暨南大学化学与材料学院导师教师师资介绍简介-徐石海

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个人信息

姓名：徐石海
部门：化学与材料学院
直属机构：实验技术中心
性别：男
--> 职务：主任
职称：教授
学位：博士
毕业院校：中山大学
联系电话： **
电子邮箱： txush@jnu.edu.cn
办公地址：广州市，暨南大学分析测试中心203房
通讯地址：广州市，暨南大学分析测试中心203房
邮编： 510632
传真：
荣誉奖励：国家级青年人才

联系方式

固定电话：
移动电话：**
微信号：xu**
QQ:

个人简介

湖南隆回人，教授，博士，博士生导师。
研究简介
一直从事海洋生物活性成分研究，先后主持国家十五“863”课题“海藻中抗肿瘤和治疗心血管疾病活性化合物的分离与鉴定（No. 2001AA628100,2004AA628030)”和十一五“863”课题 “珊瑚中抗肿瘤活性化合物的分离与结构鉴定（No. 2006AA09Z408））”、国家自然科学基金课题“抗肿瘤海洋生物碱的研究（No. **）”和“Ircinia属海绵中抗肿瘤活化合物的发现与优化（No. **）”和广东省自然科学基金课题、广东省科技计划课题、广东省自然资源厅课题和广州市科技计划课题等二十余项课题，通过这些项目的完成，从海洋生物品种海藻、珊瑚、海绵中分离鉴定从我国南海各种海洋生物品种中分离鉴定1500多种海洋天然产物，其中300余种为首次发现的新化合物，这些化合物的分属于萜类、生物碱、甾醇、神经酰胺、脂肪酸，糖类。对具有自主知识产权的且生物活性较强的4个海洋生物碱、一个二糖酯与一个环肽化合物进行全合成，并进行结构修饰得到100多个修饰化合物。在国内外权威学术期刊，如：Organic Letters，British Journal of Pharmacology，Journal of Natural Products，Steroids，Marine Drugs等期刊上发表学术论文200余篇，申请国内专利20项，授权15项。

学习经历

1993/09-1996/07，中山大学，化学系，博士
1990/09-1993/07，湘潭大学，化学系，硕士
1985/09-1988/06，湖南邵阳学院，化学系，大学

工作经历

研究工作经历
2002/10-现在，暨南大学化学与材料学院，化学系，教授，博士生导师
2008/03-2008/09，美国密西西比大学，药学院生药系做高级访问学者
1998/10-2002/10，暨南大学生命科学与技术学院，化学系，副教授；
1996/07-1998/10，暨南大学理工学院，化学系，讲师

研究方向

1、海洋药物化学的分离:从海藻、珊瑚、海绵等海洋生物及共附生微生物中分离海洋药物活性先导化合物；
2、海洋药物全合成：对具有自主知识产权的活性化合物进行全合成、结构修饰及规模化制备；
3、药物活性筛选、成药性评价及应用：活性化合物进行于化妆品、药物及材料等开发。

