肖国芝医学院副院长、教授、校实验动物中心主任、博士生导师


xiaogz@sustech.edu.cn
第一科研楼341
进入个人主页返回到师资列表
个人简介肖国芝教授是国际著名骨生物学家,现任南方科技大学医学院教授、副院长（科研和研究生管理），兼任校实验动物中心主任。ASBMR（美国骨与矿物研究协会）会士。主要研究骨骼发育和骨骼疾病 （骨质疏松、骨关节炎及癌症骨转移）的相关分子基础。北京大学医学部博士；美国密歇根大学（University of Michigan Ann Arbor）博士后，讲师，研究助理教授；美国匹茨堡大学医学院(University of Pittsburgh School of Medicine)助理教授、副教授 （Tenured Associate Professor)；美国拉什大学医学中心(Rush University Medical Center)生物化学系和骨科系正教授(Tenured Full Professor)、冠名讲席教授(Ralph and Marian C. Falk Endowed Chair Professor of Rush University)、生物化学系的研究主任；历任南方科技大学生物系系主任、致诚书院院长。曾主持多个美国国立卫生研究院(NIH)R01基金、曾主持美国国防部研究基金；目前主持国自然重点课题、国自然重大课题及科技部重大专项课题。相关的研究成果在J Clin Invest及Nat Commun等SCI杂志上发表全长SCI研究论文103篇，综述、书章节等20篇，引用约10000次，总影响因子大于715；实验室研究成果十多次在著名国际骨科研究大会上获奖；应邀国际大会及著名大学报告140次， 国际会议摘要85篇，主办或参与组织国际大会20次，主持国际大会重要专场近30次。担任J Bone Miner Res及J Biol Chem等国际学术刊物的编委、担任49个国际杂志的审稿人。担任中国、美国和意大利研究基金评审专家。深圳市高层次引进人才（A类），北京大学医学部（原北京医科大学）100周年校庆，优秀校友。

研究领域（1）研究骨与关节发育及稳态维持的分子机制；
（2）研究骨质疏松症及骨性关节炎发生发展的分子基础；
（3）研究骨机械应力信号传导机制；
（4）研究骨-骨外组织的相互作用。



教育背景1979-1984：南昌大学医学院医疗系，医疗专业，医学学士学位。
1985-1988：北京大学医学部生物化学和分子生物学系，硕士学位。
1991-1994：北京大学医学部生物化学和分子生物学系，博士学位。



工作经历2020- 南方科技大学医学院科研和研究生管理副院长、教授
2019-2020 南方科技大学致诚书院院长
2017- 南方科技大学实验动物中心主任
2015-2018 南方科技大学生物系系主任
2013-2019 南方科技大学生物系教授
2012-2017 美国拉什大学医学中心副教授，正教授、讲席教授、生物化学系科研主任
2005-2011 美国匹兹堡大学医学院，助理教授、终身副教授
1994-2005 美国密歇根大学医学院/牙学院，博士后、讲师、研究助理教授
1988-1991 北京大学医学部， 讲师
1984-1985 江西萍乡妇幼保健院，医生



获奖情况及荣誉2012 北京大学医学部（原北京医科大学） 100周年校庆，优秀校友荣誉称号
2015 深圳市鹏城****
2016 深圳市生命科学与生物技术协会副会长
2017 深圳市海外高层次人才（孔雀A类）
2019国际骨科研究联合学会，会士
2019 美国骨与矿物质研究学会，会士
2020南方科技大学年度教授奖



杂志编委会成员2020- 生物骨科材料与临床研究杂志，副主编
2009- 2015 Journal of Bone and Mineral Research (JBMR)
2010 中国生物化学与分子生物学杂志
2011- Stem Cell Discovery
2013- Journal of Biological Chemistry (JBC)
2015- Chinese Journal of Family Planning (中国计划生育学杂志)
2016-2017 Gene Reports (Associate Editor)
2018- Journal of Orthopaedic Translation (JOT)



近年代表文章From total 125 publications
Walke W,Xiao G, and Goldman D. Identification and characterization of a 47 base pair activity-dependent enhancer of the rat nicotinic acetylcholine receptor d-subunit promoter.J Neurosci. 1996; 16(11): 3641-3651.
