胡炎伟，广州市妇女儿童医疗中心临床检验部主任，医学博士，教授，主任技师，博士研究生导师，广东省****基金获得者，广东省****医学人才。


工作经历：
2012/07-2014/12，南方医科大学南方医院，检验科，主管技师；
2015/01-2017/02，南方医科大学南方医院，检验科，副主任技师；
2017/03-2018/02，英国Glenfield Hospital访问****；
2018/03-2019/06，南方医科大学南方医院，检验科，副主任技师；
2019/06-2019-09，南方医科大学南方医院，检验科，教授，主任技师；
2019/10-至今，广州市妇女儿童医疗中心，临床检验部主任，教授，主任技师；


学术任职：
1. 中华医学会检验分会青年委员会委员；
2. 中华医学会检验医学分会委员会临床生物化学学组委员；
3. 中国医师协会检验医师分会心血管检验医学委员会委员；
4. 中国生物化学与分子生物学会脂质与脂蛋白专业委员会青年委员会委员；
5. 广东省医学会检验医学分会青年委员会副主任委员；
6. 广东省肝脏病学会检验诊断专业委员会常委；
7. 中国中西医结合协会检验医学专业委员会心脑血管疾病实验诊断专家委员会副主任委员；
8. 广东省妇幼保健学会检验委员会常委；
9. 国家卫生健康委能力建设与继续教育检验医学专家委员会委员。


主持课题：
1. 国家自然基金项目 （**） 2021.1-2024.12 SE-lncRNA PSMB8-AS1/PSMB9/ ABCA1途径对胆固醇平衡和动脉粥样硬化的影响和机制研究 55万；
2 国家自然基金项目 （**） 2019.1-2022.12 LncRNA NEXN-AS1/NEXN途径介导OX-LDL对细胞焦亡和AS的影响及机制研究 57万；
3. 国家自然基金项目 （**） 2016.1-2019.12 LncRNA RP11-463O9.5对FOXC2的调控及其在胆固醇平衡和动脉粥样硬化发展中的作用 71.8万；
4. 国家自然基金项目 （**） 2014.1-2016.12 长链非编码RNA RP5-833A20.1对NFIA的调控及其在胆固醇平衡和动脉粥样硬化发生发展中作用的研究 23万；
5. 广东省自然科学基金****项目（2020B）2019.10-2023.09 100万， 动脉粥样硬化调控机制和诊断新标志物开发研究;
6. 广东省自然科学基金（2017A） 2017.05-2020.05 LncRNA RP5-833A20.1-NFIA途径介导OX-LDL对细胞自噬和AS的影响及机制研究 10万；
7 广东省自然科学基金（2014A） 2015.1-2017.12 LOC283683-NIPA1-BMPRII途径对胆固醇平衡和动脉粥样硬化的影响及机制研究 10万；
8. 广东省医学科研基金（B**） 2014.5-2016.6 长链非编码RNA RP5-833A20.1对NFIA的调控及其在胆固醇平衡和动脉粥样硬化发生发展中作用的研究 0.5万元；
9. 广州市科技计划（7） 2016.1-2018.12 LncRNARP11-463O9.5对FOXC2的调控及其在胆固醇平衡和动脉粥样硬化发展中的作用 20万；


发表论文：
主要从事心血管疾病早期诊断新标志物开发和机制研究，妇科产科常见病多发病的发病机制和诊断新标志物开发研究，以及新生儿脏器损伤早期诊断新标志物开发研究等。以第一或通讯作者在J Clin Invest（12.282）、Cell Death Differ（10.717）和Arterioscler Thromb Vasc Biol（6.604）等刊物上发表SCI收录论文50余篇。近五年代表性论文如下：
1. Hu YW*#(第一作者和并列通讯作者), Guo FX, Xu YJ, Li P, Lu ZF, McVey DG, Zheng L, Wang Q, Ye JH, Kang CM, Wu SG, Zhao JJ, Ma X, Yang Z, Fang FC, Qiu YR, Xu BM, Xiao L, Wu Q, Wu LM, Ding L, Webb TR, Samani NJ, Ye S#. Long non-coding RNA NEXN-AS1 mitigates atherosclerosis by regulating the actin-binding protein NEXN. J Clin Invest. 2019; 129(3): 1115-1128. (SCI收录, IF: 12.282)
2. Guo FX*, Wu Q, Li P, Zheng L, Ye S, Dai XY, Kang CM, Lu JB, Xu BM, Xu YJ, Xiao L, Lu ZF, Bai HL,Hu YW#(并列通讯作者), Wang Q#. The role of the LncRNA-FA2H-2-MLKL pathway in atherosclerosis by regulation of autophagy flux and inflammation through mTOR- dependent signaling. Cell Death Differ. 2019; 26(9): 1670-1687. (SCI收录, IF:10.717)
3. Dong XH*, Lu ZF*, Kang CM, Li XH, Haworth KE, Ma X, Lu JB, Liu XH, Fang FC, Wang CS, Ye JH, Zheng L, Wang Q, Ye S#, Hu YW#(并列通讯作者). The Long Noncoding RNA RP11-728F11.4 Promotes Atherosclerosis. Arterioscler Thromb Vasc Biol. 2021; 41(3): 1191-1204. (SCI收录, IF: 6.680)
