地址：广东省广州市天河区黄埔大道西601号暨南大学梁仲景楼七楼
邮编：510632
电话：
邮箱：zhangqw@jnu.edu.cn
ResearchGate: https://www.researchgate.net/profile/Qiwei_Zhang_Kevin
GoogleScholar:https://scholar.google.com/citations?user=aV89laYAAAAJ
一、个人经历
1.学习经历
2002.09-2007.06: 武汉大学病毒学国家重点实验室，病毒学 博士
1998.09-2002.06: 武汉大学生命科学学院，微生物学 本科
2.工作经历
2020.05-至今：暨南大学病原微生物研究院（广东省病毒学重点实验室），高层次引进人才，教授，博士生导师，党支部书记
2016.12-2020.04：南方医科大学公共卫生学院，教授
2010.11-2016.12：南方医科大学公共卫生学院，副教授
2015.09-2016.09：哈佛大学医学院，访问****
2015.10-2016.09：广东省南山医药创新研究院，特聘研究员
2008.08-2010.10：香港大学李嘉诚医学院，微生物系 博士后
2007.08-2008.07：香港大学李嘉诚医学院，微生物系 研究助理
二、个人简介
张其威，暨南大学病原微生物研究院/广东省病毒学重点实验室教授、博士生导师，广东省南山医药创新研究院特聘研究员，武汉大学微生物学学士、病毒学国家重点实验室博士，哈佛大学医学院访问****、香港大学医学院微生物系博士后、广东特支计划“青年拔尖人才”、广东省高校优秀青年教师、广州市珠江科技新星，主要研究方向包括呼吸道病毒的基因组学、流行病学、腺病毒载体、疫苗、抗病毒药物；在呼吸道腺病毒的基础和应用基础研究方向取得了一定成果，推动了我国呼吸道腺病毒研究的快速发展。承担国家重点研发计划、国家自然科学基金项目多项；在《New England Journal of Medicine》《EmergingInfectiousDiseases》《Journal ofVirology》《Vaccine》《EmergingMicrobesandInfections》《Frontiers in Immunology》等国际学术刊物上发表40多篇研究论文，引用2000多次；申请发明专利多项。现担任中国微生物学会医学微生物学与免疫学专委会、病毒学专委会的青年委员，NCBI人类腺病毒研究组委员，广东省精准医学应用学会免疫治疗分会委员，广东省遗传学会青年委员，2020年广东省战“疫”专家组成员，中国腺病毒研究协作组发起人；担任第13届国际腺病毒大会分会主持人，第四届全国病毒学青年****学术研讨会共同主席，首届全国腺病毒学术研讨会大会共同主席，青年****和国家自然科学基金评审专家；《Virologica Sinica》、《Frontiers in Microbiology》Editor，国家大学生创新创业训练项目指导教师、广东省“攀登计划”大学生科技创新项目指导教师。
招聘病毒学、流行病学、分子生物学、疫苗学、药学等研究方向的博士生、博士后多名，有意者随时联系。
研究方向：腺病毒基因组学、流行病学、新载体、抗病毒药物、疫苗：
（1）利用新策略开发有效特异的抗腺病毒药物和疫苗、建立优化动物感染和致病模型。
（2）鉴定发现新的腺病毒种类、腺病毒基因组重组机制研究
（3）动物腺病毒的跨种传播机制、腺病毒种属特异性机制的研究；
（4）新型动物腺病毒载体的研发；
（5）腺病毒为载体的新冠病毒疫苗研究
My research interests are the genomics, epidemiology, novel vectors, antivirals and vaccines for human adenoviruses (AdVs) and other respiratory viruses, such as novel coronaviruses, influenza viruses, etc.
1. Recently, more and more human acute respiratory disease outbreaks caused by AdV have emerged in schools, families and military. We are developing effective antiviral drugs and vaccine candidates using new strategies and optimal animal models.
2. Analysis of whole-genome sequences for these emergent AdVs and identification of the homologous recombination and transmission mechanism during adenovirus evolution.
3. The cross-species transmission (CST) of animal AdVs is a potential threat to human health and animal adenovirus vector development. The study of CST of AdVs in simians provides a scientific basis for the prevention and control of adenovirus diseases as well as for the novel simian AdV vector development.
