李磊，男，副主任技师，副研究员，广州医科大学附属第三医院生殖医学中心副主任。
研究方向:
1.辅助生殖技术的临床研究；
2.胚胎发育；
3.血管新生相关疾病的生物治疗
2009-2014年博士研究生就读于中山大学中山医学院生物化学与分子生物学专业，从事血管新生和肿瘤细胞凋亡相关方面的研究工作。发现PEDF通过促进Fas蛋白向细胞膜的转位，修复Fas-L/Fas信号通路诱导肺癌细胞凋亡[Li L. J. Biol Chem. 2014]；提出K5诱导血管内皮细胞凋亡的正反馈环路——VDAC1-Akt- GSK3β-VDAC1[Li L. J. Biol Chem. 2014];论证应用纳米载体cRGD-PEG-PEI用于靶向运输PEDF基因治疗结肠癌的有效性和可行性[Li L. Int J Pharm. 2012]；发现SERPINA3K通过Fas/FasL/ caspase-8信号通路诱导结肠癌细胞凋亡[Yao Y*, Li L*. Febs J. 2013]。2014年博士毕业后就职于广州医科大学附属第三医院生殖医学中心，从事胚胎实验室相关工作，并于2020年开始担任广州医科大学附属第三医院生殖医学中心副主任一职。主持国家自然科学基金2项，广州市科学计划项目1项。所研项目关注的是血管新生抑制因子Kallistatin在生殖系统疾病宫颈癌转移以及辅助生殖技术常见并发症卵巢过度刺激综合征中作用及其机制。迄今已在JBC、Cell Death and Disease、Journal of Cellular and Molecular Medicine、Fertility and Sterility等杂志上发表SCI论文十余篇。
主要代表作：
1.Yuling Huang^#, Haiying Liu^#, Hongzhi Du , Wenhong Zhang, Xiangjin Kang, Yang Luo, Xueliang Zhou,Lei Li*.Developmental features of DNA methylation in CpG islands of human gametes and preimplantation embryos.ExpTherMed. 2019,17: 4447-4456
2.Hanyan Liu^#, Jianqiao Liu^#, Shiping Chen, Xiangjin Kang, Hongzi Du,Lei Li^*, Elevated incidence of monozygotic twinning is associated with extended embryo culture, but not with zona pellucida manipulation or freeze-thaw procedure. Fertil Steril. 2018, 109(6):1044-1050
3.Shuhuan Fang^#, Honghai Hong^#,Lei Li^#, Dan He, Zumin Xu, Shaoyuan Zuo, Jing Han, Qiyuan Wu, Zhiyu Dai, Weibin Cai, Jianxin Ma, Chunkui Shao*, Guoquan Gao^*, Xia Yang^*, Plasminogen kringle 5 suppresses gastric cancer via regulating HIF-1alpha and GRP78. Cell Death Dis. 2017, 8(10):e3144
4.Lei Li^#, Honghai Hong^#, Shiping Chen^#, Caiqi Ma, Hanyan Liu, Yachao Yao^*, Activation of AMPK/MnSOD signaling mediates anti-apoptotic effect of hepatitis B virus in hepatoma cells. World J Gastroenterol. 2016, 22(17):4345-4353
5.Lei Li^#, Yachao Yao^#, Shuhuan Fang^#, Caiqi Ma, Yi Cen, Zumin Xu, Zhiyu Dai, Cen Li, Shuai Li, Ting Zhang, Honghai Hong, Weiwei Qi, Ti Zhou, Chaoyang Li^*, Xia Yang^*, Guoquan Gao^*, Pigment epithelial-derived factor (PEDF)-triggered lung cancer cell apoptosis relies on a p53-driven Fas-L up-regulation and Fas cell surface translocation. J Biol Chem. 2014, 289(44):30785-30799
6.Lei Li^#, Yachao Yao^#, Xiaoqiong Gu^#, Di Che, Caiqi Ma, Zhiyu Dai, Cen Li, Ti Zhou, Weibin Cai, Zhonghan Yang, Xia Yang^*, Guoquan Gao^*, Plasminogen Kringle 5 Induces Endothelial Cell Apoptosis by Triggering a Voltage-dependent Anion Channel 1 (VDAC1) Positive Feedback Loop. J Biol Chem. 2014, 289(47):32628-32638