暨南大学生命科学技术学院导师教师师资介绍简介-邢曦雯

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个人信息

姓名：邢曦雯
部门：生命科学技术学院
直属机构：生物工程学系
性别：女
--> 职务：
职称：副研究员
学位：博士
毕业院校：武汉大学
联系电话： **
电子邮箱： @qq.com
办公地址：欢迎同学骚扰，拒绝广告商
通讯地址：
邮编：
传真：
荣誉奖励：

联系方式

个人简介

邢曦雯，博士、副研究员、研究生导师。
主要研究方向为DNA甲基化、酶活性测定、生物反应可视化观测。工作3年来作为项目负责人主持了国家自然科学基金、广东省自然科学基金项目。目前发表文章23篇，申请专利2项。

硕士研究生招生方向：生物工程、化学生物学、生物化学与分子生物学、微生物学、生物医药

学习经历

2010.9 -2015.6武汉大学化学与分子科学学院化学生物学硕博连读
指导老师：周翔教授
2014.9 - 2015.3日本京都大学物质细胞研究所（iCeMS）
指导老师：Hiroshi Sugiyama教授&Masayuki Endo教授
2013.6 - 2014.1武汉大学基础医学部免疫学，交流合作
指导老师：章晓联教授
2011.9 - 2013.6武汉大学化学与分子科学学院分析化学，交流合作
指导老师：冯钰棋教授&袁必峰教授
2006.9 - 2010.6武汉大学化学与分子科学学院化学基地班理学学士

工作经历

2017.3 - 2017.12日本京都大学物质细胞研究所（iCeMS）
Hiroshi Sugiyama教授&Masayuki Endo教授实验室访学
2015.12- 至今暨南大学生科院
2016年暨南大学第四届新任教师教学竞赛二等奖

研究方向

主要论文

Xing X.^#, Feng Y.^#,Yu Z., Liu F., Hidaka K., Sugiyama H.*, Endo M.*. Metalion-induced base pair formation in the nanoscale structure. A European journal. doi: 10.1002/chem..（IF：5.317； A1二区，第一作者，Hot paper，从投稿到online下载，29天周期）
Li W.^#; Liu Y.^#; Wang Y.; Li R.; Trang P.; Tang W.; Yang Z.; Wang Y.; Sun X.; Xing X.*; Lu S.*; Liu F.*. Engineered RNase P Ribozymes Effectively Inhibit the Infection of Murine Cytomegalovirus in Animals. Theranostics, 2018, 8, 5634（IF：8.854；A1一区，共通讯作者，封面文章）
Wang Y.^#; Yang L.; Li N.; Sun C.; Xia Y.; Yuan L.; Lu J.; Liu F.*; Xing X.*.A versatile assay for alkaline phosphatase det4ection based onthymine-HgII-thymine structure generation mediated by TdT. Talanta 10.1016/j.talanta.2018.11.061（IF：4.244；A1二区，通讯作者）
Wang Y.^#, Sun X.^#, Zeng J., Deng M., Li N., Chen Q., Zhu H.,Liu F.*, Xing X.*.Label-free and sensitive detection assay for terminal deoxynucleotidyl transferase viapolyadenosine-coralyne fluorescence enhancement strategyAnalytical Biochemistry,2018, 18, 30613 (IF=2.27, A2三区，通讯作者)
Xing X.W.; Liu F.Y.; Xiao J*; So K.F.*. Neuro-protective Mechanisms of Lycium barbarum. Neuromolecular Med., 2016,18,253 (IF: 3.287，A1二区)
Endo M.*; Xing X.W.; Zhou X.; Emura T.; Hidaka K.; Tuesuwan B.; Sugiyama H.*. Single-Molecule manipulation of the duplex formation and dissociation at the G-quadruplex/i-motif site in the DNA nanostructure. ACS NANO.,2015, 9, 9922. (IF: 13.334，A1一区)
Tang F.^#; Xing X. W.^#; Chu J. M.; Yuan Q.; Zhou X.; Feng YQ. *; Yuan B. F. *. A highly sensitive fluorescence assay for methyltransferase activity by exonuclease-aided signal amplification. Analyst.,2015, 140, 4636 (^#共同一作)(IF: 4.033，A1二区)
Xing X. W.;Tang F.; Wu J.; Chu J. M.; Feng Y. Q.; Zhou X.*; Yuan B. F.*Sensitive detection of DNA methyltransferase activity based on exonuclease-mediated target recycling. Anal. Chem., 2014, 86,11269-11274.(IF: 6.320，A1二区)
Xing X. W.;Liu Y. L.; Vargas M.; Wang Y.; Feng Y. Q.; Zhou X.*; Yuan B. F.*Mutagenic and cytotoxic properties of oxidation products of 5-methylcytosine revealed by next-generation sequencing. PLoS One., 2013, 8, e72993.(IF: 3.534，A2三区)
Chen M. L.^#;Liu Y. L.^#;Xing X. W.^#; Zhou X.; Feng Y. Q.*; Yuan B. F.*Preparation of a hyper-cross-linked polymer monolithic column and its application to the sensitive determination of genomic DNA methylation. Chem-Eur. J., 2013, 19, 1035-1041. (^#共同一作)(IF: 5.696，A1二区)
11. Xing X.^#; Wang X.^#; Xu L.; Tai Y.; Dai L.; Zheng X.; Mao W.; Xu X.; Zhou X.*. Light-driven conformational regulation of human telomeric G-quadruplex DNA in physiological conditions. Org. Biomol. Chem., 2011, 9, 6639-6645. (^#共同一作) (IF: 3.696，A2三区)