4. Development of novel adenovirus vector-based coronavirus vaccines and coronavirus VLP vaccines.
三、主持的科研项目
1.国家重点研发计划：国际新发病毒变异变迁规律及靶点模型研究（2018YFE**）,
2.广东省自然科学基金面上项目：“广谱抗人呼吸道腺病毒RNAi药物的研究” 2021-2023，
3.国家自然科学基金面上项目：“人腺病毒免疫抑制小鼠感染模型的建立及其致病机制的研究”（**）
4. 国家自然科学基金面上项目：“我国新发现的14、55型腺病毒的生物学特性与基因组重组机制的研究”（**）
5.国家自然科学青年基金：“人3型、7型腺病毒双价减毒重组疫苗候选株的构建及免疫原性研究”（**）
6.广东省自然科学基金团队项目，子课题负责人：HIV潜伏激活的分子机制与新型靶向性潜伏激活剂的研究
7.广东省高等学校优秀青年教师培养计划（Yq**）
8.广东特支计划“青年拔尖人才”，2014
9.广州市珠江科技新星专项：“我国常见的人3、4、7型呼吸道腺病毒疫苗的基础研究”（2013J**）
10.广州市健康医疗协同创新重大专项“病毒感染重症救治的特异性被动免疫应用研究及腺病毒单克隆抗体药物研发”(4)子课题
11.广州市健康医疗协同创新重大专项“呼吸道重要传染病疫苗的制备及临床研究”(7)子课题
12.广州市健康医疗协同创新重大专项“呼吸道新发突发及重大传染病综合防诊治”方向三：“腺病毒流行病学特征研究”
13.广东省自然科学基金自由申请项目：“人3、4、7型腺病毒三价减毒重组疫苗候选株的构建及免疫原性研究”（S61）
14.香港大学博士后基金:Construction and Characterization of a Full-Length Infectious Molecular Clone from the HIV Type 1 CRF08_BC Isolated in China

四、发明专利
1. 《一种人3型腺病毒复制缺陷型重组病毒、构建方法及应用》，专利：3.9
2. 《一种检测扎伊尔型埃博拉病毒的荧光定量PCR试剂盒》，专利：CN5.4
3. 《人呼吸道合胞病毒荧光定量PCR试剂盒及其检测方法》，专利：ZL2.7
4. 《一种同时检测靶基因序列及已知点突变的新技术》，专利：CN5.1
5. 《人工改造的缺陷型人3型腺病毒的应用》，专利：7.0
6 《一种复制缺陷的人3型腺病毒疫苗》，专利：CN4.3

五、著作专著
美国微生物学会《Clinical Virology》的中文版（第26章“腺病毒”），科学出版社，2012年出版.
六、荣誉奖励
1. 广东特支计划“百千万工程青年拔尖人才”(2015)
2. 广东省高校优秀青年教师(2014)
3. 广州市珠江科技新星(2013)
4. 广东省千百十工程培养对象(2012)
5. 武汉市科学技术成果奖(2004)
6. 广东省大学生预防医学技能大赛二等奖(指导教师)（2017）
7. 广东省“攀登计划”大学生科技创新自然科学类资助项目(指导教师)（2017）
8. 国家级/省级大学生创新创业训练计划项目指导教师（2011-2019）
七、学术兼职
1.中国微生物学会病毒学专业委员会：青年委员（2013-2018）
2. 中国微生物学会医学微生物学与免疫学专委会：青年委员（2015-2021）
3.广东省遗传学会青年委员（2018-2023）
4.广东省精准医学应用学会免疫治疗分会委员（2018-2023）
5.广东省南山医药创新研究院特聘研究员(2015)
6.国家自然科学基金评审专家(2012)
7.青年****评审专家(2018)
8.国际腺病毒大会学术委员会委员(2018)
9.第13届国际腺病毒大会分会主持人（2018）
10.NCBI人类腺病毒研究组委员、亚洲代表(2011-)
11.中国腺病毒研究协作组：发起人、负责人（2019）
12.“首届全国腺病毒学术研讨会” 大会共同主席（2019）
13.“第四届全国病毒学青年****学术研讨会”大会共同主席（2020）
14.广东省突发事件应急管理专家组专家（2019）
15. 教育部学位与研究生教育论文评审专家(2019)
16.2020年广东省战“疫”专家组成员(2020)
17.《Frontiers in Microbiology》ResearchTopicEditor（2018-）
18.《VirologicaSinica》Editor（2019-）
19. 论文审稿人：Lancet Infectious Diseases, Emerging Infectious Diseases, Cladistics,Virulence,AntiviralResearch，AntiviralTherapy,Vaccine, Viruses, Clinical Epidemiology, International Journal of Biological Sciences, Journal of Medical Virology, Viral Immunology，Cell & Bioscience, Frontiers in Cellular and Infection Microbiology, Frontiers in Microbiology, Virologica Sinica, Microbiology and Immunology, Scientific Reports, PLoS ONE, Jornal de Pediatria, BMC Res Notes, Process Biochemistry, BMJ OPEN, 病毒学报，etc.
八、学术论文（*通讯作者）

1. Qiwei Zhang*, Donald Seto. Chimpanzee Adenovirus Vector Ebola Vaccine--Preliminary Report. New England Journal of Medicine. 2015, 373(8): 775-776. (医学一区，Top期刊，IF: 72.406)http://www.fimmu.com/info/1139/1400.htm
2. Shuping Jing#, Jing Zhang#, Mengchan Cao, Minhong Liu, Yuqian Yan, Shan Zhao, Na Cao, Junxian Ou, Kui Ma, Xiangran Cai, Jianguo Wu, Ya-Fang Mei, and Qiwei Zhang*. Household Transmission of Human Adenovirus Type 55 in Case of Fatal Acute Respiratory Disease. Emerging Infectious Diseases. 2019, 25(9): 1754-1756 (医学一区，Top期刊，IF: 7.422)http://blog.sciencenet.cn/home.php?mod=space&uid=51164&do=blog&id=**
3. Jing Zhao, Shan Zhao, Junxian Ou, Jing Zhang, Wendong Lan, Wenyi Guan, Xiaowei Wu, Yuqian Yan, Wei Zhao, Jianguo Wu, James Chodosh and Qiwei Zhang*.COVID-19: Coronavirus Vaccine Development Updates. Frontiers in Immunology. 2020, 11(3435): 602256. （医学二区，Top期刊：IF 5.085）http://mrw.so/5VXG6N
4. Zhonghua Zhou, Ziyi Yang, Junxian Ou, Hong Zhang, Qiwei Zhang*, Ming Dong* and Gong Zhang*. Temperature Dependence of the SARS-CoV-2 affinity to human ACE2 determines COVID-19 progression and clinical outcome. Computational and Structural Biotechnology Journal. 2020，（生物学二区，IF：6.018）
http://digitalpaper.stdaily.com/http_www.kjrb.com/kjrb/html/2021-01/06/content_460576.htm?div=-1
http://stdaily.com/index/kejixinwen/2020-12/28/content_**.shtml
https://enapp.chinadaily.com.cn/a/202101/06/AP5ff5600da310f03332f92bf0.html
5.Wenyi Guan, Wendong Lan, Jing Zhang, Shan Zhao, Junxian Ou, Xiaowei Wu, Yuqian Yan, Jianguo Wu and Qiwei Zhang*. COVID-19: Antiviral Agents, Antibody Development and Traditional Chinese Medicine. Virologica Sinica. 2020: 10.1007/s12250-12020-00297-12250.（医学二区，IF：3.242）http://m6z.cn/6rP9o7
6.Qiwei Zhang*, Shuping Jing, Zetao Cheng, Zhiwu Yu, Shoaleh Dehghan, Amirhossein Shamsaddini, Yuqian Yan, Min Li, and Donald Seto*. Comparative Genomic Analysis of Two Emergent Human Adenovirus Type 14 Respiratory Pathogen Isolates in China Reveals Similar yet Divergent Genomes. Emerging Microbes & Infections, 2017, 6, e93; doi:10.1038/emi.2017.78. (医学二区，IF: 6.212)
7. Hongying Fan, Zhenhui Chen, Ruqin Lin, Yangyang Liu, Xianbo Wu, Santhosh Puthiyakunnon, Ye Wang, Bo Zhu, Qiwei Zhang*, Yang Bai* and Fachao Zhi*. Bacteroides fragilis Strain ZY-312 Defense against Cronobacter sakazakii-Induced Necrotizing Enterocolitis In Vitro and in a Neonatal Rat Model. mSystems. 2019,4(4): e00305-00319. （医学二区，IF:6.633）
