个人概括
姓名：侯智尧 性别：男 职称：教授 导师资格：硕士、博士导师
单位：基础医学院 学历：博士 毕业院校：哈尔滨工程大学
电子邮件： zyhou@gzhmu.edu.cn 通信地址： 广州医科大学番禺校区
招生专业： 病理与病理生理学、肿瘤学博士研究生；生物医学工程、肿瘤学、生物化学与分子生物学 硕士研究生


研究方向
针对光能转换材料合成与应用中的基本科学问题，以电子跃迁和稀土离子能量传递为理论基础，结合医学、生物学、材料学和化学等多学科交叉的研究优势，开展新型纳米光能转换材料构建及其在肿瘤光学诊疗中应用的基础研究，实现了多模态影像导航下的近红外光响应抗肿瘤协同治疗；结合肿瘤治疗临床标准开展肿瘤微环境响应的温度可控光热治疗；同时开展纳米光能转换材料在蛋白及核酸的时间分辨检测、牙周相关疾病/神经退行性疾病治疗及骨修复方面的应用研究。


主持科研项目
(1) 国家自然科学基金面上项目，编号**，项目名称：可分解的碳酸钙包覆氧化亚铜纳米复合材料用于结直肠肿瘤微环境触发的多模态协同治疗，起止时间：2021/01-2024/12，资助金额：直接经费58 万元，在研，主持；
(2) 国家自然科学基金面上项目，编号**，项目名称：多功能羟基磷灰石纳米晶的控制合成及其在活性组织工程骨构建中的应用，起止时间：2017/01-2020/12，资助金额：直接经费62 万元，已结题，主持；
(3) 国家自然科学基金面上项目，编号**，项目名称：二氧化钛/稀土上转换发光纳米复合材料的合成及其近红外光响应光动力疗法抗肿瘤作用的研究，起止时间：2015/01-2018/12，资助金额：83 万元，已结题，主持；
(4) 国家自然科学基金青年项目，编号**，项目名称：多功能介孔SiO₂/水凝胶纳米复合纤维双重载药体系的制备，起止时间：2013/01-2015/12，资助金额：25 万元，已结题，主持；
(5) 国家自然科学基金海外及港澳****合作基金，编号**，项目名称：染料敏化上转换纳米材料的调控及在肿瘤诊疗中的应用，起止时间：2019/01-2020/12，资助金额：直接经费18 万元，已结题，国内主持；


部分代表性第一和通讯作者论文：
1. Mengyu Chang, Zhiyao Hou*, Man Wang, Chunxia Li, Jun Lin*, Recent Advances in Hyperthermia Therapy-Based Synergistic Immunotherapy, Advanced Materials, 2021, **. (IF:27.398)
2. Mengyu Chang, Zhiyao Hou*, Dayong Jin*, Jiajia Zhou, Man Wang, Meifang Wang, Mengmeng Shu, Binbin Ding, Chunxia Li, Jun Lin*, Colorectal Tumor Microenvironment‐Activated Bio‐Decomposable and Metabolizable Cu₂O@CaCO₃ Nanocomposites for Synergistic Oncotherapy, Advanced Materials, 2020, 32(43), **. (IF:27.398)
3. Mengyu Chang, Man Wang, Meifang Wang, Mengmeng Shu, Binbin Ding, Chunxia Li, Maolin Pang, Shuzhong Cui, Zhiyao Hou*, Jun Lin*, A Multifunctional Cascade Bioreactor Based on Hollow-Structured Cu₂MoS₄ for Synergetic Cancer Chemo-Dynamic Therapy/Starvation Therapy/Phototherapy/Immunotherapy with Remarkably Enhanced Efficacy, Advanced Materials, 2019, 31(53), **. (IF: 27.398)
4. MeiFang Wang, Kerong Deng, Wei Lü, Xiaoran Deng, Kai Li, Yanshu Shi, Binbin Ding, Ziyong Cheng, Zhiyao Hou*, Jun Lin*, Rational Design of Multifunctional Fe@γ-Fe₂O₃@H-TiO₂ Nanocomposites with Enhanced Magnetic and Photoconversion Effects for Wide Applications: from Photocatalysis to Imaging-guided Photothermal Cancer Therapy, Advanced Materials, 2018, 30(13), **. (IF: 27.398)
5. Bei Liu, Chunxia Li*, Piaoping Yang, Zhiyao Hou*, Jun Lin*, 808-nm-Light-Excited Lanthanide-Doped Nanoparticles: Rational Design, Luminescence Control and Theranostic Applications, Advanced Materials, 2017, 29(18), **. (IF: 27.398, ESI高被引论文)
6. Kerong Deng, Zhiyao Hou*, Xiaoran Deng, Piaoping Yang, Chunxia Li, Jun Lin*, Enhanced Antitumor Efficacy by 808 nm Laser-Induced Synergistic Photothermal and Photodynamic Therapy Based on a Indocyanine-Green-Attached W₁₈O₄₉ Nanostructure, Advanced Functional Materials, 2015, 25(47), 7280–7290. (IF:16.836)
7. Zhiyao Hou, Yuanxin Zhang, Kerong Deng, Yinyin Chen, Xuejiao Li, Xiaoran Deng, Ziyong Cheng, Hongzhou Lian, Chunxia Li*, Jun Lin*, UV-Emitting Upconversion-Based TiO₂ Photosensitizing Nanoplatform Near-Infrared Light Mediated in Vivo Photodynamic Therapy via Mitochondria-Involved Apoptosis Pathway, ACS Nano, 2015, 9(3), 2584–2599. (IF:14.588, ESI高被引论文)
8. Meifang Wang, Zhiyao Hou*, Saina Liu, Shuang Liang, Binbin Ding, Yajie Zhao, Mengyu Chang, Gang Han, Abdulaziz A. Al Kheraif, Jun Lin*, A Multifunctional Nanovaccine based on L-Arginine-Loaded Black Mesoporous Titania: Ultrasound-Triggered Synergistic Cancer Sonodynamic Therapy/Gas Therapy/Immunotherapy with Remarkably Enhanced Efficacy, Small, 2021, **. (IF:11.459)
9. Mengyu Chang, Zhiyao Hou*, Man Wang, Meifang Wang, Peipei Dang, Jianhua Liu, Mengmeng Shu, Binbin Ding, Abdulaziz A. Al Kheraif, Chunxia Li*, Jun Lin*, Cu₂MoS₄/Au Heterostructures with Enhanced Catalase-Like Activity and Photoconversion Efficiency for Primary/Metastatic Tumors Eradication by Phototherapy-Induced Immunotherapy, Small, 2020, 16(14), **. (IF:11.459)
10. Zhiyao Hou, Kerong Deng, Chunxia Li, Xiaoran Deng, Hongzhou Lian, Ziyong Cheng, Dayong Jin, Jun Lin*, 808 nm Light-triggered and hyaluronic acid-targeted dual-photosensitizers nanoplatform by fully utilizing Nd³⁺-sensitized upconversion emission with enhanced anti-tumor efficacy, Biomaterials, 2016, 101, 32–46. (IF:10.273)