个人概况
姓名：王树 性别：男
职称：教授 导师资格：博士生导师 单位：基础医学院
学历：博士 毕业院校：中国科学技术大学
电子邮件： wshunly@foxmail.com 通信地址： 广州医科大学番禺校区
招生专业：神经病学


研究方向；
主要研究方向为神经药理学，使用分子生物学、电生理记录、神经元培养及活细胞荧光成像技术以及疾病动物模型，去解析外周神经系统离子通道相关疾病的分子机制，寻找疾病治疗的新靶点，并在此基础上进行活性分子及传统中药有效成分的筛选、药理学研究和临床实验。其研究成果以第一或通讯作者发表在 Nature、 PNAS、EMBO系列等SCI杂志上，并主持多项国家及地方科研基金项目超过600万元。
主持科研项目：
1、青霉素的体内新靶点及其对青霉素皮试的影响，广州市科技计划基础与应用基础研究项目，20万，2020.04-2023.03，主持
2、龙脑镇痛止痒的神经药理机制研究，广东省普通高校基础研究与应用基础研究重点项目，广东省教育厅，25万，2019.01-2021.12，主持
3、广州医科大学高水平大学建设人才项目，2018-11至2023-11，200万元，主持
4、传统中药艾片的药理学作用机制研究，云南省应用基础研究基金重点项目，云南省科技厅，50万，2018.06-2021.05，主持
5、中科院青年创新促进会人才项目，中科院青年创新促进会基金，中国科学院，50万，2014.01-2018.12，主持
6、碘刺激性作用的离子通道靶点的发现和机制研究，国家自然科学基金青年基金项目，国家自然科学基金委，23万，2014.01-2016.12，主持
7、TRPML1通道在溶酶体生理功能和疾病机理的分子基础，国家自然科学基金，面上项目，**，2014-01至2017-12, 80万元，参加
6、离子通道药物研发体系：天然活性物质的离子通道功能和应用基础，中科院重点部署项目，中国科学院，236万，2013.01-2015.12， 主持
7、新型TRP通道活性分子作用机制研究，中科院“西部之光”重点项目，中国科学院，30万，2013.01-2015.12，主持
8、含碘类药物毒性机制研究，云南省应用基础研究基金面上项目，云南省科技厅，10万，2013.10-2016.09, 主持
9、以离子通道为靶点的心脑血管疾病天然活性分子的发现及抗心律失常先导分子AA-1和AA-2的类药性研究，中科院战略生物资源服务网络计划项目，中国科学院，120万，2016.11-2018.06，参与
10、重要新型膜离子通道门控和调节机制的结构基础子课题，国家重大科学研究计划，科技部，213.61万，2014.01-2018.08，参与
11、离子通道为靶点的心脑血管药物筛选与毒性评估模型和方法的建立及应用研究，云南省重大科技专项，云南省科技厅，275万，2015.01-2017.12，参与
部分代表性第一和通讯作者论文：
1. Yong Shao^#, Hang Yu Tian^#, Jing Jing Zhang^#, Hamed Kharrati Koopaee^#, Xing Guo, Xiao Lin Zhuang, Ming Li Li, Hojjat Asadollahpour Nanaie, Elahe Dehghani Tafti, Bahador Shojaei, Mohammad Reza Namavar, , Narges Sotoudeh, Adeola Oluwakemi Ayoola, Jia Li Li, Bin Liang*, Ali Esmailizadeh*, Shu Wang*, Dong Dong Wu*. Genomic and phenotypic analyses reveal mechanisms underlying homing ability in pigeon. Mol Biol Evol. 2019 Sep 10. (影响因子14.797)
2. Shu Wang*^#，Dan Zhang^#, Jinsheng Hu^#, Qi Jia^#, Wei Xu, Deyuan Su, Hualing Song, Zhichun Xu, Jianmin Cui, Ming Zhou, Jian Yang*, Jianru Xiao*. A clinical and mechanistic study of topical borneol-induced analgesia. EMBO Mol Med. 2017 Jun; 9(6): 802–815. (影响因子10.293)
3. Deyuan Su^#, Yin Nian^#, Fenglei Zhang^#, Jinsheng Hu, Jianmin Cui, Ming Zhou, Jian Yang*, Shu Wang*. Thiazolidine reacts with thioreactive biomolecules. Free Radic Biol Med. 2017 Mar;104:272-279 (影响因子6.020)
4. Minghui Li^#, Xiaoyuan Zhou^#, Shu Wang^#, IoannisMichailidis, Ye Gong, Deyuan Su, Huan Li, Xueming Li* & Jian Yang*. Structure of a eukaryotic cyclic-nucleotide-gated channel. Nature 2017 Feb 2;542(7639):60-65. (影响因子41.577)
5. Deyuan Su^#, Hong Zhao^#, Jinsheng Hu^#, Dan Tang, Jianmin Cui, Ming Zhou, Jian Yang*, Shu Wang*. TRPA1 and TRPV1 contribute to iodine antiseptics-associated pain and allergy. EMBO Rep. 2016 Oct;17(10):1422-1430. (影响因子8.568)
6. Shu Wang, Huai-hu Chuang. C-terminal Dimerization Activates the Nociceptive Transduction Channel Transient Receptor Potential Vanilloid 1. J Biol Chem. 2011 Nov 25; 286(47): 40601–40607. (影响因子4.773)
7. Elaine Wang^#, Hui Li^#, Shu Wang^#, Alexander Y Chuang, and Huai-huChuang.Induction of TRPV1 desensitization by a biased receptor agonist. Channels (Austin) 2011 Nov-Dec;5(6):464-7. (影响因子2.140)
8. Hui Li^#, Shu Wang^#, Alexander Y.Chuang, Bruce E.Cohen, and Huai-hu Chuang. Activity-dependent targeting of TRPV1 with a pore-permeating capsaicin analog. Proc Natl Acad Sci USA. 2011 May 17;108(20):8497-502 (影响因子9.681)