Xiao G, Cui Y, Ducy P, Karsenty G, and Franceschi RT. Ascorbic acid-dependent activation of the osteocalcin promoter in MC3T3-E1 preosteoblasts: requirement for collagen matrix synthesis and the presence of an intact OSE2 sequence.Mol Endocrinol.1997; 11:1103-1113.
Xiao G, Wang D, Benson MD, Karsenty G, and Franceschi RT. Role of the a2integrin in osteoblast-specific gene expression and activation of the Osf2 transcription factor.J Biol Chem. 1998; 273, 32988-32994.
Frendo JL,Xiao G, Fuches S, Franceschi RT, Karsentry G, and Ducy P. Functional hierarchy between two OSE2 elements in the control of osteocalcin expression in vivo.J Biol Chem.1998; 273, 30509-30516.
Wang D, Christensen, K, Chawla, K,Xiao G, Krebsbach P. and Franceschi, RT. Isolation and characterization of MC3T3-E1 murine preosteoblast subclones with distinct in vitro and in vivo differentiation/mineralization potential.J Bone Miner Res, 1999; 14:893-903.
Benson MD, Aubin JE,Xiao G, Thomas PE, and Franceschi RT. Cloning of a 2.5 kb murine bone sialoprotein promoter fragment and functional analysis of putative Cbf/runt binding sites.J Bone Miner Res. 1999; 14:396-405.
Xiao G, Jiang D, Thomas PE, Benson MD, Guan KL, Karsenty G, and Franceschi RT. MAPK pathways activate and phosphorylate the osteoblast-specific transcription factor, Osf2/Cbfa1.J Biol Chem. 2000; 275, 4453-4459.
Benson MD, Bargeon JL,Xiao G, Thomas PE, Ahn Kim, Yingqi Cui, and Franceschi RT. Identification of a homeodomain binding element in the bone sialoprotein gene promoter which is required for its osteoblast-selective expression.J Biol Chem.2000; 275: 13907-13917.
Xiao G, Jiang D, Gopalakrishnan R, and Franceschi RT. FGF-2 induction of the osteocalcin gene requires MAPK activity and phosphorylation of the osteoblast transcription factor, Cbfa1/Runx2.J Biol Chem.2002; 277:36181-36187.
Zhao M,Xiao G, Berry J, Franceschi RT, Reddi A, and Somerman MJ. Bone Morphogenetic Protein 2 induces dental follicle cells to differentiate toward a cementoblast/osteoblast phenotype.J Bone Miner Res. 2002; 17:1441-1451.
Xiao G, Gopalakrishnan R, Jiang D, Reith E, Benson MD, and Franceschi RT. BMP, extracellular matrix, and MAP kinase signaling pathways are required for osteoblast-specific gene expression and differentiation in MC3T3-E1 cells.J Bone Miner Res.2002; 17:101-110.
Jiang D, Franceschi RT, Boules H, andXiao G*. Parathyroid Hormone Induction of the Osteocalcin Gene: requirement for an osteoblast-specific element 1 sequence in the promoter and involvement of multiple signaling pathways.J Biol Chem.2004; 279:5329-5337.
Chen C, Koh AJ, Datta NS, Zhang J, Even ET,Xiao G,Franceschi RT, D'Silva NJ, and McCauley LK. Impact of mitogen-activated protein kinase (MAPK) pathway on parathyroid hormone related protein actions in osteoblasts. J Biol Chem.2004; 279, 29121-29129.
Xiao G*, Jiang D, Ge C, Zhao Z, Yumei Lai, Boules H, Phimphilai M, Yang X, Karsenty G, and Boules H, and Franceschi RT. Cooperative interactions between activating transcription factor 4 and Runx2/Cbfa1 stimulate osteoblast-specific osteocalcin gene expression.J Biol Chem,2005; 280:30689-30696.
