姓名：常好才
学历：博士研究生
职称：特聘副研究员
职务：青年英才博士后
研究方向：肿瘤发病机制及免疫治疗研究
联系电话：-8200
电子邮箱：changhc@scnu.edu.cn
通讯地址：广州天河区中山大道西55号华南师范大学生物光子学研究院（510631）
个人主页：

个人简历
发表论文
出版著作
科研项目
主要获奖
会议论文
个人空间


个人简历
主要研究领域包肿瘤与免疫细胞信号网络调控，肿瘤耐药机制及肿瘤的免疫治疗。
科研经历
2019.12-至今 华南师范大学 生物光子学研究院 博士后
2012.09-2019.12 华南师范大学 生物物理学专业 硕博连读
2008.09-2012.06 阜阳师范学院 生命科学学院 本科



发表论文
1. Haocai Chang, Zhengzhi Zou, Qiuhong Wang, Jie Li, Huan Jin, Qianxia Yin, Da Xing*, Targeting and specific activation of antigen-presenting cells by endogenous antigen-loaded nanoparticles elicits tumor-specific immunity. Advanced Science, 2020,7(1): **. (SCI, IF: 15.84)
2. Haocai Chang, Zhengzhi Zou*, Targeting autophagy to overcome drug resistance: further developments. Journal of Hematology & Oncology, 2020,13: 159. (SCI, IF: 11.059)
3. Haocai Chang, Zhenzhen Zhang, Lei Liu*, Low-dose light therapy on host immune response: physiological effects and mechanisms of action. Progress in Biochemistry and Biophysics, 2017,44 (12): 1074-1082. (SCI, IF: 0.463)
4. Zhengzhi Zou*, Haocai Chang, Haolong Li, Songmao Wang, Induction of reactive oxygen species: an emerging approach for cancer therapy. Apoptosis, 2017,22 (11): 1321-1335. (SCI, IF: 4.543)
5. Haolong Li, Lei Liu, Haocai Chang, Zhengzhi Zou, Da Xing*, Downregulation of MCL-1 and upregulation of PUMA using mTOR inhibitors enhance antitumor efficacy of BH3 mimetics in triple-negative breast cancer. Cell Death & Disease, 2018, 9: 137. (SCI, IF: 6.304)
6. Yibing Chen, Yucen Song, Wei Du, Longlong Gong, Haocai Chang, Zhengzhi Zou*, Tumor-associated macrophages: an accomplice in solid tumor progression, Journal of Biomedical Science, 2019, 26: 78. (SCI, IF: 5.762)
7. Songmao Wang, Zhengzhi Zou, Xiaoyong Luo, Yanjun Mi, Haocai Chang, Da Xing*, LRH1 enhances cell resistance to chemotherapy by transcriptionally activating MDC1 expression and attenuating DNA damage in human breast cancer. Oncogene, 2018, 37(24): 3243-3259. (SCI, IF: 7.971)
8. Pinjia Chen, Xiaoyong Luo, Peipei Nie, Baoyan Wu, Wei Xu, Xinpeng Shi, Haocai Chang, Bing Li, Xiurong Yu, Zhengzhi Zou*, CQ synergistically sensitizes human colorectal cancer cells to SN-38/CPT-11 through lysosomal and mitochondrial apoptotic pathway via p53-ROS cross-talk, Free Radical Biology and Medicine, 2017, 104: 280-297. (SCI, IF: 6.17)
9. Xiang Ao, Peipei Nie, Baoyan Wu, Wei Xu, Tao Zhang, Songmao Wang, Haocai Chang, Zhengzhi Zou*, Decreased expression of microRNA-17 and microRNA-20b promotes breast cancer resistance to taxol therapy by upregulation of NCOA3, Cell Death & Disease, 2016, 7: e2463. (SCI, IF: 6.304)




1. 国家自然科学基金-青年科学基金项目（**）：光调控机体获得性免疫应答治疗肿瘤的效应和机制探讨。24万，主持 2021.01-2023.12
2. 国家自然科学基金-面上项目（**）：NR5A2上调MDC1促进DNA损伤修复增强乳腺癌化疗耐药研究。60万，参与 2018.01-2021.12
3. 国家自然科学基金-青年科学基金项目（**）：菌核病发生进程中宿主凋亡蛋白酶的在体检测机器抗病功能分析。 22万，参与 2017.01-2019.12
4. 国家自然科学基金-青年科学基金项目（**）：在靶向Aurora-A治疗乳腺癌中自噬的作用及其诱导机制研究。 23万，参与 2015.01-2017.12
5. 国家自然科学基金-面上项目（**）：基于手性功能化磁粒快速拆分手性药物的研究。参与 2017.01-2020.12