一、基本情况
姓名:刘云军性别:男出生年月:1967、09学历（学位）:研究生（博士）
工作部门:药科学院职务:职称:教授从事专业:药物化学招生专业:药物化学
主要研究方向（最多2个）（1）小分子药物设计合成及抗肿瘤机理研究
（2）非病毒基因载体材料介导抗肝癌研究
电子信箱:liuyunjunlyj@126.com
二、学习、工作经历
1987.09-1991.07湖南科技大学化学系本科
1991.09-2000.07湖南祁阳四中
2000.09-2005.06中山大学硕士、博士
2005.07广东药学院药科学院
三、主要社会任职
1）广东省基金评审专家
2）被国外学术刊物DaltonTransactions,J.Inorg.Biochem，DNAandCellBiol,J.Coord.Chem,J.Mol.Structure,J.Biol.Inorg.Chem,Eur.J.Med.Chem,Inorg.Chim.Acta,SpectrochimActaPartA,Mol.Biol.Reports,Biochimie,J.Solution.Chem,Inorg.Chim.Commun,J.Heterochem等聘请担任论文评审专家。
四、主要学术成果（列出近年来发表的主要学术论文、专著，取得的成果、专利等）
1.近年来主持和参与的课题
1）主持一项国家自然科学基金（No31070585）,多功能钌(II)金属复合物作为非病毒基因载体介导抗肝癌研究，资助经费33.0万（在研）
2）酶促去唾液酸糖蛋白受体介导的中药脂质体研究，广东省科技厅，项目编号：S2011040003133，资助经费3.0万(第二，在研)
3）以3'－脱氧腺苷为配体的钌配合物Ru061218的制备及其抗肿瘤活性，4.0万，项目编号：07112204001212007年08月（第三）广东省科技厅（结题）
4）金属配合物和RNA或功能基因的作用机制及其生物功能,6.0万，高等学校博士学科点基金2004,第三，编号20040558031，国家教育部科技司（结题）
5）过渡金属抗肿瘤、抗病毒药物的合成、活性及其构效关系的研究广东药学院，2005年12月广东药学院博士启动，编号43540120（结题）

2.专著名称，出版社，出版时间，署名次序；
1）药学系列读书笔记《无机化学》主编，科学出版社，2010
2）《无机化学》参编，人民卫生出版社，2009
3）《无机化学学习与解题指南》主编，华中科技大学出版社，2008
4）《无机化学实验》副主编，科学出版社，2007
3.获奖情况
1）广东省"千百十工程"第七批省级培养对象
2）2012年广东药学院优秀教师
3）广东药学院第三轮重点扶持学科药学学术带头人
4）2009-2011年广东药学院重点培养教师
5）2010年广东药学院优秀统战工作者
6）10-11年度广东药学院科技工作先进个人
7）09-10年度广东药学院科技工作先进个人
8）07-08年度广东药学院科技工作先进个人
9）05-06年度广东药学院科技工作积极分子

4.近年来申报专利和发表论文情况
申报专利
1）刘云军，谢阳银，黄宏靓，林敢建，一种新型钌(II)多吡啶配合物的合成方法，申请号：201210201281.8
2）黄宏靓，林敢建，刘云军，谢阳银，一种钌配合物的合成方法，申请号：201210201201.3

近年来发表SCI收录研究论文(*通讯作者)
2012
1.X.Z.Wang,B.Y.Yang,G.J.Lin,Y.Y.Xie,H.L.Huang,Y.J.Liu^*,Cytotoxicity,cellcyclearrest,antioxidantactivityandinteractionofdibenzoxanthenesderivativeswithDNA,DNACellBiol,2012,31,1468-1474.
2.H.L.Huang,Z.Z.Li,X.Z.Wang,Z.H.Liang,Y.J.Liu^*,Cytotoxicity,apoptosis,interactionwithDNA,cellularuptake,cellcyclearrestofruthenium(II)polypyridylcomplexescontaining4,4'-dimethyl-2,2'-bipyridineasancillaryligand,J.Coord.Chem,2012,65,3287-3298.