Roca H, Phimphilai M, Gopalakrishnan R,Xiao G, and Franceschi RT. Cooprative interactions between RUNX2 and homeodomain protein binding sites are critical for the osteoblast-specific expression of the bone sialoprotein gene. J Biol Chem,2005; 280:30845-30855.
Zhao Z, Zhao M,Xiao G, and Franceschi RT. Gene transfer of the Runx2 transcription factor enhances osteogenic activity of bone marrow stromal cellsin vitroandin vivo.Mol Ther. 2005; 12(2):247-53.
Lu Y, Cai Z,Xiao G, Yao Z, Anderson JL, Roodman DG, and Zhang J. Prostate cancer cells induce osteoclastogenesis and bone resorption through RANKL-independent interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) production.Cancer Res.2007; 67(8): 3646-53.
Lu Y,Xiao G, Galson DL, Nishio Y, Mizokami A, Keller E, Yao Z, and Zhang J. PTHrP-induced production of monocyte chemoattractant protein-1 (MCP-1) by human bone marrow endothelial cells and osteoblasts promotes osteoclast differentiation in vitro: a novel role in prostate cancer bone metastasis.Int J Cancer.2007; 121(4): 724-733.
Zhu J, Jia X,Xiao G, Kang Y, Partridge, NC, Qin L. EGF-like ligands stimulate osteoclastogenesis by regulating expression of osteoclast regulatory factors in osteoblasts: implications in osteolytic bone metastases.J Biol Chem.2007; 282(37): 26656-64.
Singha UK, Jiang Y. Yu S, Luo M, Lu Y, Zhang J,Xiao G. Rapamycin inhibits osteoblast proliferation and differentiation in MC3T3-E1 cells and primary mouse bone marrow stromal cells.J Cell Biochem. 2007; 103(2): 434-46.
Ge C,Xiao G, Jiang D, and Franceschi RT. Critical role of extracellular signal-regulated kinase/MAPK pathway in osteoblast differentiation and skeletal development.J Cell Biol.2007; 176(5): 709-818. PMCID: PMC**.
Zhang X, Yu S, Galson, DL, Luo M, Fan J, Zhang J, Guan Y,Xiao G. Activating ?transcription factor 4 is critical for proliferation and survival in primary bone marrow stromal cells and calvarial osteoblasts.J Cell Biochem. 2008; 105(3): 885-95. PMCID: PMC**.
Yu S, Franceschi RT, Luo M, Fan J, Jiang D, Cao H, Lai Y, Zhang J, Patrene K, Hankenson KD, Roodman GD,Xiao G. Critical role of activating transcription factor 4 in the anabolic actions of PTH in bone.PLoS One. 2009, Oct 23;4(10):e7583. PMCID: PMC**. (This paper was listed as the "Not to be Missed" paper in the November (2009) issue of the IBMS BoneKEy, BoneKEy is published by the International Bone & Mineral Society, link:http://www.bonekey-ibms.org/).
Feng, R, Anderson G,Xiao G, Elliot G, Leoni L, Lapara MY, Roodman GD, and Lentzsch S. SDX-308, a non-steroidal anti-inflammatory agent, inhibits NF-kB activity resulting in strong inhibition of osteoclast formation/activity and multiple myeloma cell growth.Blood.2007; 109(3): 2130-2138.
Yu S, Franceschi RT, Luo M, Zhang X, Jiang D, Lai Y, Jiang Y, Zhang J,Xiao G. Parathyroid hormone increases activating transcription factor 4 expression and activity in osteoblasts: requirement forosteocalcingene expression.Endocrinology.2008; 149(4): 1960-8. PMCID: PMC**.
Yu S, Jiang Y, Galson DL, Luo M, Lai Y, Lu Y, Ouyang HJ, Zhang J,Xiao G. General transcription factor IIA-gamma increases?osteoblast-specific osteocalcin gene expression via activating transcription factor 4 and runt-related transcription factor 2.J Biol Chem. 2008; 283(9): 5542-53. PMCID: PMC**.
