温佳琳 生物医药研究院 研究助理教授 wenjl@sustc.edu.cn



教育经历
2011-2016，罗格斯新泽西州立大学，博士
2007-2011，南京大学，理学学士


工作经历
2017-，南方科技大学，前沿与交叉科学研究院，研究助理教授；
2016-2017，南方科技大学，博士后


交叉研究领域
利用氢键和库仑力等非共价作用，将催化剂分子和底物结合在一起，降低催化口袋局部Gibbs自由能，从而达到促进反应的作用。应用这一策略，有挑战性的氢化底物可以实现温和条件下的催化加氢。这一反应模式可以用于手性小分子的高效构建，也可以应用于二氧化碳的还原，实现氢能的存储。


代表文章
1.Jialin Wen, ... Lung Wa Chung, Xumu Zhang. Br?nsted acid promoted Rh-catalyzed asymmetric hydrogenation of N-unprotected indoles: a co-catalysis of transition metal and anion binding. Org. Lett. ASAP.2. Guoxian Gu, ..., Jialin Wen,* Li Dang* and Xumu Zhang*. Iridium/f-ampha-catalyzed asymmetric hydrogenation of aromatic α-keto esters. Org. Chem. Front. DOI: 10.1039/c8qo00047f.
2. Guoxian Gu,... Jialin Wen, Li Dang, and Xumu Zhang. Enantioselective Iridium-Catalyzed Hydrogenation of α?Keto Amides to α?Hydroxy Amides. Org. Lett. 2017, 19, 5920.
3. Jean-Nicolas Desrosiers*, Jialin Wen, Sergei Tcyrulnikov, … Xumu Zhang, Marisa C. Kozlowski,* Chris H. Senanayake. Enantioselective Nickel-Catalyzed Heck Cyclization to Generate Quaternary Stereocenters. Org. Lett. 2017, 19, 3338-3341.
4. Jialin Wen, Jun Jiang, Xumu Zhang*. Rhodium-Catalyzed Asymmetric hydrogenation of α, β-unsaturated carbonyl compounds via thiourea hydrogen bonding. Org. Lett. 2016, 18, 4451–4453.
5. Jialin Wen, Renchang Tan, Shaodong Liu, Qingyang Zhao, Xumu Zhang*. Strong Br?nsted acid promoted asymmetric hydrogenation of isoquinolines and quinolines catalyzed by a Rh-thiourea chiral phosphine complex via ainon binding. Chem. Sci. 2016, 7, 3047-3051.
6. Lin Yao, Jialin Wen, Shaodong Liu, Renchang Tan, Neol M. Wood, Weiping Chen, Shengyong Zhang, Xumu Zhang*. Highly enantioselective hydrogenation of α–oxy functionalized α, β-unsaturated acids catalyzed by a ChenPhos–Rh complex in CF₃CH₂OH. Chem. Comm. 2016, 52, 2273-2276.
7. Qingyang Zhao, Jialin Wen, Renchang Tan, Kexuan Huang, Pedro Metola, Rui Wang, Eric V. Anslyn*, Xumu Zhang*, Rhodium-catalyzed asymmetric hydrogenation of unprotected NH imines assisted by a thiourea. Angew. Chem. Int. Ed. 2014, 53, 8467.
联系方式
wenjl@sustech.edu.cn