杨莉
博士,教授,博导
联系方式:
电子邮件:lyang1213@yahoo.com

个人简介



个人简历：1985年新疆师范大学学士；1991年华东师范大学硕士；1995年华东师范大学理学博士；1996-1998华东师范大学生物系副教授；1998年4月-10月日本关西医科大学访问学者；1998-2004美国南伊利诺大学医学院药理学系博士后（Postdoc.）；2004-2010年美国贝勒医学院老年学研究中心助理研究员（ResearchAssociate）。
研究方向及兴趣：用电生理、生物化学和分子生物学手段研究1).突触传递及其细胞和分子调控；2).beta淀粉样蛋白（Aβ）之前体蛋白（amyloidprecursorprotein,APP）的神经生物学功能；3).神经退变性疾病（尤其是老年痴呆症）影响突触功能的机理。
其他：2011年获国家自然科学基金委资助；NeuroscienceLetter审稿人
代表性论文:

1. WangZ,YangL*,ZhengH*.2012.APP,A-betaandsynapticphysiology.CurrentAlzheimerResearch.9:217-226(*通讯作者).
2. ShimDJ,YangL,ReedJG,NoebelsJL,ChiaoPJ,ZhengH.2011.DisruptionoftheNF-kB/IkBαautoinhibitoryloopimprovescognitiveperformanceandpromoteshyperexcitabilityofhippocampalneurons.MolNeurodegener.6:42-53.
3. PeethumnongsinE,YangL,Kallhoff-MunozV,HuL,TakashimaA,PautlerRG,ZhengH.2010.Convergenceofpresenilin-andtau-mediatedpathwaysonaxonaltraffickingandneuronalfunction.JNeurosci30:13409-13418.
4. YangL*τ,WangZ,WangB,JusticN,ZhengH*.2009.AmyloidprecursorproteinregulatesCav1.2L-typecalciumchannellevelsandfunctiontoinfluenceGABAergicshort-termplasticity.JNeurosci.29:15660-15668(*通讯作者，τ同等贡献作者).此文被Facultyof1000Biology收录并做评论。Alzheimer’sResearchForum就此文发表新闻。
5. SheltonCC,ZhuL,ChauD,YangL,WangR,DjaballahH,ZhengH,LiYM.2009.Modulationof{gamma}-secretasespecificityusingsmallmoleculeallostericinhibitors.ProcNatlAcadSci(PNAS).106:20228-20233.
6. WangZ,WangB,YangL,GuoQ,AithmittiN,SongyangZ,ZhengH.2009.Presynapticandpostsynapticinteractionoftheamyloidprecursorproteinpromotesperipheralandcentralsynaptogenesis.JNeurosci.29:10788-10801.
7. WangB,YangL,WangZ,ZhengH.2007.Amyolidprecursorproteinmediatespresynapticlocalizationandactivityofthehigh-affinitycholinetransporter.ProcNatlAcadSci(PNAS)104:14140-14145.
8. YangL,WangB,LongC,WuG,ZhengH.2007.Increasedasynchronousreleaseandaberrantcalciumchannelactivationinamyloidprecursorproteindeficientneuromuscularsynapses.Neuroscience.149:768-778.
9. FengHJ,YangL,FaingoldCL.2007.Roleoftheamygdalainethanolwithdrawalseizures.BrainRes.1141:65-73.
10. LongC,YangL,EvansMS,FaingoldCL.2007.Increasedexcitatoryactivitiesinperiaqueductalgrayneuronsofratsundergoingethanolwithdrawal.Neuropharmacol.52:802-811.
11. YangL,LongC,RandallM,FaingoldCL.2003.Neuronsintheperiaqueductalgrayiscriticallyinvolvedintheneuronalnetworkforaudiogenicseizuresduringethanolwithdrawal.Neuropharmacol.44:275-281.
12. YangL,LongC,EvansMS,FaingoldCL.2002.Ethanolwithdrawalresultsinaberrantmembranepropertiesandsynapticresponsesinperiaqueductalgrayneuronsassociatedwithseizuresusceptibility.BrainRes.957:99-108.
13. YangL,LongC,FaingoldCL.2001.Thedeeplayersofsuperiorcolliculusneuronsarerequisitecomponentoftheneuronsnetworkforseizuresduringethanolwithdrawal.BrainRes.920:134-141.
14. YangL,LongC,FaingoldCL.2001.AudiogenicseizuresusceptibilityisinducedbyterminationofcontinuousinfusionofGABAoranNMDAantagonistintotheinferiorcolliculus.Exp.Neurol.171:147-152.