Ge C,Xiao G(co-first author), Jiang D, Yang Q, Hatch NE, and Franceschi RT. Identification and functional characterization of extracellular-regulated kinase/MAPK phosphorylation sites in the Runx2 transcription factor.J Biol Chem. 2009; 284(47):32533-43. PMCID: PMC**.
Li Y, Xiang M, Yuan Y,Xiao G, Zhang J, Vodovotz Y, Billiar TR, Wilson MA, and Fan J. HMGB1 upregulation of TLR2 augments hemorrhagic shock-Induced ICAM-1 expression in lung endothelial cells.Am J Physiol Regul Integr Comp Physiol. 2009; 297(6):R1670-80, PMCID: PMC**
Cao H, Yu S, Yao Z, Galson DL, Jiang Y, Zhang X, Fan J, Lu B, Guan Y, Luo M, Lai Y, Zhu, Y, Kurihara N, Patrene K, Roodman GD,Xiao G. Activating transcription factor 4 regulates osteoclast differentiation in mice.J Clin Invest.2010 Aug 2;120(8):2755-66. PMCID: PMC**.
Wu, Z, Jiao P, Huang, X, Feng Y, Feng B, Yang S, Hwang P, Du J, Hall RK,Xiao G, Xu H. MAP kinase phosphatase 3 regulates glucose homeostasis through dephosphorylation of FOXO1 in mice.J Clin Invest.2010 Nov 1;120(11):3901-11. PMCID: PMC**.
Yang S, Xu H, Yu S, Cao H, Jie Fan, Ge C, Fransceschi RT, Dong HH,Xiao G. Foxo1 mediates IGF1/Insulin regulation of osteocalcin expression by antagonizing Runx2 in osteoblasts,J Biol Chem. 2011; 286(21):19149-58. PMCID: PMC**.
Xiang M, Yin L, Li Y,Xiao G, Vodovotz Y, Billiar TR, Wilson MA, and Fan J. Hemorrhagic shock activates lung endothelial NAD(P)H oxidase via neutrophil NADPH oxidase.Am J Respir Cell Mol Biol.2011 Mar;44(3):333-40. PMCID: PMC**.
Xiao G*, Cheng H, Cao H, Chen K, Tu Y, Yu S, Jiao H, Yang S, Im HJ, Chen D, Chen J, Wu C*. Critical role of Filamin-binding LIM protein 1 (FBLP-1)/migfilin in regulation of bone remodeling.J Biol Chem. 2012 June 15;287(25):21450-60. PMCID: PMC**.
Tang W, Yang F, Li Y, de Crombrugghe B, Jiao H,Xiao G, and Zhang C. Transcriptional regulation of vascular endothelial growth factor (VEGF) by osteoblast-specific transcription factor osterix (Osx) in osteoblasts.J Biol Chem.2012 Jan 13;287(3):1671-8. PMCID: PMC**.
Xiao G*, Zhang T, Yu S, Lee A, Calabuig-Navarro V, Ringquist S, Dong HH*. ATF4 deficiency protects against high fructose-induced hypertriglyceridemia in mice.J Biol Chem.2013 Aug 30;288(35):25350-61. PMCID: PMC**.
Liu Z, Jiang Y, Li Y, Wang J, Fan L, Scott MJ,Xiao G, Li S, Billiar TR, Wilson MA, Fan J. TLR4 signaling augments monocyte chemotaxis by regulating G protein-coupled receptor kinase 2 translocation.J Immunol.2013 Jul 15;191(2):857-64. PMCID: PMC**.
Zhu K, Jiao H, Li S, Cao H, Galson DL, Zhao Z, Zhao X, Lai Y, Fan J, Im HJ, Chen D,Xiao G. ATF4 promotes bone angiogenesis by increasing VEGF expression and release in the bone environment.J Bone Miner Res.2013;28: 1870–1884. PMID: **. (This is an EDITOR'S CHOICE paper of September 2013 JBMR issue with a commentary. For a Commentary on this article, please see Schipani et al. (J Bone Miner Res. 2013;28:1866-1869. DOI: 10.1002/jbmr.2045).