4. Li S*, Hu YW#(并列通讯作者). Pathogenesis of uteroplacental acute atherosis: An update on current research. Am J Reprod Immunol. 2021; e13397. (SCI收录, IF: 2.739)
5. Kang CM*, Bai HL, Li XH, Huang RY, Zhao JJ, Dai XY, Zheng L, Qiu YR#,Hu YW#(并列通讯作者), Wang Q#. The binding of lncRNA RP11-732M18.3 with 14-3-3β/α accelerates p21 degradation and promotes glioma growth. EBioMedicine. 2019; 45:58-69. (SCI收录, IF: 6.680)
6. Hu YW*, Zhao JY, Li SF, Huang JL, Qiu YR, Ma X, Wu SG, Chen ZP, Hu YR, Yang YJ, Wang YC, Gao JJ, Sha YH, Zheng L#, Wang Q#. A RP5-833A20.1/miR-382-5p/NFIA-dependent Signal Transduction Pathway Contributes to the Regulation of Cholesterol Homeostasis and Inflammatory Reaction. Arterioscler Thromb Vasc Biol. 2015; 35(1): 87-101. (SCI收录, IF: 6.604)
7. Hu YW*, Wu SG*, Zhao JJ, Ma X, Lu JB, Xiu JC, Zhang Y, Huang C, Qiu YR, Sha YH, Gao JJ, Wang YC, Li SF, Zhao JY, Zheng L#, Wang Q#. VNN1 Promotes Atherosclerosis Progression in apoE Deficiency Mice Fed a High Fat High Cholesterol Diet. J Lipid Res. 2016; 57(8):1398-411.（SCI收录, IF: 4.810）
8. Hu YW*, Kang CM*, Zhao JJ, Nie Y, Zheng L, Li HX, Li X, Wang Q#, Qiu YR#. LncRNA PLAC2 down-regulates RPL36 expression and blocks cell cycle progression in glioma through a mechanism involving STAT1. J Cell Mol Med. 2018; 22(1):497-510. (SCI收录, IF: 4.658)
9. Wu LM*, Wu SG*, Chen F, Wu Q, Wu CM, Kang CM, He X, Zhang RY, Lu ZF, Li XH, Xu YJ, Li LM, Ding L, Bai HL, Liu XH,Hu YW#(并列通讯作者), Zheng L#. Atorvastatin inhibits pyroptosis through the lncRNA NEXN-AS1/NEXN pathway in human vascular endothelial cells. Atherosclerosis. 2020; 293(0): 26-34. (SCI收录, IF: 4.255)
10. Li KY*, Zheng L, Wang Q,Hu YW#(通讯作者). Characteristics of erythrocyte-derived microvesicles and its relation with atherosclerosis. Atherosclerosis. 2016; 255: 140-144.（SCI收录, IF:4.239）
11. Wang ZT*, Wang Z,Hu YW#（通讯作者）. Possible roles of platelet-derived microparticles in atherosclerosis. Atherosclerosis. 2016; 248:10-16.（SCI收录, IF: 4.239）
12. Yao XX*, Lu JB*, Ye ZD, Zheng L, Wang Q, Lin ZQ, Liu H, Wan H, Fu FY, Huang XY, Xiu JC, Liu ZJ#,Hu YW#(并列通讯作者). Hairy/enhancer of Split Homologue-1 Suppresses Vascular Endothelial Growth Factor-induced Angiogenesis via Downregulation of Osteopontin Expression. Sci Rep. 2017; 7(1): 898. (SCI收录, IF:4.122)
13. Liu Y*, Zheng L, Wang Q, Hu YW#(通讯作者). Emerging roles and mechanisms of long noncoding RNAs in atherosclerosis. Int J Cardiol. 2017;228:570-582.（SCI收录, IF: 4.034）
14. Zhang Y*, Zheng L, Xu BM, Tang WH, Ye ZD, Huang C, Ma X, Zhao JJ, Guo FX, Kang CM, Lu JB, Xiu JC, Li P, Xu YJ, Xiao L, Wu Q,Hu YW#(并列通讯作者), Wang Q#. LncRNA-RP11-714G18.1 suppresses vascular cell migration via directly targeting LRP2BP. Immunol Cell Biol. 2018; 96(2):175-189. (SCI收录, IF: 3.947)
