暨南大学生命科学技术学院导师教师师资介绍简介-刘忠

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个人信息

姓名：刘忠
部门：生命科学技术学院
直属机构：细胞生物学系(生物医药研究院)
性别：男
--> 职务：博士生导师
职称：副研究员
学位：博士
毕业院校：中山大学
联系电话：
电子邮箱： tliuzh@jnu.edu.cn
办公地址：暨南大学生命科学技术学院大楼5楼生物医药基地
通讯地址：广州市黄埔大道西601号暨南大学生命科学技术学院大楼5楼南生物医药基地
邮编： 510632
传真：
荣誉奖励：省级青年人才

联系方式

个人简介

刘忠，博士、副研究员、博士生导师，广东省杰出青年科学基金获得者、广东特支计划科技创新青年拔尖人才、广州市珠江科技新星、暨南“双百英才”杰出青年学者。现任广东省生物医学工程学会常务理事、副秘书长，广东省化妆品学会副理事长、常务副秘书长、原料与天然产物专委会主任委员，广东药学会制药工程专业委员会药食同源专题组副组长。
主要研究方向为肿瘤、炎症与自身免疫性疾病靶向创新药物研究与开发，功能化妆品研究与开发。近5年作为项目负责人主持了国家自然科学基金、广东省自然科学基金项目、广东省科技计划国际合作项目、广州市科技计划应用基础研究重点项目等项目12项。已在SCI国际期刊发表研究论文50余篇，申请专利9项。
博士研究生招生方向：生物医药
硕士研究生招生方向：生物医药、细胞生物学、生物工程

