马晓冬研究员

联系地址:华南师范大学脑科学与康复医学研究院
广东省广州市中山大道西55号
邮编：510631, 广州, 中国
Email: maxiaodong@m.scnu.edu.cn


1.个人简介：
南方医科大学，病理与病理生理学博士毕业，广东省****医学人才，博士生导师，独立PI。美国癌症学会会员，美国基因与细胞治疗学会会员，中国细胞生物学会会员，广东省药学会制药工程专业委员会委员。主持国家和省部级课题8项（4项国家自然基金面上项目，1项广东省自然基金重点项目，1项广东省科技计划国际合作，1项广东省自然科学基金面上项目，1项广州市科技计划）。


2.主要研究方向
非编码RNA，基因编辑和嵌合抗原受体介导的T细胞免疫治疗。主要研究内容包括：非编码RNA在炎症和肿瘤中的作用机制；CRISPR-Cas9基因编辑和筛选；CAR-T细胞治疗。利用RNA-Seq开展炎性细胞激活在胶质瘤等恶性肿瘤中的作用机制研究；利用基因敲除小鼠模型研究非编码RNA在炎症向恶性肿瘤转化中的作用机制，开展以CRISPR-Cas9和CAR-T技术编辑免疫细胞进行细胞治疗的研究。


3.主持课题：
(1)国家自然科学基金面上项目；名称：“基于TNC“一靶双点”的胰腺肿瘤CAR-T靶向治疗新策略”；项目批准号：“**”；55万元，主持，起止时间：2021.01.01-2024.12.31
(2)广东省自然科学基金-重点项目；名称：“高效整合microRNA双向优化CAR-T细胞治疗肿瘤策略研究”，项目批准号：“2017A”，50万，主持，起止时间：2017.05.01-2020.05.01

(3)国家自然科学基金面上项目；名称：“miR-CAR-T细胞的制备及其功能研究”；项目批准号：“**”；60万元，主持，起止时间：2018.01.01-2021.12.31