15. Hu YW*, Chen ZP, Hu XM, Zhao JY, Huang JL, Ma X, Li SF, Qiu YR, Wu XJ, Sha YH, Gao JJ, Wang YC, Zheng L#, Wang Q#. The miR-573/apoM/Bcl2A1-dependent signal transduction pathway is essential for hepatocyte apoptosis and hepatocarcinogenesis. Apoptosis. 2015; 20(10): 1321-1337. (SCI收录, IF: 3.592)
16. Xu BM*, Xiao L*, Kang CM, Ding L, Guo FX, Li P, Lu ZF, Wu Q, Xu YJ, Bai HL, Tang JY, Zheng L#,Hu YW#(并列通讯作者), Wang Q#. LncRNA AC096664.3/PPAR-γ/ABCG1-dependent signal transduction pathway contributes to the regulation of cholesterol homeostasis. J Cell Biochem. 2019; 120(8): 13775-13782. (SCI收录, IF: 3.448)
17. Zhao JJ*,Hu YW*(并列第一作者), Huang C, Ma X, Kang CM, Zhang Y, Guo FX, Lu JB, Xiu JC, Qiu YR, Sha YH, Gao JJ, Wang YC, Li P, Xu BM, Zheng L#, Wang Q#. Dihydrocapsaicin suppresses proinflammatory cytokines expression by enhancing nuclear factor IA in a NF-κB-dependent manner. Arch Biochem Biophys. 2016; 604:27-35.（SCI收录, IF: 3.165）
18. Hu YW*, Xiao L*, Zheng L, Wang Q#. Synaptic vesicle 2C and its synaptic-related function. Clin Chim Acta. 2017; 472:112-117. (SCI收录, IF: 2.926)
19. Xu YJ*, Li P*, Zheng L, Guo FX, Kang CM, Ding L, Xu BM, Lu JB, Xiao L, Wu Q, Lu ZF, Bai HL,Hu YW#(并列通讯作者), Wang Q#. Forkhead Box C2 Attenuates Lipopolysaccharide-Induced Cell Adhesion via Suppression of Intercellular Adhesion Molecule-1 Expression in Human Umbilical Vein Endothelial Cells. DNA Cell Biol. 2019;38(6):1-9. (SCI收录, IF: 2.918)
20. Wang T*, Zheng L, Wang Q,Hu YW#(通讯作者). Emerging roles and mechanisms of FOXC2 in cancer. Clin Chim Acta. 2018; 479:84-93. (SCI收录, IF: 2.735)
21. Xu YJ*, Zheng L,Hu YW#(并列通讯作者), Wang Q#. Pyroptosis and its relationship to atherosclerosis. Clin Chim Acta. 2018 Jan;476:28-37. (SCI收录, IF: 2.735)
22. Guo FX*,Hu YW*(并列一作), Zheng L, Wang Q#. Shear Stress in Autophagy and Its Possible Mechanisms in the Process of Atherosclerosis. DNA Cell Biol. 2017; 36(5):335-346 (SCI收录, IF: 2.634)
23. Wang YC*,Hu YW*(并列第一作者), Sha YH, Gao JJ, Ma X, Li SF, Zhao JY, Qiu YR, Lu JB, Huang C, Zhao JJ, Zheng L#, Wang Q#. Ox-LDL Upregulates IL-6 Expression by Enhancing NF-κB in an IGF2-Dependent Manner in THP-1 Macrophages.Inflammation. 2015; 38(6): 2116-2123. (SCI收录, IF: 2.618)
24. Ma X*, Zhao JY, Zhao ZL, Ye J, Li SF, Fang HH, Gu MN,Hu YW#（并列通讯作者）, Qin ZS#. Propofol Attenuates Lipopolysaccharide-Induced Monocyte Chemoattractant Protein-1 Production Through Enhancing apoM and foxa2 Expression in HepG2 Cells. Inflammation. 2015; 38(3): 1329-1336.（SCI收录, IF: 2.618）
