教育背景
工作经历
开设课程
科研项目
学术成果
社会兼职
其他




Lingtian Xie
PhD./Professor 环境研究院
研究方向: Ecotoxicology
lingtian.xie@m.scnu.edu.cn




教育背景
1997.9-2002.12, 美国路易斯安那大学拉斐特分校,进化与分子生物学，博士
1986.9-1990.7, 武汉大学,细胞生物学，学士



工作经历
2017.9-至今, 华南师范大学环境研究院，教授
2012.2-2017.8, 中国科学院沈阳应用生态研究所, 研究员



开设课程
暂无。



科研项目
9. 国家重点研发计划-场地土壤环境损害鉴定评估方法和标准-子课题，2018YFC**，2018.12-2022.11，在研。
8. 国家自然科学基金面上项目，**，食物相镉、硒在日本青鳉鱼脑中的累积规律及神经效应研究，2019.1-2022.12，62万，在研，主持。
7.华南师范大学海外引进领军人才，科研启动基金，环境毒理学，2018.5-2026.12，在研，主持。
6. 国家自然科学基金青年基金项目，**，三氯生及其降解产物对鱼类的长期毒理机制和生物累积效应，2015.01-2017.12，25万，已结题，参加。
5. 国家自然科学基金青年基金项目，**，沉积物中砷在底栖动物肠道中的生物地球化学过程及生物有效性研究，2014.01-2016.12，26万，已结题，参加。
4. 国家自然科学基金面上项目，**，不同摄入途径下日本鳉鱼对Cd、Zn的分子毒性响应差异及内在机理，2013.01-2016.12，85万，已结题，主持。
3. 中科院****项目，Y3YBR111Y3，金属在水生食物链中的传递及毒性，2012.01-2016.12，270万，已结题，主持。
2. 美国国家环保局项目：痕量金属和渗透压调节因子影响下的水生昆虫生理生态学研究，2009-2012，5万美元，已结题，课题骨干。
1. 美国自然科学基金：系统发生学探讨水生昆虫离子通路和氧化应激生理差异及机制，2009-2012，46.5万美元，已结题，课题骨干。



学术成果
[1] Shi, W.-J., D.-D. Ma, Y.-X. Jiang, L. Xie, J.-N. Zhang, G.-Y. Huang, H.-X. Chen, L.-P. Hou, Y.-S. Liu, and G.-G. Ying, *, Medroxyprogesterone acetate affects sex differentiation and spermatogenesis in zebrafish. Aquat. Toxicol., 2019. 212: p. 70-76.
[2] Shi, W.-J., L.-X. Hu, G.-Y. Huang, Y.-S. Liu, J.-N. Zhang, L. Xie, and G.-G. Ying, *, Dydrogesterone affects the transcription of genes in GnRH and steroidogenesis pathways and increases the frequency of atretic follicles in zebrafish (Danio rerio). Chemosphere, 2019. 216: p. 725-732.
[3] Li, D., L. Xie, M.J. Carvan, and L. Guo, *, Mitigative effects of natural and model dissolved organic matter with different functionalities on the toxicity of methylmercury in embryonic zebrafish. Environ. Pollut., 2019. 252: p. 616-626.
[4] Huang, G.-Y., Y.-S. Liu, Y.-q. Liang, W.-J. Shi, Y.-Y. Yang, S.-S. Liu, L.-X. Hu, H.-X. Chen, L. Xie, and G.-G. Ying, *, Endocrine disrupting effects in western mosquitofish Gambusia affinis in two rivers impacted by untreated rural domestic wastewaters. Sci. Total Environ., 2019. 683: p. 61-70.
[5] Huang, G.-Y., Y.-Q. Liang, Y.-S. Liu, W.-J. Shi, S.-S. Liu, L.-X. Hu, L. Xie, and G.-G. Ying, *, Swine farm wastewater discharge causes masculinization of western mosquitofish (Gambusia affinis). Environ. Int., 2019. 123: p. 132-140.
