俞海，Hai Yu, PhD
副教授
电话：
Email: yuhai@xmu.edu.cn



2006年毕业于上海交通大学医学院，获生物化学与分子生物学博士学位。2007年至2010年受聘为厦门大学生命科学学院博士后，进入国家传染病诊断试剂与疫苗工程技术研究中心从事生物信息学和生物大分子的分子模拟研究。现为厦门大学公共卫生学院副教授。主要研究方向为：结构疫苗学相关的蛋白设计与改造，抗体工程相关的抗体优化与分子设计，基于同源模建和分子对接技术的表位预测，利用分子动力学模拟技术研究生物分子的物理化学性质及功能机制，基于组学数据和基因编辑方法对大肠杆菌工程菌进行优化与改造。





Selected Publications:
1. Zhou L, Yu H, Wang K, Chen T, Ma Y, Huang Y, Li J, Liu L, Li Y, Kong Z, Zheng Q, Wang Y, Gu Y, Xia N, Li S. Genome re-sequencing and reannotation of the Escherichia coli ER2566 strain and transcriptome sequencing under overexpression conditions. BMC Genomics. 2020;21(1):407.
2. Zhang YL, Wang SJ, Wu YT, Hou WH, Yuan LZ, Sheng CG, Wang J, Ye JH, Zheng QB, Ma J, Xu JJ, Wei M, Li ZL, Nian S, Xiong HL, Zhang L, Shi Y, Fu BR, Cao JL, Yang CL, Li ZY, Yang T, Liu L, Yu H, Hu JD, Ge SX, Chen YX, Zhang TY, Zhang J, Cheng T, Yuan Q, Xia NS. Virus-Free and Live-Cell Visualizing SARS-CoV-2 Cell Entry for Studies of Neutralizing Antibodies and Compound Inhibitors. Small Methods. 2020.
3. Wang W, Zheng QB, Pan DQ, Yu H, Fu WK, Liu J, He MZ, Zhu R, Cai YZ, Huang Y, Zha ZH, Chen ZQ, Ye XZ, Han JL, Que YQ, Wu T, Zhang J, Li SW, Zhu H, Zhou ZH, Cheng T, Xia NS. Near-atomic cryo-electron microscopy structures of varicella-zoster virus capsids. Nat Microbiol. 2020;5(12):1542-+.
4. Wang DN, Liu XL, Wei MX, Qian CY, Song S, Chen J, Wang ZP, Xu Q, Yang YR, He MZ, Chi X, Huang SW, Li TT, Kong ZB, Zheng QB, Yu H, Wang YB, Zhao QJ, Zhang J, Xia NS, Gu Y, Li SW. Rational design of a multi-valent human papillomavirus vaccine by capsomere-hybrid co-assembly of virus-like particles. Nat Commun. 2020;11(1).
5. Qian CY, Liu XL, Xu Q, Wang ZP, Chen J, Li TT, Zheng QB, Yu H, Gu Y, Li SW, Xia NS. Recent Progress on the Versatility of Virus-Like Particles. Vaccines-Basel. 2020;8(1).
6. Li TT, Zheng QB, Yu H, Wu DH, Xue WH, Xiong HL, Huang XF, Nie MF, Yue MX, Rong R, Zhang SB, Zhang YY, Wu YT, Wang SJ, Zha ZH, Chen TT, Deng TT, Wang YB, Zhang TY, Chen YX, Yuan Q, Zhao QJ, Zhang J, Gu Y, Li SW, Xia NS. SARS-CoV-2 spike produced in insect cells elicits high neutralization titres in non-human primates. Emerg Microbes Infec. 2020;9(1):2076-90.
7. Zheng QB, Zhu R, Xu LF, He MZ, Yan XD, Liu DX, Yin ZC, Wu YT, Li YC, Yang LS, Hou WH, Li SX, Li ZZ, Chen ZQ, Li ZH, Yu H, Gu Y, Zhang J, Baker TS, Zhou ZH, Graham BS, Cheng T, Li SW, Xia NS. Atomic structures of enterovirus D68 in complex with two monoclonal antibodies define distinct mechanisms of viral neutralization. Nat Microbiol. 2019;4(1):124-+.
8. Zheng QB, Jiang J, He MZ, Zheng ZZ, Yu H, Li TT, Xue WH, Tang ZM, Ying D, Li ZK, Song S, Liu XL, Wang KH, Zhang ZQ, Wang DN, Wang YB, Yan XD, Zhao QJ, Zhang J, Gu Y, Li SW, Xia NS. Viral neutralization by antibody-imposed physical disruption. Proc Natl Acad Sci U S A. 2019;116(52):26933-40.
9. Zhang ZQ, Wei X, Lin YL, Huang F, Shao J, Qi JL, Deng TT, Li ZZ, Gao SQ, Li SY, Yu H, Zhao QJ, Le SW, Gu Y, Xia NS. HIV-1 Membrane-Proximal External Region Fused to Diphtheria Toxin Domain-A Elicits 4E10-Like Antibodies in Mice. Immunol Lett. 2019;213:30-8.
10. Wang ZT, Xu LF, Yu H, Lv P, Lei Z, Zeng Y, Liu G, Cheng T. Ferritin nanocage-based antigen delivery nanoplatforms: epitope engineering for peptide vaccine design. Biomater Sci-Uk. 2019;7(5):1794-800.
