教育背景
工作经历
开设课程
科研项目
学术成果
社会兼职
其他




张涛
研究员（教授)、 博士生导师 生物光子学研究院
研究方向: 光谱分析、分子影像，生物功能探针
-8503 zt@scnu.edu.cn




教育背景
广东省“特支计划”青年拔尖人才，广州市“珠江科技新星”，香港浸会大学博士学位；课题组近年来致力于分子靶点的功能探针技术开发，通过设计构建特定功能探针，结合当前新兴的光、声、磁等光子学影像技术，在活体层面对原位分子靶点进行标记、成像和光学靶向干预。在包括PNAS,J. Am. Chem. Soc., ACS Nano, Nano Research等国内外权威期刊上发表SCI论文30余篇，授权国家发明专利10项，美国专利1项。


工作经历



开设课程



科研项目
主持项目
广东省“特支计划”青年拔尖人才（2018）
国家自然科学基金-面上项目（2018-2021）
广州市“珠江科技新星”（2018）
广东省自然科学基金-面上项目（2019-2022）
广东省科技专项（2017-2019）
国家自然科学基金-青年项目（2016-2018）
广东省自然科学基金-博士启动项目（2015-2017）
广东省教育厅青年创新人才项目（2015-2017）



学术成果
代表性论文：
1. J. Zheng, Q. Zeng, R. Zhang, D. Xing*, T. Zhang*, Dynamic-reversible photoacoustic probe for continuous ratiometric sensing and imaging of redox status in vivo. J. Am. Chem. Soc. 2019, 141, 19226-29230.
2. T. Zhang, R. Lan, C.-F. Chan, G.-L. Law, W.-K. Wong*, K.-L. Wong*, In vivo selective cancer-tracking gadolinium eradicator as new-generation photodynamic therapy agent, PNAS, 2014, 111, E5492-E5497.
3. T. Zhang, X. Zhu, C. C. W. Cheng, W.-M. Kwok, H.-L. Tam, J. Hao, D. W. J. Kwong, W.-K. Wong*, K.-L. Wong*, Water-soluble mitochondria-specific ytterbium complex with impressive NIR emission. J. Am. Chem. Soc., 2011, 133, 20120.
4. L. Du, H. Qin, T. Ma, T. Zhang*, D. Xing*, In vivo imaging-guided photothermal/photoacoustic synergistic therapy with bioorthogonal metabolic glycoengineering-activated tumor targeting nanoparticles. ACS Nano, 2017, 11, 8930−8943.
5. J. Zheng, Y. Wu, D. Xing*, T. Zhang*, Synchronous detection of glutathione/hydrogen peroxide for monitoring redox status in vivo with a ratiometric upconverting nanoprobe. Nano Research, 2019, 12, 931-938.