3.L.Xu,N.J.Zhong,H.L.Huang,Z.H.Liang,Z.Z.Li,Y.J.Liu^*,Synthesis,Characterization,Cellularuptake,Apoptosis,Cytotoxicity,DNA-bindingandantioxidantactivitystudiesofruthenium(II)complexes,Nucleosides,NucleotidesandNucleicAcids,2012,31,575-591.
4.L.Xu,N.J.Zhong,Y.Y.Xie,H.L.Huang,Z.H.Liang,Z.Z.Li,Y.J.Liu^*,Synthesis,DNA-binding,photocleavage,cytotoxicityandapoptosisstudiesofruthenium(II)complexescontaining3,6-dimethyldipyrido[3,2-a:2',3'-c]phenazine,J.Coord.Chem,2012,65,55-68.
5.L.Xu,Y.Y.Xie,N.J.Zhong,Z.H.Liang,J.He,H.L.Huang,Y.J.Liu^*,DNA-bindingandphotocleavage,cytotoxicity,apoptosisandantioxidantactivitystudiesofruthenium(II)complexes,TransitionMetChem,2012,37,197-205.
6.Y.J.Liu^*,Z.H.Liang,X.L.Hong,Z.Z.Li,J.H.Yao,H.L.Huang,Synthesis,characterization,cytotoxicity,apoptoticinducingactivity,cellularuptake,interactionofDNAbindingandantioxidantactivitystudiesofruthenium(II)complexes,Inorg.Chim.Acta,2012,387,117-124.
2011
7.H.L.Huang,Z.Z.Li,Z.H.Liang,J.H.Yao,Y.J.Liu^*,Synthesis,cellularuptake,apopotosis,cytotoxicity,interactionwithDNAandantioxidantactivityofruthenium(II)complexes,Eur.J.Med.Chem,2011,46,3282-3290.
8.H.L.Huang,Z.Z.Li,Z.H.Liang,Y.J.Liu^*,Cellcyclearrest,cytotoxicity,apoptosis,DNA-binding,photocleavageandantioxidantactivityofoctahedralruthenium(II)complexes,Eur.J.Inorg.Chem,2011,36,5538-5547.
9.Y.J.Liu^*,Z.H.Liang,Z.Z.Li,J.H.Yao,H.L.Huang,Cellularuptake,cytotoxicity,apoptosis,antioxidantactivityandDNAbindingofpolypyridylruthenium(II)complexes,J.Orgnamet.Chem,2011,696,2728-2735.
10.Y.J.Liu^*,Z.H.Liang,Z.Z.Li,J.H.Yao,H.L.Huang,Ruthenium(II)polypyridylcomplexes:SynthesisandstudiesofDNA-binding,photocleavage,cytotoxicity,apoptosis,cellularuptakeandantioxidantactivity,DNAandCellBiology,2011,30,829-838.
11.Y.J.Liu^*,Z.Z.Li,Z.H.Liang,J.H.Yao,H.L.Huang,Cytotoxicity,apoptosis,cellularuptake,cellcyclearrest,photocleavageandantioxidantactivityof1,10-phenanthrolineruthenium(II)complexes,DNAandCellBiology,2011,30,839-848.
12.Z.H.Liang,Z.Z.Li,H.L.Huang,Y.J.Liu^*,Ruthenium(II)complexes:synthesis,cytotoxicityinvitro,apoptosis,DNA-binding,photocleavageandantioxidantactivitystudies,J.Coord.Chem,2011,64,3342-3352.
13.Z.Z.Li,Z.H.Liang,H.L.Huang,Y.J.Liu^*,Ruthenium(II)complexes:cellularuptake,cytotoxicity,DNA-binding,photocleavageandantioxidantactivitystudies,J.Mol.Structure,2011,1001,36-42.