主要论文

1、Liang, YongQian; Liao, XiaoJian; Zhao, BingXin* and Xu, Shihai*，Novel 3,4-seco-3,19- dinorspongian and 5,17-epoxy-19-norspongian diterpenes from the marine spongeSpongiasp., Organic Chemistry Frontiers, 2020, 7,3253–3261.
2、Lin, Xiao; Zhou,Yongjun; Liu,Liyun; Zhu, Hongrui;Chen,Yeping;Wang,Shuping; Sun,Fan; Chai, Ling; Liu, Buming; Xu, Shihai* and Hou-Wen Lin*, Compound Discovery and Structure-Activity Relationship Study of Neoantimycins Against Drug-Resistant Cancer Cells, Frontiers in Chemistry, 2019,7（481）,1-10.
3、Jiao, FuRong; Gu, BinBin; Zhu, HongRui; Zhang,Yun; Liu,Ke Chun; Zhang,Wei;Han, Hua *;
Xu, Shihai* and Hou-Wen Lin*, Asperfloketals A and B, the First Two Ergostanes with Rearranged A and D Rings: From the Sponge-Associated Aspergillus flocculosus 16D-1, The Journal of Organic Chemistry,2020,doi.org/10.1021/acs.joc.0c02049
4、Chen, Shengtian; Wang, Junfeng; Lin, Xiuping; Zhao, Bingxin; Wei, Xiaoyi; Li, Guangqiang; Kaliaperumal, Kumaravel; Liao, Shengrong; Yang, Bin; Zhou, Xuefeng; Liu, Juan; Xu, Shihai*; Liu, Yonghong*, Chrysamides A-C, Three Dimeric Nitrophenyl trans-Epoxyamides Produced by the Deep-Sea-Derived Fungus Penicillium chrysogenum SCSIO41001, Organic Letters, 2016, 18(15): 3650-3653.
5、Xu, WenJie; Liao, XiaoJian; Xu, ShiHai*; Diao, JianZhong; Du, Bin; Zhou, XuLong; Pan, Shan-Shan，Isolation, Structure Determination, and Synthesis of Galaxamide, A Rare Cytotoxic Cyclic Pentapeptide from a Marine Algae Galaxaura filamentosa，Organic Letters, 2008, 10(20): 4569-4572.
6、Xiong, Sheng; Pang, Hui-dan，Fan, Jun，Ge, Feng，Yang, Xiaoxia，Liu, Qiuying，Liao, Xiaojian，Xu, Shihai*，In vitro and in vivo antineoplastic activity of a novel bromopyrrole and its potential mechanism of action，British Journal of Pharmacology，2010, 159(4): 909-918.
7、Ding, LiJian; Yuan, Wei; Liao, XiaoJian; Han, BingNan; Wang, ShuPing; Li, ZhiYong; Xu, ShiHai*; Zhang, Wei*; Lin, HouWen*, Oryzamides A-E, Cyclodepsipeptides from the Sponge-Derived Fungus Nigrospora oryzae PF18, Journal of Natural Products,2016, 79(8): 2045-2052.
8、Li, DaiChun; Yang,Yan; Zhang, Bing; Liao, Xiao Jian; Jiang, ZhiHui; Xu, ShiHai*and Zhao, BingXin*, Three New Butenolides from the Green Alga Caulerpa racemosavar. Turbinata，Chem. Biodiversity , 2020, 17, e**，1-6
9、Liu,TingTing; Liao, XiaoJian; Xu, ShiHai*and Zhao, BingXin*, Solieritide A, a new polyketide from the red alga Solieriasp.，Natural Product Research，2020，3，1-7
10、Guana, ZhuoBin; Liang, Yong Qian; Lin, JiaLi; Liao, XiaoJian; Xu, ShiHai*and Zhao, BingXin*, Two new pyrrolidine alkaloids from the red alga Acanthophora spicifera，Natural Product Research，2020,3,1-7
11、Pang, Xiaoyan;Lin, Xiuping; Zhou, Xuefeng;Yang, Bin; Tian, Xinpeng;Wang, Junfeng*；Xu, ShiHai*; Yonghong Li*, New quinoline alkaloid and bisabolane-type sesquiterpenoid derivatives from the deep-sea-derived fungus Aspergillus sp. SCSIO06786，Fitoterapia，2020，104406，（140），1-5
12、Liang, Yong Qian; Liao, Xiao Jian; Lin, Jia Li; Xu, Wei; Chen, Guo Dong*; Zhao, Bing Xin*; Xu, Shi Hai*，Spongiains A-C: Three new spongian diterpenes with ring A rearrangement from the marine sponge Spongiasp.,Tetrahedron, 2019, 75(27): 3802-3808.
13、Pang, Xiaoyan; Cai, Guodi; Lin, Xiuping; Salendra, Limbadri; Zhou, Xuefeng; Yang, Bin; Wang, Junjian; Wang, Junfeng*; Xu, Shihai*; Liu, Yonghong*，New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus Penicillium sp. SCSIO41015 ，Marine Drugs,2019, 17(7): 0-398.