8. Qiwei Zhang*,Seto D, Zhao S, Zhu L, Zhao W, Wan C*. Genome Sequence of the First Human Adenovirus Type 14 Isolated in China. Journal of Virology, 2012, 86(12): 7019-7020（医学二区，Top期刊，IF:4.663）

9. Qiwei Zhang*, Donald Seto, Bin Cao, Suhui Zhao, and Chengsong Wan*. Genome Sequence of Human Adenovirus Type 55, a Re-Emergent Acute Respiratory Disease Pathogen in China. Journal of Virology, 2012，86(22)：12441-12442（医学二区，Top期刊，IF:4.663）
10. Donald Seto, Chodosh J, Brister JR, Jones MS, Members of the Adenovirus Research Community (Qi-Wei Zhang et al).Using the Whole-Genome Sequence To Characterize and Name Human Adenoviruses. Journal of Virology, 2011, 85(11): 5701-5702. （医学二区，Top期刊，IF: 4.663）.
11. Yuqian Yan, Junxian Ou, Shan Zhao, Kui Ma, Wendong Lan, Wenyi Guan, Xiaowei Wu, Jing Zhang, Bao Zhang, Wei Zhao, Chengsong Wan, Weifeng Shi, Jianguo Wu, Donald Seto, Zhiwu Yu* and Qiwei Zhang*. Characterization of Influenza A and B Viruses Circulating in Southern China During the 2017–2018 Season. Frontiers in Microbiology. 2020,11(1079): 10.3389/fmicb.2020.01079.（生物学二区，Top期刊，IF: 4.259）
12. Zetao Cheng#, Yuqian Yan#, Shuping Jing, Wen-Gang Li, Wei-Wei Chen, Jing Zhang, Min Li, Shan Zhao, Na Cao, Junxian Ou, Suhui Zhao, Xianbo Wu*, Bin Cao*, Qiwei Zhang*. Comparative Genomic Analysis of Re-emergent Human Adenovirus Type 55 Pathogens Associated With Adult Severe Community-Acquired Pneumonia Reveals Conserved Genomes and Capsid Proteins.Frontiers in Microbiology,2018, 9(1180). （生物学二区，Top期刊，IF: 4.259）https://mp.weixin.qq.com/s/B-dq-f59FgNvsJlHzKOiXQ
13.Jing Zhang, June Kang, Shoaleh Dehghan, Siddharth Sridhar, Susanna Lau, Junxian Ou, Patrick Woo, Qiwei Zhang*, Donald Seto*. A Survey of Recent Adenoviral Respiratory Pathogens in Hong Kong Reveals Emergent and Recombinant Human Adenovirus Type 4 (HAdV-E4) Circulating in Civilian Populations.Viruses,2019, 11(2):129. （医学二区，IF：3.816）http://m6z.cn/5B0s7B
14. Haibin Pan, Yuqian Yan, Jing Zhang, Shan Zhao, Liqiang Feng, Junxian Ou, Na Cao, Min Li, Wei Zhao, Chengsong Wan, Ashrafali M Ismail, Jaya Rajaiya, James Chodosh, Qiwei Zhang*. Rapid Construction of a Replication-Competent Infectious Clone of Human Adenovirus Type 14 by Gibson Assembly.Viruses, 2018, 10(10):568. （医学二区，IF：3.816）https://www.sohu.com/a/_749000
15. Qiwei Zhang, Su X, Seto D, Zheng B-j, Tian X, Sheng H, Li H, Wang Y, Zhou R*. Construction and characterization of a replication-competent human adenovirus type 3-based vector as a live-vaccine candidate and a viral delivery vector. Vaccine, 2009, 27(8): 1145-1153. (医学二区，Top期刊，IF:3.485)
