詹雅娴 职称/职位：药理学副教授
学位：博士



教育、工作经历
2016/09—至今，广州中医药大学，中药学院，副教授
2019/08-2020/08，美国Drexel University，访问****
2013/08—2016/07，广州中医药大学，中药学院，博士后（副研究员）
2009/09—2013/05，香港科技大学，生命科学部生物系，博士（硕博连读）

研究方向
中药防治炎症疾病及肿瘤研究工作，特别是岭南中药对日光性皮肤疾病的作用机制及物质基础研究。

科研及教学课题
主持国家自然科学基金1项、中国博士后科学基金2项、省部级科研课题1项，2017年获得学校“青年英才”项目，并参与多项国家级和省级纵向课题。共发表学术论文34篇，其中第一/通讯作者的SCI收载学术论文15篇。申请专利4项。

主要学术任职
1、广东省药品监督管理局审评认证中心专家
2、广东省药理学会中药药理专业委员会委员
3、广州市医药行业专业技术资格评审委员
4、广东省青年科学家协会会员
5、中华中医药学会会员
6、中国药理学会会员
7、杂志审稿专家：Cell proliferation，Molecular Medicine Reports，Biomedicine &pharmacotherapy，Molecules等

代表性论文论著
1.QY Zhong1, B Lin1, YT Chen, YP Huang, WP Feng, Y Wu, GH Long, YN Zou, Y Liu, BQ Lin, NL Sang, Zhan JYX*. Gender differences in UV-induced skin inflammation, skin carcinogenesis and systemic damage. Environmental Toxicology and Pharmacology. Environ Toxicol Pharmacol. 2021, 81:103512.
2.Wang ML1, Zhong QY1, Lin BQ, Liu YH, Huang YF, Chen Y, Yuan J, Su ZR*, Zhan JYX*. Andrographolide sodium bisulfate attenuates UV-induced photo-damage by activating the keap1/Nrf2 pathway and downregulating the NF-κB pathway in HaCaT keratinocytes. International Journal of Molecular Medicine. 2020; 45(2): 343-352.
3.Liang JL1, Wu, JZ1, Liu, YH, Zhang, ZB, Wu, QD, Chen, HB, Huang,YF, Dou, YX, Zhou, JT, Su, ZR*, Zhan JYX*. Patchoulene Epoxide Isolated from Patchouli Oil Suppresses Acute Inflammation through Inhibition of NF-κB and Downregulation of COX-2/iNOS. Mediators of Inflammation. 2017; 2017: **.
4.Xu LQ1, Yu XT1, Gui SH, Xie JH, Wang XF, Su ZQ, Li YC, Lai XP, Zhan JYX*, Xie YL*. Protective Effects of Li-Fei-Xiao-Yan Prescription on Lipopolysaccharide-Induced Acute Lung Injury via Inhibition of Oxidative Stress and the TLR4/NF-κB Pathway. Evid Based Complement Alternat Med. 2017; 2017: **.
5.Luo DD1, Chen XY1, Zhang ZB, Sun CY, Zheng YF, Liu YH, Wang XF, Wang Q, Zhan JYX*, Su ZR*. Different effects of (+)-borneol and (-)-borneol on the pharmacokinetics of osthole in rats after oral administration. Molecular Medicine report 2017; 15 (6) : 4239.
6.Guo HZ1, Zhang ZB1, Su ZQ, Sun CY, Zhang X, Zhao XN, Lai XP, Su ZR, Li YC*, Zhan JYX*. Enhanced anti-tumor activity and reduced toxicity by combination andrographolide and bleomycin in ascitic tumor-bearing mice. European Journal of Pharmacology 2016; 776: 52-63.
7.Zhan JYX1, Wang XF1, Liu YH, Zhang ZB, Wang L, Chen JN, Huang S, Zeng HF*, Lai XP*. Andrographolide sodium bisulfate prevents UV-induced skin photoaging through inhibiting oxidative stress and inflammation. Mediators of Inflammation 2016; 2016: **.
8.Zhang X1, Xie YL1, Yu XT, Su ZQ, Yuan J, Li YC, Su ZR, Zhan JYX*, Lai XP*. Protective Effect of Supercritical-Carbon Dioxide Fluid Extract from Flowers and Buds of Chrysanthemum indicum Linnén against UV-induced Photoaging in Mice. Rejuvenation Research 2015; 18(5): 437-448.
9.Zhan JYX, Yao P, Bi CWC, Zheng KYZ, Zhang WL, Chen JP, Dong TTX, Su ZR, Tsim KWK. The Sulfur-Fumigation Reduces Chemical Composition and Biological Properties of Angelicae Sinensis Radix. Phytomedicine 2014; 21(11): 1318-1324.
10.Zhan JYX, Zheng KYZ, Zhang WL, Chen JP, Yao P, Bi CWC, Dong TTX, Tsim KWK. Identification of Angelica oil as a suppressor for the biological properties of Danggui Buxue Tang: a Chinese herbal decoction composes of Astragali Radix and Angelica Sinensis Radix. Journal of Ethnopharmacology 2014; 154(3): 825-831.
11.Lin RF 1, Feng XX 1, Li CW, Zhang XJ, Yu XT, Zhou JY, Zhang X, Xie YL, Su ZR *, Zhan JYX *. Prevention of UV radiation-induced cutaneous photoaging in mice by topical administration of patchouli oil. Journal of Ethnopharmacology 2014; 154(2): 408-418.
12.Liang CL1, Wu JB1, Lai JM, Ye SF, Lin J, Ouyang H, Zhan JYX*, Zhou JY*. Protection Effect of Zhen-Wu-Tang on Adriamycin-Induced Nephrotic Syndrome via Inhibiting Oxidative Lesions and Inflammation Damage. Evidence-Based Complementary and Alternative Medicine 2014; 2014: 131604.
13.Zhan JYX, Zhang WL, Zheng KY, Zhu KY, Chen JP, Chan PH, Dong TT, Choi RC, Lam H, Tsim KW, Lau DT. Chemical changes of Angelicae Sinensis Radix and Chuanxiong Rhizoma by wine treatment: chemical profiling and marker selection by gas chromatography coupled with triple quadrupole mass spectrometry. Chinese Medicine 2013; 8 (1): 12.
14.Zhan JYX, Zheng KYZ, Zhu KY, Zhang WL, Bi CWC, Chen JP, Du CYQ, Dong TTX, Lau DTW, Tsim KWK. Importance of wine-treated Angelica Sinensis Radix in a herbal formula, Si Wu Tang, in treating woman aliments. Planta Medica 2013; 79(7): 533-537.
15.Zhan JYX, Zheng KYZ, Zhu KY, Bi CWC, Zhang WL, Du CYQ, Fu Q, Dong TTX, Choi RCY, Tsim KWK, Lau DTW. Chemical and biological assessment of Angelicae Sinensis Radix after processing with wine: an orthogonal array design to reveal the optimized conditions. Journal of Agricultural and Food Chemistry 2011; 59: 6091-6098.