2008,03-2008,8 美国密西西比大学药学院生药系高级访问学者
1993,9-1996,7 中山大学化学与化工学院有机化学攻读博士研究生,取得博士学位
1990,9-1993,7 湘潭大学化学学院有机化学攻读硕士研究生,取得硕士学位
1985,9-1988,7 邵阳学院化学系大学学习
工作经历:
1998年12月晋升副教授,2002年12月晋升教授,2000年1月在分析化学担任硕士研究生导师,2004年1月在水生生物学担任博士研究生生导师.研究方向:
海洋药物提取及应用:从海藻、海绵及珊瑚等海洋生物中提取活性物质,并对活性物质进行合成和药效学研究,将活性物质开发成海洋药物或者食品、化妆品的添加剂。主要论文:
A series of new 5,6-epoxysterols from a Chinese sponge Ircinia aruensis, Steroids,2008,73;568-573)
Methyl (4,5-dibromo-1-methyl- 1H-pyrrole-carbonyl-2-amino)acetate, Acta Crystallographica Section E 2004, 60: o1283-o1284
Dibromophakellin methanol hemisolvate, Acta Crystallographica Section E,2004 E60: o782-o783
Isolation and Crystal Structure of Stigmast-4-ene-3β,6β-diol,Chinese Journal of Structural Chemistry,2004,23(6):631-634
1,4-bis(phenylmethoxy) benzene, Acta Crystallographica Section E,2004,60: o711-o712
Three New Ceramides from the Sponge Spongia suriganensis,Chinese Journal of Organic Chemistry,2006,26(1):56-59
Synthesis of N-(Methoxycarbonylalkyl)bromopyrrole-2-carboamides,Chinese Journal of Organic Chemistry,2005,25(11):1420-1426
Syntheses and α-Glucosidase Inhibitions of Aldisin and Its Derivatives,Chinese Journal of Organic Chemistry,2005,25(8):954-958
Studies on the Chemical Constituents of the Algae Hydroclathrus clathratus,Chinese Journal of Organic Chemistry,2004,24(9):1060-1063
Synthesis of N-(Pyrrole-2-carbonyl)-amino Acid Methyl Esters,Chinese Journal of Organic Chemistry,2004,24(7):802-805
3-[(4,5-Dibromo-1-methyl-1H-pyrrole-2-carbonyl) amino]propanoic acid ,Acta Crystallographica Section E, 2005,61: o2150-o2151
Studies on the Chemical Constituents of the Algae Sargassum polycystcum,Chinese Journal of Organic Chemistry,2002,22(2):138-140
24-Methylenecholest-4β,6β-ene-diol , Acta Crystallographica Section E, 2005, 61: o1959-o1960
Bis(benzotriazol-1-yloxy)methane , Acta Crystallographica Section E, 2006, 62: o4981-o04982
Study on the Chemical Constituents of Marine Sponge Polymastia Sobustia,Chinese Journal of Organic Chemistry,2001,21(1):45-48
Isolation and Identification of Two New Constituents from Algae,Acta Pharmaceutica Sinaca, 2000,35(1):26-28
Isolation and Structural Determination of Heterocyclic Alkaloidal Compounds,Chinese Journal of Organic Chemistry,2000,20(2):248-250
N-Methyl-3-(4-bromo-1H-pyrrole-2- carbonyl) aminopropionitrile, Acta Crystallographica Section E ,2005, 61: o1291-o1293
承担课题:
1、珊瑚中抗肿瘤活性化合物的分离与结构鉴定,十一五“863”基金资助;
2、Ircinia属海绵中抗肿瘤活性化合物的发现与优化,国家自然科学基金资助;
3、Ircinia属海绵中抗肿瘤活性化合物的分离与鉴定,广东省自然科学基金资助;
4、I类抗肿瘤海洋药物aldisin的临床前研究,广东省科学计划专项基金资助;
5、I类抗肿瘤海洋药物HWT的合成工艺放大及临床前研究,广州市科学计划重大专项基金资助
荣誉与奖励:
专利情况
1、The Method of Full Synthesis of Pyrrololactam Alkaloid aldisin, Patent No. ZL200310117582.3
2、The Method of Full Synthesis of Pyrrololactam Alkaloid Bromoaldisin, Application No. 200510033829.2
简介: