基本情况
陈兰美，男，1982.02生，副教授/硕导。2008.7获中山大学理学博士学位，现为广东医科大学药学院教师。现主持一项国家自然科学基金（青年基金）、广东省自然科学基金面上项目，在研多项广东省教育厅，广东省卫生厅项目。2014年入选广东省高等学校 “千百十人才培养工程”校级培养对象，2015年入选广东省高校优秀青年教师培养计划。主要研究领域：靶向性金属抗肿瘤药物的设计、抗肿瘤活性及机制研究。联合培养研究生3名，在读研究生2名。
联系方式
Phone:**
E-mail:lanmeichen@126.com
教育经历
1999.9-2003.7,信阳师范学院化学化工学院获理学学士学位
2003.9-2008.7,中山大学化学化工学院获理学博士学位（硕博连读）
工作经历
2008.07—2013.12广东医科大学，讲师；
2014.01—至今 广东医科大学，副教授；
2019.08—2020.03澳大利亚MurdochUniversity，Centre for Molecular Medicine and Innovative Therapeutics，访问****。
科研项目
（1）2017年度国家自然科学基金项目（青年基金）(主持)：Cyclo-Ru-IQ的设计、合成及其抑制Nrf2逆转非小细胞肺癌顺铂耐药的分子机制，(No. **, 2018.01-2020.12.)
（2）2016年度广东省中医药局科研课题（主持）：纳米硒增敏木犀草素诱导肺癌细胞凋亡的机制研究（No: **, 2016.4-2018.1.）
（3）广东省高等学校优秀青年教师培养计划（主持）：靶向线粒体的咪唑类钌配合物的合成及诱导癌细胞自噬、凋亡的相关机制研究，(No: YQ**,2016.01-2018.12，主持)。
（4）广东省自然科学基金(主持)：钌配合物功能化纳米金负载siRNA逆转肿瘤多药耐药的研究，(No:S20**,2013.10-2015.10)。
近5年发表论文：
[1]Yanan Liu¹, Chunfang Wei¹, Ange Lin, Jiali Pan, Xu Chen, Xufeng Zhu, Youcong Gong, Guanglong Yuan,Lanmei Chen*, Jie Liu*, Zhaohui Luo, Responsive functionalized MoSe₂nanosystem for highly efficient synergistic therapy of breast cancer,Colloids and Surfaces B: Biointerfaces,2020, 189, 110820.（IF=3.973）
[2]Yanan Liu, Ange Lin, Jiawei Liu, Xu Chen, Xufeng Zhu, Youcong Gong, Guanglong Yuan,Lanmei Chen*, Jie Liu*, Enzyme-Responsive Mesoporous Ruthenium for Combined Chemo-Photothermal Therapy of Drug-Resistant Bacteria,ACS Appl. Mater. Interfaces,2019, 11, 26590?26606. (IF=8.456)
[3]Meng Xu, Yayu Wen, Yanan Liu, Xianjie Tan, Xu Chen, Xufeng Zhu, Chunfang Wei,Lanmei Chen*, Zhong Wang, Jie Liu*, Hollow mesoporous ruthenium nanoparticles conjugated bispecific antibody for targeted anti-colorectal cancer response of combination therapy.Nanoscale,2019,11, 9661-9678.(IF=7.233)
[4]Yanan Liu¹, Hui Zhou¹, Tiantian Yin, Youcong Gong, Guanglong Yuan,Lanmei Chen*, Jie Liu*, Quercetin-modified gold-palladium nanoparticles as a potential autophagy inducer for the treatment of Alzheimer's disease.Journal of Colloid and Interface Science,2019,552, 388-400.(IF=6.361)
[5]Xufeng Zhu, Yayu Wen, Yingyu Zhao, Yanan Liu, Jing Sun, Jiawei Liu, Jie Liu*,Lanmei Chen*, Functionalized chitosan-modified defect-related luminescent mesoporous silica nanoparticles as new inhibitors for hIAPP aggregation.Nanotechnology,2019,30, 315705.(IF=3.404)
[6]Jincan Chen, Yao Zhang,Xin-ming Ji,Ji She,Guangzhi Dongye,Yu Zhong,Yuan-yuan Deng, Jie Wang, Bo-yang Guo,Lanmei Chen*,Ruthenium(II) salicylate complexes inducing ROS-mediated apoptosis bytargeting thioredoxin reductase,Journal of Inorganic Biochemistry, 2019, 193, 112-123.(IF=3.224)