9. Shu Wang, Kinning Poon, Robert Oswald, and Huai-hu Chuang. Distinct Modulations of Human Capsaicin Receptor by Protons and Magnesium through Different Domains. J Biol Chem. 2010 Apr 9; 285(15): 11547–11556. (影响因子5.328)
10. Shu Wang, Tai-Ran Xing, Ming-Liang Tang, Wu Yong, Chen-Chen Li, Di-Yun Ruan. Effects of Cd2+ on transient outward and delayed rectifier potassium currents in acutely isolated rat hippocampal CA1 neurons. Naunyn Schmiedebergs Arch Pharmacol.2008 May;377(3):245-53. (影响因子2.830)
11. Shu Wang, Pu Hu, Hui-Li Wang, Ming Wang, Ju-Tao Chen, Di-Yun Ruan. Effects of Cd2+ on AMPA receptor-mediated synaptic transmission in rat hippocampal CA1 area. Toxicol Lett.2008 Feb 15;176(3):215-22. (影响因子3.249)
12. Shu Wang, Yan Gu, Hui-Li Wang, Xin-Mei Li, Ming Wang, Li-Guang Sun, Di-Yun Ruan. Inhibitory effect of Cd2+ on glycine-induced chloride current in rat hippocampal neurons. Brain Res Bull.2006 May 31;69(6):680-6. (影响因子1.684)
13. Hao Sun, Hui-Li Wang, Shu Wang*. d-serine relieves chronic lead exposure-impaired long-term potentiation in the CA1 region of the rat hippocampus in vitro. Neurosci Lett. 2007 Mar 1; 417(2): 118-22. (影响因子2.085)
14. Minghui Li, Wei K Zhang, Nicole M Benvin, Xiaoyuan Zhou, Deyuan Su, Huan Li, Shu Wang, Ioannis E Michailidis, Liang Tong, Xueming Li & Jian Yang*. Structural basis of dual Ca2+/pH regulation of the endolysosomal TRPML1 channel. Nat Struct Mol Biol.2017 Mar;24(3):205-213. (影响因子13.333)
15. Ahmed, Shu Wang, Huai-Hu Chuang, and Robert Oswald. Mechanism of AMPA receptor activation by partial agonists: disulfide trapping of closed lobe conformations. J Biol Chem. 2011 Oct 7;286(40):35257-66. (影响因子4.773)
16. Wu Yong, Min-Min Zhang, Shu Wang, Di-Yun Ruan. Effects of sodium valproate on synaptic transmission and neuronal excitability in rat hippocampus. Clin Exp Pharmacol Physiol. 2009 Nov;36(11):1062-7. (影响因子1.936)
17. Wu Yong, Tai-Ran Xing, Shu Wang, Liang Chen, Pu Hu, Chen-Chen Li, Hui-li Wang, Ming Wang, Ju-Tao Chen, Di-Yun Ruan. Protective Effects of Gastrodin on Lead-Induced Synaptic Plasticity Deficits in Rat Hippocampus. Planta Med. 2009 Aug;75(10):1112-7. (影响因子2.037)
18. Hui-Li Wang, Xiang-Tao Chen, Bin Yang, Fang-Li Ma, Shu Wang, Ming-Liang Tang, Ming-Gao Hao, and Di-Yun Ruan. Case-control study of blood lead levels and attention deficit hyperactivity disorder in Chinese children. Environ Health Perspect.2008 Oct;116(10):1401-6. (影响因子6.123)
19. Pu Hu, Lei Sun, Zhi-Qiang Zhu, Xiao-Wei Hou, Shu Wang, Shan-Shan Yu, Hui-Li Wang, Ping Zhang, Ming Wang, Li-Wen Niu, Mai-Kun Teng, Di-Yun Ruan. Crystal structure of Natratoxin, a novel snake secreted phospholipasesA2 neurotoxin from Najaatra Venom inhibiting A-type K+ currents. Proteins.2008 Aug;72(2):673-83. (影响因子3.419)
20.Zhi-Dian Niu, Ju-Tao Chen, Shu Wang, Ming Wang, Xin-Mei Li and Di-Yun Ruan. Inhibition of delayed rectifier K+ currents by copper in acutely dissociated rat hippocampal CA1 neurons. Toxicol Lett.2006 Sep 10;165(3):289-96. (影响因子2.784)
21. Hui-Li Wang, Xiang-Tao Chen, Le Luo, Zhi-Yi Lou, Shu Wang, Ju-Tao Chen, Ming Wang, Li-Guang Sun and Di-Yun Ruan. Reparatory effects of nicotine on NMDA receptor-mediated synaptic plasticity in the hippocampal CA1 region of chronically lead-exposed rats. Eur J Neurosci.2006 Mar;23(5):1111-9. (影响因子3.709)