张笑人，广州医科大学附属肿瘤医院/肿瘤研究所、呼吸疾病国家重点实验室 “南山****”****、研究组长、博士生导师，广州市高层次人才。

研究兴趣
主要研究免疫细胞的发育分化的转录和表观遗传调控及其在自身免疫性疾病、肿瘤等重大慢性疾病发生发展中的作用和防治策略，特别关注肿瘤微环境中炎症/免疫在肿瘤发生发展及对药物和细胞治疗敏感性调控，发现肿瘤的诊断、治疗反应性、预后和复发预测的生物靶标，为肿瘤的防治提供新的策略和制剂。
学习经历
1992.9-1995.7 山东省医学科学院 病毒免疫学硕士
1995.9-1998.7 上海第二医科大学（现上海交通大学医学院）免疫学博士
研究经历
1998.7-1999.11 讲师
上海第二医科大学（现上海交通大学医学院）免疫学研究所
1999.12- 2001.10 Postdoctoral Fellow
Department of Immunology, Holland Laboratory, American Red Cross/the George Washington University, USA
2001.10- 2004.12 Visiting Fellow,
Laboratory of Immunoregulation, NIAID, NIH, USA
2004.12- 2009.06 Research Fellow,
Laboratory of Immunoregulation, NIAID, NIH, USA
2008.7-2020.4 研究员、特聘研究员、课题组长
中国科学院上海生命科学研究院
2018.3-现在“南山****”****、课题组长
广州医科大学附属肿瘤医院/肿瘤研究所、呼吸疾病国家重点实验室 呼吸病和微环境研究组

承担的研究项目
1、国家自然科学基金重大研究计划培育项目，胸腺衰老和退化的表观遗传调控机制，2020.1-2022.12，批准号：**，负责人，68万
2、国家自然科学基金重大研究计划培育项目，H3K27去甲基化酶Jmjd3在肠道IgA产生中的关键作用及其调控机制研究，2018.1-2020.12，批准号：**，负责人，60万
3、国家自然科学基金面上项目，组蛋白H3K27去甲基化酶Jmjd3在胸腺髓质上皮细胞发育分化和建立T细胞中枢免疫耐受中的关键作用，2016.1-2019.12，批准号：**，负责人，60万
4，国家自然科学基金面上项目，IkB家族成员Bcl-3调控B细胞命运决定的机制研究，2014.1-2017.12，批准号：**，负责人，80万
5，国家自然科学基金面上项目，Bcl-3调控边缘区B细胞发育和功能的表观遗传机制，2013，批准号：**，负责人，15万
6，国家自然科学基金面上项目，髓质区胸腺上皮细胞发育分化的表观遗传机制，2010.1-2012.12，批准号：**，负责人，38万
7，国家自然科学基金重大研究计划，髓质区胸腺上皮细胞发育分化的表观遗传机制，2009.1-2011.12，批准号：**，负责人，60万
8，国家重点基础研究发展计划，红斑狼疮免疫发病机理的解析和诊治新策略硏究，2014.1-2018.12，2014CB541904，参加 142.5万
9，国家重点研发计划“重大慢性非传染性疾病防控研究”重点专项，肿瘤微环境-内在驱动分子互动机制与干预途径，2017.1-2021.12，2016YFC**，参加，50万
10，国家重点基础研究发展计划，胸腺的起源、发生、维持与退化 课题二 胸腺上皮细胞发育及其表观遗传调控，2011.1-2015.12，批准号：2011CB946102，课题负责人，250万
11，中国科学院－澳大利亚科学院合作项目，临床应用材料的生物反应性研究，2014.1-2016.12，批准号：GJHZ1409，负责人，100万
12，上海市科委科技行动计划，重组CD40胞外段（CD40-N）蛋白发酵纯化的中试工艺及抗B细胞淋巴瘤的临床前研究，2018.6-2021.6，批准号**，负责人，70万
13, 国家重点研发计划干细胞及转化研究专项, 炎症微环境中间充质干细胞对肝肾纤维化的调控作用及干预策略 课题三“肝肾纤维化的干预新策略2018-2022，批准号：2018YFA**，参与，100万
发表论文
1, Shao T^#, Su Z, Li Y, Zhang X, You Q*. Chitinase-3 like-protein-1 function and its role in diseases. Signal Transduct Target Ther. 2020 Sep 14;5(1):201.
