姓　　名： 吴川六
地　　址： 厦门大学化学北楼535
邮　　编： 361005
电　　话： +86 (0)
传　　真： +86 (0)
电子邮件： chlwu@xmu.edu.cn
课题组主页： http://chem.xmu.edu.cn/kydw_ktz/clwu/index.html





教育与科研经历
博士(厦门大学，2005-2010)
学士(厦门大学，2001-2005)
研究助理（新加坡国立大学，2008-2009）
博士后（瑞士苏黎世联邦理工学院，2010-2012）

研究方向
1）发展高质量的多肽分子（荧光）探针，研究蛋白质分子的功能
2）以荧光分子探针为工具，研究肿瘤细胞表面的化学性质
3）构建响应型的分子递送系统，提高多肽等分子探针或药物分子的进细胞效率

在研科研项目
自然科学基金委面上项目、青年科学基金等

获奖情况
ETH fellowship (2010)

代表性论文
1. “The Interplay of Disulfide Bonds, α-Helicity, and Hydrophobic Interactions Leads to Ultrahigh Proteolytic Stability of Peptides”, Y. Chen, C. Yang, T. Li, M. Zhang, Y. Liu, M.A. Gauthier, Y. Zhao, and C. Wu*, Biomacromolecules, 2015, 16, 2347-2355.
2. “Extraordinary Modulation of Disulfide Redox-Responsiveness by Cooperativity of Twin-Disulfide Bonds”, L. Zhai, J. Liang, X. Guo, Y. Zhao, and C. Wu*, Chem. Eur. J., 2014, 20, 17507-17514.
3. “Exploring and Exploiting Dynamic Noncovalent Chemistry for Effective Surface Modification of Nanoscale Metal–Organic Frameworks”, S. Liu, L. Zhai, C. Li, Y. Li, X. Guo, Y. Zhao, and C. Wu*, ACS Appl. Mater. Interfaces, 2014, 6, 5404-5412.
4. “Broad Control of Disulfide Stability through Microenvironmental Effects and Analysis in Complex Redox Environment”, C. Wu, S. Wang, L. Brulisauer, J-C. Leroux*, and M.A. Gauthier*, Biomacromolecules, 2013, 14, 2383-2388.
5. “Twin Disulfides for Orthogonal Disulfide Pairing and the Directed Folding of Multicyclic Peptides”, C. Wu, J-C. Leroux*, and M.A. Gauthier*, Nature Chem., 2012, 4, 1044-1049.
6. “Interplay of Chemical Micro-Environment and Redox Environment on Thiol-Disulfide Exchange Kinetics”, C. Wu, C. Belenda, J-C. Leroux, and M.A. Gauthier*, Chem. Eur. J., 2011, 17, 10064-10070.
7. “Stable and Functionable Mesoporous Silica-Coated Gold Nanorods as Sensitive Localized Surface Plasmon Resonance (LSPR) Nanosensors”, C. Wu and Q.H. Xu*, Langmuir, 2009, 25, 9441-9446.
8. “Molecule-Scale Controlled-Release System Based on Light-Responsive Silica Nanoparticles”, C. Wu, C. Chen, J. Lai, J. Chen, X. Mu, J. Zheng and Y. Zhao*, Chem. Commun., 2008, 2662-2664.
9. “Fluorescent Core-Shell Silica Nanoparticles as Tunable Precursors: Towards Encoding and Multifunctional Nano-Probes”, C. Wu, J. Hong, X. Guo, C. Huang, J. Lai, J. Zheng, J. Chen, X. Mu and Y. Zhao*, Chem. Commun., 2008, 750-752.
10. “Hybrid Silica-Nanocrystal-Organic Dye Superstructures as Post-encoding Fluorescent Probes”, C. Wu, J. Zheng, C. Huang, J. Lai, S. Li, C. Chen and Y. Zhao*, Angew. Chem. Int. Ed., 2007, 46, 5393-5396.