姓 名:
申河清 性 别:
男
电 话:
+86- 职 称:
研究员
通讯地址:
厦门市集美大道1799号
邮政编码:
361021 电子邮件:
hqshen@iue.ac.cn


简历：
博士，研究员，博士生导师，厦门大学公共卫生学院兼职教授，国际暴露科学学会会员。
1991年6月本科毕业于太原理工大学应用化学系；
1997年7月硕士毕业于中科院大连化学物理研究所；
2005年3月博士毕业于德国慕尼黑技术大学(Technical University Munich)；
2005年3月 – 2006年3月在亥姆霍兹慕尼黑研究中心-德国环境卫生研究中心的生态化学研究所(Institute of Ecology Chemistry, Helmholtz Zentrum München - German Research Center for Environmental Health)作博士后研究；
2006年4月 – 2009年3月在丹麦哥本哈根大学医院作研究****(Senior Staff Cand. Sci., Dept. Growth and Reproduction, Copenhagen University, Rigshospitalets)。

研究领域：
环境污染物的暴露科学和健康效应，即多学科交叉的暴露科学（exposure science）、毒理学、环境流行病学研究，涉及环境中化学微污染物（micro-pollutants）的监测、人群暴露监测（human bio-monitoring）、暴露组学（exposomics）和暴露标志物（exposure biomarkers），污染物的效应标志物（response biomarkers）和系统生物学技术筛选（systems biology）、环境-表观基因相互作用（environment epigenetic），环境流行病学（environmental epidemiology）。