11. Wang KH, Zhou LZ, Zhang X, Song CL, Chen TT, Li JJ, Zheng MH, Wang YB, Zheng QB, Zheng ZZ, Yu H, Wu T, Gu Y, Zhang J, Zhao QJ, Li SW, Xia NS. Hepatitis E vaccine candidate harboring a non-particulate immunogen of E2 fused with CRM197 fragment A. Antiviral Res. 2019;164:154-61.
12. Shen CG, Zhang MW, Chen YZ, Zhang LM, Wang GS, Chen JY, Chen SY, Li ZZ, Wei FX, Chen J, Yang KY, Guo SX, Wang YJ, Zheng QB, Yu H, Luo WX, Zhang J, Chen HL, Chen YX, Xia NS. An IgM antibody targeting the receptor binding site of influenza B blocks viral infection with great breadth and potency. Theranostics. 2019;9(1):210-31.
13. Liu XL, Chen J, Wang ZP, Wang DN, He MZ, Qian CY, Song S, Chi X, Kong ZB, Zheng QB, Wang YB, Yu H, Zhao QJ, Zhang J, Li SW, Gu Y, Xia NS. Neutralization sites of human papillomavirus-6 relate to virus attachment and entry phase in viral infection. Emerg Microbes Infec. 2019;8(1):1721-33.
14. Li TT, Zhang ZY, Zhang ZQ, Qiao JM, Rong R, Zhang YY, Yao QB, Li ZK, Shen HL, Huang F, Xue WH, Gao SQ, Li SY, Zheng QB, Yu H, Zhang J, Gu Y, Li SW, Xia NS. Characterization of native-like HIV-1 gp140 glycoprotein expressed in insect cells. Vaccine. 2019;37(11):1418-27.
15. Li TT, Zhang ZY, Zhang ZQ, Qiao JM, Rong R, Zhang YY, Yao QB, Li ZK, Shen HL, Huang F, Xue WH, Gao SQ, Li SY, Zheng QB, Yu H, Zhang J, Gu Y, Li SW, Xia NS. Characterization of native-like HIV-1 gp140 glycoprotein expressed in insect cells. Vaccine. 2019;37(11):1418-27.
16. Chen TT, Wang KH, Chi X, Zhou LZ, Li JJ, Liu LQ, Zheng QB, Wang YB, Yu H, Gu Y, Zhang J, Li SW, Xia NS. Construction of a bacterial surface display system based on outer membrane protein F. Microb Cell Fact. 2019;18.
17. Zhu R, Xu LF, Zheng QB, Cui YX, Li SW, He MZ, Yin ZC, Liu DX, Li SX, Li ZZ, Chen ZQ, Yu H, Que YQ, Liu C, Kong Z, Zhang JB, Baker TS, Yan XD, Zhou ZH, Cheng T, Xia NS. Discovery and structural characterization of a therapeutic antibody against coxsackievirus A10. Sci Adv. 2018;4(9).
18. Zheng MH, Jiang J, Zhang X, Wang N, Wang KH, Li Q, Li TT, Lin QS, Wang YB, Yu H, Gu Y, Zhang J, Li SW, Xia NS. Characterization of capsid protein (p495) of hepatitis E virus expressed ID in Escherichia coli and assembling into particles in vitro. Vaccine. 2018;36(16):2104-11.
19. Xin L, Yu H, Hong QY, Bi XJ, Zhang X, Zhang ZQ, Kong ZB, Zheng QB, Gu Y, Zhao QJ, Zhang J, Li SW, Xia NS. Identification of Strategic Residues at the Interface of Antigen-Antibody Interactions by In Silico Mutagenesis. Interdiscip Sci. 2018;10(2):438-48.
20. Xin L, Yu H, Hong Q, Bi X, Zhang X, Zhang Z, Kong Z, Zheng Q, Gu Y, Zhao Q, Zhang J, Li S, Xia N. Identification of Strategic Residues at the Interface of Antigen-Antibody Interactions by In Silico Mutagenesis. Interdisciplinary sciences, computational life sciences. 2018;8(2):438-48.
21. Wei MX, Wang DN, Li ZH, Song S, Kong XL, Mo XB, Yang YR, He MZ, Li ZY, Huang B, Lin ZJ, Pan HR, Zheng QB, Yu H, Gu Y, Zhang J, Li SW, Xia NS. N-terminal truncations on L1 proteins of human papillomaviruses promote their soluble expression in Escherichia coli and self-assembly in vitro. Emerg Microbes Infec. 2018;7.
22. Lin QS, Li TT, Chen YX, Lau SY, Wei MX, Zhang YY, Zhang ZY, Yao QB, Li JJ, Li ZH, Wang DN, Zheng QB, Yu H, Gu Y, Zhang J, Chen HL, Li SW, Xia NS. Structural Basis for the Broad, Antibody-Mediated Neutralization of H5N1 Influenza Virus. J Virol. 2018;92(17).
23. Li ZH, Song S, He MZ, Wang DN, Shi JJ, Liu XL, Li YB, Chi X, Wei SP, Yang YR, Wang ZP, Li JJ, Qian HL, Yu H, Zheng QB, Yan XD, Zhao QJ, Zhang J, Gu Y, Li SW, Xia NS. Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity. Nat Commun. 2018;9.