[7]Jincan Chen¹, Yao Zhang¹, Guodong Li, Fa Peng, Xinming Jie, Ji She, Guangzhi Dongye, Zhilin Zou, Shiwen Rong,Lanmei Chen^*, Cytotoxicity in vitro, cellular uptake, localization and apoptotic mechanism studies induced by ruthenium(II) complex,Journal of Biological Inorganic Chemistry, 2018, 23: 261-275.（IF= 3.632）
[8]Jincan Chen¹, Yao Zhang¹, Baojun Li, Guodong Li, Xinming Jie, Ying Cui, Zhilin Zou, Xiaofeng Huang, Jiaoyue Qu,Lanmei Chen^*, A comparative study on in vitro cytotoxicity, cellular uptake, localization and apoptosis-inducing mechanism of two ruthenium(II) complexes,Transition Metal Chemistry,2018, 43:149-159.（IF= 1.016）
[9]Jincan Chen, Fa Peng, Yao Zhang, Baojun Li, Ji She, Xinming Jie, Zhilin Zou, Man Chen,Lanmei Chen^*, Synthesis, characterization, cellular uptake and apoptosis-inducing properties of two highly cytotoxic cyclometalated ruthenium(II) β-carboline complexes,European Journal of Medicinal Chemistry, 2017, 140, 104-117.（IF= 4.833）
[10]Shuang Zhao, Litao Ma, Chengwen Cao, Qianqian Yu,Lanmei Chen^*, Jie Liu^?, Curcumin-loaded redox response of self-assembled micelles for enhanced antitumor and anti-inflammation efficacy,International Journal of Nanomedicine, 2017, 12: 2489-2504.（IF= 4.300）
[11]Yan-hui Zhou, Meng Xu, Ya-nan Liu, Yan Bai, Yu-qian Deng, Jie Liu^*,Lanmei Chen^*, Green synthesis of Se/Ru alloy nanoparticles using gallic acid andevaluation of theiranti-invasive effects in HeLa cells,Colloids and Surfaces B: Biointerfaces,2016, 144, 118–124.（IF= 3.973）
[12]Lanmei Chen¹, Guodong Li¹, Fa Peng, Xinming Jie, Guangzhi Dongye, Kangrong Cai, Ruibing Feng, Baojun Li, Qingwang Zeng, Kaiyi Lun, Jincan Chen^*, Bilian Xu^*, The induction of autophagy against mitochondria-mediated apoptosis in lung cancer cells by a ruthenium (II) imidazole complex,Oncotarget, 2016, 7(49), 80716-80734.（IF=5.0）
[13]Lan-mei Chen¹, Fa Peng¹, Guo-dong Li, Xin-ming Jie, Kang-rong Cai, Chun Cai, Yu Zhong, Hua Zeng, Wu Li, Zhen Zhang, Jin-can Chen^*, The studies on the cytotoxicity in vitro, cellular uptake, cell cycle arrest and apoptosis-inducing properties of ruthenium methylimidazole complex [Ru(MeIm)₄(p-cpip)]²⁺,Journal of Inorganic Biochemistry, 2016, 156: 64-74.（IF=3.224）
[14]Jin-can Chen¹, Guo-dong Li¹, Fa Peng, Xin-ming Jie, Guang-zhi Dongye, Yu Zhong, Rui-bing Feng, Bao-jun Li, Jiao-yue Qu, Yan Ding,Lan-mei Chen^?, Investigation of inducing apoptosis in human lung cancer A549 cells and related mechanism of a ruthenium(II) polypyridyl complex,Inorganic Chemistry Communications, 2016, 35–39.（IF= 1.795）






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