2, Song L^#, Cao L, Liu R, Hui Ma, Li Y, Shang Q, Zheng Z, Zhang L, Zhang W, Han Y, Zhang X, Yang H, Wang Y, Melino G, Shao C, Shi Y*. The Critical Role of T Cells in Glucocorticoid-induced Osteoporosis. Cell Death and Disease. 2020, Accepted
3, Zhang H^#, Hu Y^#, Liu D^#, Liu Z, Xie N, Liu N, Zhang J, Jiang Y, Li C, Wang Q, Chen X, Ye D, Sun D, Zhai Y, Liu Y, Chen CD, Huang X, Shi Y, Zhang X^*. The histone demethylase Kdm6b regulates the maturation and cytotoxicity of TCRαβ+CD8αα+ intestinal intraepithelial lymphocytes. 2020, Submitted. (通讯作者)
4, Shao C^#, Jing Y^#, Zhao S^#, Yang X, Hu Y, Huang Y, Ye F, Gao L, Liu W, Sheng D, Li R, Zhang X^*, Wei L^*. LPS/Bcl3/YAP1 signaling promotes Sox9+HNF4α+ hepatocyte-mediated liver regeneration after hepatectomy. 2020, Submitted. (共同通讯作者)
5, Hu Y^#, Zhang H^#, Xie N, Liu D, Jiang Y, Liu Z, Ye D, Liu S, Tao Y, Chen X, Li C, Wang Q, Li L, Jiang W, You Q, Huang X, Liu Y, Zhang X^*. Bcl-3 promotes TNF-induced hepatocyte apoptosis by regulating the deubiquitination of RIP1. 2020, Revised. (通讯作者)

6, Shen J^#, Hu L, Yang L, Zhang M, Sun W, Lu X, Lin G, Huang C*, Zhang X*, Chin YE*. Reversible Acetylation Modulates Dishevelled-2 Puncta Formation in Canonical Wnt Signaling Activation. Signal Transduction and Targeted Therapy. 2020, July 6; 5(1):115 (共同通讯作者)

7, Liu Z^#, Zhang H^#, Hu Y^#, Liu D, Li L, Li C, Wang Q, Huo J, Liu H, Xie N, Huang X, Liu Y, Chen CD, Shi Y, Zhang X*. Critical role of histone H3 lysine 27 demethylase Kdm6b in the homeostasis and function of medullary thymic epithelial cells. Cell Death and Differentiation. 2020 Apr 28. doi: 10.1038/s41418-020-0546-8. [Epub ahead of print] (通讯作者)
8, Chen X^#, Wang C^#, Jiang Y^#, Wang Q, Tao Y, Zhang H, Zhao Y, Hu Y, Li C, Ye D, Liu D, Jiang W, Chin EY, Chen S, Liu Y, Wang M*, Liu S* and Zhang X*. Bcl-3 promotes Wnt signaling through sustaining the acetylation of β-catenin at lysine 49 in colorectal cancer. Signal Transduction and Targeted Therapy. 2020 May 1;5(1):52，封面文章 (共同通讯作者)
9, Zhou Y^#, Fu B^#,*, Xu X, Zhang J, Tong X, Wang Y, Dong Z, Zhang X, Shen N, Zhai Y, Kong X, Sun R, Tian Z*, Wei H*. Sci Transl Med. 2020 Apr 1;12(537). pii: eaax1798. doi: 10.1126/scitranslmed.aax1798