学习经历

2003-2008，博士，中山大学（2003-2008）/ 香港理工大学（2005-2008）
1999-2003，学士，中山大学

工作经历

2009至今：暨南大学生命科学技术学院/ 生物医药研究院/ 生物医药研究开发基地
所在实验室：基因工程药物国家工程研究中心、广东省生物工程药物重点实验室

研究方向

1. 肿瘤、炎症与自身免疫性疾病靶向创新药物研究与开发。
2. 功能化妆品研究与开发、化妆品功效检测与安全性评价。

主要论文

（*为通讯作者）
[1]Peng-Chao Zhang#, Xiao Liu#, Man-Mei Li#, Yan-Yan Ma, Hong-Tao Sun, Xu-Yan Tian, Yan Wang, Min Liu, Liang-Shun Fu, Yi-Fei Wang, Hong-Yuan Chen*, Zhong Liu*, AT-533, a novel Hsp90 inhibitor, inhibits breast cancer growth and HIF-1α/VEGF/VEGFR-2-mediated angiogenesis in vitro and in vivo, Biochem Pharmacol. 2020, 172:113771.
[2]Hu LB#, Huang WH#, Ding Y#, Liu M, Wang M, Wang Y, Zhang W, Li YL, Ye WC, Li MM*, Liu Z*, PHMH, a diarylheptanoid from Alpinia officinarum attenuates VEGF-induced angiogenesis via inhibition of the VEGFR-2 signaling pathway. Food Funct. 2019. 10: 2605-2617.
[3]Hu LB#, Wang Y#, Chen Z, Fu, LS, Wang S, Zhang XY, Zhang PC, Lu XP, Jie HY, Li MM*, Wang YF*, Liu Z*, Hsp90 Inhibitor SNX-2112 Enhances TRAIL-Induced Apoptosis of Human Cervical Cancer Cells via the ROS-Mediated JNK-p53-Autophagy-DR5 Pathway. Oxid Med Cell Longev. 2019, 2019: **.
[4]Wu Y#, Zhang XY#, Li HQ, Deng PF, Li HR, He TQ, Rong JH, Zhao JH*, Liu Z*, A core/shell stabilizedpolysaccharide-based nanoparticle with intracellular environment-sensitive drug delivery for breast cancer therapy. J Mater Chem B. 2018, 6:6646-6659.
[5]Wang Y#, Zhou PJ#, Qin SR#, Xu DD, Liu YK, Fu WY, Ruan BB, Zhang L, Zhang Y, Wang XY, Pan YW, Wang S, Yan HZ, Qin JH, Wang XY, Liu QY, Du ZY*, Liu Z*, Wang YF*. The curcuminanalogs 2-pyridyl cyclohexanone induces apoptosis via inhibition of the JAK2-STAT3 pathway in human esophageal squamous cell carcinoma cells. Front Pharmacol. 2018, 9:820.
[6]Liu Q#, Xiao XH#, Hu LB, Jie HY, Wang Y, Ye WC*, Li MM*, Liu Z*. Anhuienoside C ameliorates collagen-induced arthritis through inhibition of MAPK and NF-κB signaling pathways. Front Pharmacol. 2017, 8:299.
[7]Zhang L#, WangXY#, Zhou PJ#, He Z, Yan HZ, Xu DD, Wang Y, Fu WY, Ruan BB, Wang S, Chen HX, Liu QY, Zhang YX, Liu Z*, Wang YF*. Use of immune modulation by human adipose-derived mesenchymal stem cells to treat experimental arthritis in mice. Am J Transl Res. 2017, 9(5): 2595-2607.
[8]Xie ZZ#, Li MM#, Deng PF, Wang S, Wang L, Lu XP, Hu LB, Chen Z, Jie HY, Wang YF, Liu XX*, Liu Z*. Paris saponin-induced autophagy promotes breast cancer cell apoptosis via the Akt/mTOR signaling pathway. Chem-Biol Interact.2017, 264:1-9.
[9]Liu Z#, Liu G#, Zhang GL#, Li J, He YQ, Zhang SS, Wang Y, He WY, Cheng GH, Yang X, Xu J, Wang J*, Binding of human recombinant mutant soluble ectodomain of FGFR2IIIc to c subtype of FGFRs: implications for anticancer activity. Oncotarget, 2016, 7(42):68473-68488.
[10]Shao FY#, Wang S#, Li, HY#, Chen WB, Wang GC, Ma DL, Wong NS, Xiao H, Liu QY, Zhou GX, Li YL, Li MM*, Wang YF*, Liu Z*. EM23, a natural sesquiterpene lactone, targets thioredoxin reductase to activate JNK and cell death pathways in human cervical cancer cells. Oncotarget, 2016, 7(6):6790-6808.
[11]Li H#, Li M#, Wang G, ShaoF, Chen W, Xia C, Wang S, Li Y*, Zhou G* and Liu Z*. EM23, a natural sesquiterpene lactone from Elephantopus mollis, induces apoptosis in human myeloid leukemia cells through thioredoxin- and reactive oxygen species-mediated signaling pathways, Front Pharmacol, 2016, 7:77.