[6] Hou, L., S. Chen, H. Chen, G. Ying, D. Chen, *, J. Liu, Y. Liang, R. Wu, X. Fang, C. Zhang, and L. Xie, *, Rapid masculinization and effects on the liver of female western mosquitofish (Gambusia affinis) by norethindrone. Chemosphere, 2019. 216: p. 94-102.
[7] Dong, W., F. Wang, M. Fang, J. Wu, S. Wang, M. Li, J. Yang, M. Chernick, D.E. Hinton, D.-S. Pei, H. Chen, N. Zheng, J. Mu, *, L. Xie, *, and W. Dong, *, Use of biological detection methods to assess dioxin-like compounds in sediments of Bohai Bay, China. Ecotoxicol. Environ. Saf., 2019. 173: p. 339-346.
[8] Cao, J., *, G. Wang, T. Wang, J. Chen, G. Wenjing, P. Wu, X. He, and L. Xie, *, Copper caused reproductive endocrine disruption in zebrafish (Danio rerio). Aquat. Toxicol., 2019. 211: p. 124-136.
[9] 闫亮, 穆磊, 陈红星, 郭忠宝, 罗永巨, and 谢凌天*, 氟西汀与三氯生复合暴露对麦穗鱼的毒性效应. 应用生态学报, 2018. 29(9): p. 3058-3066.
[10] 谢凌天*, 应光国, 陈红星, 罗艺璇, 黄国勇, 史文俊, 罗永巨, and 董武, 硒对水生生物双重生物效应研究进展. 华南师范大学学报 (自然科学版), 2018. 50(5): p. 52-59.
[11] Wang, F., M. Fang, D.E. Hinton, M. Chernick, S. Jia, Y. Zhang, L. Xie, W. Dong, and W. Dong, *, Increased coiling frequency linked to apoptosis in the brain and altered thyroid signaling in zebrafish embryos (Danio rerio) exposed to the PBDE metabolite 6-OH-BDE-47. Chemosphere, 2018. 198: p. 342-350.
[12] Hou, L.-p., H. Chen, C.-e. Tian, *, W.-J. Shi, Y. Liang, R.-r. Zhang, X.-w. Fang, C.-p. Zhang, Y.-q. Liang, and L. Xie, *, The progestin norethindrone affects sex differentiation and alters transcriptional profiles of genes along the hypothalamic–pituitary–gonadal and hypothalamic–pituitary–adrenal axes in juvenile zebrafish Dario renio. Aquat. Toxicol., 2018. 201: p. 31-39.
[13] Ma, S., #, Y. Zhou, #, H. Chen, L. Hou, J. Zhao, J. Cao, S. Geng, Y. Luo, *, D. Schlenk, and L. Xie, *, Selenium accumulation and the effects on the liver of topmouth gudgeon Pseudorasbora parva exposed to dissolved inorganic selenium. Ecotoxicol. Environ. Saf., 2018. 160: p. 240-248.
[14] Ma, S., #, X. Zeng, #, H. Chen, S. Geng, L. Yan, Y. Luo, L. Xie, and Q. Zhang, *, The differences in bioaccumulation and effects between Se(IV) and Se(VI) in the topmouth gudgeon Pseudorasbora parva. Scientific reports, 2018. 8(1): p. 13860.
[15] Li, D., H. Chen, R. Bi, H. Xie, Y. Zhou, Y. Luo, *, and L. Xie, *, Individual and binary mixture effects of bisphenol A and lignin-derived bisphenol in Daphnia magna under chronic exposure. Chemosphere, 2018. 191: p. 779-786.
[16] Hou, L.-p., H. Chen, C.-e. Tian, *, Y. Liang, R.-r. Wu, X.-m. Zhang, X.-w. Fang, C.-p. Zhang, J.-j. Hu, L.-y. Song, Y.-q. Liang, D. Schlenk, and L. Xie, *, Alterations of secondary sex characteristics, reproductive histology and behaviors by norgestrel in the western mosquitofish (Gambusia affinis). Aquat. Toxicol., 2018. 198: p. 224-230.
