导师姓名：祝诗发
性别：男
职称：教授
招生专业：有机化学
招生层次：招收博士、硕士研究生
招生专业所属院系：化学与化工学院
研究方向：有机合成、药物合成、金属有机、不对称有机合成
联系电话：18998366022
电子邮件：zhusf@scut.edu.cn
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导师简介：
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祝诗发，博士，副教授，硕士生导师。2001年6月本科毕业于湖南大学化学化工学院，同年考入中科院上海有机所硕博连读，导师朱仕正研究员，2006年6月获中科院上海有机所理学博士学位。同年9月赴美，先后在SyracuseUniversity和UniversityofSouthFlorida从事博士后研究，主要研究方向为金属催化不对称有机合成。2009年5月，作为“海外优秀引进人才”进入华南理工大学化学与化工学院工作，2011年入选“教育部新世纪优秀人才支持计划”。已在J.Am.Chem.Soc.,Angew.Chem.Int.Ed.,Org.Lett.,JOC等杂志上发表SCI论文近30篇，申请中国专利7项，美国专利2项，目前主要从事过渡金属催化有机合成方面的研究工作。

主要学习工作经历：
1997.09－2001.07湖南大学化学化工学院，获学士学位
2001.09－2006.07中国科学院上海有机所，获博士学位
2006.09－2007.01SyracuseUniversity化学系，博士后研究
2007.01－2008.12UniversityofSouthFlorida化学系，博士后研究
2009.03－今华南理工大学化学与化工学院海外优秀人才引进计划,副教授

研究兴趣：
有机合成；药物合成；金属有机化学；不对称有机合成；目前已发表文章近30篇，申请美国专利2篇、中国专利7篇

近年来主持的部分科研项目：
1.教育部新世纪优秀人才支持计划，（主持），2011.1-2013.12
2.国家自然科学基金面上项目（主持），2012.1-2015.12；
3.国家自然科学基金青年科学基金项目（主持），2010.1-2012.12
4.广东省自然科学基金博士启动基金（主持），2009.10-2011.9；
5.华南理工大学中央高校基本科研业务费（主持），2010.1-2012.12
6.华南理工大学科研启动费（主持），2010.1-2012.12
7.中科院上海有机所氟化学重点实验室开放基金(主持),2010.11-2012.10
8.温州大学有机化学与皮革化工重中之重学科开放基金(主持),2010.11-2012.10
9广东省自然科学基金团队项目（参与），2011.1-2013.12
10.国家科技支撑973项目（参与），2011.01-2015.08

代表文章
1.ShifaZhu*,ChaoWang,LijuanChen,RenxiaoLiang,YinfengYu,HuanfengJiang.ModularApproachforSynthesisofVicinalDiaminesContainingAxialChiral1,1′-Binaphthylfrom1,2-DiaminoethanebyPd-CatalyzedN-ArylationReactions,Org.Lett.2011,13,1146-1149.
2.
3.ShifaZhu*,LijuanChen,RenxiaoLiang,ChaoWang,XiujunWang,YanweiRen,HuanfengJiang.Apracticalsystemtosynthesizethemultiple-substituted2,5-dihydrofuranbytheintermoleculardipolarcycloadditionreactionsinvolvingacceptor/acceptorsubstituteddiazoreagents.Tetrahedron2011,67,5507-5515.

4.ShifaZhu,XueXu,JasonPerman,PeterX.Zhang*.AGeneralandEfficientCobalt(II)-BasedCatalyticSystemforHighlyStereoselectiveCyclopropanationofAlkeneswithalfa-CyanodiazoacetatesJ.Am.Chem.Soc.,2010,132,12796-12799.

5.ShifaZhu,JoshuaV.Ruppel,HongjianLu,LukaszWojtas,PeterX.Zhang*.Cobalt-CatalyzedAsymmetricCyclopropanationwithDiazosulfones:RigidificationandPolarizationofLigandChiralEnvironmentviaHydrogenBondingandCyclization.J.Am.Chem.Soc.,2008,130,5042-5043.(HighlightedbySYNFACTS,2008,7,720.andAngew.Chem.Int.Ed.,2009,48,850.)

6.ShifaZhu,JasonPerman,X.PeterZhang*.Acceptor/Acceptor-SubstitutedDiazoReagentsforCarbeneTransfers:Cobalt-CatalyzedAsymmetricZ-CyclopropanationofAlkeneswithα-Nitro-Diazoacetates.Angew.Chem.,Int.Ed.,2008,47,8460-8463.(HighlightedbySYNFACTS,2009,1,74.andAngew.Chem.Int.Ed.,2009,48,850.)