2010
14.Y.J.Liu^*,C.H.Zeng,H.L.Huang,L.X.He,F.H.Wu,Synthesis,DNA-binding,photocleavage,cytotoxicityandantioxidantactivityofruthenium(II)polypyridylcomplexes.EurJ.Med.Chem,2010,45,564-571.
15.Y.J.Liu^*,C.H.Zeng,Z.H.Liang,J.H.Yao,H.L.Huang,Z.Z.Li,F.H.Wu,Synthesisofruthenium(II)complexesandcharacterizationoftheircytotoxicityinvitro,apoptosis,DNA-bindingandantioxidantactivity,Eur.J.Med.Chem.2010,45,3087-3095.
16.Y.J.Liu^*,Z.H.Liang,Z.Z.Li,C.H.Zeng,J.H.Yao,H.L.Huang,F.H.Wu,2-(3,5-Dibromo-4-hydroxyphenyl)imidazo[4,5-f][1,10]phenanthrolinoruthenium(II)complexes:synthesis,characterization,cytotoxicity,apoptosis,DNA-bindingandantioxidantactivity,BioMetals,2010,23,739-752.
17.Y.J.JunLiu^*,C.H.Zeng,J.H.Yao,F.H.Wu,L.X.He,H.L.Huang,Synthesis,structure,DNA-bindingproperties,andcytotoxicityofruthenium(II)polypyridylcomplexes,Chemistry&Biodiversity,2010,7,1770-1783.
18.H.L.Huang,Y.J.Liu^*,C.H.Zeng,L.X.He,F.H.Wu,InvitroCytotoxicity,Apoptosis,DNA-Binding,andAntioxidantActivityStudiesofRuthenium(II)Complexes,DNAandCellBiology,2010,29(5),261-270.
19.H.L.Huang,Y.J.Liu^*,C.H.Zeng,J.H.Yao,Z.H.Liang,Z.Z.Li,F.H.Wu,Studiesofruthenium(II)polypyridylcomplexesoncytotoxicityinvitro,apoptosis,DNA-bindingandantioxidantactivity,J.Mol.Structure,2010,966,136-143.
20.C.H.Zeng,Y.J.Liu,Z.Z.Li,Z.H.Liang,H.L.Huang,F.H.Wu,DNA-binding,antioxidantactivityandinvitrocytotoxicityinducedbyruthenium(II)complexescontainingpolypyridylligands,TransitionMetalChemistry,2010,35(6)731-736.
21.F.H.Wu,Z.Z.Li,C.H.Zeng,Z.H.Liang,Y.J.Liu^*,Bis(2,9-dimethyl-1,10-phenanthroline-κ²N,N)(10,11,12,13-tetrahydrodipyrido[3,2-a:2',3'-c]phenazine-κ2N4,N5)ruthenium(II)bis(perchlorate)dehydrate.ActaCryst,2010,E66,m211.
22.C.H.Zeng,Z.Z.Li,Z.H.Liang,Y.J.Liu,F.H.Wu,Bis(4,4'-dimethyl-2,2'-bipyridine)dipyro[3,2-a:2',3'-c](6,7,8,9-tetrahydro)phenazineruthenium(II)perchlorateacetonitrilesolvatehydrate,ActaCryst,2010,E66,m552-m553.
2009
23.Y.J.Liu^*,C.H.Zeng,F.H.Wu,J.H.Yao,L.X.He,H.L.Huang,Synthesis,characterization,photocleavageofDNAandcytotoxicityofruthenium(II)mixed-ligandcomplexesJ.MolecularStructure,2009,932,105-111.
24Y.J.Liu^*,C.H.Zeng,SynthesisandDNAinteractionstudiesofruthenium(II)complexeswithisatino[1,2-b]-1,4,8,9-tetraazatriphenyleneasanintercalativeligandTransitionMet.Chem,2009(5),34,455–462.