Yu S, Sharma R, Nie D, Jiao H, Lai Y, Fan J, Im HJ, Chen D, Wang Q,Xiao G. ADAR1 is required for osteoblast differentiation and bone homeostasis.Gene513 (2013) 101–110. PMCID: PMC**.
Yu S, Zhu K, Lai Y, Zhao Z, Fan J, Im HJ, Chen D,Xiao G. ATF4 promotes β-catenin expression and osteoblastic differentiation of bone marrow mesenchymal stem cells.Int J Biol Sci.2013; 9(3):256-266. PMCID: PMC**.
Zheng L, Zhu K, Jiao H, Zhao Z, Zhang L, Liu M, Chen D, Yao Z,Xiao G. PTHrP expression in human MDA-MB-231 breast cancer cells is critical for tumor growth and survival and osteoblast inhibition.Int J Biol Sci.2013 Aug 21;9(8):830-41. PMCID: PMC**.
Xu P, Wen Z, Shi X, Li Y, Fan L, Xiang M, Li A, Scott MJ,Xiao G, Li S, Billiar TR, Wilson MA, Fan J. Hemorrhagic shock augments Nlrp3 inflammasome activation in the lung through iompaired pyrin induction.J Immunol. 2013 May 15;190(10):5247-55. PMCID: PMC**.
Cao H, Zhu K, Qiu L, Li S, Niu H, Hao M, Yang S, Zhao Z, Lai Y, Anderson JL, Fan J, Im HJ, Chen D, Roodman GD,Xiao G. Critical role of AKT in myeloma-induced osteoclast formation and osteolysis.J Biol Chem. 2013 Oct 18;288(42):30399-410. PMCID: PMC**.
Yan D, Kc R, Chen D,Xiao G, Im H. Bovine lactoferricin-induced anti-inflammation is, in part, via upregulation of IL-11 by secondary activation of STAT3 in human articular cartilage.J Biol Chem. 2013 Nov 1;288(44):31655-69. PMID: **.
Wang B, Jin H, Zhu M, Li J, Zhao L, Zhang Y, Tang D,Xiao G, Xing L, Boyce BF, Chen D. Chondrocyte β-catenin signaling regulates postnatal bone remodeling through modulation of Rankl/Opg expression and osteoclast differentiation.Arthritis Rheumatol.2014 Jan;66(1):107-20. doi: 10.1002/art.38195. PMID: .
Li S, Shu B, Zhang Y, Li J, Guo J, Wang Y, Ren F,Xiao G, Chang Z, Chen D. CHIP regulates osteoclast formation through promoting TRAF6 protein degradation.Arthritis Rheumatol.2014 Jul;66(7):1854-63. doi: 10.1002/art.38521. PMID: **.
Qu H, Tu Y, Guan JL,Xiao G, Wu C. Kindlin-2 tyrosine phosphorylation and interaction with Src serve as a regulatable switch in the integrin outside-in signaling circuit.J Biol Chem.2014 Nov 7;289(45):31001-13. PMID: **
Zhu K, Yi J, Xiao Y, Lai Y, Song P, Zheng W, Jiao H, Fan J, Wu C, Chen D, Zhou J,Xiao G. Impaired bone homeostasis in amyotrophic lateral sclerosis mice with muscle atrophy.JBiol. Chem. 2015 Mar 27;290(13):8081-94. doi: 10.1074/jbc.M114.603985. Epub 2015 Feb 3. PMID: **
Wu C, Jiao H, Lai Y, Zheng W, Chen K, Deng W, Song P, Zhu K, Cao H, Galson DL, Fan J, Im HJ, Liu Y, Chen J, Chen D,Xiao G. Kindlin-2 controls TGF-β signaling and Sox9 expression to regulate chondrogenesis.Nat Commun.2015 Jul 7;6:7531. doi: 10.1038/ncomms8531. PMID: **
Zhao Y, Zhou J, Liu D, Dong F, Cheng H, Wang W, Pang Y, Wang Y, Mu X, Ni Y, Li Z, Xu H, Hao S, Wang X, Ma S, Wang QF,Xiao G, Yuan W, Liu B, Cheng T. ATF4 plays a pivotal role in the development of functional hematopoietic stem cells in mouse fetal liver.Blood. 2015 Nov 19;126(21):2383-91. doi: 10.1182/blood-2015-03-633354. Epub 2015 Sep 17. PMID: **
Zhu K, Song P, Lai Y,Xiao G. Prolyl hydroxylase domain proteins regulate bone mass through their expression in osteoblasts.Gene. 2016 Dec 5;594(1):125-130. doi: 10.1016/j.gene.2016.09.011. PMID: **.