[17] Chen, H., #, X. Zeng, #, L. Mu, L. Hou, B. Yang, J. Zhao, D. Schlenk, W. Dong, L. Xie, and Q. Zhang, *, Effects of acute and chronic exposures of fluoxetine on the Chinese fish, topmouth gudgeon Pseudorasbora parva. Ecotoxicol. Environ. Saf., 2018. 160: p. 104-113.
[18] Chen, H., Z. Guo, Y. Zhou, D. Li, L. Mu, P.L. Klerks, Y. Luo, *, and L. Xie, *, Accumulation, depuration dynamics and effects of dissolved hexavalent chromium in juvenile Japanese medaka (Oryzias latipes). Ecotoxicol. Environ. Saf., 2018. 148: p. 254-260.
[19] Bi, R., *, X. Zeng, *, L. Mu, L. Hou, W. Liu, P. Li, H. Chen, D. Li, A. Bouchez, J. Tang, and L. Xie, Sensitivities of seven algal species to triclosan, fluoxetine and their mixtures. Scientific reports, 2018. 8(1): p. 15361.
[20] 穆磊, 吴星, 陈红星, 谢凌天*, and 罗永巨*, 硒预暴露对夹杂带丝蚓铜累积及毒性的影响. 生态学杂志, 2017. 36(8): p. 2282-2288.
[21] Wu, X., S. Wang, H. Chen, Z. Jiang, H. Chen, M. Gao, R. Bi, P.L. Klerks, H. Wang, Y. Luo, *, and L. Xie, *, Assessment of metal contamination in the Hun River, China, and evaluation of the fish Zacco platypus and the snail Radix swinhoei as potential biomonitors. Environ. Sci. Pollut. Res., 2017. 24(7): p. 6512-6522.
[22] Li, D., R. Bi, H. Chen, L. Mu, L. Zhang, Q. Chen, H. Xie, Y. Luo, *, and L. Xie, *, The acute toxicity of bisphenol A and lignin-derived bisphenol in algae, daphnids, and Japanese medaka. Environ. Sci. Pollut. Res., 2017. 24(30): p. 23872-23879.
[23] 李莉霞, 李丹, 高蜜, 穆磊, 陈红星, and 谢凌天*, 大型蚤对五价砷抗性选择的响应. 生态毒理学报, 2016. 11(3): p. 237-242.
[24] 高蜜, 吴星, 陈红星, and 谢凌天*, 葫芦岛海产品重金属含量及健康风险分析. 生态学杂志, 2016. 35(1): p. 205-211.
[25] Xie, L., *, X. Wu, H. Chen, Y. Luo, *, Z. Guo, J. Mu, E.R. Blankson, W. Dong, and P.L. Klerks, The bioaccumulation and effects of selenium in the oligochaete Lumbriculus variegatus via dissolved and dietary exposure routes. Aquat. Toxicol., 2016. 178: p. 1-7.
[26] Xie, L., *, X. Wu, H. Chen, W. Dong, *, A.M. Cazan, and P.L. Klerks, A low level of dietary selenium has both beneficial and toxic effects and is protective against Cd-toxicity in the least killifish Heterandria formosa. Chemosphere, 2016. 161: p. 358-364.
[27] Li, D., Q. Chen, J. Cao, H. Chen, L. Li, N. Cedergreen, H. Xie, and L. Xie, *, The chronic effects of lignin-derived bisphenol and bisphenol A in Japanese medaka Oryzias latipes. Aquat. Toxicol., 2016. 170: p. 199-207.
[28] Gao, M., P.L. Klerks, X. Wu, H. Chen, and L. Xie, *, Metal concentrations in sediment and biota of the Huludao Coast in Liaodong Bay and associated human and ecological health risks. Arch. Environ. Contam. Toxicol., 2016. 71(1): p. 87-96.
