杨云青教授
发布时间:2012-05-03 浏览次数:
分子药物研究所兼职教授,博士生导师.
联系方式:
电话:办公室:(0592)218-7230
实验室:(0592)218-0372
手机:(86)**
电邮:jamesyang@xmu.edu.cn
教育背景:
美国国立卫生研究院博士后(9/1994-12/1996)
美国纽约哥伦比亚大学生化和分子生物物理系
生物化学博士(9/1988-9/1994)美国得克萨斯州休斯顿大学生化和生物物理科学系
英语文凭(9/1984-8/1985)上海科技大学科技干部进修学院
微生物学学士(2/1978-2/1982)厦门大学生物学系
工作经历:
教授/博士生导师(3/2006–现在)厦门大学生命科学学院生物医学科学系
研究员ResearchOfficer(12/2001-12/2005)/研究助理教授(12/1998–12/2001)香港大学分子生物研究所/生理系
研究科学家AssociateResearchScientist(1/1997-12/1998)美国纽约哥伦比亚大学生化和眼科系
助研/助教(9/1988-8/1994)美国得克萨斯州休斯顿大学生化和生物物理科学系
助理工程师(2/1982-8/1988)广州市微生物研究所
科研课题和奖项:
1.APSNAward,3rdWorldCongressofNephrology,Singapore,2005
2.BestAbstractAward,InternationalSocietyofNephrology2004ConferenceonPreventionofProgressionofRenalDisease
3.PfizerGlobalResearchandDevelopmentgrant(PrincipalInvestigator),Thepolyolpathwayindiabeticnephropathy.HK$273,000,May2004–April2005
4.HongKongResearchGrantCouncilgrant(PrincipalInvestigator),Thepolyolpathwayasathriftypathwaypromotingenergystorage.HK$1,387,800,Sept.2003–Aug.2006
5.HongKongResearchGrantCouncilgrant(PrincipalInvestigator),Theroleofosmoticresponseelementbindingproteininosmoregulation.HK$800,400,Sep2000-Aug2003
6.HongKongResearchGrantCouncilgrant(Co-Investigator),Molecularbasisofalcohol-inducedbirthdefects,thecriticalroleofPax6.HK$1,203,000,Sept.2003–Aug.2006
7.RGCDirectAllocation(PrincipalInvestigator),Thepolyolpathwayinagouti-inducedlipogenesisandobesity.HK$120,000,Aug.2002–Sept.2003
8.SeedFundingforBasicResearchgrant(PrincipalInvestigator),Effectsofkidney-specific
overexpressionofaldosereductaseonurine-concentratingmechanism.HK$120,000,Feb.2002–Jan.2003
9.CRCGgrant(PrincipalInvestigator),Thecontributionofaldosereductasetothepathogenicdevelopmentofdiabeticnephropathy,HK$120,000,May2000-April2001
10.CRCGgrant(PrincipalInvestigator),Theroleofpolyolpathwayinsenilecataractdevelopmentandaging.HK$120,000,July1999–June2001.
11.NIH/NEIPostdoctoralFellowship(NEIEY07105),ColumbiaUniversity,1994-1995
近年论文与著作:
论文:
1.Yang,JY*,Tam,WY,Tam,S,Guo,H,Wu,X,Li,G,Chau,JF,Klein,JD,Chung,SK,Sands,JM,Chung,SS(2006:Geneticrestorationofaldosereductasetothecollectingtubulesrestoresmaturationoftheurineconcentratingmechanism.Am.J.PhysiolRenalPhysiol291:F186-F195.*通信作者
2.Wang,Y.,B.C.B.Ko,J.Y.Yang*,T.T.L.Lam,Z.Jiang,J.Zhang,S.K.ChungandS.S.MChung(2005)Transgenicmiceexpressingdominant-negativeOREBPinlensexhibitfibercellelongationdefectassociatedwithincreasedDNAbreaks.J.Biol.Chem.280:19986-91.*通信作者
3.Lam,A.,B.C.BKo,S.Tam,R.Morris,J.Y.Yang,S.K.Chung,andS.S.M.Chung(2004)Osmoticresponseelementbindingprotein(OREBP)isanessentialregulatorofurineconcentratingmechanism.J.Biol.Chem.279:48048-54.