社会任职：

获奖及荣誉：

代表论著：
1. Zhang J, Liu F, Chen R, Feng T, Dong S, Shen H*, Levels of Polychlorinated Biphenyls and Organochlorine Pesticides in Edible Shellfish from Xiamen (China) and Estimation of Human Dietary Intake. Food Chem. Toxicol. 2012, 50, 4285–4291
2. XuW, BaoH, LiuF, LiuL, ZhuY-G, SheJ, DongS, CaiM, LiL, LiC, ShenH*. Environmental exposure to arsenic may reduce human semen quality: associations derived from a Chinese cross-sectional study. Environ. Health2012, 11:46
3. Peng S, Zhang J*, Tian M, Wang Z, Shen H*. Determination of Global DNA Methylation in Biological Samples by Liquid Chromatography-Tandem Mass Spectrometer (液相色谱-串联质谱法测定生物样本全基因组DNA甲基化). Ch. J. Anal. Chem. 2012, 40 (8), 1201-1206
4. Zhang J, Yan L, Tian M, Huang Q, Peng S, Dong S, Shen H*. The metabonomics of combined dietary exposure to phthalates and polychlorinated biphenyls in mice. J. Pharm. Biomed. Anal. 2012, 66, 287-297
5. Krysiak-Baltyn K, Skakkeb？k NE, Toppari J, Jensen T, Virtanen H, Schramm K-W, Shen H, Vartiainen T, Kiviranta H, Taboureau O, Brunak S, Main K. Association between chemical pattern in breast milk and congenital cryptorchidism: modeling of complex human exposure. Int. J. Androl. 2012, 35 (3), 294-302
6. Liu L, Xia T, Guo L, Cao L, Zhao B, Zhang J, Dong S, Shen H*. Expressing urine from a gel disposable diaper for biomonitoring using phthalates as an example. J. Expo. Sci. Environ. Epidemiol., 2012, 22, 625-631
7. Peng S, Yan L, Zhang* J, Shen H*. Hepatotoxicity of perfluorooctanoic acid in human hepatocytes using metabonomics(利用代谢组学技术研究全氟辛酸的人肝脏毒性机制). Ch. J. Chromatogr. 2012, 30 (02): 123-127
8. Tian M, Peng S, Martin FL, Zhang J, Liu L, Wang Z, Dong S, Shen H*. Perfluorooctanoic acid induces gene promoter hypermethylation of glutathione-S-transferase Pi in human liver L02 cells. Toxicology. 2012, 296 (1-3) 48-55
9. Liao Y, Wang J, Huang Q, Fang C, Kiyama R, Shen H*, Dong S*. Evaluation of cellular response to perfluorooctane sulfonate in human umbilical vein endothelial cells. Toxicol. in Vitro 2012, 26(3): 421-428
10. Shen H, Henkelmann B, Rambeck WA, Mayer R, Wehr U, Schramm K-W. Physiologically based persistent organic pollutant accumulation in pig tissues and their edible safety differences: An in vivo study. Food Chem. 2012,132 (4)1830-1835
11. Fang C, Wu X, Huang Q, Liao Y, Liu L, Qiu L, Shen H*, Dong S*. PFOS elicits transcriptional responses of the ER, AHR and PPAR pathways in Oryzias melastigma in a stage-specific manner. Aquatic Toxicol. 2011, 106-107, 9-19
12. Shen H, Henkelmann B, Rambeck WA, Mayer R, Wehr U, Schramm K-W. The predictive power of the elimination of dioxin-like pollutants from pigs: An in vivo study. Environ. Int. 2012, 38 73-78
13. Liu F, Ni H-G, Chen F, Luo Z-X, Shen H*, Liu L, Wu P. Metal accumulation in the tissues of grass carps (Ctenopharyngodon idellus) from fresh water around a copper mine in Southeast China. Environ. Monit. Assess. 2012, 184(7), 4289-4299
14. Wang X, Suo Y, Yin R, Shen H*, Wang H*. Ultra-performance liquid chromatography/tandem mass spectrometry for accurate quantification of global DNA methylation in human sperms. J. Chromatogr. B. 2011, 879, 1647-1652
15. Zhao B, Shen H*, Liu F, Liu S, Niu J, Guo F, Sun X. Exposure to organochlorine pesticides is independent risk factor of hepatocellular carcinoma: A case-control study, J. Expo. Sci. Environ. Epidemiol. 2012, 22, 541-548
16. Liu L, Bao H, Liu F, Zhang J, Shen H*. Phthalates exposure of the Chinese reproductive age couples and their effect on male semen quality, a primary study. Environ. Int. 2012, 42,78-83
17. Zhao B, Liu F, Liu S, Niu J, Guo F, Sun X, Shen H*. A case-control study of the association between human exposure to selected chlorinated pesticides and primary hepatocellular carcinoma. Epidemiology 2011, 22, S145
Before 2010
18. Kristina Voigt, Rainer Brueggemann, Hagen Scherb, Heqing Shen, Karl-Werner Schramm. 2010. Evaluating the relationship between chemical exposure and cryptorchidism by discrete mathematical method using PyHasse software. Environ. Model. Softw. 25:1801-1812.