[29] Chen, H., L. Mu, J. Cao, J. Mu, P.L. Klerks, Y. Luo, *, Z. Guo, and L. Xie, *, Accumulation and effects of Cr(VI) in Japanese medaka (Oryzias latipes) during chronic dissolved and dietary exposures. Aquat. Toxicol., 2016. 176: p. 208-216.
[30] Chen, H., J. Cao, L. Li, X. Wu, R. Bi, P.L. Klerks, and L. Xie, *, Maternal transfer and reproductive effects of Cr(VI) in Japanese medaka (Oryzias latipes) under acute and chronic exposures. Aquat. Toxicol., 2016. 171: p. 59-68.
[31] 陈红星, 吴星, 毕然, 李莉霞, 高蜜, 李丹, and 谢凌天*, 水环境中Cr(VI)对鱼类毒性机理研究进展. 应用生态学报, 2015. 26(10): p. 3226-3234.
[32] Li, L., H. Chen, R. Bi, and L. Xie, *, Bioaccumulation, subcellular distribution, and acute effects of chromium in Japanese medaka (Oryzias latipes). Environ. Toxicol. Chem., 2015. 34(11): p. 2611-2617.
[33] Chen, J., J. Cao, *, J. Wang, R. Jia, W. Xue, and L. Xie, *, Fluoride-induced apoptosis and expressions of caspase proteins in the kidney of carp (Cyprinus carpio). Environ. Toxicol., 2015. 30(7): p. 769-781.
[34] Cao, J., #*, J. Chen, #, L. Xie, J. Wang, *, C. Feng, and J. Song, Protective properties of sesamin against fluoride-induced oxidative stress and apoptosis in kidney of carp (Cyprinus carpio) via JNK signaling pathway. Aquat. Toxicol., 2015. 167: p. 180-190.
[35] Wu, X., M. Gao, L. Wang, Y. Luo, R. Bi, L. Li, and L. Xie, *, The arsenic content in marketed seafood and associated health risks for the residents of Shandong, China. Ecotoxicol. Environ. Saf., 2014. 102: p. 168-173.
[36] Keller, R.H., *, L. Xie, D.B. Buchwalter, K.E. Franzreb, and T.R. Simons, Mercury bioaccumulation in Southern Appalachian birds, assessed through feather concentrations. Ecotoxicology, 2014. 23(2): p. 304-316.
[37] Conley, J.M., A.T. Watson, L. Xie, and D.B. Buchwalter, *, Dynamic selenium assimilation, distribution, efflux, and maternal transfer in Japanese medaka fed a diet of Se-enriched mayflies. Environ. Sci. Technol., 2014. 48(5): p. 2971-2978.
[38] Chen, J., #, J. Cao, #, Y. Luo, #, L. Xie, *, J. Song, W. Xue, R. Jia, and J. Song, Expression of ERK and p-ERK proteins of ERK signaling pathway in the kidneys of fluoride-exposed carp (Cyprinus carpio). Acta histochemica, 2014. 116(8): p. 1337-1341.
[39] Cao, J., *, J. Chen, J. Wang, *, P. Klerks, and L. Xie, *, Effects of sodium fluoride on MAPKs signaling pathway in the gills of a freshwater teleost, Cyprinus carpio. Aquat. Toxicol., 2014. 152: p. 164-172.
[40] Wu, X., L. Xie, L. Xu, S. Wang, and Y. Jia, *, Effects of sediment composition on cadmium bioaccumulation in the clam Meretrix meretrix Linnaeus. Environ. Toxicol. Chem., 2013. 32(4): p. 841-847.
[41] Cao, J., J. Chen, J. Wang, *, X. Wu, Y. Li, and L. Xie, *, Tissue distributions of fluoride and its toxicity in the gills of a freshwater teleost, Cyprinus carpio. Aquat. Toxicol., 2013. 130: p. 68-76.
[42] Xie, L. and D.B. Buchwalter, *, Cadmium exposure route affects antioxidant responses in the mayfly Centroptilum triangulifer. Aquat. Toxicol., 2011. 105(3): p. 199-205.