[12]Xu DD#, Zhou PJ#, Wang Y#, ZhangY, Zhang R, Zhang L, Chen SH, Ruan BB, Xu HP, Fu WY, Hu CZ, Tian L, Qin JH, Wang S, Wang X, Liu QY, Ren Z, Gu XQ, Li YH, Liu Z*, Wang YF*. miR-150 suppresses the proliferation and tumorigenicity of leukemia stem cells by targeting the Nanog signaling pathway, Front Pharmacol, 2016, 7:439.
[13]Fan Z^#, Sun ZH^#, Liu Z^#, Chen YC, Liu HX, Li HH, Zhang WM. Dichotocejpins A-C: New Diketopiperazines from a Deep-Sea-Derived Fungus Dichotomomyces cejpii FS110. Mar Drugs. 2016, 14(9):164.
[14]Shao FY#, Du ZY#, MaDL, Chen WB, Fu WY, Ruan BB, Rui W, Zhang JX, Wang S, Wong NS, Xiao H, Li MM, Liu X, Liu QY, Zhou XD, Yan HZ, Wang YF, Chen CY, Liu Z*, Chen HY*. B5, a thioredoxin reductase inhibitor, induces apoptosis in human cervical cancer cells by suppressing the thioredoxin system, disrupting mitochondrion-dependent pathways and triggering autophagy. Oncotarget, 2015, 6(31):30939-30956.
[15]Xu JJ#, Liu Z#, Tang W#, Wang GC, Chung HY, Liu QY, Zhuang L, Li MM*, Li YL*. Tangeretin from citrus reticulate inhibits respiratory syncytial virus replication and associated inflammation in vivo. J Agric Food Chem. 2015, 63 (43):9520–9527.
[16]Xu GG, LiuX, Lin YQ, He GS, Wang WJ, Xiong W, Luo HY, Liu Z*, Zhao JH*. Thermal hydrolysis of poly(L-lactic acid) films and cytotoxicity of water-soluble degradation products. J Appl Polym Sci. 2015, 132(25), DOI: 10.1002/app.42064.
[17]Qiu XX#, ZhongMG#, Xiang YF, Qu C, Pei Y, Zhang YJ, Yang CR, Gasteiger J, Xu J, Liu Z*, Wang YF*. Self-Organizing Maps for the Classification of Gallic Acylate Polyphenols as HSV-1 Inhibitors. Med Chem. 2014, 10, 388-401.
[18]Wang R#, Shao FY#, Liu Z*, Zhang JX, Wang SX, Liu JY, Liu H, Chen HY, Liu KS, Xia M, Wang YF*. The Hsp90 inhibitor SNX-2112, induces apoptosis in multidrug resistant K562/ADR cells through suppression of Akt/NF-κB and disruption of mitochondria-dependent pathways. Chem-Biol Interact. 2013, 205(1): 1-10.
[19]Zhong MG#, Xiang YF#, Qiu XX,Liu Z*, Kitazato K*, Wang YF*. Natural products as a source of anti-herpes simplex virus agents, RSC Adv. 2013, 3(2): 313-328.
[20]Zhang WJ#, Liu Z#, Li SM, Lu YZ, Chen YC, Zhang HB, Zhang GT, Zhu YG, Zhang GY, Zhang WM, Liu JS, Zhang CS*. Fluostatins I-K from the South China Sea-Derived MicromonosporarosariaSCSIO N160. J Nat Prod. 2012, 75 (11): 1937-1943.
[21]Liu JY#, Liu Z#, Wang DM, Li MM, Wang SX, Wang R, Chen JP, Wang YF*, Yang DP*. Induction of apoptosis in K562 cells by dicyclohexylammonium salt of hyperforin through a mitochondrial-related pathway. Chem-Biol Interact. 2011, 190(2-3): 91-101.
[22]Wang SX#, Ju HQ#, Liu KS, Zhang JX, Wang X, Xiang YF, Wang R, Liu JY, Liu QY, Xia M, Xing GW, Liu Z*, Wang YF*. SNX -2112, a novel Hsp90 inhibitor, induces G2/M cell cycle arrest and apoptosis in MCF-7 cells. Biosci Biotech Bioch. 2011, 75(8): 1540-1545.
[23]Liu Z#, Huang SL#, Li MM, Huang ZS, Lee KS*, Gu LQ*. Inhibition of thioredoxin reductase by mansonone F analogues: implications for anticancer activity. Chem-Biol Interact. 2009, 177(1): 48-57.
[24]Liu Z, Du ZY, HuangZS, Lee KS*, Gu LQ*. Inhibition of thioredoxinreductase by curcumin analogs. Biosci Biotech Bioch. 2008, 72(8): 2214-2218.
[25]Qiu X#, Liu Z#, Shao WY, Liu X, Jing DP, Yu YJ, An LK, Huang SL, Bu XZ*, Huang ZS, Gu LQ. Synthesis and evaluation of curcumin analogues as potential thioredoxinreductase inhibitors. Bioorg Med Chem. 2008, 16(17): 8035-8041.
[26]HuangP, Chen A, He W, Li Z, Zhang G, Liu Z, Liu G, Liu X, He S, Xiao G, Huang F, Stenvang J, Brünner N, Hong A, Wang J. BMP-2 induces EMT and breast cancer stemness through Rb and CD44.Cell Death Discov. 2017,3:17039.
