姓名:
刘永宏性别:
男
职务:
广东省海洋药物重点实验室副主任职称:
研究员
通讯地址:
广州市新港西路164号中国科学院南海海洋研究所中科院海洋生物资源可持续利用重点实验室
邮政编码:
电子邮件:
yonghongliu@scsio.ac.cn

简历：
1、刘永宏，男，1972年4月生，2002年毕业于韩国釜山大学药学大学海洋天然药物化学专业博士，之后去日本大阪大学药学大学，葡萄牙里斯本新大学科技学院化学系做博士后，2006回国到中国科学院南海海洋研究所，任“百人计划”研究员，2009年任广东省海洋药物重点实验室副主任。
研究领域：
主要研究领域为海洋生物活性物质的研究，以海洋天然产物化学研究为基础，以海洋生物中防治重要疾病创新药物先导结构的发现与优化为主要研究方向。主要研究内容包括：综合运用现代分离、分析技术与活性追踪相结合的方法，研究发现海洋生物中用于防治严重危害人类健康的重要疾病创新药物先导结构或目标分子；对发现的重要活性先导化合物进行系统的结构修饰或合成研究，探讨相关衍生物的结构与活性的关系，发现结构简单、活性强、毒性小的新药研究目标分子。近年来，开展了一些海洋化学生态学研究，旨在通过海洋生物学，生态学和海洋天然产物化学等多学科的配合，从仿生学的观点，以抗污损生物附着活性筛选为导向，结合现代色谱学，现代波谱学，现代色谱-波谱联机技术，快速分离并结构确定海洋生物中的抗藤壶幼虫附着靶向化学防御物质，改构活性成分，发现生产新的抗附着先导结构，研究抗附着活性与结构关系，总结出显效基团，在此基础上进行抗其它污损生物附着活性的研究，探讨海洋生物抗附着化合物与环境竞争适应机制，揭示海洋生物的抗附着活性化合物的化学生态学作用，为研制海洋生物来源的新型无毒绿色防污剂奠定基础。



社会任职：

获奖及荣誉：
2005年度第二批“引进国外杰出人才”入选者，美国化学学会会员。为JournalofNaturalProducts,Bioorganic&MedicinalChemistry,Bioorganic&MedicinalChemistryLetters,JournalOfAgricultureAndFoodChemistry,ProcessBiochemistry,Molecules等杂志审稿人。长期从事海洋生物及天然药物的化学成分和新药研究,在对20余种海绵，海星的药用植物，药用动物的活性成分研究过程中，发现了100余种新化合物,300多个已知化合物,2种新骨架结构成分及一些重要的新药先导化合物,它们分别具有抗癌，抗病毒，抗疟疾，抗艾滋病,抗氧化等活性。主持，参与包括国家自然科学基金，中国科学院“百人计划”，教育部留学回国启动基金，973项目，蛋白质重大研究计划，韩国科学与工程基金，日本振兴财团，葡萄牙科技基金，香港王宽诚基金资助的科技项目等20余项。近些年发表论文100篇，在NaturalProductReports,Phytochemistry,JournalofNaturalProducts,PlantaMedica,JournalofChromatographyA，MarineBiology,AntonieVanLeeuwenhoekInternationalJournalofGeneralandMolecularMicrobiology，FoodChemistry等SCI论文上发表文章50篇,其中第一作者20篇，被引百余次，参编著作4部,申报专利10项，获授权4项。

代表论著：
(1)刘大有刘永宏等中药美容人民卫生出版社1998.(2)刘永宏《中华海洋本草》软体动物化学成分部分上海科学技术出版社.(3)LiuY,ZhangS,JungJ,XuT.Bioactivefuranosesterterpenoidsfrommarinesponge德国Springer出版的系列丛书《TopicsinHeterocyclicChemistry》中的一章，2007.(4)ZhouX,XuT,LiuY.Alismaorientale,acommonTraditionalChineseMedicineasadiureticagent，《EncyclopediaofMedicinalPlant》中的一章，2009，StadiumPreeLLC,U.S.A.论文20101.YangX,DongG,ZhouX,ChaiX,LiY,YangB,ZhangW,LiuY.AntitumorsteroidsfromthestarfishArchastertypicus.FoodChemistry2011,124，1634-1638(SCIIF:3.146).2.YanH,LiuY.IdentificationofepidioxysterolfromSouthChinaSeaurchinTripneustesgratillaLinnaeusanditscytotoxicactivity.JournalofFoodBiochemistryaccept(SCIIF:0.779).3.ChaiX,SunJ,TangL,YangX,LiY,HuangH,ZhouX,YangB,LiuY.AnovelcyclopentenederivativeandapolyhydroxylatedsteroidfromaSouthChinaSeagorgonianMenellasp.Cheimcal&PharmaceuticalBulletin2010,58(10),1391-1394(SCIIF:1.698).4.RenS,MaW,XuT,YinH,ZhouX,YangX,GaoQ,XuS,LiuY.TwonewalkaloidsfromtheSouthChinaSeamarinespongeDysideasp.JournalofAntibioticsaccept(SCIIF:1.628).5.ZhouX,XuT,WenK,YangX,XuS,LiuY.AnewN-acyltaurinefromtheseaurchinGlyptocidariscrenularis.Bioscience,BiotechnologyandBiochemistry2010,74(5),1089-1091(SCIIF:1.326).6.YangX,LiS,WuL,LiY,FengL,ShenY,TianJ,TangJ,WangN,LiuY,ZhangW.AbiesatrinesA-J:anti-inflammatoryandanti-tumortriterpenoidsfromAbiesgeorgeiOrr.Organic&BiomolecularChemistry2010,8,2609-2616(SCIIF:3.762).7.LiuY,JungJ,XuT,YinH.NewcyclitolderivativefromaspongeSarcotragusspecies.NaturalProductsResearch2010accept(SCIIF:0.81).8.ZhouX,LiuY,TangL,ZhangP,WuJ.ChemicalconstituentsfromtherootsofActinidiachinensis.ChemistryofNaturalCompounds2010,46(2),308-309(SCIIF:0.572).9.ZhouX,WenK,YangX,HuangR,DongG,YangB,SunJ,LiuY.ChemicalconstituentsfromtheseaurchinGlyptocidariscrenularis.BiochemicalSystematicsandEcology2010,38,103-105(SCIIF:1.131).10.HuangR,LiuY.Diketopiperazinesfrommarineorganisms.Chemistry&Biodiversity2010,doi:10.1002/cbdv.200900211(SCIIF:1.962).11.DongG,LiuY,YangX,ZhouX.Chemicalconstituentsandbioactivitiesofstarfish.Chemistry&Biodiversity2010doi:10.1002/cbdv.200900344(SCIIF:1.962).12.HuangL,WenK,GaoX,LiuY.HypolipidemiceffectoffucoidanfromLaminariajaponicainhyperlipidemicrats.PharmaceuticalBiology2010,48(4),422-426(SCIIF:0.672).13.YangX,FengL,LiS,LiuX,LiY,WuL,ShenY,TianJ,ZhangX,LiuX,WangN,LiuY,Zhang,W.Isolation,structure,andbioactivitiesofabiesadinesA–Y,twenty-fivenewditerpenesfromAbiesgeorgeiOrr.BioorganicMedicinalChemistry2010,18,744-754(SCIIF:2.822).14.XuY,LiuY,XuT,XieS,SiY,LiuY,ZhouH,LiuT,XuD.AnewfurostanolglycosidefromTribulusterrestris.Molecules2010,15,613-618(SCIIF:1.738).15.HuangR,MaW,DongJ,ZhouX,XuT,LeeK,YangX,XuS,LiuY.Anew1,4-diazepinefromSouthChinaSeamarinespongeCallyspongiaspecies.Molecules2010,15,871-877(SCIIF:1.738).16.PengY,ZhengJ,HuangR,WangY,XuT,ZhouX,LiuQ,ZengF,JuH,YangX,LiuY.PolyhydroxysteroidsandsaponinsfromtheChinaSeastarfishAsterinasp.andtheirbiologicalactivities.Chemical&PharmaceuticalBulletin2010,58(6)856-858(SCIIF:1.698).17.ZhouX,XuT,YangX,XuS,LiuY.ChemicalandbiologicalaspectsofmarinespongeofthegenusXestospongia.Chemistry&Biodiversity2010,7,2201-2227.