10, Li X, Zhang C, Zhao T, Su Z, Li M, Hu J, Wen J, Shen J, Wang C, Pan J, Mu X, Ling T, Li Y, Wen H, Zhang X, You Q*. Lysine-222 succinylation reduces lysosomal degradation of lactate dehydrogenase a and is increased in gastric cancer. J Exp Clin Cancer Res. 2020 Aug 28;39(1):172
11, Xu X^#, Zhou Y, Fu B, Zhang J, Dong Z, Zhang X, Shen N, Sun R, Tian Z, Wei H*. PBX1 promotes development of natural killer cells by binding directly to the Nfil3 promoter. FASEB J. 2020 Mar 19. doi: 10.1096/fj.R. [Epub ahead of print]
12, Gong Z^#, Shang B, Chu Y, Chen X, Li Q, Liu K, Chen Y, Huang Y, Han Y, Shang Q, Zheng Z, Song L, Li Y, Liu R, Xu C, Zhang X, Liu B, Wang L, Shao C, Wang Y, Shi Y*. Fibrotic liver microenvironment promotes Dll4 and SDF-1-dependent T-cell lineage development. Cell Death Dis. 2019 Jun 5;10(6):440
13, Jiang Y^#, Li C^#, Wu Q^#, An P, Huang L, Wang J, Chen C, Chen X, Zhang F, Ma L, Liu S, He H, Xie S, Sun Y, Liu H, Zhan Y, Tao Y, Liu Z, Sun X, Hu Y, Wang Q, Ye D, Zhang J, Zou S, Wang Y, Wei G, Liu Y, Shi Y, Eugene Chin Y, Hao Y, Wang F*, Zhang X*. Iron-dependent histone 3 lysine 9 demethylation controls B cell proliferation and humoral immune responses. Nature Communications. 2019 Jul 3;10(1):2935. (共同通讯作者)
14, Wang Q^#, Chen X^#, Jiang Y^#, Liu S, Liu H, Sun X, Zhang H, Liu Z, Tao Y, Li C, Hu Y, Liu D, Ye D, Liu Y, Wang M*, Zhang X*. Elevating H3K27me3 levels sensitizes colorectal cancer to chemotherapy. J Mol Cell Biol. 2020 Feb 20;12(2):125-137. (共同通讯作者)
15, Liu H^#, Ye D^#, Chen A^#, Tan D, Zhang W, Jiang W, Wang M*, Zhang X*. A pilot study of new promising non-coding RNA diagnostic biomarkers for early-stage colorectal cancers. Clin Chem Lab Med. 2019, Jun 26;57(7):1073-1083 (共同通讯作者)
16, Zhang YS^#, Xin DE, Wang Z, Song X, Sun Y, Zou QC, Yue J, Zhang C, Zhang JM, Liu Z, Zhang X, Zhao TC, Su B, Chin YE*. STAT4 activation by leukemia inhibitory factor confers a therapeutic effect on intestinal inflammation. EMBO J. 2019 Mar 15;38(6). pii: e99595
17, Zhang L^#, Liu Y, Wang B, Xu G, Yang Z, Tang M, Ma A, Jing T, Xu X, Zhang X, Liu Y*. POH1 deubiquitinates pro-interleukin-1β and restricts inflammasome activity. Nat Commun. 2018; 9(1):4225. doi: 10.1038/s41467-018-06455-z.