25.Y.J.Liu^*,J.F.He,J.H.Yao,W.J.Mei,F.H.Wu,Effectoftheancillaryligandsonthebindingofruthenium(II)complexes[Ru(dmp)₂(MCMIP)]²⁺and[Ru(dmb)₂(MCMIP)]²⁺withDNA.J.Coord.Chem,2009,62,665–675.
26.Y.J.Liu*,J.C.Chen,F.H.Wu,K.C.Zheng,EffectsofsubstituentontheDNA-bindingofruthenium(II)complexescontainingasymmetrictridentateintercalativeligandsTransitionMetalChemistry,2009(4),34,297–305.
27.F.H.Wu,C.H.Zeng,Y.J.Liu^*,X.Y.Guan,L.X.He,DNAinteractionstudiesofruthenium(II)polypyridylcomplex:[Ru(dmb)₂(ITAP)](ClO₄)₂(ITAP=isatino[1,2-b]-1,4,8,9-tetraazatriphen-
ylene),J.Coord.Chem,2009,62(21),3512-3521.
28.Y.Liu,Y.J.Liu^*,J.H.Yao,W.J.Mei,F.H.Wu,EffectofsubstituentsonDNA-bindingbehaviorsofruthenium(II)complexes:[Ru(dmb)₂(dtmi)]²⁺and[Ru(dmb)₂(dtni)]²⁺.J.Coord.Chem,2009,62,1701–1708.
2008
29.Y.J.Liu*,X.Y.Wei,F.H.Wu,W.J.Mei,L.X.He,InteractionstudiesofDNAbindingofruthenium(II)mixed-ligandcomplexes:[Ru(phen)₂(dtmi)]²⁺and[Ru(phen)₂(dtni)]²⁺.SpectrochimicaActaPartA:MolecularandBiomolecularSpectroscopy,2008,70(1),171–176.
30.Y.J.Liu^*,X.Y.Guan,X.Y.Wei,L.X.He,W.J.Mei,J.H.Yao,Ruthenium(II)complexescontaining2,9-dimethyl-1,10-phenanthrolineand4,4'-dimethyl-2,2'-bipyridineasancillaryligands:synthesis,characterizationandDNA-binding.TransitionMetalChemistry,2008,33,289–294.
31.Y.J.Liu^*,W.J.Mei,J.Z.Lu,H.J.Zhao,L.X.He,F.H.Wu,Ruthenium(II)complexesof2-(2'-pyridyl)naphthoimidazole:synthesis,characterizationandDNA-bindingstudies,J.Coord.Chem,2008,61(20),3213–3224.
2007
32.Y.J.Liu^*,N.Wang,W.J.Mei,F.Chen,L.X.He,L.Q.Jian,R.J.Wang,F.H.Wu,PhotoinducedcleavageandDNA-bindingoftheRuthenium(II)polypyridylcomplex[Ru(phen)₂(ipbd)](ClO₄)₂.TransitionMetalChemistry,2007,32,332–337.
33.Y.J.Liu^*,X.Y.Wei,W.J.Mei,L.X.He,Synthesis,characterizationandDNAbindingstudiesofruthenium(II)complexes:[Ru(bpy)₂(dtmi)]²⁺and[Ru(bpy)₂(dtni)]²⁺,TransitionMetalChemistry,2007,32,762–768.
2006
34.Y.J.Liu,H.Chao,Y.X.Yuan,H.J.Yu,L.N.Ji,Ruthenium(II)mixed-ligandcomplexescontaining2-(6-methyl-3-chromonyl)imidazo[4,5-f][1,10]phenanthroline:Synthesis,DNA-bindingandphotocleavagestudies,InorgChimicaActa,2006,359(12),3807–3814.
35.Y.J.Liu,H.Chao,H.J.Yu,Y.X.Yuan,L.N.Ji,Bis(2,2'-bipyridine)[2-(2-pyridyl)-1H-benzimidazol-1-yl]ruthenium(II)perchlorateacetronitrilesolvatemonohydrate,Acta,Cryst,2006,E62,m585-m587.
