个人信息
姓名： 何向伟
生日： 1967年9月24日
国籍： 美国


教育经历：
高中
上海第五十一中学／中国上海，1981年8月－1984年7月
大学
复旦大学／中国上海，理学士，1984年8月－1988年7月
研究生
贝勒医学院生物医学研究生院，哲学博士，
1991年8月－1997年12月
导师：Shelley Sazer, 哲学博士，副教授
论文：裂殖酵母有丝分裂的调控
博士后培训：
博士后****，麻省理工学院生物系，1998年1月－2001年9月
博士后奖学金，美国国立卫生研究院，1998 －2001
导师：Peter Sorger, 哲学博士，教授
学术职位：
德州大学休斯顿医学院生物化学和分子生物学系助理教授2001年10月至2004年6月
贝勒医学院助理教授，副教授（2013年3月升职）
分子及人类遗传学系（主要职位）生物化学和分子生物学系（兼职）2004年7月1日起。
浙江大学生命科学研究院教授、博士生导师、资深研究员2013年8月至今


科研信息
A.科研资助：
裂殖酵母中着丝体与纺锤体的相互作用
国立卫生研究院普通医学科学RO1 GM068676
何向伟（主持人）
直接资助$175，000/每年，总直接资助$11,575,000
2003年8月1日－2008年7月30日
2009年9月1日－2013年8月30日
浙江大学生命科学研究院学术特区建设项目经费
985项目子项目1811/013
何向伟（负责人）总资助￥6000,000
2013年-2018年
DNA损伤修复蛋白的作用机制
中国科技部973项目子项目2015CB910602
￥1500,000
2015年-2019年
B.发表论文
1.Shi, Z-Z., Carter, B.Z., Habib, G.M., He. X., Sazer, S., Lebovitz, R.M., and Lieberman, M.W. (1996) A single mouse glutathione synthetase gene encodes six mRNAs with different 5' ends. Arch. Biochem. Biophys 331: 215- 224.
2.Shi, Z-Z., Habib, G.M., Rhead, W.J., Gahl, W.A., He. X., Sazer, S., and Liebermen, M.W. (1996) Mutations in the glutathione synthetase gene causes 5-oxoprolinuria. Nature Genetics 14 (3): 361-365.
3.Noguchi, E., Hayashi, N., Yanagida, M., He, X., Mueller, U.W., Sazer, S. and Nishimoto, T. (1996) Dis3, implicated in mitotic control, binds directly to Ran and enhances the GEF activity of RCC1. EMBO J. 15: 5595-5605.
4.Matynia, A., Dimitrov, K., Mueller, U.W., He, X., and Sazer, S. (1996) Perturbations in the spi1p GTPase cycle of Schizosaccharomyces pombe through its GTPase-activating protein and guanine nucleotide exchange factor components result in similar phenotypic consequences. Mol. Cell. Biol. 16 (11): 6352-6362.
5.He, X., Patterson, T.E., and Sazer, S. (1997) The Schizosaccharomyces pombe spindle checkpoint protein mad2p blocks anaphase and genetically interacts with the anaphase-promoting complex. Proc Natl Acad Sci U S A. 94(15): 7965-70.
6.He, X., Jones, M. H., Winey, M. and Sazer, S. (1998) Mph1, a member of the Mps1-like family of dual specificity protein kinases, is required for the spindle checkpoint in S. pombe. J. Cell Science. 111: 1635-47.
7.Balasubramanian, M.K., McCollum, D., Chang, L, Wong, K.C., Naqvi, N.I.,
He, X., Sazer, S. and Gould, K.L. (1998) Isolation and characterization of new fission yeast cytokinesis mutants. Genetics 149(3): 1265-75.
8.He, X., Hayashi, N., Walcott, N., Azuma, Y., Patterson, T.E., Nishimoto, T., and Sazer, S. (1998) The identification of cDNAs that affect the mitosis-to-interphase transition in Schizosaccharomyces pombe, including sbp1, which encodes a spi1p-GTP-binding protein. Genetics 148(2): 645-656.
9.He, X., Asthana, S. and Sorger, P.K. (2000) Transient sister chromatid separation and elastic deformation of chromosomes during mitosis in budding yeast. Cell 101: 763-775.
10.He, X., Rines, D., Espelin, C. and Sorger, P. K. (2001) Molecular analysis of kinetochore-microtubule attachment in budding yeast. Cell 106:195-206
11.Jones, M. H., He, X. and Winey, M. (2001) Yeast Dam1p has a role at the kinetochore in assembly of the mitotic spindle.Proc Natl Acad Sci U S A. 98 (24):13675-80.
