刘夏雯，女，博士，副教授，硕士研究生导师。广州市高层次人才-青年后备人才。广东省药学会药物分析专业委员会委员。2010-2013年于于广州医科大学攻读博士学位。同年7月进入广州医科大学药学院药物研发中心工作。主要从事新药开发中的药物代谢以及小分子于代谢酶相互作用机制研究。作为项目负责人主持国家自然科学基金一项和省市级课题多项。近五年以第一作者/通讯作者在Frontiers in pharmacology, Journal of pharmaceutical and biomedical analysis等杂志发表SCI文论多篇。指导学生获得广州医科大学大学生创新创业训练项目立项两项。
【联系邮箱】lxwgzhmu@gzhmu.edu.cn

【研究方向】1. 新药开发中药物的体内外药代动力学研究；2. 小分子与代谢酶的相互作用机制研究
【主要科研项目】
1. 广州市属高校科研项目，，Naftopidil及代谢物通过FXR-UGT2B15抑制雄激素蓄积发挥抗前列腺癌的机制研究在研，主持
2.国家自然科学基金青年项目，**，从naftopidil对映体诱导雄激素代谢探讨抗良性前列腺增生新靶点，结题，主持
3.广州市属高校科研项目，，手性药物naftopidil影响雄激素代谢与预防前列腺癌作用相关性，结题，主持
【主要论文及著作（代表性）】
1. Xiawen Liu, Yi Rong, Xingfei Zhang, Junjun Huang, Yi Cai, Biyun Huang, Liu Zhu, Bo Wu, Ning Hou, Chengfeng Luo. Human UDP-Glucuronosyltransferase 2B4 and 2B7 are responsible for naftopidil glucuronidation in Vitro. Frontiers in Pharmacology. 2018, 8, doi: 10.3389/fphar.2017.00984.
2. Xiawen Liu, Lijun Zhu, Biyun Huang, Junjun Huang, Yi Cai, Liu Zhu, Bo Wu, Xiaojing Fu, Xingfei Zhang, Yi Rong, Qing Xiao, Jiewen Guo, Arong Li, Yifei Guo, Mu Yuan. Poor and enantioselective bioavailability of naftopidil enantiomers is due to extensive and stereoselective metabolism in rat liver. Journal of Pharmaceutical and Biomedical Analysis. 2017, 132, pp 165-172.
3. Yi Rong, Biyun Huang, Junjun Huang, Liu Zhu, Xiawen Liu*. A rapid and simple ultraperformance liquid chromatography coupled to tandem mass spectrometry (UPLC-MS/MS) method for the detection of glucuronic acid-conjugated steroid metabolites. Journal of Chinese Pharmaceutical Sciences. 2016, 25(4), pp 291-301.
4. Xiawen Liu, Xingfei Zhang, Junjun Huang, Yi Rong, Chengfeng Luo, Jiewen Guo, Liu Zhu, Biyun Huang, Mu Yuan*. Enantiospecific determination of naftopidil by RRLC-MS/MS reveals stereoselective pharmacokinetics and tissue distributions in rats. Journal of Pharmaceutical and Biomedical Analysis. 2015, 112: 147-154
5. Lijun Zhu^#, Xiawen Liu^#, Liu Zhu, Xingfei Zhang, Xiaojing Fu, J unjun Huang, Mu Yuan*. Identification of human cytochrome P450 isozymes involved in the metabolism of naftopidil enantiomers in vitro. Journal of Pharmacy and Pharmacology. 2014, 66(11):1534-1551 （Co-first author）
6. Yunying Zhang^#, Xiawen Liu^#, Mu Yuan*, Lijun Zhu. Simultaneous stereoselective analysis of naftopidil and O-desmethyl naftopidil enantiomers in rat feces using an online column-switching high performance liquid chromatography method. Journal of Biomedical Chromatography. 2014, 28:1030-1035 （Co-first author）
7. Xiawen Liu, Yunying Zhang, Mu Yuan*, Yinxiang Sun. Determination of Naftopidil enantiomers in rat plasma using chiral solid phases and pre-column derivatization high performance Liquid Chromatography. Journal of Chromatography B. 2012 (907) 140-145.