[27]YuanN, Xu L, Zhang L, Ye H, Zhao J, Liu Z, Rong J. Superior hybrid hydrogels of polyacrylamide enhanced by bacterial cellulose nanofiber clusters. Mater Sci Eng C. 2016,67:221-30.
[28]ZhangY, Zhou SY, Yan HZ, Xu DD, Chen HX, Wang XY, Wang X, Liu YT, Zhang L, Wang S, Zhou PJ, Fu WY, Ruan BB, Ma DL, Wang Y, Liu QY, Ren Z, Liu Z, Zhang R, Wang YF. miR-203 inhibits proliferation and self-renewal of leukemia stem cells by targeting survivin and Bmi-1. Sci Rep. 2016,6:19995.
[29]Wang WJ, Wang L, Liu Z, Jiang RW, Liu ZW, Li MM, Zhang QW, Dai Y, Li YL, Zhang XQ, Ye WC. Antiviral benzofurans from Eupatorium chinense. Phytochemistry. 2016, 122:238-45.
[30]Lu D, DongD, Liu Z, Wang Y, Wu B. Metabolism elucidation of BJ-B11 (a heat shock protein 90 inhibitor) by human liver microsomes:identification of main contributing enzymes.Expert Opin Drug Metab Toxicol. 2015,11(7):1029-40.
[31]Liu Q, Zhu XZ, Feng RB, Liu Z, Wang GY, Guan XF, Ou GM, Li YL, Wang Y, Li MM, Ye WC, Crude triterpenoid saponins from Anemone laccida (Di Wu) exert anti-arthritic efects on type II collagen-induced arthritis in rats. Chin Med. 2015, 10:20.
[32]Feng RB, FanCL, Liu Q, Liu Z, Zhang W, Li YL, Tang W, Wang Y, Li MM, Ye WC. Crude triterpenoid saponins from Ilex latifolia (Da Ye Dong Qing) ameliorate lipid accumulation by inhibiting SREBP expression via activation of AMPK in a non?alcoholic fatty liver disease model. Chin Med. 2015, 10:23.
[33]Chen H, Liu X, Clayman ES, Shao F, Xiao M, Tian X, Fu W, Zhang C, Ruan B, Zhou P, Liu Z, Wang Y, Rui W. Synthesis and evaluation of a CBZ-AAN-Dox prodrug and its in vitro effects on SiHa cervical cancer cells under hypoxic conditions.Chem Biol Drug Des. 2015:86(4):589-98.
[34]Tian YX, Shen YD, Zhang XZ, Ye LB, Li ZH, Liu Z, Zhang JJ, Wu SG. Design Some New Type-I c-met Inhibitors Based on Molecular Docking and Topomer CoMFA Research. Mol Inform, 2014, 33(8):536-543.
[35]Zhang W, Ma L, Li S, Liu Z, Chen Y, Zhang H, Zhang G, Zhang Q, Tian X, Yuan C, Zhang S, Zhang W, Zhang C. Indimicins A-E, Bisindole Alkaloids from the Deep-Sea-Derived Streptomyces sp. SCSIO 03032. J Nat Prod. 2014, 77:1887-1892.
[36]Liu C, Liu Z, Li M, Li X, Wong YS, Ngai SM, Zheng W*, Zhang Y, Chen T*. Enhancement of auranofin-induced apoptosis in MCF-7 human breast cells by selenocystine, a synergistic inhibitor of thioredoxin reductase. PLoS One. 2013, 8(1):e53945
[37]Yang XW, Peng K, Liu Z, Zhang GY, Li J, Wang N*, Steinmetz A, Liu Y*. Strepsesquitriol, a Rearranged Zizaane-Type Sesquiterpenoid from the Deep-Sea-Derived Actinomycete Streptomyces sp. SCSIO 10355. J Nat Prod. 2013, 76 (12),:2360-2363.
[38]Qin J*, Lan W, Liu Z, Huang J, Tang H, Wang H*. Synthesis and biological evaluation of 1, 3-dihydroxyxanthone mannich base derivatives as anticholinesterase agents. Chem Cent J. 2013, 7(1):78.
[39]Wu ZC, Li S, Nam SJ, Liu Z, Zhang C*. Nocardiamides A and B, two cyclohexapeptides from the marine-derived actinomycete nocardiopsis sp. CNX037. J Nat Prod. 2013, 76 (4):694-701.
[40]Wu X, Lan P, Liu Z, Ruan ZX, Wang H, Wang GC, Ye WC, Li YL*. 3D-QSAR studies of natural steroidal saponins as anticancer agents in human nasopharyngeal carcinoma epithelial cells. Lett Drug Des Discov. 2013, 10(3):245-252.