(SCIIF:1.926).18.XuY,BaiL,LiuY,XuT,LiuY,XieS,SiY,ZhouH,LiuT,XuD.AnewtriterpenoidsaponinfromPulsatillacernua.Molecules2010,15,1891-1897(SCIIF:1.738).200919.WangL,ZhaoD,XuT,ZhouX,YangX,LiuY.AnewtriterpenehexaglycosidefromthebarkofKalopanaxseptemlobus(Thunb.)Koidz.Molecules2009,14,4497-4504(SCIIF:1.738).20.WangL,ChengD,WangH,DiL,ZhouX,XuT,YangX,LiuY.ThehepatoprotectiveandantifibroticeffectsofSaururuschinensisagainstcarbontetrachlorideinducedhepaticfibrosisinrats.JournalofEthnopharmacology2009,126,487-491(SCIIF:2.322).21.YangB,DongJ,ZhouX,YangX,LeeK,WangL,ZhangS,LiuY.Proline-containingdipeptidesfromthemarinespongeaCallyspongiaspecies.HelveticaChimicaActa2009,92,1112-1117(SCIIF:1.435).22.WangB,DongJ,ZhouX,LeeKJ,HuangR,ZhangS,LiuY.NucleosidesfrommarinespongesincludingknownonesfromHaliclonasp.ZeitschriftFurNaturforschung2009,64c,143-148(SCIIF:0.8).23.WangB,LeeK,ZhangS,JungJ,LiuY.2-Palmitamidoethanesulfonicacid,newaminoethylsulfonicacidderivativefrommarinespongeHaliclonasp.ChemistryofNaturalCompounds2009,45(1),137-138(SCIIF:0.572).24.WangL,ZhaoD,LiuY.GC-MSanalysisofthesupercriticalCO₂fluidextractionofEphedrasinicarootsanditsantisudorificactivity.ChemistryofNaturalCompounds2009,45(3),434-436(SCIIF:0.572).25.ZhouX,TangL,ZhangP,ZhaoX,PiH,ZhangY,RuanH,LiuY,WuJ.Theinterleukin-18inhibitoryactivitiesofechinocysticacidanditssaponinsfromImpatienspritzelliivar.hupehensis.ZeitschriftFurNaturforschung2009,64c,369-372(SCIIF:0.8).26.ZhouX,TangL,LiuY.AnisomericmixtureofnovelcerebrosidesisolatedfromImpatienspritzelliireduceslipopolysaccharide-inducedreleaseofIL-18fromhumanperipheralbloodmononuclearcells.Lipids2009,44(8),759-763(SCIIF:2.382).200827.LiuY,MurakamiN,WangL,ZhangS.Preparativehigh-performanceliquidchromatographyforthepurificationofnaturalacylatedanthocyaninsfromredradish(RaphanussativusL).JournalofChromatographicScience2008,46(8),743-746(SCIIF:0.863).28.LiuY,JiH,ZhangS,JungJ,XuT.TrisoxazolemacrolidesfromthespongeSarcotragusspecies.ChemistryofNaturalCompounds2008,44(1),140-141(SCIIF:0.572).29.LiuY,JiH,DongJ,ZhangS.LeeK,MatthewS.AntioxidantalkaloidfromSouthChinaSeamarinespongeIotrochotasp.ZeitschriftFurNaturforschung2008,63c,636-638(SCIIF:0.8).30.WangL,ZhaoD,LiuY.QualityassessmentofVeratrumnigrumL.byLC-ELSDfingerprintsandLCquantitativeanalysis.Chromatographia2008,68,961-967(SCIIF:1.098).31.TaoH,WangL,CuiZ,ZhaoD,LiuY.DimericproanthocyanidinsfromrootsofEphedrasinicaStapf.PlantaMedica2008,74,1823-1825(SCIIF:2.037).32.WangL,LiW,LiuY.HypotensiveeffectandtoxicologyoftotalalkaloidsandveratraminefromrootsandrhizomesofVeratrumnigrumL.inspontaneouslyhypertensiverats.Pharmazie2008,63(8),606-610(SCIIF:0.812).33.WangL,ZhaoD,ChengD,LiuY.ent-SauchinonefromSaururuschinensis.Heterocycles2008,75(5),1241-1246(SCIIF:1.165).34.YinH,ZhangS,LuoX,LiuY.PreparativeisolationandpurificationoftwobenzoxazinoidglucosidesfromAcanthusilicifoliusL.byhigh-speedcounter-currentchromatography.JournalofChromatographyA2008,1205,177-181(SCIIF:4.101).35.JiangS,LiX,ZhangL,SunW,DaiS,XieL,LiuY,LeeK.CulturableactinobacteriaisolatedfrommarinespongeIotrochotasp.MarineBiology2008,153(5),945-952(SCIIF:1.999).200736.LiuY,WangL,JungJ,ZhangS.Sesterterpenoids.NaturalProductReports2007,24(6),1401-1429(SCIIF:9.202).37.LiuY,ZhangS,JungJ,XuT.Variabilin,achemotaxonomicmarkerforthefamillyIrciniidae.ZeitschriftFurNaturforschung2007,62c,473-476(SCIIF:0.8).38.LiuY,JiH,ZhangS,MurakamiN,XuT.Structure-activityrelationshipsof1'-acetoxychavicolacetatehomologuesasnewnuclearexportsignalinhibitors.Pharmazie2007,62(9),659-662(SCIIF:0.812).39.LiuY,MurakamiN,AbreuP,JiH,ZhangS.AntimalarialflavonolglycosidesfromEuphorbiahirta.PharmaceuticalBiology2007,45(4),278-281(SCIIF:0.672).40.JiangS,SunW,ChenM,DaiS,ZhangL,LiuY,LeeK,LiX.DiversityofculturableactinobacteriaisolatedfrommarinespongeHaliclonasp.AntonieVanLeeuwenhoekInternationalJournalofGeneralandMolecularMicrobiology2007,92(4),405-416(SCIIF:1.983).41.AbreuP.LiuY,Ozoroalide,anewmacrolidefromOzoroainsignis.Fitoterapia2007,78,388-389(SCIIF:1.363).42.JungJ,ShindeP,HongJ,LiuY,SimC.SecondarymetabolitesfromamarinespongeDiscodermiacalys.BiochemicalSystematicsandEcology2007,35,48-51(SCIIF:1.131).200643.LiuY,ZhangS,AbreuP.Heterocyclicterpenes:linearfurano-andpyrroloterpenoids.NaturalProductReports2006,23(4),630-651(SCIIF:9.202).44.LiuY,AbreuP.TirucallanetriterpenesfromtherootsofOzoroainsignis.Phytochemistry2006,67,1309-1315(SCIIF:3.104).45.LiuY,AbreuP.LongchainalkylandalkenylphenolsfromOzoroainsignis.JournaloftheBrazilianChemicalSociety2006,17(3),527-536(SCIIF:1.458).46.LiuY,JungJ,ZhangS.LinearpyrrolosesterterpenesfromaspongeSarcotragusspecies.BiochemicalSystematicsandEcology2006,34,774-776(SCIIF:1.131).47.LiuY,JungJ,ZhangS.IndolealkaloidsfromaspongeSarcotragusspecies.BiochemicalSystematicsandEcology2006,34(5),453-456(SCIIF:1.131).48.LiuY,JungJ,JiH,ZhangS.GlycerolipidsfromaSarcotragusspeciessponge.Molecules2006,11,714-719(SCIIF:1.738).49.LiuY,JungJ,ZhangS.Anunsaturatedω-hydroxymethylesterfromaspongeSarcotragusspecies.ChemistryofNaturalCompounds2006,42(4),487-488(SCIIF:0.572).

承担科研项目情况：