Kc R, Li X, Kroin JS, Liu Z, Chen D,Xiao G, Levine B, Li J, Hamilton JL, van Wijnen AJ, Piel M, Shelly DA, Brass D, Kolb E, Im HJ. PKCδ null mutations in a mouse model of osteoarthritis alter osteoarthritic pain independently of joint pathology by augmenting NGF/TrkA-induced axonal outgrowth.Ann Rheum Dis. 2016 Dec;75(12):2133-2141.PMID: **
Zhang M, Yang H, Lu L, Wan X, Zhang J, Zhang H, Liu X, Huang X,Xiao G, Wang M. Matrix replenishing by BMSCs is beneficial for osteoarthritic temporomandiblar joint cartilage.Osteoarthritis Cartilage. 2017 May 19. pii: S1063-4584(17)30993-7
Xiao M, Wang Y, Tao C, Wang Z, Yang J, Chen Z, Zou Z, Li M, Liu A, Jia C, Huang B, Yan B, Lai P, Ding C, Cai D,Xiao G, Jiang Y, Bai X. Osteoblasts support megakaryopoiesis through production of interleukin 9.Blood.2017;129(24):3196–3209. doi:10.1182/blood-2016-11-749838.
Zhang Y, Xu S, Li K, Tan K, Liang K, Wang J, Shen J, Zou W, Hu L, Cai D, Ding C, Li M,Xiao G, Liu B, Liu A, Bai X. mTORC1 inhibits NF-kB/NFATc1 signaling and prevents osteoclast precursor differentiation, in vitro and in mice.J Bone Miner Res, 2017 Sep;32(9):1829-1840.
Sun Y*, Guo C, Ma P, Lai Y, Yang F, Cai J, Sheng Y, Cheng Z, Tian R, Deng Y, Xiao G*, Wu C*. Kindlin-2 association with Rho GDP-Dissociation Inhibitor α suppresses Rac1 activation and podocyte injury.J Am Soc Nephrol. 2017 Dec;28(12):3545-3562.
Guo L, Cai T, Chen K, Wang R, Wang J, Cui C, Yuan J, Zhang K, Liu Z, Deng Y,Xiao G, Wu C. Kindlin-2 regulates mesenchymal stem cell differentiation through control of YAP1/TAZ.J Cell Biol. 2018 Apr 2;217(4):1431-1451. doi: 10.1083/jcb.. Epub 2018 Mar 1. PMID: **
Wang T, Li S, Yi D, Zhou GQ, Chang Z, Ma PX,Xiao G, Chen D. CHIP Regulates Bone Mass by Targeting Multiple TRAF Family Members in Bone Marrow Stromal Cells.Bone Res.2018 Mar 29;6:10. doi: 10.1038/s41413-018-0010-2. eCollection 2018. PMID: **.
Yang X, Xia R, Yue C, Zhai W, Du W, Yang Q, Cao H, Chen X, Obando D, Zhu Y, Chen X, Chen J, Piganelli J, Wipf P, Jiang Y,Xiao G, Wu C, Jiang J, Lu B. ATF4 Regulates CD4+ T Cell Immune Responses through Metabolic Reprogramming.Cell Rep. 2018 May 8;23(6):1754-1766. doi: 10.1016/j.celrep.2018.04.032.
