光纳米材料的表面修饰方法，授权专利号：ZL**0.7。