王玉强教授简介
药物研究的第一步是发现有生物活性的化合物，然后是研究这些化合物的作用机理和药理活性。王玉强实验室目前主要从事治疗神经退行性疾病如脑中风、老年痴呆和帕金森、心血管疾病药物如心肌缺血等疾病药物的设计、化学合成、药理活性与作用机理的研究及创新药物的研究与开发。
王玉强教授从事DNA-minor groove binding 药物CC-1065衍生物的研究多年, 他的实验室合成了100多个CC-1065衍生物, 其中的YW-053是目前已知抗癌活性最强的少数化合物之一，其体外抗癌活性比临床应用的抗癌药物阿霉素强一百万倍 (J. Amer. Chem. Soc. 117, 8917, 1995)。
王玉强教授在美国首次GMP合成治疗老年痴呆药物 memantine，作为核心成员，其团队在美国将memantine 成功开发。Memantine 2003年先后在欧美上市，2011年在日本上市，2013年在中国上市。Memantine 2013年的销售额18亿美元, 属于“重磅炸弹”级药物。
王玉强实验室近年开展了对中药有效成份分子结构进行系统的化学修饰的工作。在中药穿心莲、川芎及丹参有效成份的结构修饰方面已卓有成效，发现了比天然产物疗效更高，毒性更低的新化合物。其中具有独特作用机理和良好治疗效果的治疗缺血性脑中风新药已完成临床前研究。
王玉强教授1981年毕业于山东师范大学化学系, 获学士学位；1987年获美国University of Texas Health Science Center at Houston and M. D. Anderson Cancer Center博士学位。 随后进入美国耶鲁大学 (Yale) 医学院做博士后研究。九十年代初进入美国加州硅谷的生物医药公司从事药物的研究与开发，2005年回国任暨南大学教授，药学院院长，现任暨南大学新药研究所所长，博士生导师。2010年获广州经济技术开发区科技领军人才称号。
代表性论文
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