14、Ding, Lijian; Ren, Lu; Li, Shuang; Song, Jingjing; Han, Zhiwen; He, Shan*; Xu, Shihai*, Production of New Antibacterial 4-Hydroxy-alpha-Pyrones by a Marine Fungus Aspergillus niger Cultivated in Solid Medium,Marine Drugs,2019, 17(6): 1-8.
15、Zhang, Jun*; Ling, Wei; Yang, Zhiqiang; Liang, Yan; Zhang, Linyan; Guo, Can; Wang, Kailing; Zhong, Balian; Xu,Shihai*; Xu, Ying*, Isolation and Structure-Activity Relationship of Subergorgic Acid and Synthesis of Its Derivatives as Antifouling Agent，Marine Drugs, 2019, 17(2): 1-11.
16、Lai, Wei; Qin, Sheng Ying; Zou, Ge; Liao, Xiao Jian; Chen, Guo Dong; Zhang, Hua; Zhao, Bing Xin*;Xu, Shi Hai*，Sinulaspirolactam A, a novel aza-spirocyclic valerenane sesquiterpenoid from soft coral Sinulariasp.，Journal of Asian Natural Products Research, 2019, 21(5): 494-501.
17、Sun, Yueguang; Li, Hang bin; Zhou, Rong; Wang, Hailin; Feng, Pengju*; Xu, Shihai*，Total Synthsis of Thermoactionamide andIts Analogue,Heterocycles, 2019, 98(6): 789-797.
18、Lunagariya, Jignesh; Bhadja, Poonam; Zhong, Shenghui; Vekariya, Rohit; Xu, Shihai*，Marine Natural Product Bis-indole Alkaloid Caulerpin: Chemistry and Biology，Mini Reviews in Medicinal Chemistry, 2019, 19(9): 751-761.
19、Ding, Lijian*; Xu, Peng; Li, Te; Liao, Xiaojian; He, Shan*; Xu, Shihai*,Asperfurandiones A and B, two antifungal furandione analogs from a marine-derived fungus Aspergillus versicolor，Natural Product Research,2019, 33(23): 3404-3408.
20、Li, Jing; Wang, Zhuo; Yang, Fan; Jiao, WeiHua; Lin, HouWen*; Xu, ShiHai*，Two new steroids with cytotoxicity from the marine sponge Dactylospongia eleganscollected from the South China Sea，Natural Product Research, 2019, 33(9): 1340-1344.
21、Liang, YongQian; Liao, XiaoJian; Zhao, BingXin*; Xu, ShiHai*，(+ )- and (-)-Spongiterpene, a pair of new valerenane sesquiterpene enantiomers from the marine spongeSpongiaSp.，Natural Product Research, 2019, 16(9): 1-5.
22、Zhang, Hua; Lai,Wei; Guan, ZhuoBin; Liao, XiaoJian; Zhao, BingXin*& Xu, ShiHai*, A newthiodiketopiperzainefromthemarinespongeTedaniasp. ，Natural Product Research，2019.2.1-6
23、Lin,JiaLi; Liang, YongQian; Liao, XiaoJian;Yang,JianTing; Li, Dai-Chun; Huang,YuLing; Jiang, ZhiHui; Xu, ShiHai*& Zhao, BingXin*, AcanthophoraineA, anew pyrrolidine alkaloid fromtheredalgaAcanthophora spicifera，Natural Product Research，2019,4,1-7，
24、Zhou, Rong; Liao, XiaoJian;Li,Hangbin; Li,Jing; Feng,Pengju*; Zhao,Binxin*; Xu, ShiHai*，Isolation and Synthesis of Misszrtine A: A Novel Indole Alkaloid From Marine Sponge-Associated Aspergillus sp. SCSIO XWS03F03，Frontiers in Chemistry, 2018, 6(6): 1-7.
25、Zhang, Jun*;Yang, Zhiqiang; Liang, Yan; Zhong, Liping; Lin, Huiting; Zhong, Balian; Li, Liangchun*; Xu,Shihai*; Liu,Yonghong*，Four New C9 Metabolites from the Sponge-Associated Fungus Gliomastix sp ZSDS1-F7-2，Marine Drugs, 2018, 16(7): 0-231.
26、Zhou, Rong;Sun,Yueguang; Li,Hangbin; Long, Weili; Liao, XiaoJian;Feng,Pengju*; Xu, ShiHai*，Synthesis and Biological Evaluation of Reniochalistatins A–E and a Reniochalistatin E Analogue，ChemMedChem, 2018, 13(9): 2202-2207.
27、Li, Jing; Yang, Fan;Wang, ZhuoWei ; Wang，ShuPing; Zhao，BinXin; Jiao, WeiHua*;Xu, ShiHai*and Lin,HouWen*, Unusualantiinflammatorymeroter- penoidsfrom the marine spongeDactyl ospongiasp.，Org. Biomol. Chem., 2018, 16, 6773 - 6782.
28、Hangbin Li，Xiaojian Liao，Yueguang Sun，Rong Zhou，Weili Long，Le Li，Liuqun Gu*and Shihai Xu*，An Economical Synthesis of Caulerpin and Evaluation of Its New Anticancer Activities，ChemistrySelect，2018,3,12406–12409.
