个人简介

---

职称：教授
学科专业：生物化学与分子生物学
研究方向：
（1）肿瘤信号通路与靶向药物；
（2）细胞氧化应激与毒性作用
电子邮箱：jjw703@jnu.edu.cn
个人信息：蒋建伟，江苏溧阳人，研究生学历，博士学位，教授，博士生导师。1988年毕业于中山大学；1991年中山大学获硕士学位；2005年暨南大学获博士学位，师从张洹研究员。1999年受聘为暨南大学医学院副教授，2000年受聘为硕士生导师，2012年在波士顿大学Boston medical center 从事博士后研究，导师Mengwei Zeng。2015年受聘教授，2018年受聘为博士生导师。一直从事肿瘤信号通路与靶向药物的研究；细胞氧化应激与毒性作用的研究。主持及参与国家自然科学基金2项，省自然科学基金、省科技计划，广州市科技计划，华南肿瘤学国家重点实验室开放课题等项目16项；发表核心期刊论文90篇，SCI收录论文20篇。担任Int J oncol, Int J Radiat Biol, Oncology Letter, Oncotarget, RSC Advances, Tumor Biology, Phytother Research, Oncology Report, Cancer Chemotherapy and Pharmacology, Experimental and Therapeutic Medicine, Mol Med Rep, Cell Proliferat；中国药理学通报，暨南大学学报，中国病理生理杂志等杂志的审稿人。

---

学习科研经历

---

2015.10-至今，暨南大学医学院生物化学与分子生物学系，教授，博士生导师
1999.10-2015.09，暨南大学医学院生物化学与分子生物学系，副教授，硕士生导师
1991.07-1999.09，暨南大学医学院生物化学与分子生物学系，助教，讲师
2012.01-2012.10，美国波士顿大学Boston medical center，博士后研究
2001.09-2005-07，暨南大学医学院，获博士学位
1988.09-1991.06，中山大学生物系，获硕士学位
1984.09-1988.06，中山大学生物系，获学士学位

---

主要论文

---

1. Wan-Jing Cen(#), Yi Feng, Shu-Shu Li, Wei-Liang Huang, Tao Zhang, Wu Zhang, Wei-Dong Kong(*), Jian-Wei Jiang(*). Iron overload induces G1 phase arrest and autophagy in murine preosteoblast cells. journal of cellular physiology, 2018: 1-11,| DOI: 10.1002/jcp.26405 IF: 4.08
2. J-Y Ke(#), W-J Cen(#), X-Z Zhou, Y-R Li, W-D Kong(*), J-W Jiang(*). Iron overload induces apoptosis of murine preosteoblast cells via ROS and inhibition of AKT pathway. Oral Diseases.2017.9,23(6):784-794. IF:2.011
3. Jun-Yu Ke(#), Wu Zhang(#), Rui-Song Gong, Wan-Jing Cen, Hui-Qun Huang, Ye-Rong Li , Wei-Dong Kong (*), Jian-Wei Jiang (*). A monomer purified from Paris polyphylla (PP-22) triggers S and G2/M phase arrest and apoptosis in human tongue squamous cell carcinoma SCC-15 by activating the p38/cdc25/cdc2 and caspase 8/caspase 3 pathways. Tumour Biol. 2016 , 11,37 (11):14863-14872 .IF:3.65
4. Zeping Han(#), Baoxia Li, Juanjuan Wang, Xiangqiang Zhang, Zhenhua Li, Liting Dai, Mingrong Cao, Jianwei Jiang(*). Norcantharidin Inhibits SK-N-SH Neuroblastoma Cell Growth by Induction of Autophagy and Apoptosis. Technol Cancer Res Treat. 2017,2,16(1):33-44. IF: 2.204
5. Jiming Liu(#), Qiang Li, Zhilong Liu, Liuming Lin, Xiangqiang Zhang, Mingrong Cao(*), Jianwei Jiang(*). Harmine induces cell cycle arrest and mitochondrial pathway-mediated cellular apoptosis in SW620 cells via inhibition of the Akt and ERK signaling pathways. Oncol Rep. 2016,6,35(6):3363-3370. IF: 2.662
6. ian Yang(#), Yu-Bo Zhang, Zhong-Nan Wu, Xiang-Qiang Zhang, Jian-Wei Jiang, Yao-Lan Li(*),Guo-Cai Wang(*). Six new prenylated acetophenone derivatives from the leaves of Acronychia oligophlebia. Fitoterapia. 2015, 105, 156-159. IF: 2.698
7. Peng Zhang(#), Chun-rong Huang, Wei Wang, Xia-kai Zhang , Jia-jin Chen , Juan-juan Wang, Chen Lin(*), Jian-wei Jiang(*). Harmine Hydrochloride Triggers G2 Phase Arrest and Apoptosis in MGC-803 Cells and SMMC-7721 Cells by Upregulating p21, Activating Caspase-8/Bid, and Downregulating ERK/Bad Pathway. Phytother Res. 2016.1,30(1):31-40.IF: 3.092
8. Jing-Hong Chen(#), Peng Zhang(#), Wen-dan Chen(#), Dan-Dan Li, Xiao-Qi Wu, Rong Deng, Lin Jiao, Xuan Li, Jiao Ji, Gong-kan Feng, Jian-Wei Jiang(*), Xiao-feng Zhu(*). ATM-mediated PTEN phosphorylation promotes PTEN nuclear translocation and autophagy in response to DNA-damaging agents in cancer cells. Autophagy.2015;11(2):239-252. IF=11.753；
9. Yu Li(#)(*), Kimberly Wong, Amber Giles, Jianwei Jiang , Jong Woo Lee, Andrew C. Adams, Alexei Kharitonenkov, Qin Yang, Bin Gao, Leonard Guarente, Mengwei Zang(*). Hepatic SIRT1 Attenuates Hepatic Steatosis and Controls Energy Balance in Mice by Inducing Fibroblast Growth Factor 21. Gastroenterology. 2014; 146(2): 539- 549.e7. IF: 18.392;
10. Jin-Hua He(#), Xiao-Li Liao, Wei Wang, Dan-Dan Li, Wen-Dan Chen, Rong Deng, Dajun Yang, Ze-Ping Han, Jian-Wei Jiang(*), XiaoFeng Zhu(*). Apogossypolone, a small-molecule inhibitor of Bcl-2, induces radiosensitization of nasopharyngeal carcinoma cells by stimulating autophagy[J]. Int J oncol. 2014,9.45(3),1099- 1108, IF:3.079

---

学术兼职

---

1、广东省生物化学与分子生物学学会理事
2、广东省肿瘤药理学会常务委员
3、广东省抗癌协会抗肿瘤药物专业委员会常务委员

---