?Hu, J.; Chen, Y.; Xu, X.; Wu, F.; Xing, X.; Xu, Z.; Xu, J.; Weng, X.; Zhou, X. Discrimination between 5-hydroxymethylcytosine and 5-methylcytosine in DNA by selective chemical labeling. Bioorg. Med. Chem. Lett. 2014, 24, 294-297.
?Huang, R.; Wang, J.; Mao, W.; Fu, B.; Xing, X.; Guo, G.; Zhou, X. A novel combined bisulfite UDG assay for selective 5-methylcytosine detection. Talanta.2013, 117, 445-448 .
?Hong, T.; Wang, T.; Guo, P.; Xing, X.; Ding, F.; Chen, Y.; Wu, J.; Ma, J.; Wu, F.; Zhou, X. Fluorescent strategy based on cationic conjugated polymer fluorescence resonance energy transfer for the quantification of 5-(hydroxymethyl)cytosine in genomic DNA. Anal. Chem. 2013, 85, 10797-10802.
?Guo, P.; Yan, S.; Hu, J.; Xing, X.; Wang, C.; Xu, X.; Qiu, X.; Ma, W.; Lu, C.; Weng, X.; Zhou, X. Selective detection of 5-formyl-2'-deoxycytidine in DNA using a fluorogenic hydroxylamine reagent. Org. Lett.2013,15, 3266-3269.
?Yuan, L.; Tian, T.; Chen, Y.; Yan, S.; Xing, X.; Zhang, Z.; Zhai, Q.; Xu, L.; Wang, S.; Weng, X.; Yuan, B.; Feng, Y.; Zhou, X. Existence of G-quadruplex structures in promoter region of oncogenes confirmed by G-quadruplex DNA cross-linking strategy. Sci. Rep.2013, 3, 1811.
?Mao, W.; Hu, J.; Hong, T.; Xing, X.; Wang, S.; Chen, X.; Zhou, X. A convenient method for selective detection of 5-hydroxymethylcytosine and 5-formylcytosine sites in DNA sequences. Org. Biomol. Chem.2013, 11, 3568-3572.
?Tang, Y.; Chu, J. M.; Huang, W.; Xiong, J.;Xing, X. W.; Zhou, X.; Feng, Y. Q.; Yuan, B. F. Hydrophilic material for the selective enrichment of 5-hydroxymethylcytosine and its liquid chromatography-tandem mass spectrometry detection. Anal. Chem. 2013, 85, 6129-6135.
?Hu, J.; Xing, X.; Xu, X.; Wu, F.; Guo, P.; Yan, S.; Xu, Z.; Xu, J.; Weng, X.; Zhou, X. Selective chemical labelling of 5-formylcytosine in DNA by fluorescent dyes. Chem-Eur. J.2013, 19,5836-5840.
Wang, T.; Hong, T.; Tang, T.; Zhai, Q.; Xing, X.; Mao, W.; Zheng, X.; Xu, L.; Wu, J.; Weng, X.; Wang, S.; Tian, T.; Yuan, B.; Huang, B.; Zhuang, L.; Zhou, X.Application of N-halogeno-N-sodiobenzene sulfonamide reagents to the selective detection of 5-methylcytosine in DNA sequences. J. Am. Chem. Soc. 2013, 135, 1240-1243.

主要著作

承担课题

1.国家青年基金《HCV解旋酶长路运动行为的分子研究》
2.省青年基金《基于核酸探针的HCV 解旋酶活性及单分子观测》
3.校青年基金《基于纳米材料修饰核酸适配子的策略高灵敏度检测生物样本中的HCV》