16. Yuqian Yan, Shuping Jing, Liqiang Feng, Jing Zhang, Zhiwei Zeng, Min Li, Shan Zhao, Junxian Ou, Wendong Lan, Wenyi Guan, Xiaowei Wu, Jianguo Wu, Donald Seto and Qiwei Zhang*. Construction and Characterization of a Novel Recombinant Attenuated and Replication-Deficient Candidate Human Adenovirus Type 3 Vaccine: “Adenovirus Vaccine Within an Adenovirus Vector”. Virologica Sinica. 2020: 10.1007/s12250-12020-00234-12251.（医学二区，IF：3.242）https://mp.weixin.qq.com/s/H0hsYKmfJSiMPlzEIF1_IQ
17. Qiwei Zhang, Su X, Gong S, Zeng Q, Zhu B, Wu Z, Peng T, Zhang C, Zhou R. Comparative genomic analysis of two strains of human adenovirus type 3 isolated from children with acute respiratory infection in southern China. Journal of General Virology2006, 87(6): 1531-1541. (IF:3.529)
18. Qiwei Zhang*, Shoaleh Dehghan, Donald Seto. Pitfalls of restriction enzyme analysis in identifying, characterizing, typing, and naming viral pathogens in the era of whole genome data, as illustrated by HAdV type 55. Virologica Sinica, 2016, 31(5):448-453. 医学二区，IF：3.242）
19. Guiyuan Han, Hongling Niu, Suhui Zhao, Bing Zhu, Changbing, Wang, Yungang Liu, Mingjie Zhang, Shu Yang, Feitong Liu, Chengsong Wan, Qiwei Zhang*. Identification and typing of respiratory adenoviruses in Guangzhou, Southern China using a rapid and simple method. Virologica Sinica,2013, 28(2):103-108. 医学二区，IF：3.242）
20. Zhiwu Yu, Zhiwei Zeng, Jing Zhang, Yuxian Pan, Manjun Chen, Yonghui Guo, Nan Yu, James Chodosh, Ning Fu, Xiaoyan Che & Qiwei Zhang*. Fatal Community-acquired Pneumonia in Children Caused by Re-emergent Human Adenovirus 7d Associated with Higher Severity of Illness and Fatality Rate. Scientific Reports, 2016, 6:37216. （IF: 4.259）
21. Suhui Zhao, Chengsong Wan, Changwen Ke, Jason Seto, Shoaleh Dehghan, Lirong Zou, Jie Zhou, Zetao Cheng, Shuping Jing, Zhiwei Zeng, Jing Zhang, Xuan Wan, Xianbo Wu, Wei Zhao, Li Zhu, Donald Seto*, Qiwei Zhang*. Re-emergent Human Adenovirus Genome Type 7d Caused an Acute Respiratory Disease Outbreak in Southern China After a Twenty-one Year Absence. Scientific Reports, 2014(4): 7365，DOI: 10.1038/srep07365. (IF: 4.259)
22. Zhiwei Zeng, Jing Zhang, Shuping Jing, Zetao Cheng, Silvia Bofill-Mas, Carlos Maluquer de Motes, Ayalkibet Hundesa, Rosina Girones, Donald Seto*,Qiwei Zhang*. Genome Sequence of a Cynomolgus Macaque Adenovirus (CynAdV-1) Isolate from a Primate Colony in the United Kingdom. Genome Announcements.2016, 4(6): e01193-01116.