Yi YS, Jian J, Gonzalez-Gugel E, Shi YX, Tian Q, Fu W, Hettinghouse A, Song W, Liu R, He M, Qi H, Yang J, Du X,Xiao G, Chen L, Liu CJ. p204 Is Required for Canonical Lipopolysaccharide-induced TLR4 Signaling in Mice.EBioMedicine.2018 Mar;29:78-91
Xu S, Zhang Y, Wang J, Li K, Tan K, Liang K, Shen J, Cai D, Jin D, Li M,Xiao G, Xu J, Jiang Y, Bai X. TSC1 regulates osteoclast podosome organization and bone resorption through mTORC1 and Rac1/Cdc42.Cell Death Differ. 2018 Sep;25(9):1549-1566
Chen H, Wang Y, Dai H, Tian X, Cui ZK, Chen Z, Hu L, Song Q, Liu A, Zhang Z,Xiao G, Yang J, Jiang Y, Bai X. Bone and plasma citrate is reduced in osteoporosis.Bone. 2018 Sep;114:189-197.
Guo L, Cui C, Zhang K, Wang J, Wang Y, Lu Y, Chen K, Yuan J,Xiao G, Tang B, Sun Y, Wu C. Kindlin-2 links mechano-environment to proline synthesis and tumor growth.Nat Commun.2019 Feb 19;10(1):845. doi: 10.1038/s41467-019-08772-3. PMID: **
Zhao L, Huang J, Fan Y, Li J, You T, He S,Xiao G, Chen D. Exploration of CRISPR/Cas9-based gene editing as therapy for osteoarthritis.Ann Rheum Dis. 2019 May;78(5):676-682. doi: 10.1136/annrheumdis-2018-214724. Epub 2019 Mar 6. PMID: **
Huang J, Zhao L, Fan Y, Liao L, Ma PX,Xiao G, Chen D. The microRNAs miR-204 and miR-211 maintain joint homeostasis and protect against osteoarthritis progression.Nat Commun.2019 Jun 28;10(1):2876. doi: 10.1038/s41467-019-10753-5. PMID: **.
Liu R, Chen Y, Fu W, Wang S, Cui Y, Zhao X, Lei ZN, Hettinghouse A, Liu J, Wang C, Zhang C, Bi Y,Xiao G, Chen ZS, Liu CJ. Fexofenadine inhibits TNF signaling through targeting to cytosolic phospholipase A2 and is therapeutic against inflammatory arthritis.Ann Rheum Dis.2019 Nov;78(11):1524-1535. doi: 10.1136/annrheumdis-2019-215543. Epub 2019 Jul 13. PMID: **
Gao H, Guo Y, Yan Q, Yang W, Li R, Lin S, Bai X, Liu C, Chen D, Cao H,Xiao G. Lipoatrophy and metabolic disturbance in mice with adipose-specific deletion of Kindlin-2.JCI Insight. 2019 Jul 11;4(13).
Cao H,Xiao G(2019): Kindlin Signaling and Bone.Encyclopedia of Bone Biology,Elsevier
Wang Y, Yan Q, Zhao Y, Liu X, Lin S, Zhang P, Ma L, Lai Y, Bai X, Liu C, Wu C, Feng JQ, Chen D, Cao H,Xiao G. Focal adhesion proteins Pinch1 and Pinch2 regulate bone homeostasis in mice.JCI Insight. 2019 Nov 14;4(22). pii: 131692. doi: 10.1172/jci.insight.131692. PMID: **.
Cao H, Yan Q, Wang D, Lai Y, Zhou B, Zhang Q, Jin W, Lin S, Lei Y, Ma L, Guo Y, Wang Y, Wang Y, Bai X, Liu C, Feng JQ, Wu C, Chen D, Cao X,Xiao G. Focal adhesion protein Kindlin-2 regulates bone homeostasis in mice.Bone Res.2020 Jan 2;8:2. doi: 10.1038/s41413-019-0073-8. eCollection 2020. PMID: **.