19. ？smet ？ok, Menekse Keski Donmez, Mine Uner, Erkan Demirkaya, Bernhard Henkelmann, Heqing Shen, Jarmila Kotalik, Karl-Werner Schramm. 2009. Polychlorinated dibenzo-p-dioxins, dibenzofurans and polychlorinated biphenyls levels in human breast milk from different regions of Turkey. Chemosphere 76: 1563-1571.
20. Konrad Krysiak-Baltyn, Niels Erik Skakkeb？k, Jorma Toppari, Thomas Jensen, Helena Virtanen, Karl-Werner Schramm, Heqing Shen, Terttu Vartiainen, Hannu Kiviranta, Olivier Taboureau, S？ren Brunak, Katharina Main. 2009. Country-specific chemical signatures of persistent environmental compounds in breast milk. Int. J. Androl. 32:1-9.
21. Heqing Shen, Bernhard Henkelmann, Walkiria Levy, Adam Zsolnay, Peter Weiss, Gert Jakobi, Manfred Kirchner, Wolfgang Moche, Katharina Braun and Karl-Werner Schramm. 2009. Altitudinal and chiral signature of persistent organochlorine pesticides in air, soil, and spruce needles (Picea abies) of the Alps. Environ. Sci. Technol. 43:2450-2455.
22. ？smet ？ok, Menekse Keski Donmez, M. Hakan Sat？ro？lu, Batu Ayd？nuraz, Bernhard Henkelmann, Heqing Shen, Jarmila Kotalik, Karl-Werner Schramm. 2008. Concentrations of polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and dioxin-like PCBs in adipose tissue of infertile men. Arch. Environ. Contam. Toxicol. 55:143-152.
23. Heqing Shen, Katharina M. Main, Anna-Maria Andersson, Ida N. Damgaard, Helena E. Virtanen, Niels E. Skakkebaek, Jorma Toppari, and Karl-Werner Schramm. 2008. Concentrations of persistent organochlorine compounds in human milk and placenta are higher in Denmark than in Finland. Hum. Reprod. 23:201-210.
24. Heqing Shen, Katharina M Main, Helena E Virtanen, Ida N Damggard, Anne-Maarit Haavisto, M Kaleva, KA Boisen, Ida M Schmidt, Marla Chellakooty, Niels E Skakkebaek, Jorma Toppari, Karl-Werner Schramm. 2007. From mother to child: Investigation of prenatal and postnatal exposure to persistent bioaccumulating toxicants using breast milk and placenta biomonitoring. Chemosphere 67:256-262.
25. Mart Simm, Ott Roots, Jonne Kotta, Ain Lankov, Bernhard Henkelmann, Heqing Shen, Karl-Werner Schramm. 2006. PCDD/Fs in sprat (Sprattus sprattus balticus) from the gulf of Finland, the Baltic Sea. Chemosphere 65:1570-1575.
26. Ida N Damgaard, Niels E Skakkeb？k, Jorma Toppari, Helena E Virtanen, Heqing Shen, Karl-Werner Schramm, J？rgen H Petersen, Tina K Jensen, Katharina M Main and the Nordic Cryptorchidism. 2006. Study group, Persistent pesticides in human breast milk and Cryptorchidism. Environ. Health Persp. 114:1133-1138.
27. Heqing Shen, H.E. Virtanen, Katharina M. Main, M. Kaleva, A.M. Andersson, Niels E. Skakkeb？k, Jorma Toppari and Karl-Werner Schramm. 2006. Enantiomeric ratios as an indicator of exposure processes for persistent pollutants in human placentas. Chemosphere 62:390-395.
28. H. Shen, K.M. Main, M. Kaleva, H. Virtanen, A.-M. Haavisto, N.E. Skakkebaek, J. Toppari and K.-W. Schramm. 2005. Prenatal organochlorine pesticides in placentas from Finland: Exposure of male infants born during 1997–2001. Placenta 26:512-514.
29. Liangmo Zhou, Mengyan Nie, Qinghai Wang, Daoqian Zhu, Heqing Shen. 1999. Enthalpy-entropy compensation effect in gas chromatographic enantiomeric separation. Ch. J. Chem. 17:363-376.
30. Heqing Shen, Qinghai Wang, Daoqing Zhu, Liangmo Zhou. 1999. A study of a molecular mechanics field used in simulating enantiorecognition. Ch. Chem. Letters 10:415-418.
31. Duan Zhang, Zhanguo lu, Heqing Shen, Liangmo Zhou, Wenshen Guo. 1997. The asymmetrical reduction of 1-4’-hydroxyphenyl-1-butanone complexed with solid l-cedrol, Ch. J. Synthetic Chem, A5:559 .
32. Heqing Shen, Qinghai Wang, Daoqing Zhu, Liangmo Zhou. 1998. Study of four pentylated α-, β-cyclodextrin chiral stationary phases on capillary gas chromatography. Ch. J. Anal. Chem. 26:211-214.
33. Heqing Shen, Qinghai Wang, Daoqing Zhu, Liangmo Zhou. 1998. Study on 2,6-Dipentyl-β-cyclodextrin as a stationary phase in capillary gas chromatographic separation of enantiomers. J. Inst. Anal. 17:45-46.
Heqing Shen, Qinghai Wang, Daoqing Zhu, Liangmo Zhou. 1997. Molecular modeling method and its applications in chiral recognition mechanism. Ch. J. Anal. Chem. 25:110-114.

承担科研项目情况(研究经费)：
育龄男性全氟烷烃类化合物暴露和精子DNA甲基化关系研究 2012.1-2015.12
用胶质纸尿片采集尿液作为婴幼儿易代谢内分泌干扰物测定的可行性研究 2010.11-2012.11
环境污染物的人群暴露与健康 2009.04-2012.04