7.XinCui,XueXu,HongjianLu,ShifaZhu,LukaszWojtas,andX.PeterZhang*,EnantioselectiveCyclopropenationofAlkyneswithAcceptor/Acceptor-SubstitutedDiazoReagentsviaCo(II)-BasedMetalloradicalCatalysis.J.Am.Chem.Soc.,2011,133,3304-3307.

8.ShifaZhu,YuanxiLiao,ShizhengZhu*.Transition-Metal-CatalyzedFormationoftransAlkenesviaCouplingofaldehydes.Org.Lett.2004,6,377-380.

9.VelusamySubbarayan,JoshuaV.Ruppel,ShifaZhu,JasonA.Perman,X.Peter*.Zhang,HighlyAsymmetricCobalt-CatalyzedAziridinationofAlkeneswithTrichloroethoxysulfonylAzide(TcesN3).Chem.Commun.2009,28,4266-4268.

10.ShifaZhu,YuanxiLiao,ShizhengZhu*.TheFirstExampleofCatalyticAziridinationMediatedbyArsoniumYlides:PreparationoftransPentafluorophenyl-ContainingAziridines,Synlett2005,1429-1432.

11.ShizhengZhu*,ShifaZhu,GuifangJin,andZhantingLi*.StrongPhenyl-perfluorophenyl-StackingInteractionsandC-H…F-CHydrogenBondingInteractionsinTheCrystallineofCorrespondingAromaticaldimines.TetrahedronLetters2005,46,2713-2716.

12.ShifaZhu,ChunhuiXing,ShizhengZhu*.StereoselectivePreparationofTrifluoromethylContaining1,4-OxathiolaneDerivativesThroughRingExpansionReactionof1,3-Oxathiolanes,Tetrahedron2006,62,829–832.

13.ShizhengZhu*,ShifaZhu,YuanxiLiao.Rhodium(II)-CatalyzedAdditionof2-Diazo(fluoroalkyl)acetoacetatestoSulfides:aSimpleSynthesisofStableSulfoniumYlides.JournalofFluorineChemistry2004,125,1071–1076.

14.ShifaZhu,ShizhengZhu*,YuanxiLiao,ChaofengHuang,ZhantingLi*.Co-existingIntermolecularHalogenBondingandHydrogenBondingintheCompoundTrans-5,10-bis(1-bromodifluoroacetyl-1-ethoxycarbonyl-methylidene)Thianthrene.ChineseJournalofChemistry2004,22,896-898.

15.ShifaZhu,ShizhengZhu*.Rh2(OAc)4-CatalyzedFormationoftransAlkenesFromtheReactionofAldehydeswithPerfluorophenylDiazomethaneThroughTelluriumYlide.TetrahedronLett.2006,47,5897-5900.

16.ShifaZhu,WanPang,ChunhuiXing,ShizhengZhu,LewisBase-CatalyzedFormationofα-TrifluoromethylAlcoholfromCF3SiMe3andCarbonyl-ContainingCompounds,ChineseJournalofChemistry,2007,25,2,233-236.

17.RuixinZhu,ShifaZhu,JunhongZhou,MinboChen*.TheAtomsinMolecules(AIM)AnalysisofAbnormalBondingofSeveralFluorinatedSupramolecularSystems,ActaChimicaSinica2006,164,191-197.

18.WanPang,ShifaZhu,HuanfengjiangandShizhengZhu*.Transitionmetal-catalyzedformationofCF3-substitutedα,β-unsaturatedalkeneandthesynthesisofα-trifluoromethylsubstitutedβ-aminoester.Tetrahedron2006,62,11760-11765.

19.ChunhuiXing,XianfuLi,ShifaZhu,ShizhengZhu*.Synthesisof(E)-α-Per(poly)fluoroalkanesulfonyl-α,β-unsaturatedKetonesandtheirHeteroDiels-AlderReactionswithVinylEther,TetrahedronLett.2006,47,4951-4955.

20.Huiwang,ShifaZhu,QinyingDeng*,ShiZhengZhu*.Afacilesynthesisof4-gem-difluoromethyleneβ-lactam　anditsderivativesfromBrCF2CF2Br,　JournalofFluorineChemistry2006,127,1195-1203.