18, Huo J^#, Chen X, Zhang H, Hu Y, Jiang Y, Liu S, Zhang X*. Bcl-3 promotes proliferation and chemosensitivity in BL1 subtype of TNBC cells. Acta Biochim Biophys Sin (Shanghai). 2018 Nov 1;50(11):1141-1149 (通讯作者)
19, Huang C^#, Zhang Z, Chen L, Lee HW, Ayrapetov MK, Zhao TC, Hao Y, Gao J, Yang C, Mehta GU, Zhuang Z, Zhang X, Hu G, Chin YE*. Acetylation within the N- and C-terminal domains of Src regulate distinct roles of STAT3-mediated tumorigenesis. Cancer Res. 2018 Jun 1;78(11):2825-2838
20, Tao Y^#, Liu Z^#, Hou Y^#, Wang S, Liu S, Jiang Y, Tan D, Ge Q, Li C, Hu Y, Liu Z, Chen X, Wang Q, Wang M*, and Zhang X*. Alternative NF-κB signaling promotes colorectal tumorigenesis through transcriptionally up-regulating Bcl-3. Oncogene. 2018 Nov;37(44):5887-5900 (共同通讯作者)
21, Chen P^#, Zhang H^#, Sun X, Hu Y, Jiang W, Liu Z, Liu S, Zhang X*. microRNA-449a modulates medullary thymic epithelial cell differentiation. Scientific Reports. 2017; 7(1):15915 (通讯作者)
22, Wei Y^#, Zhan Y^#, Chen P, Liu Z, Zhang H, Liu D, Zhang J, Yu M, Mo W, Zhang J*, Zhang X*. Expression, Purification and Biological Characterization of the Extracellular Domain of Human RANK in Pichia pastoris. BMC Biotechnology. 2017; 17:87. (共同通讯作者)
23, Chen R^#, Wang L, Liu S, Chen X, Hu Y, Liu H, Zhang H, Jiang Y, Ye D, Li L, Liu D, Pan X, Wei L, Li X*, Zhang X*. Bcl-3 is a novel biomarker of renal fibrosis in chronic kidney diseases. Oncotarget. 2017; 8:97206-97216. (共同通讯作者)
24, Ma L^#, Huang C, Wang XJ, Xin DE, Wang LS, Zou QC, Zhang YS, Tan MD, Wang YM, Zhao TC, Chatterjee D, Altura RA, Wang C, Xu YS, Yang JH, Fan YS, Han BH, Si J, Zhang X, Cheng J, Chang Z, Chin YE*. Lysyl Oxidase 3 Is a Dual-Specificity Enzyme Involved in STAT3 Deacetylation and Deacetylimination Modulation. Molecular Cell. 2017 Jan 19;65(2):296-309.
25, Chen X^#, Cao X^#, Sun X, Lei R, Chen P, Zhao Y, Jiang Y, Yin J, Chen R, Ye D, Wang Q, Liu Z, Liu S, Cheng C, Mao J, Hou Y, Wang M, Siebenlist U, Eugene Chin YE, Wang Y, Cao L, Hu G*, Zhang X*. Bcl-3 regulates TGFβ signaling by stabilizing Smad3 during breast cancer pulmonary metastasis. Cell Death Dis. 2016 Dec 1;7(12):e2508. doi: 10.1038/cddis.2016.405. (共同通讯作者)
26, Ge QL^#, Liu SH^#, Ai ZH, Tao MF, Ma L, Wen SY, Dai M, Liu F, Liu HS, Jiang RZ, Xue ZW, Jiang YH, Sun XH, Hu YM, Zhao YX, Chen X, Tao Y, Zhu XL, Ding WJ, Yang BQ, Liu DD, Zhang XR*, Teng YC*. RelB/NF-κB links cell cycle transition and apoptosis to endometrioid adenocarcinoma tumorigenesis. Cell Death Dis. 2016 Oct 6;7(10):e2402. doi: 10.1038/cddis.2016.309. (共同通讯作者)
