---

个人介绍
职称：教授
研究方向：经典名方个性化防治抑郁症，痴呆机制与转化
电子邮箱：hdn_2001********，hdn_2001**********
脑病个性化防治跨学科研究所所长，博士生导师。美国罗格斯大学心理学博士。近年来在以越鞠丸好忘方等经典名方优势性抗抑郁抗痴呆研究取得重要进展，主持多项国家及省级重点课题，一作/通讯作者发表中文期刊与SCI论文各40篇，海外学术会议主持或报告10余场。任中国生理学会中医药与脑稳态调控专委会创会主任委员，中华中医药学会中基分会常务理事，国际脑与行为遗传学会常务理事等。曾获省****，省双创团队领军人才等称号。

---

科研成果

---

①代表性课题：
2019-2022 国家自然科学基金面上项目（动物模型）“基于抑郁症和气虚证应激共易感性的病证结合动物模型研究”81万
2017-2019 江苏双创团队项目主持人 300万
2017-2020 国家自然科学基金委面上项目“PACAP-CREB 信号通路的越鞠丸快速抗抑郁机制研究”60万
②代表性论文：
1. Tang J, Lu L, Wang Q, Liu H, Xue W, Zhou T, Xu L, Wang K, Wu D, Wei F, Tao W, Chen G*. Crocin Reverses Depression-Like Behavior in Parkinson Disease Mice via VTA-mPFC Pathway. Mol Neurobiol. 2020 Jul;57(7):3158-3170.
2. Huang Z, Chen J, Tang J, Xue W, Tao W, Wu H, Wang D, Chen G*. 2019 Involvement of NMDA-AKT-mTOR Signaling in Rapid Antidepressant-Like Activity of Chaihu-jia-Longgu-Muli-tang on Olfactory Bulbectomized Mice. Wang X, Zou Z, Shen Q, Front Pharmacol. 2019;9:1537.
3.Chen G*, Xue WD, Zhu J 2018 Full genetic analysis for genome-wide association study of Fangji: a powerful approach for effectively dissecting the molecular architecture of personalized traditional Chinese medicine. Acta Pharmacol Sin. 2018 Feb 8. doi: 10.1038/aps.2017.137
4. Wu R,Zhang H,Xue W, Zou ZL, Lu C, Xia B,Wang W,Chen G* 2016 Transgenerational impairment of hippocampal Akt-mTOR signaling and behavioral deficits in the offspring of mice that experience postpartum depression-like illness. Prog Neuropsychopharmacol Biol Psychiatry. 28;73:11-18
5.Ren L,TaoW, Zhang H, Xue W, Tang J, Wu R, Xia B, Wu H,Chen G*. 2016 Two Standardized Fractions of Gardenia jasminoides Ellis with Rapid Antidepressant Effects Are Differentially Associated with BDNF Up-regulation in the Hippocampus. J Ethnopharmacol. 2016
6.Xue W, Wang W, Gong T, Zhang H, Tao WW, Xue l, Sun Y, Wu H, Wang F, Chen G* 2016 PKA-CREB-BDNF signaling regulated long lasting antidepressant activities of Yueju but not ketamine. Sci Rep 2016，26331
7.Tang J, Xue W, Xia B, Ren L, Tao W, Chen C, Zhang H, Wu R, Wang Q, Wu H, Duan J, Chen G*. 2015 Involvement of normalized NMDA receptor and mTOR-related signaling in rapid antidepressant effects of Yueju and ketamine on chronically stressed mice. Sci Rep. 2015 28;5:13573.
8.Wu R, Zhu D, Xia Y, Wang H, Tao W, Xue W, Xia B, Ren L, Zhou X, Li G, Chen G*. 2015 A role of Yueju in fast-onset antidepressant action on major depressive disorder and serum BDNF expression: a randomly double-blind, fluoxetine-adjunct, placebo-controlled, pilot clinical study. Neuropsychiatr Dis Treat. 2015;11:2013-21.
9.Xue W, Zhou X, Yi N, Jiang L, Tao W, Wu R, Wang D, Jiang J, Ge X, Wang Y, Wu H, Chen G*. 2013. Yueju pill rapidly induces antidepressant-like effects and acutely enhances BDNF expression in mouse brain. Evidence-Based Complementary and Alternative Medicine. 2013:184367
10.王省，陈刚，试论枢转少阳与快速抗抑郁，中医杂志，2017年第58卷第2期：174-176
11.王旭东,乔明琦,张樟进,陈刚,陈家旭,图娅.中医药治疗抑郁症的研究进展.南京中医药大学学报,2016,32(1):93-96.
12.陈茵,邹之璐,何骁隽,周欣,黄志恒,李筱琪,李文佳,张煜萱,陈刚.抑郁症气虚证候模型小鼠的药物反证与分子信号研究[J].南京中医药大学学报, 2018, 34(02): 147-151

---

获奖及荣誉

---

1、江苏省****
2、江苏省双创人才
3、江苏省双创团队领军人才
4、江苏省中医药领军人才

---

学术兼职

---

1、中国生理学会中医药与脑稳态调控专委会主任委员；
2、中国生理学会理事；
3、中华中医药学会中医基础理论分会常务理事；
4、世界中医药联合会李时珍医药应用与研究专业委员会常务理事；
5、世界中医药联合会信神医学专业委员会常务理事
6、国际行为和神经遗传学会（IBANGs）常务理事（Member-at-large）；
7、粤港澳脑病中医药产学研创新技术联盟发起人

---