29、Li, Jing; Yang, Fan;Liu, Li; Jiao, WeiHua*;Xu, ShiHai*and Lin, HouWen*，PopolohuanonesG-I, Dimeric Sesquiterpene Quinones with IL-6 Inhibitory Activity from the Marine Sponge Dactylospongia elegans，Chem.Biodiversity, 2018,15,e**,1-7
30、Wang, Ying; Lin, Xiu Ping; Ju, Zhi Ran; Liao, Xiao Jian; Huang, Xiao Jun; Zhang, Chen; Zhao, Bing Xin*; Xu, Shi Hai*, Aspergchromones A and B, two new polyketides from the marine sponge-associated fungus Aspergillus sp SCSIO XWS03F03，Journal of Asian Natural Products Research,2017, 19(7): 684-690.
31、Bai, Defa; Yu, Siming; Zhong, Shenghui; Zhao, Bingxin; Qiu, Shaoling; Chen, Jianwei; Lunagariya, Jignesh; Liao, Xiaojian*; Xu, Shihai*，D-Amino Acid Position Influences the Anticancer Activity of Galaxamide Analogs: An Apoptotic Mechanism Study，International Journal of Molecular Sciences, 2017, 18(3): 0-544.
32、Chen, Shengtian; Wang, Junfeng; Wang, Zhen; Lin, Xiuping; Zhao,Bingxin; Kaliaperumal, Kumaravel; Liao, Xiaojian; Tu,Zhengchao; Li, Jianlin; Xu, Shihai*; Liu, Yonghong*，Structurally diverse secondary metabolites from a deep-sea-derived fungus Penicillium chrysogenum SCSIO 41001 and their biological evaluation，Fitoterapia, 2017, 117: 71-78.
34、Zhang, Jun*; Ip, Fanny C. F.; Liang, Yan; Ip, Nancy Y.; Zhong, BaLian; Lai, ChunWang; Xu, Shihai*，A new iridoid glycoside and a new cinnamoyl glycoside from Scrophularia ningpoensis Hemsl，Natural Product Research, 2017, 31(20): 2361-2368.
35、Zou,Ge; Liao, Xiaojian; Peng,Qi; Chen, GuoDong; Wei,FangYing; Xu, ZhengXiong; Zhao, Bing Xin*and Xu, Shi Hai*, A new α-pyrone fromthe deep-sea actinomycete Nocardiopsis dassonvillei subsp.dassonvilleiDSM43111(T)，Journal of Asian Natural Products Research,2017，15（11），1232-1238.
36、Ju, Zhiran; Qin, Xiaochu; Lin, Xiuping; Wang, Junfeng; Kumaravel Kaliyaperumal; Tian, Yongqi; Liu, Juan ; Liu, Fen; Tu, Zhengchao; Xu, Shi Hai*;Liu, Yonghong*,New phenyl derivatives from endophytic fungus Botryosphaeria sp. SCSIO KcF6 derived of mangrove plant Kandelia candel，Natural Product Research, 2016, 30(2): 192-198.
37、Sun, Huan; Liu, Fen; Feng, Mei-Ran; Peng, Qi; Liao, Xiao-Jian; Liu, Ting-Ting; Zhang, Jun*; Xu, Shi Hai*,Isolation of a new cytotoxic polyhydroxysterol from the South China Sea soft coral Sinulariasp.,Natural Product Research, 2016,30(24): 2819-2824.
38、Ding, Lijian; Yuan, Wei; Peng, Qi; Sun, Huan;Xu, Shi Hai*，Secondary Metabolites Isolated from the Sponge-Associated Fungus Nigrospora oryzae，Chemistry of Natural Compounds, 2016, 52(5): 969-970.
39、Ding, Lijian; Yuan, Wei; Li, Yingxin; Liao, Xiaojian; Sun, Huan; Peng, Qi; Han, Bingnan; Lin, Houwen; Li, Zhiyong*; Yang, Fan*; Xu, Shi Hai*，Hypocrol A, a new tyrosol derivative from a sponge-derived strain of the fungus Hypocrea koningii，Natural Product Research,2016, 30(14): 1633-1638.
40、Lunagariya, Jignesh; Zhong, Shenghui; Chen, Jianwei; Bai, Defa; Bhadja, Poonam; Long, Weili; Liao, Xiaojian*; Tang, Xiaoli*; Xu, Shi Hai*，Design and Synthesis of Analogues of Marine Natural Product Galaxamide, an N-methylated Cyclic Pentapeptide, as Potential Anti-Tumor Agent in Vitro，Marine Drugs,2016, 14(9): 0-161.
41、Peng, Qi; Liu, Fen; Sun, Huan; Liao, XiaoJian; Feng, MeiRan; Liu, TingTing; Xu, ZhengXiong; Zhang, Jun*;Xu, Shi Hai*，A new sesquiterpene from the gorgonian coral Menella sp.，Natural Product Research, 2016, 30(20): 2299-2304.