4.发表论文
(1)Ming Liu#,Xu Wang#,Wei Li,Xinfang Yu,Pedro Flores-Villanueva,Zijun Y Xu-Monette,Ling Li,Mingzhi Zhang,Ken H Young,Xiaodong Ma*,Yong Li*. Targeting PD-L1 in non-small cell lung cancer using CAR T cells. Oncogenesis.2020 Aug 13;9(8):72.
(2)Jiexuan Wang#, Xun Li#, Mingtian Zhong#, Yansheng Wang, Liming Zou, Miaomiao Wang, Xiaoli Gong, Xinjie Wang, Chengzhi Zhou*, Xiaodong Ma*, Ming Liu*. miR-301a Suppression within Fibroblasts Limits the Progression of Fibrosis through the TSC1/mTOR Pathway. Mol Ther Nucleic Acids.2020 May 26;21:217-228.
(3)Xinjie Wang,Mingtian Zhong,Yong Liu,Peixiang Ma,Lu Dang,Qingzhou Meng,Wenwei Wan,Xiaodong Ma,Jia Liu,Guang Yang,Zifeng Yang,Xingxu Huang,Ming Liu. Rapid and Sensitive Detection of COVID-19 Using CRISPR/Cas12a-based Detection with Naked Eye Readout, CRISPR/Cas12a-NER. Sci Bull (Beijing).2020 May 5.doi: 10.1016/j.scib.2020.04.041.
(4)Xinjie Wang,Pinpin Ji,Huiying Fan,Lu Dang,Wenwei Wan,Siyuan Liu,Yanhua Li,Wenxia Yu,Xiangyang Li,Xiaodong Ma,Xu Ma,Qin Zhao,Xingxu Huang,Ming Liao. CRISPR/Cas12a technology combined with immunochromatographic strips for portable detection of African swine fever virus. Commun Biol.2020 Feb 11;3(1):62.doi: 10.1038/s42003-020-0796-5
(5)Xiaoli Gong#, Liming Zou#, Miaomiao Wang#, Yingheng Zhang, Shuxian Peng, Mingtian Zhong, Jiankui Zhou, Xun Li*, Xiaodong Ma*. Gramicidin inhibits cholangiocarcinoma cell growth by suppressing EGR4. Artif Cells Nanomed Biotechnol. 2020 Dec;48(1):53-59.
(6)Xinjie Wang#, Zhiwei Liu#, GuangLei Li#, Lu Dang, Shisheng Huang, Lei He, Yu’e Ma, Cong Li, Ming Liu, Guang Yang, Xingxu Huang, FeiZhou*, Xiaodong Ma*. Efficient Gene Silencing by Adenine Base Editor Mediated Start Codon Mutation. Molecular Therapy. 2020 Feb 5;28(2):431-440.doi: 10.1016/j.ymthe.2019.11.022.
(7)Lei Wang; Qipan Deng; Ming Liu; Zhaojian Gong; Shanshan Zhang; Hui Hu; Zhongxin Lu; Zijun Xu-Monette; Ken Young; Xiaodong Ma*; Yong Li*. Glyphosate Induces Benign Monoclonal Gammopathy and Promotes Multiple Myeloma Progression in Mice. Journal of Hematology & Oncology, 2019 Jul 5;12(1):70.
(8)Xun Li#, Mingtian Zhong#, Jiexuan Wang#, Lei Wang, Zhanwen Lin, Zhi Cao, Zhujuan Huang, Fengxue Zhang, Yong Li, Ming Liu*, Xiaodong Ma*. miR-301a promotes lung tumorigenesis by suppressing Runx3. Molecular Cancer, 2019 May 23;18(1):99.
(9)LeiWang, Munish Kumar, Qipan Deng, XuWang, MingLiu, Zhaojian Gong, Shanshan Zhang, Xiaodong Ma,Zijun Y. Xu-Monette, Min Xiao, Qing Yi, Ken H.Young, Kenneth S.Ramos, YongLi*. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induces peripheral blood abnormalities and plasma cell neoplasms resembling multiple myeloma in mice. Cancer Lett.2019 Jan;440-441:135-144.
(10) Xun Li#, Zhanwen Lin#, Lei Wang #, Qin Liu, Zhi Cao, Zhujuan Huang, Mingtian Zhong, Shuxian Peng, Yingheng Zhang, Yong Li, Xiaodong Ma*. RNA-Seq Analyses of the Role of miR-21 in Acute Pancreatitis. Cellular Physiology and Biochemistry, 2018;51(5):2198-2211.
(11) Mingtian Zhong#,Zhujuan Huang#,Lei Wang#,Zhanwen Lin,Zhi Cao,Xun Li,Fengxue Zhang,Hongqi Wang,Yong Li*, Xiaodong Ma*.Malignant Transformation of Human Bronchial Epithelial Cells Induced by Arsenic through STAT3/miR-301a/SMAD4 Loop. Scientific Reports. 2018 Sep 5;8(1):13291.
(12) Ming Liu*, Xu Wang,Lei Wang,Xiaodong Ma,Zhaojian Gong, Shanshan Zhang,Yong Li*. Targeting the IDO1 pathway in cancer: from bench to bedside. J Hematol Oncol. 2018 Aug 2;11(1):100.
(13) Jiajia Xi#,Qian Huang#,Lei Wang#, Xiaodong Ma,Qipan Deng,Munish Kumar,Zhiyuan Zhou,Ling Li,Zhaoyang Zeng,Ken H. Young,Mingzhi Zhang, Yong Li*. miR-21 deleption in marcrophages promotes tumoricidal polarization and enhances PD-1 immunotherapy. Oncogene. 2018 Jun;37(23):3151-3165.
(14) Qian Huang,#Jiajia Xia,#Lei Wang,#,Xu Wang, Xiaodong Ma,Qipan Deng, Yong Lu,Munish Kumar,Zhiyuan Zhou,Ling Li,Zhaoyang Zeng, Ken H. Young,Qing Yi, Mingzhi Zhang,Yong Li*. miR-153 suppresses IDO1 expression and enhances CAR T cell immunotherapy. J Hematol Oncol.2018 Apr 23;11(1):58.
(15) Xiaodong Ma*,Daniel J. Conklin, Fenge Li, Zhongping Dai, Xiang Hua, Yan Li, Zijun Y. Xu-Monette, Ken H. Young, Wei Xiong, Marcin Wysoczynski, Srinivas D. Sithu, Sanjay Srivastava, Aruni Bhatnagar, Yong Li*. The oncogenic microRNA miR-21 promotes regulated necrosis in mice. Nat Commun.2015 May 20;6:7151.


5.书籍章节撰写：
(1)Xiaodong Ma, Lei Wang, Zhi Cao et al. (2017) Physiological and Pathological Functions of Mammalian MicroRNAs in book entitled “Comprehensive Toxicology 3nd”.