27, Sun X^#, Liu S^#, Chen P, Fu D, Hou Y, Hu J, Liu Z, Jiang Y, Cao X, Cheng C, Chen X, Tao Y, Li C, Hu Y, Liu Z, Zhan Y, Mao J, Wang Q, Ma Y, Cong X, Sun R, Shi Y, Wang M*, Zhang X*. miR-449a inhibits colorectal cancer progression by targeting SATB2. Oncotarget. 2016 Jul 28;8(60):100975-100988 (共同通讯作者)
28, Zhan Y^#, Wei Y, Chen P, Zhang H, Liu D, Zhang J, Liu R, Chen R, Zhang J, Mo W^#, Zhang X*. Expression, purification and biological characterization of the extracellular domain of CD40 from Pichia pastoris. BMC Biotechnol. 2016 Jan 25;16(1):8. doi: 10.1186/s12896-016-0237-1. (共同通讯作者)
29, Liu Z^#, Cao W^#, Xu L, Chen X, Zhan Y, Yang Q, Liu S, Chen P, Jiang Y, Sun X, Tao Y, Hu Y, Li C, Wang Q, Wang Y*, Chen CD*, Shi Y*, Zhang X*. The histone H3 lysine-27 demethylase Jmjd3 plays a critical role in specific regulation of Th17 cell differentiation. J Mol Cell Biol. 2015 Dec;7(6):505-16 (共同通讯作者)
30, Zhang R^#, Jin S, Rao W, Song F, Yin Q, Wang Y, Wang L, Xi Y, Zhang X, Wang M*, Ge H*. OVA12, a novel tumor antigen, promotes cancer cell growth and inhibits 5-fluorouracil-induced apoptosis. Cancer Lett. 2015 Feb 1;357(1):141-51
31, Liu S^#, Sun X^#, Wang M^#, Hou Y, Zhan Y, Jiang Y, Liu Z, Cao X, Chen P, Liu Z, Chen X, Tao Y, Xu C, Mao J, Cheng C, Li C, Hu Y, Wang L, Chin YE, Shi Y, Siebenlist U, Zhang X*. A microRNA 221- and 222-mediated feedback loop maintains constitutive activation of NFκB and STAT3 in colorectal cancer cells. Gastroenterology. 2014 Oct;147(4):847-859 (通讯作者)
32, Chen P^#, Zhang J^#, Zhan Y, Su J, Du Y, Xu G, Shi Y, Siebenlist U, Zhang X*. Established thymic epithelial cell progenitor/ stem cell lines differentiate into mature thymic epithelial cells and support T cell development. PloS One. 2013 Sep 23;8(9):e75222. doi: 10.1371/journal.pone.**. (通讯作者)
33, Liu Z^#, Jiang Y^#, Hou Y^#, Hu Y, Cao X, Tao Y, Xu C, Liu S, Wang S, Wang L, Shi Y, Siebenlist U, Zhang X*. The IκB family member Bcl-3 stabilizes c-Myc in colorectal cancer. J Mol Cell Biol. 2013 Aug;5(4):280-2. (通讯作者)
34, Zhang X*^#, Paun A^#, Claudio E, Wang H, Siebenlist U*. The Tumor Promoter and NF-κB modulator Bcl-3 regulates splenic B cell development. J Immunol. 2013 Nov 15. 191(12):5984-92 (共同通讯作者)
35, Liu B^#, Liu YF, Du YR, Mardaryev AN, Yang W, Chen H, Xu ZM, Xu CQ, Zhang XR, Botchkarev VA, Zhang Y, Xu GL*. Cbx4 regulates the proliferation of thymic epithelial cells and thymus function. Development. 2013 Feb;140(4):780-8.
36, Chen Q^#, Shou P, Zhang L, Xu C, Zheng C, Han Y, Li W, Huang Y, Zhang X, Shao C, Roberts AI, Rabson AB, Ren G, Zhang Y, Wang Y, Denhardt DT, Shi Y*. An Osteopontin-integrin interaction plays a critical role in directing adipogenesis and osteogenesis by mesenchymal stem cells. Stem Cells. 2013 Oct 7. doi: 10.1002/stem.1567.
