葛远龙, 博士
暨南大学，衰老与再生医学研究院，副研究员、专硕导师
出生年月：1985.8 籍 贯：江苏省连云港市
手 机：159 1436 6996 邮 箱：geyuanlong @jnu.edu.com

学习工作经历：
2019.8-至今 暨南大学，衰老与再生医学研究院，副研究员
2016.7-2019.7 中山大学，生命科学学院，特聘副研究员
2012.9-2016.7 中山大学，中山医学院，博士
2008.9-2012.7 清华大学, 生命科学学院，硕士
2003.9-2007.7 中国农业大学，生物学院，学士

研究方向：
1、肿瘤细胞中端粒长度维持的分子机制研究；探索以端粒维持机制为靶标的肿瘤治疗策略。
2、端粒、端粒酶在体细胞衰老中的作用机制；筛选具有延缓细胞衰老作用的小分子化合物。

承担课题：
1、暨南大学跃升计划项目，**，端粒酶RNA TERC在血管内皮细胞衰老及血管疾病中的作用研究，2020/01-2021/12，8万元，在研，主持。
2、国家自然科学基金青年科学基金项目，**，p53在ALT肿瘤细胞DNA损伤耐受中的机制研究，2018/01-2020/12，20万元，在研，主持。
3、中山大学青年教师培育项目，171gpy97 ，T淋巴细胞端粒DNA损伤应答机制研究，2017/01-2019/06, 15万元，已结题，主持。

发明专利：
1、赵勇，葛远龙，伍姝。“P53转录抑制剂 PFTα HBr在制备抗端粒酶阴性p53阳性肿瘤药物中的应用”。发明专利。公开(公告)号：CNA。

第一作者论文：
1、Shu Wu^#, Yuanlong Ge^#, Xiaocui Li, Yiding Yang, Haoxian Zhou, Kaixuan Lin, Zepeng Zhang, and Yong Zhao* (2020). BRM-SWI/SNF Chromatin Remodeling Complex Enables Functional Telomeres by Promoting Co-expression of TRF2 and TRF1. PLOS Genetics. 16(6): e**.（二区，TOP）
2. Yuanlong Ge^#, Shu Wu#, Zepeng Zhang, Xiaocui Li, Feng Li, Siyu Yan, Haiying Liu, Junjiu Huang, Yong Zhao. (2019) Inhibition of p53 and/or AKT as a New Therapeutic Approach Specifically Targeting ALT Cancers. Protein & cell 10 (11), 808-824.（一区，TOP）封面文章
3. Zepeng Zhang#, Tianpeng Zhang#, Yuanlong Ge^#, Mengfan Tang, Wenbin Ma, Qinfen Zhang, Shengzhao Gong, Woodring E. Wright, Jerry Shay, Haiying Liu#, Yong Zhao. (2019). 2D gel electrophoresis reveals dynamics of t-loop formation during the cell cycle and t-loop in maintenance regulated by heterochromatin state. Journal of Biological Chemistry. 294(16): p. 6645-6656. （二区）
4. Juanhong Liu#, Yuanlong Ge^#, Shu Wu, Delin Ma, Weijie Xu, Ye Zhang, Yan Yang. (2019). Association between Antidiabetic Agents Use and Leukocyte Telomere Shortening Rates in Patients with Type 2 Diabetes. Aging 11, 741-755. （二区）
5. Yuanlong Ge#, Shu Wu#, Yong Xue, Jun Tao, Feng Li, Yanlian Chen, Haiying Liu, Wenbin Ma, Junjiu Huang, and Yong Zhao. (2016). Preferential extension of short telomeres induced by low extracellular pH. Nucleic Acids Research, 44, 8086-8096. （一区，TOP）
6. Shu Wu#, Yuanlong Ge^#, Laiqiang Huang, Haiying Liu, Yong Xue, and Yong Zhao. (2014). BRG1, the ATPase Subunit of SWI/SNF Chromatin Remodeling Complex, Interacts with HDAC2 to Modulate Telomerase Expression in Human Cancer Cells. Cell Cycle, 13(18): 2869-2878. （三区）

非一作论文：
1、Xin Nie, Danqing Xiao, Yuanlong Ge, Yujie Xie, Haoxian Zhou, Tian Zheng, Xiaocui Li, Haiying Liu, Hui Huang, Yong Zhao. (2021). TRF2 recruits nucleolar protein TCOF1 to coordinate telomere transcription and replication. Cell Death & Differentiation, 28, 1062–1075.
2、Zhouli Cheng, Mengli Zhang, Huaipeng Lin, Chao Gao, Junbin Song, Zhihong Zheng, Linpeng Li, Yanan Zhang, Xiaoqi Shen, Hao Zhang, Zhenghui Huang, Wuqiang Zhan, Cheng Zhang, Xu Hu, Yi-Ping Sun, Lubing Jiang, Lei Sun, Yanhui Xu, Chen Yang, Yuanlong Ge, Yong Zhao, Xingguo Liu, Hui Yang, Pengyuan Liu, Xing Guo, Kunliang Guan, Yue Xiong, Mingliang Zhang, Dan Ye. (2020). The Zscan4-Tet2 Transcription Nexus Regulates Metabolic Rewiring and Enhances Proteostasis to Promote Reprogramming. Cell Reports, 32(2), 2211-1247.
3. Haiying Liu, Yiding Yang, Yuanlong Ge, Juanhong Liu, Yong Zhao. (2019). TERC promotes cellular inflammatory response independent of telomerase. Nucleic Acids Research, 47(15), 8084-8095.
4. Feng Li, Yuanlong Ge, Dan Liu, Zhou Songyang. (2019). The Role of Telomere-Binding Modulators in Pluripotent Stem Cells. Protein Cell 11, 60–70.
5. Qian Hu, Yujie Xie, Yuanlong Ge, Xin Nie, Haiying Liu, and Yong Zhao. (2018). Resting T Cells are Hypersensitive to DNA Damage Due to Defective DNA Repair Pathway. Cell Death and Disease, 9(6): 662.
6. Feng Li, Kim Hyeung, Zhejian Ji, Tianpeng Zhang, Bohong Chen, Yuanlong Ge, Yang Hu, Xuyang Feng, Xin Han, Huimin Xu, Youwei Zhang, Hongtao Yu, Dan Liu, Wenbin Ma, and Songyang Zhou. (2018). The BUB3-BUB1 Complex Promotes Telomere DNA Replication. Molecular Cell 70, 395-407.e394.
7. Haiying Liu #, Qianqian Liu#, Yuanlong Ge, Qi Zhao, Xiaohui Zheng, and Yong Zhao. (2016). hTERT promotes cell adhesion and migration independent of telomerase activity. Scientific Reports, 6(22886).
8. Huiyun Liu, Qi Zhao, Tianpeng Zhang, Yue Wu, Yunxia Xiong, Shike Wang, Yuanlong Ge, Jinhui He, Peng Lv, Tianmiao Ou, Jiaheng Tan, Ding Li, Lianquan Gu, Jian Ren, Yong Zhao, and Zhishu Huang. (2016). Conformation Selective Antibody Enables Genome Profiling and Leads to Discovery of Parallel G-Quadruplex in Human Telomeres. Cell Chemical Biology 23, 1261-1270.