25. Li SF*,Hu YW* (并列第一作者), Zhao JY, Ma X, Wu SG, Lu JB, Hu YR, Wang YC, Gao JJ, Sha YH, Zheng L#, Wang Q#. Ox-LDL Upregulates CRP Expression Through the IGF2 Pathway in THP-1 Macrophages. Inflammation. 2015;38(2):576-583. (SCI收录, IF: 2.618)
26. Bai HL*, Lu ZF*, Zhao JJ*, Ma X, Li XH, Xu H, Wu SG, Kang CM, Lu JB, Xu YJ, Xiao L, Wu Q, Ye S, Wang Q, Zheng L,Hu YW#(通讯作者). Microarray profiling analysis and validation of novel long non-coding RNAs and mRNAs as potential biomarkers and their functions in atherosclerosis. Physiol Genomics. Physiol Genomics. 2019; 51(12): 644-656. (SCI收录, IF: 2.581)
27. Gao JJ*,Hu YW* (并列第一作者), Wang YC, Sha YH, Ma X, Li SF, Zhao JY, Lu JB, Huang C, Zhao JJ, Zheng L#, Wang Q#. ApoM Suppresses TNF-α-Induced Expression of ICAM-1 and VCAM-1 Through Inhibiting the Activity of NF-κB. DNA Cell Biol. 2015 Aug;34(8):550-6.(SCI收录, IF: 2.574)
28. Xu H*,Hu YW* (并列第一作者), Zhao JY, Hu XM, Li SF, Wang YC, Gao JJ, Sha YH, Kang CM, Lin L, Huang C, Zhao JJ, Zheng L#, Wang Q#. MicroRNA-195-5p acts as an anti-oncogene by targeting PHF19 in hepatocellular carcinoma. Oncol Rep. 2015; 34(1): 175-182. (SCI收录, IF: 2.486)
29. Lu JB*, Yao XX*, Xiu JC,Hu YW#（通讯作者）. MicroRNA-125b-5p attenuates lipopolysaccharide- induced monocyte chemoattractant protein-1 production by targeting inhibiting LACTB in THP-1 macrophages. Arch Biochem Biophys. 2016;590:64-71. (SCI收录, IF: 2.466)
30. Huang C*,Hu YW* (并列第一作者), Zhao JJ, Ma X, Zhang Y, Guo FX, Kang CM, Lu JB, Xiu JC, Sha YH, Gao JJ, Wang YC, Li P, Xu BM, Zheng L#, Wang Q#. Long Non-Coding RNA HOXC-AS1 Suppresses Ox-LDL-Induced Cholesterol Accumulation Through Promoting HOXC6 Expression in THP-1 Macrophages. DNA Cell Biol. 2016; 35(11):722-729.(SCI收录, IF: 2.236)
31. Ma X*, Li SF, Qin ZS, Ye J, Zhao ZL, Fang HH, Yao ZW, Gu MN,Hu YW#（通讯作者）. Propofol up-regulates expression of ABCA1, ABCG1, and SR-B1 through the PPARγ/LXRα signaling pathway in THP-1 macrophage-derived foam cells. Cardiovasc Pathol. 2015; 24(4): 230-235.（SCI收录, IF: 2.190）
32. Kang CM*,Hu YW* (并列第一作者), Nie Y,Zhao JY,Li SF,Chu S,Li HX,Huang QS,Qiu YR#. Long non-coding RNA RP5-833A20.1 inhibits proliferation, metastasis and cell cycle progression by suppressing the expression of NFIA in U251 cells. Mol Med Rep. 2016; 14(6): 5288-5296. (SCI收录, IF: 1.692)
33. Sha YH*,Hu YW* (并列第一作者), Gao JJ, Wang YC, Ma X, Qiu YR, Li SF, Zhao JY, Huang C, Zhao JJ, Lu JB, Kang CM, Zheng L#, Wang Q#. Lipoxin A4 promotes ABCA1 expression and cholesterol efflux through the LXRα signaling pathway in THP-1 macrophage-derived foam cells. Int J Clin Exp Pathol. 2015; 8(6): 6708-15. (SCI收录, IF: 1.581)