37, Wang S, Liu Z, Wang L, Zhang X*. NF-kappaB signaling pathway, inflammation and colorectal cancer. Cell Mol Immunol. 2009 Oct; 6(5):327-34. (通讯作者)
38, Zhang X^#, Wang H, Claudio E, Brown K, Siebenlist U*. A role for the IkappaB family member Bcl-3 in the control of central immunologic tolerance. Immunity. 2007 Sep;27(3):438-52.
39, Zhang XR^#, Zhang LY, Devadas S, Li L, Keegan AD, Shi YF*. Reciprocal expression of TRAIL and CD95L in Th1 and Th2 cells: role of apoptosis in T helper subset differentiation. Cell Death and Differentiation. 2003 Feb;10(2):203-10.
40, Roberts AI^#, Devadas S, Zhang X, Zhang L, Keegan A, Greeneltch K, Solomon J, Wei L, Das J, Sun E, Liu C, Yuan Z, Zhou JN, Shi Y*. The role of activation-induced cell death in the differentiation of T-helper-cell subsets. Immunol Res. 2003;28(3):285-93.
41, Wang R^#, Zhang L, Zhang X, Moreno J, Celluzzi C, Tondravi M, Shi Y*. Regulation of activation-induced receptor activator of NF-kappaB ligand (RANKL) expression in T cells. Eur J Immunol. 2002 Apr;32(4):1090-8.
42, Wang R^#, Zhang L, Zhang X, Moreno J, Luo X, Tondravi M, Shi Y*. Differential regulation of the expression of CD95 ligand, receptor activator of nuclear factor-kappa B ligand (RANKL), TNF-related apoptosis-inducing ligand (TRAIL), and TNF-alpha during T cell activation. J Immunol. 2001 Feb 1; 166(3):1983-90

国家发明专利
1，预防和治疗结直肠癌的方法和试剂 专利申请号：7.2(第一申请人)
2，抑制肿瘤转移的方法和试剂 专利申请号：8.7 (第一申请人) 已授权，专利号：ZL8.7 授权公开日2016.6.22
3，利用microRNA海绵技术预防和治疗肿瘤的方法 专利申请号：6.9 (第一申请人)，已授权，专利号：ZL6.9授权公开日2017.5.10
4，一种CD40胞外区的表达纯化及其应用专利申请号：6.8 (第一申请人), 已授权，专利号：6.8
5，Bcl-3作为诊断早期肾纤维化的标志物的应用 专利申请号：7.4 (第一申请人)
6，CD40突变体及其在弥漫性大B淋巴瘤的治疗中应用 专利申请号：6.4 (第一申请人)
7，长链非编码RNA在结直肠癌中的应用 专利申请号：6.5 (第一申请人)
8，一种CD40单克隆抗体制备方法及其应用，专利申请号：8.X (第一申请人)
9，非经典NF-?B通路抑制剂及其应用，专利申请号：3.2 (第一申请人)
10, 铁剂在提升缺铁性贫血病人B细胞水平中的应用，专利申请号：2.6 (共同第一申请人)
11, 与间皮素结合的单克隆抗体及其制备方法，专利申请号：4.3 (第一申请人)
培养人才
博士生：刘占杰、曹新伟、陈鹏飞、毛杰、程春燕、蒋宇航、刘志、陶煜、陈希、孙小华、李翠峰、胡一鸣、张浩浩、王琪、叶德佶、刘丹丹、蒋文霞（在读）、赵婷（在读）、王竟尧（在读）
硕士生：詹誉、张届、李玲玲、陈然、霍君好慧、孙东麟（在读）、陈伟峰（在读）、赵秋梅（在读）、肖丽萍（在读）、粱伟飞（在读）
博士后和青年人才：钱国军、刘三宏、刘寒梢、黄沾、刘占杰、朱文博、陈鹏飞、陈希、李翠峰、胡一鸣、蒋宇航（在站博后）、张浩浩（在站博后）、谢宁峡（在站博后）、陶煜（在站博后）、刘丹丹（在站博后）
电子邮箱：xrzhang@sibs.ac.cn