4.Kuang,K.,Y.Li,Z.Wang,J.Li,Q.Wen,Y.Yang,P.Iserovich,P.S.Reinach,J.Sparrow,F.P.J.DieckeandJ.Fischbarg(2001)CornealendothelialNKCC:molecularidentification,location,andcontributiontofluidtransport.Am.J.Physiol.CellPhysiol.,280:C491-C499.
5.Ko,B.C.B,C.W.Turck,K.W.YLee,Y.YangandS.S.MChung(2000)Purification,identificationandcharacterizationofanosmoticresponseelementbindingprotein(OREBP).Biochem.Biophys.Res.Comm.,270,52-61.
6.Kelz,M.B.,J.R.Kuszak,Y.Yang,W.Ma,C.Steffen,K.Al-Ghoul,Y.J.Zhang,J.S.Chen,E.J.NestlerandA.Spector(2000)Delta-FosBinducedcataract.Invest.Ophthalmol.Vis.Sci.41,3523-3538.
7.Yang,Y.,A.Spector,W.Ma,R.-R.Wang,K.LarsenandN.J.Kleiman(1998)Theeffectofcatalaseamplificationonimmortallensepithelialcelllines.Exp.EyeRes.67,647-656.
8.Spector,A.,J.R.Kuszak,W.Ma,R-R.Wang,Y-S.HoandY.Yang(1998)Theeffectofphotochemicalstressuponthelensesofnormalandglutathioneperoxidase-1knockoutmice.Exp.EyeRes.67,457-471.
9.Spector,A.,Y-S.Ho,R-R.Wang,W.Ma,Y.YangandW-C.Li(1998)EvaluationoftheantiperoxidedefensesystemofthelensutilizingGSHperoxidasetransgenicsandknockouts.InMontagnier,L.,R.OlivierandC.Pasquier,eds.OxidativeStressinCancer,AIDS,andNeurodegenerativeDiseases.pp.507-515.MarcelDekker,Inc.,NewYork.
应邀演讲:
1.Yang,J.Y.Hypertonicity-inducedrenalDNAdamageandapotosisandosmoprotectionbyaldosereductase.(Invitedspeech)2005WorldDNAandGenomeDay,April,2005,Dalian,China.
会议文摘和待发表文章
2.Tam,W.Y.,J.Y.Yang*,G.H.Li,.X.C.Wu,F.L.Chau,S.Tam,J.D.Klein,S.K.Chung,J.M.SandsandS.S.M.Chungand(2005)Possiblemolecularmechanismsforaldosereductasedeficiencyinduced
diabetesinsipidus.(Oralpresentationtothe3rdWorldCongressonNephrology,2005,Singapore,APSNAward)Nephrology,10(supplement),344.
3.Yang,J.Y.*,X.C.Wu,F..L.Chau,I.Y.Szeto,SidneyTam,P.J.Oates,S.K.ChungandS.S.M.Chung(2005)Thepolyolpathwayisaglucosemetabolicshuntpromotinglipidsynthesis.*corresponding.
4.Yang,J.Y.,H.Guo,X.C.Wu,F.L.Chau,S.Tam,S.K.ChungandS.S.M.Chung(2004)Kidneylocaldeficiencyofaldosereductaseissufficienttocausepolyuriaandpolydipsiainmice.OrallypresentedandwononeoftheBestAbstractAwardsattheInternationalSocietyofNephrology
2004ConferenceonPreventionofProgressionofRenalDisease.*corresponding.
专业学会会籍:
美国糖尿病学会
版权所有?华侨大学生物医学学院
