Yang K. Xiang教授，博士，美国加州大学戴维斯分校医学院药理学系教授，研究方向代谢与心衰和老年痴呆的相关性Metabolism, heart failure and Alzheimer’s disease。2000美国奥勒冈州科学院细胞与发育生物学Ph.D.，随后在斯坦福大学从事博后研究工作，师从诺贝尔奖得主Dr. Brian Kobilka (布莱恩·克比尔卡，获得2012年诺贝尔化学奖)。是美国心脏病协会、美国生物化学与分子生物学、美国药理学与实验治疗学会委员等多个国际科研组织的成员和负责人。分别在伊利诺伊大学和加州大学任助理教授和副教授，共获得美国NIH研究经费536.8万美元、VA Merit Award研究经费150.8万美元,美国心脏病协会基金72万美元、以及其它经费资助49万美元。在包括Science、Nature、Cell、PNAS、EMBO J.、JBC等杂志上发表论文共80多篇，论文被引用达到近5000次 (H factor 38)。美国专利一项。他还是许多生物技术领域重要期刊包括Circulation Research 和Diabetes 编委and Nature Communication, Science Signaling, JBC, JMCC, J. Cell Biology, Molecular Pharmacology, Plos One, Cardiovascular Research, BBA等杂志审稿人。

主要科研项目及成果： 1. R01HL127764 Abel & Xiang (Co-PI)，04/01/15 – 03/31/19，1.8 NIH/NHLBI $377,808 Insulin Inhibition of beta-AR Signaling in Myocardium. The goal of this project will directly test the potential of newly identified drug targets for reducing the risk of heart failure in people with diabetes by inhibiting β2AR and GRK2 signaling. 2. R01HL121059 Navedo (PI) 07/01/15 – 04/30/19 1.2 NIH/NIHLB $348,930 Coupling of vascular Cav1.2 channels in health and disease. The goal of this project is to understand the molecular mechanisms and functional implications of coupling of Cav1.2 channels in vascular smooth muscle during physiological and pathological conditions such as diabetes. Role: Co-Investigator 3. VA MERIT Chiamvimonvat (PI) 01/01/15 – 12/31/18 0.6 ca Department of Veteran Affairs $285,000 Regulation of ion channels in the heart. The major goal of the study is to determine the distinct regulation of cardiac calcium channel in ventricular myocytes and pacemaking cells. Role: Co-Investigator 4. R01 HL112413-01 Abel & Xiang (Co-PI) 06/01/15 – 5/30/19 1.8 ca NIH/NHLBI $250,000 Cardiac dysfunction in the metabolic syndrome: crosstalk between hyperinsulinemia and β-adrenergic signaling. The goal of this project is to determine how insulin and adrenergic signaling pathways are changed by obesity and examine if such changes alter the effectiveness of commonly used heart failure drugs in obese patients. Role: Co-PI 5. R01HL098200 Navedo (PI) 08/15/16 – 05/30/20 0.6 ca NIH/NIHLB $255,793 Calcium sparklets-induced vascular dysfunction during diabetes. The goal of this project is to define the molecular mechanisms by which glucose-mediated increases in Ca2+ sparklet activity contribute to vascular dysfunction during type 2 diabetes. Role: Collaborator 6. VA MERIT 1I01BX002900 Xiang (PI) 04/01/16 – 03/31/20 1.8 ca Department of Veteran Affairs $245,000 Molecular mechanisms of insulin resistance under chronic stress. The major goal of the study is to understand how insulin regulates glucose uptake in beta 2 adrenergic receptor-dependent manners and elucidate the contribution of this mechanism to the development of insulin resistance. Role: Principle Investigator 7. FAPESP SPRINT 07427 Xiang (PI) 10/1/2016 – 09/30/2018 0 ca Protein Quality Control of dysfunctional/atrophic skeletal muscle: role of b2 adrenergic receptor, FAPESP SPRINT, Role: Principle Investigator

所获荣誉和奖励： 2006 American Heart Association Scientist Development Award 2009 Alzheimer’s Association New Investigator Award 2012 American Heart Association Established Investigator Award 2012 Shanghai Eastern Scholar 2017 Editorial Board member, Circulation Research 2018 Editorial Board Member, Diabetes 2018 Treasurer, ASPET Division of Molecular Pharmacology

部分论文及著作：

Li YS, Yu D, Li Y, Zhao X, Zhong Z, Xia M and Xiang Y. (1991) Analysis of 245 deaths of advanced Schistosomiasis japonica. Hunan Medicine, (in Chinese) 8(4): 197-198

Li Y, Li YS, Xiang Y, He Y, Hu S, Yu D and Xia M. (1992) Studies on the relevance between Schistosomiasis japonica and HBV infection. J. of Schisitosomiasis Control. (in Chinese) 4(3): 162-164

He Y, Li YS, Li Y, Xiang Y, Hu S and Yu D (1993) Defects on the children growth and nutrition by Schistosomiasis japonica. J. of Schisitosomiasis Control. (in Chinese) 5(6): 260-263

Li Y, Li YS, Xiang Y, Yu D and Cheng S. (1993) Effects on the working ability of patients with chronic S.japonicum infection. J. of Schisitosomiasis Control. (in Chinese) 5(6): 330-332

Li YS, Yu DB, Li Y, Yuan LP, Xiang Y, Zhao X, Zhong Z and Xia M (1993) A study and analysis of the deaths due to advanced Schistosoma japonicum infection in Dongting Lake area of China. J. of Tropical Medicine and Hygiene (England), 96:128-130

联系邮箱：ykxiang@ucdavis.edu