12.Meriin, A. B., Zhang, X., He, X., Newman, G. P., Chernoff, Y. O. and Sherman, M. Y. (2002) Huntingtin toxicity in yeast model depends on polyglutamine aggregation mediated by a prion-like protein Rnq1. J. Cell Biology 157 (6) 997-1004.
13.Rines, D.R., He, X. and Sorger, P. K. (2002) Quantitative microscopy of green fluorescent protein-labeled yeast. Methods Enzymol. 351:16-34.
14.Kadura S, He X, Vanoosthuyse V, Hardwick KG and Sazer S. (2004) The A78V Mutation in the Mad3-like Domain of Schizosaccharomyces pombe Bub1p Perturbs Nuclear Accumulation and Kinetochore Targeting of Bub1p, Bub3p, Mad3p and Spindle Assembly Checkpoint function. Mol. Biol. Cell 16 (1): 385-95
15.Liu X, McLeod I, Anderson S, Yates J.3rd and He X. (2005) Molecular analysis of the kinetochore architecture in fission yeast. EMBO J 24(16): 2919-30
16.Joglekar, A.P., Bouck, D., Finley, K., Liu, X., Wan, Y., Berman, J., He, X., Salmon, E.D., Bloom, K.S. (2008) Molecular architecture of the kinetochore- microtubule attachment site is conserved between point and regional centromeres. J Cell Biol. 181(4): 587-94
17.Song J.S., Liu X., Liu X.S. and He, X. (2008) A high-resolution map of nucleosome positioning on a fission yeast centromere. Genome Res. 18(7): 1064-72
18. Yao J., and He, X. (2008) Kinetochore assembly: building a molecular machine that drives chromosome movement. Mol. BioSysems. 10: 1039/b719627
19.Ezzeddine, N., Zheng, D., Chen C.A., Zhu W., He, X. and Shyu A. (2008).Deadenylation is prerequisite for P-body formation and mRNA decay in mammalian cells. J Cell Biol.14;182 (1):89-101
20.Lu, N., Yu, X., He, X., and Zhou, Z. Detecting apoptotic cells and monitoring their clearance in the nematode Caenorhabditis elegans. Methods Mol. Biol. (2009) 559: 357-70.
21.Pidoux, A.L., Choi, E.S., Abbott, J., Liu, X., Kagansky, A., Castillo, A.G., Hamilton, G.L., Richardson, W., Rappsilber, J., He, X. and Allshire, R. C. (2009) Fission yeast Scm3: A CENP-A receptor required for integrity of subkinetochore chromatin. Mol. Cell 33; (3):299-311
22.Kim JH, Zhao Y, Pan X, He X, Gilbert HF. (2009) The unfolded protein response is necessary but not sufficient to compensate for defects in disulfide isomerization. J Bio Chem 284 (16): 10400-8.
23.Gao, Q., Courtheoux, T., Gachet, Y., Tournier, S. and He, X. (2010) A non-ring-like form of the Dam1 complex modulates microtubule dynamics in fission yeast. PNAS 107(30):13330-5
24.Xi,Y., Yao, J., Chen, R., Li, W. and He, X. (2011) Nucleosome fragility reveals novel functional states of chromatin and poises genes for activation.Genome Research 21(5): 718-24
25.Chen, K., Xi, Y., Pan, X., Li, Z., Kaestner, K., Tyler, J., Dent, S., He, X., Wei Li
DANPOS: Dynamic Analysis of Nucleosome Position and Occupancy by Sequencing. (2013) Genome Research 23(2):341-51
26.Yao J1, Liu X, Sakuno T, Li W, Xi Y, Aravamudhan P, Joglekar A, Li W, WatanabeY,He X. Plasticity and epigenetic inheritance of centromere-specific histone H3 (CENP-A)-containing nucleosome positioning in the fission yeast. 2013 J Biol Chem. 288(26):19184-96.
27.Courtwright A.M. and He, X. (2002) Dam1 is the right one: phosphoregulation of kinetochore biorientation.Developmental Cell 3: 610-1。
28.Gao Q, Tanaka T.U, He X. (2006) GFP-based Microscopic Approaches for Whole Chromosome Analysis in Yeasts. In Yeast Gene Analysis (Academic Press).
3.学术服务
1. 生物化学杂志，编委 (任期2009 - 2014)