[43] Klerks, P.L., *, L. Xie, and J.S. Levinton, Quantitative genetics approaches to study evolutionary processes in ecotoxicology; a perspective from research on the evolution of resistance. Ecotoxicology, 2011. 20(3): p. 513-523.
[44] Xie, L., D.H. Funk, and D.B. Buchwalter, *, Trophic transfer of Cd from natural periphyton to the grazing mayfly Centroptilum triangulifer in a life cycle test. Environ. Pollut., 2010. 158(1): p. 272-277.
[45] Buchwalter, D.B., *, L. Xie, and Y. Arai, Final Report: Assessing Mercury Contamination and Bioavailability in Great Smoky Mountains National Park Aquatic Habitats. 2009.
[46] Xie, L., D. Lambert, C. Martin, D.J. Cain, S.N. Luoma, and D. Buchwalter, *, Cadmium biodynamics in the oligochaete Lumbriculus variegatus and its implications for trophic transfer. Aquat. Toxicol., 2008. 86(2): p. 265-271.
[47] Xie, L., J.L. Flippin, N. Deighton, D.H. Funk, D.A. Dickey, and D.B. Buchwalter, *, Mercury (II) bioaccumulation and antioxidant physiology in four aquatic insects. Environ. Sci. Technol., 2008. 43(3): p. 934-940.
[48] Buchwalter, D.B., *, D.J. Cain, C.A. Martin, L. Xie, S.N. Luoma, and T. Garland, Aquatic insect ecophysiological traits reveal phylogenetically based differences in dissolved cadmium susceptibility. Proceedings of the National Academy of Sciences, 2008. 105(24): p. 8321-8326.
[49] Xie, L., K. Thrippleton, M.A. Irwin, G.S. Siemering, A. Mekebri, D. Crane, K. Berry, and D. Schlenk, *, Evaluation of estrogenic activities of aquatic herbicides and surfactants using an rainbow trout vitellogenin assay. Toxicol. Sci., 2005. 87(2): p. 391-398.
[50] Schlenk, D., *, Y. Sapozhnikova, M.A. Irwin, L. Xie, W. Hwang, S. Reddy, B.J. Brownawell, J. Armstrong, M. Kelly, and D.E. Montagne, In vivo bioassay-guided fractionation of marine sediment extracts from the Southern California Bight, USA, for estrogenic activity. Environ. Toxicol. Chem., 2005. 24(11): p. 2820-2826.
[51] Xie, L., *, Y. Sapozhnikova, O. Bawardi, and D. Schlenk, Evaluation of wetland and tertiary wastewater treatments for estrogenicity using in vivo and in vitro assays. Arch. Environ. Contam. Toxicol., 2004. 48(1): p. 81-86.
[52] Xie, L. and P.L. Klerks, *, Changes in cadmium accumulation as a mechanism for cadmium resistance in the least killifish Heterandria formosa. Aquat. Toxicol., 2004. 66(1): p. 73-81.
[53] Xie, L. and P.L. Klerks, *, Metallothionein-like protein in the least killifish Heterandria formosa and its role in cadmium resistance. Environ. Toxicol. Chem., 2004. 23(1): p. 173-177.
[54] Xie, L. and P.L. Klerks, *, Fitness cost of resistance to cadmium in the least killifish (Heterandria formosa). Environ. Toxicol. Chem., 2004. 23(6): p. 1499-1503.
[55] Xie, L., * and P.L. Klerks, Responses to selection for cadmium resistance in the least killifish, Heterandria formosa. Environ. Toxicol. Chem., 2003. 22(2): p. 313-320.


社会兼职
国际期刊Ecotoxicology副主编。
国际期刊Chemosphere， Environmental Toxicology and Chemistry等编委。
应用生态学报和生态学杂志编委。
国际环境毒理与化学学会（SETAC）、中国毒理学会会员。



其他
欢迎生态、环境、生物、化学、动物、植物等相关专业背景学生报考硕士/博士研究生，共同探讨生物化学的分子奥秘！
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