主要著作

承担课题

主持国家级科研项目：
1、国家自然基金面上项目，**，海藻中抗污损活性物质研究，2017/01-2020/12
，65万元，在研，主持
2、国家自然基金面上项目，**，海绵中抗海洋污损生物的代谢产物研究，2019/01-2022/12，62万元，在研，主持
3、国家自然基金面上项目，**，珊瑚中抗污损活性物质研究，2014/01-2017/12，82万元，在研，主持
4、国家自然基金面上项目，**，南海海绵共附微生物中活性先导化合物发现，
2012/01-2015/12,65万元，已结题，主持
5、国家自然基金面上项目，**，Ircinia属海绵中抗肿瘤活性化合物的发现与
优化，2008/01-2010/12,28万元，已结题，主持
6、国家自然基金面上项目，**，抗肿瘤海洋生物碱研究，2001/01-2003/12,16
万元，已结题，主持
7、国家“十四五”重点研发项目，2018YFC**，深海动植物药物先导化合物高效挖掘与候选药物成药性研究,总经费2367万元，子课题：抗胶质瘤候选药物环五肽GL712的系统成药性评价,2018YFC**, 2018,09-2021,09，经费150万元/2367万元，在研，主持；
8、国家“十三五”海洋“863”重点研发项目，海洋生物功能天然产物的发掘、优化与合成，远海大型生物全新天然产物的发现与药物先导化合物优化；54万元/1001万元
9、科技部863计划，2001AA628100，海藻中抗肿瘤和治疗心血管疾病活性化合物的分
离与鉴定，35万元，2002/01-2004/12，已结题，主持
10、科技部863计划，**Z408，珊瑚中抗肿瘤活性化合物的分离与结构鉴定，80
万元，2006/12-2009/11，已结题，主持

发明专利

1、徐石海; 钟生辉; 白德发; 陈建维，一种环五肽合成方法，2016-10-02, 中国, ZL 27.2.
2、龙伟立，李杭斌，徐石海*，赵冰心，一种简易高效合成蕨藻红素的方法，2019-09-17，中国, ZL 8.9.
3、李杭斌，龙伟立，徐石海*，一种简单合成蕨藻红素的方法，2019-09-17，中国, ZL 4.8.
4、周荣，徐石海*，一种活性环八肽Reniochalistatin E及其类似物的合成方法，2019-05-08, 中国,ZL6.9.
5、周荣，徐石海*，冯鹏举，廖小建，赵冰心，一种活性生物碱Misszrtlide的合成方法，2019-09-17，中国,ZL 9.6.
6、孙月光，李杭斌，徐石海*，一种抗菌活性环六肽Thermoactinoamide A 的合成方法，2020-09-04，中国,ZL7.6.
7、周荣，孙月光，徐石海*，廖小建，一类广泛活性环七肽Reniochalistatin A-D的合成方法，2020-12-15，中国,ZL 0.5.

讲授课程

本科：《有机化学》，《有机化学实验》
硕士研究生：《天然产物化学》，《有机波谱学》
博士研究生：《化学方法导论》一个章节

荣誉奖励

国家级青年人才

社会职务

1、中国家药学会海洋药物专业委员会理事
2、中国生物化学与分子生物学会海洋生物化学与分子生物学分会理事
3、广东省化学化工学会有机化学专业委员会理事
4、广东省高等学校实验教学指导委员会副主任委员
5、广东省实验室安全委员会专家组组长
6、《实验室研究与探索》、《实验技术与管理》编委
7、国家自然基金通讯评审专家
8、广东省、福建省、江西省、河北省、江苏省等科技项目评审专家
9、暨南大学分析测试中心主任
10、广东海洋协会副会长