Yang H, Wen Y, Zhang M, Liu Q, Zhang H, Zhang J, Lu L, Ye T, Bai X,Xiao G*, Wang M*. MTORC1 coordinates the autophagy and apoptosis signaling in articular chondrocytes in osteoarthritic temporomandibular joint.Autophagy. 2020 Feb;16(2):271-288. doi: 10.1080/**.2019.**. Epub 2019 Apr 21.
Feng X, Pan J, Li J, Zeng C, Qi W, Shao Y, Liu X, Liu L,Xiao G, Zhang H, Bai X, Cai D. Metformin attenuates cartilage degeneration in experimental osteoarthritis via the regulation of AMPK/mTOR.Aging(Albany NY). 2020 Jan 16;12. doi: 10.18632/aging.102635. [Epub ahead of print]. PMID: **.
Zhu K, Lai Y, Cao H, Liu C, Bai X, Yan Q, Ma L, Chen D, Kanaporis G, Wang J, Li L, Cheng T, Wang Y, Wu C,Xiao G. Kindlin-2 modulates MafA and β-catenin expression to regulate β-cell function and mass in mice.Nat Commun.2020 Jan 24;11(1):484. doi: 10.1038/s41467-019-14186-y.PMID: **.
Chen S, Qin L, Wu X, Fu X, Lin S, Chen D,Xiao G, Shao Z and Cao H. Moderate fluid shear stress regulates heme oxygenase-1 expression to promote autophagy and ECM homeostasis in the nucleus pulposus cells.Front Cell Dev Biol.2020 Mar 3;8:127. doi: 10.3389/fcell.2020.00127. eCollection 2020. PMID: **
Li J, Zhang B, Liu W, Lu K, Pan Ha, Wang T, Yi D, Huang J, Zhao L, Ning G, Xing C,Xiao G, Liu-Bryan, R, Feng S, Chen D. Metformin limits osteoarthritis development and progression through activation of AMPK signaling.Ann Rheum Dis.2020 May;79(5):635-645. doi: 10.1136/annrheumdis-2019-216713. Epub 2020 Mar 10. PMID: **
Lei Qin, Liu W. Cao H,Xiao G. Molecular mechanosensors in osteocytes.Bone Res.2020 Jun 8;8:23. doi: 10.1038/s41413-020-0099-y. eCollection 2020. PMID: **
Shu B, Zhao Y, Zhao S, Pan H, Xie R, Yi D, Lu K, Yang J, Xue C, Huang J, Wang J, Zhao D, Xiao G, Wang Y, Chen D. Inhibition of Axin1 in osteoblast precursor cells leads to defects in postnatal bone growth through suppressing osteoclast formation.Bone Res.2020 Aug 12;8:31. doi: 10.1038/s41413-020-0104-5. eCollection 2020. PMID: **.
Lei Y, Fu X, Li P, Lin S, Yan Q, Lai Y, Liu X, Wang Y, Bai X, Liu C, Chen D, Zou X, Cao X, Cao H,Xiao G. LIM domain proteins Pinch1/2 regulate chondrogenesis and bone mass in mice.Bone Res. 2020 Oct 13;8:37. doi: 10.1038/s41413-020-00108-y. eCollection 2020. PMID: **.https://doi.org/10.1038/s41413-020-00108-y
Xuekun Fu, Bo Zhou, Qinnan Yan, Chu Tao, Lei Qin, Xiaohao Wu, Sixiong Lin, Sheng Chen, Yumei Lai, Xuenong Zou, Zengwu Shao, Meiqing Wang, Di Chen, Wenfei Jin, Youqiang Song, Huiling Cao, Ge Zhang,Guozhi Xiao. Kindlin-2 regulates skeletal homeostasis by modulating PTH1R in mice.Signal Transduct Target Ther.(in press)