[41]ZhangW, Liu Z, Li S, Yang T, Zhang Q, Ma L, Tian X, Zhang H, Huang C, Zhang S, Ju J, Shen Y, Zhang C*. Spiroindimicins A-D:new bisindole alkaloids from a deep-sea-derived actinomycete. Org Lett, 2012, 14 (13), 3364-3367.
[42]He F, Liu Z, Yang J, Fu P, Peng J, Zhu WM*, Qi SH*. A novel antifouling alkaloid from halotolerant fungus Penicilliumsp. OUCMDZ-776, Tetrahedron Lett. 2012, 53(18):2280-2283.
[43]Li MM, Wu S, Liu Z, Zhang W, Xu J, Wang Y, Liu JS, Zhang DM, Tian HY, Li YL*, Ye WC*. Arenobufagin, a bufadienolide compound from toad venom, inhibits VEGF-mediated angiogenesis through suppression of VEGFR-2 signaling pathway. Biochem Pharmacol. 2012, 83(9):1251-1260.
[44]Liu KS, Ding WC, Wang SX, Liu Z, Xing GW, Wang Y, Wang YF*. The heat shock protein 90 inhibitor SNX-2112 inhibits B16 melanoma cell growth in vitro and in vivo. Oncol Rep. 2012, 27(6):1904-1910.
[45]Liu KS, Liu H, Qi JH, Liu QY, Liu Z, Xia M, Xing GW, Wang SX*, Wang YF*. SNX-2112, an Hsp90 inhibitor, induces apoptosis and autophagy via degradation of Hsp90 client proteins in human melanoma A-375 cells. Cancer Lett. 2012, 318(2):66-74.
[46]Zhang XQ, Xu FF, Wang L, Huang MY, Liu Z, Zhang DM, Wang GC, Li YL, Ye WC*, Two pairs of new diastereoisomeric flavonolignans from the seeds of Hovenia acerba. Phytochem Lett. 2012, 5(2):292-296.
[47]Liu XT, Schwan WR, Volk TJ, Rott M, Liu M, Huang P, Liu Z, Wang Y, Zitomer NC, Sleger C, Hartsel S, Monte A*, Zhang L*. Antibacterial Spirobisnaphthalenes from the North American Cup Fungus Urnula craterium. J Nat Prod. 2012, 75(9):1534-1538.
[48]Liu KS, Zhang Y, Ding WC, Wang SX, Xiang YF, Yang P, Chen ZP, Zheng K, Liu Z, Xia M, Wang YF*. The selective Hsp90 inhibitor BJ-B11 exhibits potent antitumor activity via induction of cell cycle arrest, apoptosis and autophagy in Eca-109 human esophageal squamous carcinoma cells. Int J Oncol. 2012, 41:2276-2284.
[49]Zhai QQ, Gong GQ, Liu Z, Luo Y, Xia M, Xing GW, You XF, Wang YF*. Preclinical pharmacokinetic analysis of SNX-2112, a novel Hsp90 inhibitor, in rats. Biomed Pharmacother. 2011, 65(2):132-136.
[50]Sun F, Liu JY, He F, Liu Z, Wang R, Wang DM, Wang YF*, Yang DP*. In-vitro antitumor activity evaluation of hyperforin derivatives. J Asian Nat Prod Res. 2011, 13(8):688-699.
[51]Ju HQ, Wang SX, Xiang YF, Liu Z, Liu JY, Chen ZP, Zeng FL, Xia M, Liu ZH, Xing GW*, Wang SY*, Wang YF*. BJ-B11, a novel Hsp90 inhibitor, induces apoptosis in human chronic myeloid leukemia K562 cells through the mitochondria-dependent pathway. Eur J Pharmacol. 2011, 666:26-34.
[52]Shao M, Wang Y, Liu Z, Zhang DM, Cao HH, Jiang RW, Fan CL, Zhang XQ, Chen HR, Yao XS, Ye WC*. Psiguadials A and B, two novel meroterpenoids with unusual skeletons from the leaves of Psidium guajava. Org Lett. 2010, 12(21):5040-5043.
[53]Zhou GX*, Mo SY, He HX, Shi JG, Ye WC, Liu Z. Jiang RW*, Molecular structure and tautomerization of the 1:1 complex of luteoskyrin and rugulosin J Mol Struct. 2010, 979(1):86-91.
[54]Tian HY, Wang L, Zhang XQ, Wang Y, Zhang DM, Jiang RW, Liu Z, Liu JS, Li YL, Ye WC*. Bufogargarizins A and B two novel 19-norbufadienolides with unprecedented skeletons from the venom of bufo bufo gargarizans. Chem Eur J. 2010, 16(36):10989-10993.
[55]Zhai QQ, Gong GQ, Luo Y, Wang QD, Xia M, Xing GW, Li YC, Jiang JH, Liu Z, Liu QY, Wang YF*. Determination of SNX-2112, a selective Hsp90 inhibitor in plasma samples by high-performance liquid chromatography and its application to pharmacokinetics in rats. J Pharm Biomed Anal. 2010, 53(4):1048-1052.