21.JunLi,YongbinHan,TeresaB.Freedman,ShifaZhu,DeborahJ.KerwoodandYan-YeungLuk*,　Utilizingthehighdielectricconstantofwater:efficientsynthesisofaminoacid-derivatizedcyclobutenones.TetrahedronLett.2008,49,2128-2131.

22.WanPang;ShifaZhu;HuanfengJiang;ShizhengZhu*.Anovelsynthesisof5-perfluorophenyl4,5-dihydro-1H-pyrazolesinTHForwater.JournalofFluorineChemistry2007,128,1379-1384.

23.WanPang;ShifaZhu;HuanfengJiang;ShizhengZhu*.Rh(II)-catalyzedformationandrearrangementoftrifluoroacetyl-containingsulfurylides.Tetrahedron2007,63,4543-4547.

24.WanPang;ShifaZhu;ChunhuiXing;NianhuaLuo;HuanfengJiang;ShizhengZhu*.SynthesisofstablearsoniumandsulfurylidesfromperfluoroalkanesulfonyldiazocarbonylcompoundsandtheirX-raydiffractionanalysis;JournalofFluorineChemistry2008,129,343-348.
25.WeibingLiu,HuanfengJiang*,ShifaZhu,etal.,Hydroalkylationleadingtoheterocycliccompounds(Part2):practicalsynthesisofpolysubstituted1,2,3,4-tetrahydropyridinesthroughmulticomponentreactions(MCRs).Tetrahedron,2009,65(38),7985.

26.WeibingLiu,HuanfengJiang*,PengZhou,ShifaZhuDABCO-Induced[2+2+2]CycloadditionReactionofEthylPropiolateandArylaldehydestoSynthesize4-Aryl-4H-pyrans,Synlett2009,20,3295.

27.HuaCao,HuanfengJiang*,RonghuanMai,ShifaZhu,ChaorongQi,Silver-CatalyzedOne-PotCyclizationReactionofElectron-DeficientAlkynesand2-Yn-1-ols:AnEfficientDominoProcesstoPolysubstitutedFuransAdv.Synth.Catal.2010,352,143.

28.WanPang,ShifaZhu,YongXin,HuanfengJiang,ShizhengZhu，Rh2(OAc)4catalyzedformationoffluorine-containingpolysubstitutedfuransfromdiazocompoundsandaromaticalkynes,Tetrahedron,2010,66,1261-1266.

29.ZhengwangChen,JinghaoLi,HuanfengJiang,ShifaZhu,YibiaoLiandChaorongQi,Silver-CatalyzedDifunctionalizationofTerminalAlkynes:HighlyRegio-andStereoselectiveSynthesisof(Z)-β-HaloenolAcetates,Org.Lett.2010,12,3262-3265.

书刊章节:

30.ShifaZhu,X.PeterZhang*,“Cobalt(II)Acetate”,ine-EROSEncyclopediaofReagentsforOrganicSynthesis;Wiley-Interscience,2009.



专利:
31.轴手性咪唑盐化合物及其制备方法，祝诗发，王朝，专利申请号：CN201110008913.4

32.轴手性邻二胺化合物及其制备方法，祝诗发，王朝，专利申请号：CN201110008898.3

33.氮杂卡宾金络合物的制备方法，祝诗发，梁仁校，陈丽娟,CN201110107960.4

34.氮杂卡宾铜络合物的制备方法，祝诗发，梁仁校，陈丽娟,CN201110107949.8

35.氮杂卡宾银络合物的制备方法，祝诗发，梁仁校，陈丽娟,CN201110107958.7

36.1-芳基-2-氟代芳基乙烯及其衍生物、其合成和应用。朱仕正、祝诗发，03129584

37.含氟芳基亚胺化合物及其共晶化合物的合成和应用。朱仕正、祝诗发，00410089085.1

38.Cobalt-catalyzedasymmetriccyclopropanationwithdiazosulfones.X.Zhang,ShifaZhu，PCTInt.Appl.(2009),WO2009114849A120090917(美国专利，2009)

39.PeterX.Zhang,ShifaZhu,Cobalt-CatalyzedAsymmetricCyclopropanationofAlkenewith-nitro-diazoacetates,U.S.Pat.Appl.Publ.(2010),US2010081838A120100401(美国专利,2010)

招生计划：
硕士生：有机化学名额：2-3人
本科生：欢迎对有机化学感兴趣的优秀本科生来实验室实习；名额：2-3