23. Xiangyu Wang, Qi Sun, Zhonghua Ye, Ying Hua, Na Shao, Yanli Du, Qiwei Zhang*, Chengsong Wan*. Computational approach for predicting the conserved B-cell epitopes of hemagglutinin H7 subtype influenza virus.Experimental and Therapeutic Medicine, 2016, 12(4): 2439-2446. （IF: 1.448）

24. Yi Chen, Fanghua Liu, Changbing Wang, Mingqi Zhao, Li Deng, Jiayu Zhong, Yingying Zhang, Jun Ye, Shuping Jing, Zetao Cheng, Yongxin Guan, Yi Ma, Yuanyuan Sun, Bing Zhu*, Qiwei Zhang*.Molecular Identification and Epidemiological Features of Human Adenoviruses Associated with Acute Respiratory Infections in Hospitalized Children in Southern China, 2012-2013. PLoS ONE,2016, 11(5): e**. (IF:3.0)
25. Qiwei Zhang*, Xiaomin Zhang, Hao Wu, Donald Seto, Hao-Jie Zhang, Zhiwei Chen, Chengsong Wan and Bo-Jian Zheng*. Parental LTRs Are Important in a Construct of a Stable and Efficient Replication-Competent Infectious Molecular Clone of HIV-1 CRF08_BC. PLoS ONE, 2012, 7: e31233. (IF:3.0)
26. Suhui Zhao, Ying Zhou, Chunhui Wang, Yu Yang, Xianbo Wu, Yao Wei, Li Zhu, Wei Zhao, Qiwei Zhang*, Chengsong Wan*. The N-Terminal Domain of EspF Induces Host Cell Apoptosis after Infection with Enterohaemorrhagic Escherichia coli O157:H7. PLoS ONE2013, 8(1):e55164. (IF:3.0)
27.Xiangyu Wang, Zhonglu Ren, Qi Sun, Xuan Wan, Yaqing Sun, Ying Hua, Muqing Fu, Na Shao, Yanli Du, Chengsong Wan*, Qiwei Zhang*. Evaluation and comparison of newly built linear B-cell epitope prediction software from a users’ perspective. Current Bioinformatics, 2017,12:DOI: 10.2174/**66**8 (IF:1.189)
28. Jian Shang, Yuan Zheng, Jiayin Mo, Wenbiao Wang, Zhen Luo, Yongkui Li, Xulin Chen, Qiwei Zhang, Kailang Wu, Weiyong Liu, Jianguo Wu*. Sox4 represses host innate immunity to facilitate pathogen infection by hijacking the TLR signaling networks. Virulence, 2021, 12(1):704-722. (IF: 5.5)
29. Xiao-Min Zhang, Hao Wu, Qiwei Zhang, Terrence Chi-Kong Lau, Hin Chu, Zhi-Wei Chen, Dong-Yan Jin and Bo-Jian Zheng. A novel mutation, D404N, in the connection subdomain of reverse transcriptase of HIV-1 CRF08_BC subtype confers cross-resistance to NNRTIs. Journal of Antimicrobial Chemotherapy,2015, 70(5): 1381-90. (药学一区，Top期刊，IF: 5.439)
30. Ashrafali M. Ismail1#, Tiange Cui#, Kalpana Dommaraju, Gurdeep Singh, Shoaleh Dehghan, Jason Seto, Susmita Shrivastava, Nadia B. Fedorova, Neha Gupta, Timothy B. Stockwell, Ramana Madupu, Albert Heim, Adriana E. Kajon, Eric G. Romanowski, Regis P. Kowalski, Jambulingam Malathi, Kuzhanthai L. Therese, Hajib Narahari Madhavan, Qiwei Zhang, Leonardo J. Ferreyra, Morris S. Jones, Jaya Rajaiya, David W. Dyer, James Chodosh*, and Donald Seto*. Genomic analysis of a large set of currently –and historically –important human adenovirus pathogens. Emerging Microbes & Infections, 2018, 7(1): 10. (医学二区，IF: 6.212)
31. Tingting Chen, Xiaoen He, Peiru Zhang, Yawen Yuan, Xinyue Lang, Jianhai Yu, Zhiran Qin, Xujuan Li, Qiwei Zhang, Li Zhu, Bao Zhang, Qinghua Wu and Wei Zhao.Research advancements in the neurological presentation of flaviviruses. Reviews in Medical Virology. 2019, 29(1): e2021. (医学二区，IF:5.034)
32. T. Huang, J. Yang, J. Zhang, W. Ke, F. Zou, C. Wan, L. Wang, X. Zhang, F. Liang, S. Mei, Q. Zhang, Z. Rong, B. Yang* and H. Zheng*. MicroRNA-101-3p Downregulates TLR2 Expression, Leading to Reduction in Cytokine Production by Treponema pallidum-Stimulated Macrophages. Journal of Investigative Dermatology. 2020, 140(8): 1566-1575 e1561. (IF: 7.143, 一区)
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