2020
22. N. Wang, Q. Zeng, R. Zhang, D. Xing*, T. Zhang*, Eradication of solid tumors by chemodynamic theranostics with H2O2-catalyzed hydroxyl radical burst, Theranostics, 2021, 11, 2334-2348.
21. X. Jin^#, Q. Zeng^#, J. Zheng, D. Xing*, T. Zhang*, Aptamer-functionalized upconverting nanoformulations for light-switching cancer-specific recognition and in situ photodynamic–chemo sequential theranostics, ACS Appl. Mater. Interfaces, 2020, 10.1021/acsami.0c14730.
20. J. Zheng, Q. Zhan, L. Jiang, D. Xing, T. Zhang*, K.-L. Wong*, A bioorthogonal time-resolved luminogenic probe for metabolic labelling and imaging of glycans. Inorg. Chem. Front., 2020,7, 4062-4069.
19. X. Li, Y. Zhao, T. Zhang*, D. Xing*, Mitochondria-specific agents for photodynamic cancer therapy: A key determinant to boost the efficacy, Adv. Healthcare Mater. 2020, **.
18. R. Zhang, J. Zheng, T. Zhang*, In vivo selective imaging of metabolic glycosylation with a tetrazine-modified upconversion nanoprobe, RSC Advances, 2020, 10, 15990 – 15996.
17. Y. Wu, J. Zheng, Q. Zeng, T. Zhang*, D. Xing*, Light-responsive charge-reversal nanovector for high-efficiency in vivo CRISPR/Cas9 gene editing with controllable location and time. Nano Research, 2020, 13, 2399–2406.
16. Y. Wu, J. Zheng, D. Xing*, T. Zhang*, Near-infrared light controlled fluorogenic labeling of glycoengineered sialic acids in vivo with upconverting photoclick nanoprobe. Nanoscale, 2020, 10361-10368.
2019
15. J. Zheng, Q. Zeng, R. Zhang, D. Xing*, T. Zhang*, Dynamic-reversible photoacoustic probe for continuous ratiometric sensing and imaging of redox status in vivo. J. Am. Chem. Soc. 2019, 141, 19226-29230.
14. J. Zheng, Y. Wu, D. Xing*, T. Zhang*, Synchronous detection of glutathione/hydrogen peroxide for monitoring redox status in vivo with a ratiometric upconverting nanoprobe. Nano Research, 2019, 12, 931-938.
13. Q. Zeng, R. Zhang, T. Zhang*, D. Xing*, H2O2-responsive biodegradable nanomedicine for cancer-selective dualmodal imaging guided precise photodynamic therapy, Biomaterials, 2019, 207, 39-48.
12. Y. Wu, G. Guo, J. Zheng, D. Xing*, T. Zhang*, Fluorogenic “photoclick” labeling and imaging of DNA with coumarin-fused tetrazole in vivo. ACS Sensors, 2019, 4, 44−51.
2016-2018
11. W. Fang, Y. Wei, Y. Ye, T. Zhang*, D. Xing*, Oxyhemoglobin-monitoring photodynamic theranostics with an 808 nmexcited upconversion optical nanoagent. Chemical Engineering J., 2018, 350, 108-119.
10. T. Ma, J. Zheng, T. Zhang*, D. Xing*, Ratiometric photoacoustic nanoprobes for monitoring and imaging of hydrogen sulfide in vivo. Nanoscale, 2018, 10, 13462-13470.
9. L. Du, H. Qin, T. Ma, T. Zhang*, D. Xing*, In vivo imaging-guided photothermal/photoacoustic synergistic therapy with bioorthogonal metabolic glycoengineering-activated tumor targeting nanoparticles. ACS Nano, 2017, 11, 8930−8943.
8. Q. Ding, Q. Zhan, X. Zhou, T. Zhang*, D. Xing*, Theranostic upconversion nanobeacons for tumor mRNA ratiometric fluorescence detection and imaging-monitored drug delivery. Small, 2016, 12, 5944.（Front Cover）
Before 2015
7. T. Zhang, R. Lan, L. Gong, B. Wu, Y. Wang, D. W. J. Kwong, W.-K. Wong, K.-L. Wong,* D. Xing*, An amphiphilic BODIPY-porphyrin conjugate: intense two-photon absorption and rapid cellular uptake for two-photon-induced imaging and photodynamic therapy, ChemBioChem, 2015, 16, 2357 – 2364. (Back Cover)
6. T. Zhang, R. Lan, C.-F. Chan, G.-L. Law, W.-K. Wong*, K.-L. Wong*, In vivo selective cancer-tracking gadolinium eradicator as new-generation photodynamic therapy agent, PNAS, 2014, 111, E5492-E5497.
5. T. Zhang, C.-F. Chan, R. Lan, W.-K. Wong, K.-L. Wong, Highly selective and responsive visible to near-IR ytterbium emissive probe for monitoring mercury(II), Chem. Eur. J. 2014, 20, 970 – 973
4. T. Zhang, C.-F. Chan, R. Lan, P.-S. Chan, N.-K. Mak, W.-K. Wong*, K.-L. Wong*, Selective differentiation of cancer cells by porphyrin-based ytterbium complexes targeting anionic phospholipid membrane. Chem. Commun., 2013, 49, 7252-7254.
3. T. Zhang, X. Zhu, W.-K. Wong*, H.-L. Tam, W.-Y. Wong*, Light-harvesting ytterbium (III)-porphyrinate-BODIPY conjugates: synthesis, excitation-Energy transfer, and two-photon-induced near-infrared-emission studies. Chem. Eur. J., 2013, 19, 739-748.
2. T. Zhang, C.-F. Chan, J. Hao, G.-L. Law, W.-K. Wong*, K.-L. Wong*, Fast uptake, water-soluble, mitochondria-specific erbium complex for a dual function molecular probe – imaging and photodynamic therapy. RSC Advances, 2013, 3, 382-385.
1. T. Zhang, X. Zhu, C. C. W. Cheng, W.-M. Kwok, H.-L. Tam, J. Hao, D. W. J. Kwong, W.-K. Wong*, K.-L. Wong*, Water-soluble mitochondria-specific ytterbium complex with impressive NIR emission. J. Am. Chem. Soc., 2011, 133, 20120.


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