36.Y.J.Liu,H.Chao,J.H.Yao,Y.X.Yuan,L.N.Ji,Bis(1,10-phenanthroline)[2-(2-pyridyl)-1H-benzim-idazol-1-yl]ruthenium(II)perchlorate–toluene–acetonitrile(2/2/1),ActaCryst,2006,E62,m2128–m2129.
2005
37.Y.J.Liu,H.Chao,L.F.Tan,Y.X.Yuan,W.Wei,L.N.Ji,Interactionofpolypyridylruthenium(II)complexcontainingasymmetricligandwithDNA,J.Inorg.Biochem,2005,99,530–537.
38.Y.J.Liu,H.Chao,J.H.Yao,L.F.Tan,Y.X.Yuan,L.N.Ji,Ruthenium(II)complexescontainingasymmetric2-(pyrazin-2-yl)naphthoimidazole:syntheses,characterization,DNA-bindingandphotocleavagestudies,InorgChimicaActa,2005,358(6),1904–1910.
2004
39.Y.J.Liu,H.Chao,J.H.Yao,H.Li,Y.X.Yuan,L.N.Ji,Synthesis,characterizationandDNAinteractionstudiesoftheRuthenium(II)complexes[Ru(bpy)₂(ipbp)]²⁺and[Ru(ipbp)(phen)₂]²⁺(ipbp=3-(1H-Imidazo[4,5-f][1,10]phenanthrolin-2-yl)-4H-1-benzopyran-2-one;bpy=2,2'-bipyridine,phen=1,10-phenanthroline),HelveticaChimicaActa,2004,87,3119–3130.
合作研究论文
40.W.J.Mei,N.Wang,Y.J.Liu,Y.Z.Ma,D.Y.Wang,B.X.Liang,StudiesoncytotoxicandDNA-bindingpropertiesoftworuthenium(II)complexesofasubstitutedphenanthrolineligand,TransitionMetalChemistry,2008,33,499–503.
41.W.J.Mei,X.Y.Wei,Y.J.Liu,B.Wang,Studiesontheinteractionsofanovelruthenium(II)complexwithG-quadruplexDNA,TransitionMetalChemistry,2008,33,907-910.
42.H.Li,Y.J.Liu,J.Xu,Z.H.Xu,L.N.Ji,W.S.Li,H.Y.Chen,DNA-enhancedassemblyof[Ru(bpy)₂ITATP]^3+/2+onanITOelectrode,ElectrochimicaActa,2007,52(15),4956–4961.
43.X.L.Wang,H.Chao,X.L.Hong,Y.J.Liu,L.N.Ji,Bis(2,2′-bipyridine)cobalt(III)complexescontainingasymmetricligands:Synthesis,DNA-bindingandphotocleavage.TransitionMetalChemistry,2005,30,305–311.
44.L.F.Tan,H.Chao,Y.J.Liu,H.Li,B.Sun,L.N.Ji,DNA-bindingandphotocleavagestudiesof[Ru(phen)₂(NMIP)]²⁺,InorgChimicaActa,2005,358(7),2191–2198.
45.L.F.Tan,H.Chao,H.Li,Y.J.Liu,B.Sun,W.Wei,L.N.Ji,Synthesis,characterization,DNA-bindingandphotocleavagestudiesof[Ru(bpy)₂(PPIP)]²⁺and[Ru(phen)₂(PPIP)]²⁺,J.Inorg.Biochem,2005,99(2),513–520.
46.X.L.Wang,H.Chao,H.Li,X.L.Hong,Y.J.Liu,L.F.Tan,L.N.Ji,DNAinteractionsofcobalt(III)mixed-polypyridylcomplexescontainingasymmetricligands,J.Inorg.Biochem,2004,98,1143–1150.