主要著作

承担课题

主持的主要科研项目：
1. 国家自然科学基金青年科学基金项目（**），2011-2013
2. 广东省科技计划对外科技合作项目（2013B），2014-2016
3. 广东省自然科学基金面上项目（S94），2012-2014
4. 广东省自然科学基金博士启动项目（005506），2010-2012
5. 广州市珠江科技新星项目（8），2016-2019
6. 广州市科技计划应用基础研究重点项目（12C**），2011-2013
7. 药用资源化学与药物分子工程教育部重点实验室资助课题（CMEMR2015-B08），2015-2018
8. 天然药物及仿生药物国家重点实验室资助课题（K**），2012-2013
9. 暨南大学科研培育与创新基金跃升计划项目（**），2015-2016
10. 暨南大学引进优秀人才科研启动基金（**），2009-2011
入选的人才计划
1.广东省自然科学杰出青年基金获得者（2017）
2.广东特支计划青年拔尖人才（2016）
3.广州市珠江科技新星（2016）
4.“暨南双百英才计划”杰出青年学者（2016）
5.广东省高校“千百十工程”第七批校级培养对象（2012）
6.广东高校优秀青年创新人才培养计划（2010）

发明专利

讲授课程

《基因工程药物》
《细胞信号转导理论与技术》
《高级生物化学》

荣誉奖励

省级青年人才

社会职务

广东省生物医学工程学会常务理事、副秘书长
广东省化妆品学会副理事长、常务副秘书长
广东省化妆品学会原料与天然产物专业委员会主任委员
广东省药学会制药工程专业委员会药食同源专题组副组长